대한예방의학회:학술대회논문집
The Korean Society for Preventive Medicine (KSPM)
- 기타
Domain
- Health Sciences > Clinical Medicine
1999.10a
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In a case-control study to evaluate the factors involved in the development of hepatocellular carcinoma, polymorphisms of the p53 gene were compared in 68 cases mostly infected with hepatitis C virus (HCV) and 68 controls matched for sex and age: DNA from peripheral blood leukocytes was analyzed by the polymerase chain reaction-single strand conformation polymorphism method and direct sequencing. Polymorphisms analyzed were those in exon 4 (CCC vs. CGC, Pro vs. Arg at codon 72, Al allele vs. A2 allele), intron 2 (C vs. G at nucleotide 38, Al vs. A2), intron 3 (C vs. A at nucleotide 65, Al vs. A2; absence and presence of 16 base pair repeat at nucleotides 24 to 39, Al vs. A2), intron 6 (A vs. G at nucleotide 62, Al vs. A2) and intron 7 (C and T vs. T and G at nucleotides 72 and 92, Al vs. A2). A significantly higher frequency of the allele for CCC (Pro, Al) at codon 72 of exon 4 was found in cases (39%) than in controls (26%) (p<0.05). Highly significant linkage of the polymorphisms in exon 4, intron 2, intron 3 and intron 7, and between the intron 3-16 bp duplication and polymorphism in intron 6 also was found. Matched Fair analysis showed significantly higher frequencies of certain haplotypes (1-1-1-1-2-2 or 1-1-2-1-2-1 for exon 4, intron 2, intron 3, the intron 3-16 bp duplication, intron 6 and intron 7) in cases than in controls (p=0.014, OR=2.27, 95% CI= 1.08-5.12). No preference of specific p53 polymorphisms for specific HCV genotype was detected. These findings suggest that in hepatocarcinogenesis mainly due to HCV infection, genetic factors may be involved and that genetic markers can serve as predictors of a high-risk group for hepatocarcinogenesis.
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Kim Suk-Il;Kang Hyung-Gon;Jeon Yoo-Young;Kim Jae-Sun;Ban Hae-Sook;Choi Myeng-Rye;Kim Jong-Man 27
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Lee Kyung-Jong;Jang Jae-Yeon;Park Jae-Beom;Joo In-Soo;Kim Jae-Ill;Kim Byoung-Suck;Kim Jong-Koo;Cheong Ho-Keun 49
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Sohn Hae-Sook;Chun Jin-Ho;Lee Jong-Tae;Park Soo-Kyung;Jeong Kui-Woon;Urm Sang-Hwa;Kim Sung-Jun 66
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Park Jong-Ku;Kim Ki-Soon;Kim Chun-Bae;Lee Tae-Yong;Lee Kang-Sook;Lee Duk-Hee;Lee Sun-Hee;Jee Sun-Ha;Suh Il;Koh Kwang-Wook;Ryu So-Yeon;Park Kee-Ho;Park Woon-Je 71
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Kim K.S.;Park J.K.;Kim C.B.;Ryu S.Y.;Lee T.Y.;Lee K.S.;Lee D.H.;Lee S.h.;Jee S.h.;Suh I.;Koh K.W.;Park K.H.;Park W.J. 73
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Lee J.M.;Ichiba M.;Lee K.H.;Ha M.N.;Choi I.M.;Lee S.Y.;Ihm H.J.;Choi J.W.;Hwang E.S.;Cho S.H.;Kang D.H. 94
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Kim Mi-Kyung;Kim Ji-Young;Lee Won-Chul;Choi Kyu-Yong;Park Kye-Wol;Meng Kwang-Ho;Lee Yang-Cha 106
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Kim Hyun-Ja;Chang Ho-Soon;Kim Mi-Kyung;Choi Bo-Youl;Park Kyung-Nam;Choi Ho-Soon;Lee Sang-Sun 118
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Kang Dae-Hee;Park Sue-Kyung;Yoo Keun-Young;Chang In-Jin;Chung Hyung-Hwa;Shin Sang-Gu;Ahn Sei-Hyun;Noh Dong-Young;Choe Kuk-Jin 134
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Park Sue-Kyung;Yoo Keun-Young;Lee Seong-Jun;Lee C.K.;Ahn Se-Hyun;Noh Dong-Young;Choe Kuk-Jin;Kang Dae-Hee 135
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Chun Jin-Ho;Kim Hak-Joon;Sohn Hae-Sook;Urm Sang-Hwa;Park Soo-Kyung;Yu Byung-Chul;Lee Jong-Tae 150
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Chun Byung-Yeol;Sin Kam;Ahn Moon-Young;Lim Pu-Tol;Bae Yun-Taek;Kang Yune-Sik;Kim Keon-Yeop;Lee Young-Sook;Park Ki-Soo;Son Jae-Hee;Lee Sang-Won;Oh Hee-Sook 152
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Kang Weechang-Kang;Lee Sang-Il;Lee Moo-Song;Kang Young-Ho;Gu Hui-Jo;Lee Young-Jo;Noh Meang-Suk 177
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Noh Maeng-Suk;Lee Young-Jo;Kang Wee-Chang;Lee Sang-Il;Lee Moo-Song;Kwak Min-Jeong;Lee Seok-Ho;Choi Ji-Yoon 179
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Lee Seok-Ho;Yoo Keun-Young;Choi Ji-Yoon;Kang Wee-Chang;Noh Meang-Suk;Lee Young-Jo;Kwak Min-Jeong 181
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Ahn Hyun-Cheol;Kim Yong-Bae;Lee Gap-Soo;Hwang Kyu-Yoon;Lee Sung-Soo;Ahn Kyu-Dong;Lee Byung-Kook 189
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Kim Joon-Youn;Shin Hai-Rim;Kim Jung-Il;Kim Doo-Hee;Choi Suk-Ryol;Seoh Jung-Il;Hong Young-Seoub;Kim Sung-Ryul;Roberts Norman B. 196
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Korean Research Group for Cardiovascular Disease Prevention and Control Korean Research Group for Cardiovascular Disease Prevention and Control 198
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Park Wee-Hyun;Chun Byung-Yeol;Jun Jae-Eun;Cho Yong-Keun;Chae Shung-Chull;Lee Young-Sook;Son Jae-Hee 200
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Koo Jung-Wan;Lee Won-Chul;Han Ji-Youn;Hwang In-Young;Park Cho-Hyun;Chung In-Sik;Paik Nam-Sun;Kim Hoon-Kyo 238
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Moon Ok-Ryun;Yi Sang-Gu;Ha Ho-Soo;Lee Sin-Jae;Yoon Tae-Ho;Lee Yoon-Hyeon;Kim Nam-Soon;Jeong Bak-Keun;Choi Soon-Ye;Whang Kyung-Hwa;Wen Yong;Piao Song-Lin;Jhang Jing-Ho 242
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Chun Ki-Hong;Lee Soon-Young;Lee Yun-Hwan;Song Mi-Sook;Park Ju-Won;Lee Yeon-Kyung;Paek Kyung-Won 244
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Jo So-Yeon;Choe Jung-Myeong;Choe Bong-Geun;Song Jong-Il;Yun Tae-Yeong;Park Sun-Yeong;Yu Dong-Jun;Kim Eun-Mi 265
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Yun Sung-Ho;Kang Young-Ah;Kim Sang-Kyu;Hwang Tae-Yoon;Lee Kyeong-Soo;Kim Seok-Beom;Kang Pock-Soo 273
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Kim Joon-Youn;Jung Kap-Yeol;Kim Doo-Hee;Kim Jung-Il;Kim Sang-Woo;Park Tae-Hyuk;Kim Won-Sul;Kim Dong-Il 281
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Park Sue-Kyung;Yoo Keun-Young;Lee Seong-Jun;Lee C.K.;Ahn Se-Hyun;Noh Dong-Young;Choe Kuk-Jin;Kang Dae-Hee 317
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Lee Soon-Young;Yun Yeon-Sook;Lee Cheol-Ho;Kim Seon-Woo;Kim Ki-Whan;Kim Young-Ok;Park Ju-Won;Song Jie-Young 318
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Rhee Jung-Ae;Sohn Seok-Joon;Shin Jun-Ho;Kweon Sun-Seog;Im Jeong-Soo;Kim Sang-Yong;Shin Min-Ho;Lee Su-Jin 326
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Jeong Kui-Won;Urm Sang-Hwa;Kim Sung-Jun;Yu Byeng-Cheul;Choi Soon-Seok;Jeong Soo-Jin;Bae Ki-Taek 330
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Choi Jin-Su;Sohn Seok-Joon;Park Kyeong-Soo;Kweon Sun-Seog;Im Jeong-Soo;Kim Sang-Yong;Shin Min-Ho;Lee Su-Jin 337
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Moon Ok-Ryun;Kim Chang-Yup;Jo Hong-Jun;Kim Yoon;Kim Su-Young;Lee Young-Sung;Song Yoon-Mi;Sung Woo-Sun;Kim Nam-Soon 341
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Park Jong-Ku;Kim Chun-Bae;Kang Myung-Guen;Lee Sung-Soo;Kim Dal-Rae;Choi Seo-Young;Han Chang-Ho;Kim Min-Gi;Cho Young-Jin 347
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