Let R be a commutative ring, M be a Noetherian R-module, and N a 2-absorbing submodule of M such that r(N :R M) = 𝖕 is a prime ideal of R. The main result of the paper states that if N = Q1 ∩ ⋯ ∩ Qn with r(Qi :R M) = 𝖕i, for i = 1, . . . , n, is a minimal primary decomposition of N, then the following statements are true. (i) 𝖕 = 𝖕k for some 1 ≤ k ≤ n. (ii) For each j = 1, . . . , n there exists mj ∈ M such that 𝖕j = (N :R mj). (iii) For each i, j = 1, . . . , n either 𝖕i ⊆ 𝖕j or 𝖕j ⊆ 𝖕i. Let ΓE(M) denote the zero-divisor graph of equivalence classes of zero divisors of M. It is shown that {Q1∩ ⋯ ∩Qn-1, Q1∩ ⋯ ∩Qn-2, . . . , Q1} is an independent subset of V (ΓE(M)), whenever the zero submodule of M is a 2-absorbing submodule and Q1 ∩ ⋯ ∩ Qn = 0 is its minimal primary decomposition. Furthermore, it is proved that ΓE(M)[(0 :R M)], the induced subgraph of ΓE(M) by (0 :R M), is complete.