본 실험은 각각의 마취방법이 체성감각유발전위 (SEPs) 파형에 미치는 영향을 알아보고 SEP의 측정에 적절한 마취방법을 찾고자 시행하였다. 임상적으로 건강하고 크기와 나이가 비슷한 다섯 마리의 잡종견을 대상으로 SEPs를 측정하고 각각의 측정값을 분석하였다. SEPs측정을 위해 후 경골신경을 자극하였고 요추 5-6번 사이에서 channel 1의 LP1과 LN1, 흉추 11-12사이에서 channel 2의 TP1, TN1을 기록하였다. 실험에 사용한 마취방법 중. Acepromazine + Thiopental Na + Isoflurane, Acepromazine + Propofol + Isoflurane, Diazepam + Xylazine, Xylazine + Ketamine, Acepromazine + Propofol infusion, 및 Propofol infusion등의 방법만이 SEPs측정이 가능하였고, 파형은 명확하였으며, 측정에 요구되어지는 일정 시간인 25분 이상 동안 마취 유지가 가능하였다. 또한 각 마취군에서의 SEPs 파형을 Acepromazine + Thiopental Na + Isoflurane군과 비교해 보았을 때 latency의 경우, Acepromazine + Propofol + Isoflurane군의 ST(stimulating point)-LN1, SP-TP1, Diazepam + Xylazine 군의 Chl-Ch2, Xylazine + Ketamine군의 Chl-Ch2, Acepromazine + Propofol infusion군의 ST-LP1와 Chl-Ch2에서 부분적으로 유의적인 차가 있었다. Conduction velocity의 경우, Acepromazine + Propofol + Isoflurane군의 ST-LN1, Diazepam + Xylazine군의 Chl-Ch2, Xylazine + Ketamine군의 Chl-Ch2, Acepromazine + Propofol infusion군의 ST-LP1, 그리고 Propofol infusion군의 ST-LN1의 측정값에서 유의적인 차가 있었지만 전반적으로는 전체적인 파형의 유의적인 변화는 없었다. 이상의 결과를 토대로 SEPs 측정시 흡입마취로는 Acepromazine + Thiopental + Isoflurane과 Acepromazine + Propofol + Isoflurane, 주사마취로는 Diazepam + Xylazine과 Xylazine + Ketamine, 점적마취로는 Acepromazine + Propofol infusion과 Propofol infusion 방법이 사용 가능한 것으로 확인되었다.

본 연구에서는 개에서 전침술이 isoflurane 마취시의 MAC 및 심맥관계에 미치는 영향 및 전침처치시간에 따른 차이에 대하여 조사하였다. 임상적으로 건강한 19개월령, 수컷 비글견 8두를 사용하였다. 대조군, 비혈위 전기자극군, 30분간 전침군(SP-6) 및 연속 전침군(SP-6C)으로 나누어 군 당 5두씩 무작위로 최소 7일간의 휴약기를 두며 실험에 사용하였다. 전침처치는 SP-6 혈위에 2-4V 20Hz로 30분간(SP-6)또는 MAC의 측정이 끝날 때 까지 연속적으로(SP-6C) 실시하였다. SP-6C군에서의 전침자극시간은 70-90분이었다. Isoflurane으로 마취를 유도한 후 전침을 실시하고 MAC와 cardiovascular parameters를 측정 하였다. 전침 후 MAC는 SP-6 및 SP-6C 군에서 각각 21.3$\pm$8.0% 및 16.1$\pm$4.6% 씩 유의적으로 저하되었으나(p<0.05) 전침시간에 따른 유의성은 없었다. 그러나 대조군과 비혈위 전기자극군에 비해서는 유의적으로 저하되었다(p<0.05). 전침처치 후 심맥관계에는 유의성 있는 변화가 인정되지 않았다. 이상의 결과로 보아, SP-6혈위에 대한 전침은 개에서 심맥관계의 부작용을 최소화하면서isoflurane의 MAC을 유의성 있게 감소시켰으며, 이러한 효과는 30분간의 전침자극으로 충분하다고 사료된다.

The frequencies of gamma-ray-induced micronuclei (MN) in cytokinesis-blocked (CB) lymphocytes at several doses were measured in three donors of Korean native cattle and Korean native goat. Measurements performed after irradiation showed a dose-related increases in MN frequency in each of the donors studied. When analysed by linear-quadratic model the line of best fit was cattle : y : 0.1016D +$0.0118D^2$+0.0147, goat : y = 0.1353D +$0.0043D^2$+0.0087 (y : number of MN/CB cells and D = irradiation dose in Gy). The relative sensitivity of goat lymphocytes compared with cattle lymphocytes was estimated by best fitting linear-quadratic model based on the radiation-induced MN data over the range from 0 Gy to 4 Gy. In the case of MN frequency with 0.05, 0.1, 0.2, 0.4 and 0.8, the relative sensitivities of goat lymphocytes were 1.106. 1.166. 1.140, 1.069 and 0.976 respectively. Our in vitro radiobiological study confirmed that the cytogenetic response obtained in blood from cattle and goat can be utilized for application in environmental studies.

본 연구에서는 개의 Helicobacter 균속 감염을 비침습적 방법으로 진단하기 위해 분변을 시료로한 PCR 검사법을 확립하고 그 효능을 검정하고자 하였다. 분변 PCR 분석은 분변에서 채취된 DNA에서 Helicobacter 균속의 16S RNA의 특이적인 영역에 반응하는 primer를 이용해 수행하였다. 분변 PCR분석법에 의한 결과와 위조직 검사 법 결과를 비교해 본 결과 분변 PCR분석법은 높은 특이도 (100%)와 민감도(96%)를 나타내었다. 도한 확립된 분볍 PCR분석법을 이용해 국내 애완결들의 위내 Helicobacter 균속 감염율을 조사한 결과 감염율이 72.1%로 나타났다. 이상의 결과 본 연구에서 확립한 분변 PCR 분석법은 개의 Helicobacter 균 감염을 진단할 수 있는 새로운 비침습적 진단방법으로 이용될 수 있으리라 사료된다.

Selectin은 조직 염증반응의 초기화에 관여하는 결합 단백질이며, 맥관내피에서 백혈구의 rolling과 tethering을 매개한다. 따라서 selectin inhibitor를 이용하여, 이들 selectin의 수용체인 sLex 에 대한 block을 유도함으로서 염증반응의 초기화를 억제할 수 있다는 가정하에, 본 연구에서는 장기이식 후 reperfusion에서 발생하는 손상에 대한 selectin inhibitor의 효과를 알아보았다. Beagle 견을 사용하여 신장이식을 실시하였다 공여 신장은 60분의 warm ischemia를 유도한 후 UW solution으로 관류하고 24시간동안 냉장보관하여 자가이식하였으며, 반대쪽 신장은 적출하였다. 술 후 7일동안 혈청 creatinine치를 측정하였다 2차실험으로, 12마리의 Beagle견을 사용하여 4시간의 reperfusion 후 조직학적 변화와 myeloperoxidase의 활성을 조사하였다. 각 실험의 대조군은 생리 식염수를,비교군은 TBC1269 (selectin inhibitor)를 신장 적출 전과 신장이식 수술 후 reperfusion 직전에 각각 투여하였다. 혈청 creatinine은 신장이식후 급격히 증가 하였으나, 두군 사이에 유의적인 차이는 없었다. 신장피질의 백혈구 침윤은, 4시간 reperfusion후 생리식염수를 투여받은 군에서 2배의 유의적인 증가를 보였다. 그러나, TBC 1269로 처리한 군에서는 백혈구의 침윤이 유의적인 억제를 보였으며, 허혈에의한 조직학적 변화도 유의적으로 적었다. 개의 신장이식 수술에서 Selectin의 차단은 warm renal ischemia에서 기인된 손상을 개선하지는 못하나, 백혈구의 침윤을 억제하므로 delayed graft function과 관련된 술 후 염증반응의 초기화를 억제하는 효과가 있는 것으로 사료된다.

질병을 유발하는 세균의 분리와 동정, 그리고 그 세균에 대한 항생제 감수성 검사는 치료에 효과적인 항생제를 선택하는 데에 있어서 중요하다 본 연구의 목적은 항생제 감수성의 경향을 알아보고 치료를 위한 효과적인 항생제 선택을 위해 세균을 동정하는 것이었다. 1999년 7월부터 2000년 9월 사이에 서울대학교 수의과대학 부속동물병원에 내원한 개로부터 실험재료를 채취하여 호기배양을 실시하였다. 피부(63개), 뇨(45개), 외이도(31개), 안결막(18개)으로부터 채취한 총 157개 시료를 이용하였다 내원한 환자의 피부, 외이도, 결막에서 가장 많이 분리된 세균은 S. intermedius였다. 내원한 환자의 뇨에서 가장 많이 분리된 세균은 E. coli 였다. 분리된 그람 양성 세균의 대부분은 ampicillin(80.6%), erythromycin(68.8%), penicillin(86.2%), tetracycline(89.2%) 에 대해 저항성을 나타내었다. 반면, 분리된 그람 음성 세균의 대부분은 ampicillin(73.4%), trimethoprim-sulfa(53.3%) 에 대해 저항성을 나타내었다 E. coli는 ciprofloxacin(6l.5%), piperacillin(69.2%) 에 대해 저항성을 나타내었다 분리 동정된 세균의 채취부위에 따른 항생제 감수성의 차이는 뇨중의 S. aureus를 제외하고는 특이할 만한 사항이 없었다.

질병에 이환된 개체로부터 이환되지 않은 개체를 구분하기 위해 사용되는 대부분의 진단검사는 판별의 기준점 (cut-off value)을 필요로 한다. ROC (receiver operating characteristic) 곡선은 이러한 목적으로 흔히 사용되고 있으며 진단의 기준점을 다양하게 변화시킬 때 진단검사의 정확도 (민감도와 특이도)를 제시해주는 지표로 활용되고 있다. 저자들은 수의학관련 연구자들이 이 방법을 효과적으로 사용할 수 있도록 EXCEL에 내장된 비쥬얼 베이직으로 binormal ROC 곡선의 최대우도비를 계산해주는 프로그램을 작성하였다. 방사선 분야의 자료와 미생물학 자료를 예제로 들어 이 프로그램의 활용성을 높이고자 하였고 이 분야에 관심이 있는 연구자는 저자에게 연락하여 이 프로그램을 얻을 수 있다.

The purpose of this study was to examine the effect of Ga-As(Gallium-Arsenide, wave length; 904 nm) infrared laser irradiation on healing of the experimentally crush injured rat sciatic nerves. The bilateral sciatic nerves of 43 adult male Sprague-Dawley rats were compressed surgically with a straight hemostat (1 mm width). The right legs of all the rats were irradiated using a 27 mW Ga-As infrared laser (laser irradiated group). The radiation procedure was administered for 3 minutes every day for 1, 3, 5, and 7 weeks in each group. Left legs were not irradiated and served as the control group. The numbers of total myelinated axon and degenerated myelin in the sciatic nerves of bilateral legs were measured and analyzed with mage analysis system in order to make a morphological analysis of the effect of the Ga-As infrared laser on injured nerves. Total number of myelinated axons was increased with time interval, especially in the 1, 3. and 5 week of irradiated group. Conversely, the number of degenerated myelin was decreased with time interval, especially in the irradiated group. The effects in the irradiated group were more pronounced than those of the control group. In conclusion, the Ga-As infrared laser irradiation is a useful adjuvant therapy to the regeneration of the peripheral nerve injury.

The effect of GnRH alone and concomitant with PMSG on the prevention of implantation. termination of pregnancy, and concentration of plasma progesterone were studied in pregnant rats. GnRH 50, 100 or 200 ug alone and concomitant with PMSG 25 or 50 IU were administered once on day 2 or 9 of gestation, respectively. Rats were autopsied on days 7 or 20. Administration of GnRH on day 2 did not result in the prevention of implantation and termination of pregnancy but resulted in termination of pregnancy administering on day 9. Administration of GnRM concomitant with PMSG on day 2 or 9 resulted in prevention of implantation and termination of pregnancy, but injection of GnRH 50 ug concomitant with PMSG 25 IU on day 9 had only one live fetus. Administration of GnRH alone and concomitant with PMSG on day 2 had no effect on the concentration of plasma progesterone determining on day 7. Administration of GnRH concomitant with PMSG on day 2 resulted in decrease of progesterone level determining on day 20 but GnRH alone was normal level. Administration of GnRH alone and concomitant with PMSG on day 9 resulted in decrease of the concentration of progesterone but was normal concentration administering GnRH 50 ug concomitant with PMSG 25 IU.

Cordyceps is reputed for its broad biological activities and as a tonic for replenishing vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the development of new type Cordyceps, the effects of the fruiting bodies of cultivated fungus of Paecilomyces japonica grown on silkworm larvae on fatigue and hematotoxicity were investigated. The antifatigue activity of dongchongxiacao (Paecilomyces japonica) was studied in mice using weight loaded forced swimming performance method. The water extract of dongchongxiacao(25 mg/kg of body weight, intraperitoneal injection at 12 and 36 hours before irradiation and 30 minute and 24 hours after irradiation) showed a significant antifatigue effect in normal mice and radiation-induced fatigue mice (p<0.0005). In the experiment on the improvement of hematotoxicity, a significant difference from the irradiated controls was seen at day 3 of the group treated with dongchongxiacao and substantial differences from the irradiated controls at day 7 was also detected.

This experiment was carried out to investigate the optimal dose of intravitreal gentamicin that decreases intraocular pressure effectively and minimizes complications in dog. After inhalation anesthesia, gentamicin was injected intravitreally into the left eyes at doses of 10, 15 and 20 mg with 1 mg dexamethasone, respectively. Sterilized isotonic saline and dexamethasone mixture into the right eyes for control. Six dogs were used in each group. Intraocular pressures were measured using applanation tonometer(Mentore, Tono-Pen) until 5 months after injection of gentamicin. Ocular examinations were performed using direct ophthalmoscopy. The ocular volumes of both eyes were measured. Intraocular pressures of eyes injected with 10. 15 and 20 mg of gentamicin were decreased significantly compared with control eyes. Severe corneal opacity and neovascularization occurred in 20 mg treated group. Intraocular hemorrhage was observed in 3 dogs of 20 mg treated group. Ocular volume was significantly decreased(p <0.05) in 20 mg treated group, compared with 10 and 15 mg treated group. It is considered that intravitreal gentamicin injection at dose of 10 mg or 15 mg decrease intraocular pressure effectively and minimize complications such as corneal opacity, hyphema and phthisis bulbus.

In 2001, eight small-sized dogs and three medium-sized dogs with or without clinical signs such as vomiting, dyspnea and enlargement of superficial lymph nodes were diagnosed as lymphoma by radiography, ultrasonography and cytology. Among them, six were female mainly over 7 years old and others were male around 4 years old. There were six cases of multicentric form lymphoma, three cases of mediastinal form, an alimentary and an extranodal form, respectively. Radiographic findings were enlarged cranial mediastinal lymph node, sternal lymph node, and tracheobronchial lymph nodes on thorax and hepatomegaly, splenomegaly, and enlarged sublumbar lymph nodes on abdomen. Ultrasonographic findings revealed enlarged abdominal lymph nodes and multifocal hypoechoic lesions on the liver. Especially, severe wall thickness of small bowel was observed in a dog with alimentary lymphoma. Three dogs were dead during chemotherapy, and three dogs were dead without any treatment. Three dogs did not return and two treated dog showed normal status. Radiography and ultrasonography, although not giving an final diagnosis for lymphoma, are useful for assessment and diagnosis of lymphoma.

Vitamin D is one of important factors involved in the regulation of bone metabolism. In osteoporosis, the therapeutic effect of vitamin D on the healing process has still been controversial. To conform the effect of $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ on osteoporosis, the change of serum calcium, serum phosphorus, serum alkaline phosphatase, bone mineral density and bone mineral content of osteoporotic tibia were examined comparatively in normal control group(positive control), CFA control(negative control), CFA+$1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.01 ug/kg group and CFA+$1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.1 ug/kg group after osteoporosis was induced by single injection of complete Freund's adjuvant(CFA) in rats. In change of serum calcium. the significantly increased value was shown on 2nd and 5th week(P< 0.05) after treatment in $1{\alpha}$, 25 dihydroxy-vitamin D$_3$ 0.01 ug/kg group and on 3rd week(P<0.05) after treatment in $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.1 ug/kg group than CFA control. In change of serum phosphorus, the significantly increased value was shown on 2nd week(P<0.05) after treatment in $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.01 ug/kg group and on 3rd and 4th week(P<0.05) after treatment in $1{\alpha}$, ,25 dihydroxy-vitamin $D_3$ 0.1 ug/kg group than CFA control. The value of bone mineral density and bone mineral content of tibia was increased in both $1{\alpha}$,25 dihydroxy-vitamin $D_3$ 0.01 ug/kg group and $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.1 ug/kg group than CFA control, and the increase rate of that was higher in $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.1 ug/kg group than $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ 0.01 ug/kg group. Considering above findings collectively, it was considered that $1{\alpha}$, 25 dihydroxy-vitamin $D_3$ was effective in preventing the complete Freund's adjuvant-induced osteoporotic decrease of bone mass.

2002년 5월 도축중 발견된 거세수소의 근육 병변에 대한 검사 의뢰가 들어왔다. 이 병변의 육안적 소견은 광범위한 근육의 지방침윤이었고, 병리조직학적 검사에서 근섬유가 지방조직에 의해 대치된 것이 관찰되었으며, 기타 염증 소견은 관찰되지 않았다. 본 증례는 골격근의 광범위한 부분이 지방조직으로 대치된 지방증(steatosis)으로 진단되어 이에 보고하는 바이다.

A 9-year-old male Yorkshire terrior with recurrent chronic otitis externa and otitis interna was referred to the Veterinary Medical Teaching Hospital of Seoul National University. Radiographic findings indicated mineralization around the right ear canal. A tan nodular mats, 1 cm in diameter. was noted near the tympanum after total ear canal ablation. Cytologically. the imprint smear of the cut surface of the mass produced clusters of cells with abundant and weakly basophilic cytoplasm, one small round nucleus and one or two nucleoli, mixed with both degenerate and non degenerate neutrophils. The location of the nuclei was eccentric, and some cells contained somewhat coarse black granules in their cytoplasms, on which the mass was diagnoted as ceruminous gland adenoma or hyperplasia associated with inflammation. Histopathologic examination of the tumor was compatible with a diagnosit of ceruminous gland adenoma. The patient is responding well to sugery and antimicrobial treatment.

Male pseudohermaphrodites is one of abnormalities of phenotypic sex and have an XY chromosome constitution and testes, but the internal or external genitalia are to some degree those of a female. We surveyed one case which were referred in Veterinary Medical Teaching Hospital of Seoul National University. When patient was purchased, its phenotype was entirely female that have female external genitalia. However, from the age of 6 months, clitoris was gradually increased to Os clitoris, and patients showed male behavior. Critical clinical sign was trauma of protruded Os clitoris. In radiographic and ultrasonographic examination, he had normal vagina and urinary bladder. In chromosome examination, he had an XY chromosome constitution. This case was performed removal of Os clitoris and ovariohysterectomy.

A 9-year-old male Maltese with foamy nasal discharge, respiratory distress, and sneezing followed by epistaxis was presented to the Veterinary Medical Teaching Hospital of Seoul National University. Radiography showed no significant findings from an open mouth view. Rhinoscopy also did not find any remarkable lesions in the nasal cavity. But when vigorously swabbing the nasal cavity, numerous cells having round nuclei, coarse reticular chromatin, one large nucleolus and distinct cytoplasmic vacuoles, which is typical for canine transmissible venereal tumor cells were collected. We thoroughly searched for any primary transmissible venereal tumor at the other areas of the body other than the nasal cavity, but found none. The patient responded well to vincristine, and the clinical signs resolved with no respiratory distress, sneezing or epistaxis.

Transmissible venereal tumor (TVT) is a contagious, sexually transmitted tumor and, in the natural setting, affects only dogs. We surveyed two cases which were serviced in veterinary medical teaching hospital of Seoul National University. Through this report we studied the method for treatment or n by chemotherapy and surgical resection. in treatment or TVT, surgical resection is not considered an effective method, but chemotherapy and radiation. In these two cases, chemotherapy was very effective and in the second case, there was no effect of surgical method. For treatment of TVT, chemotherapy was very effective, but surgical resection was not recommended.

A female, 14-year-old mixed dog weighing 4 kg and a female,8-year-old schnauzer dog weighing 6 kg showing vaginal discharges and vomiting for a few weeks were examined for the preoperative check of anterior cruciate ligament rupture and the recheck after the surgery of nephrectomy. There were no distinct abnormal signs except for the increased CBC at schnauzer dog on blood chemistry analysis. Radiographic and ultrasonographic findings were a large abdominal mass and a cyst-like hypoechogenic or anechogenic cavitary lesion on the ovary region. These findings were consistent with an ovarian cyst. Thereafter highly suspected ovarian cysts by diagnostic imaging were supported by high estrogen concentration on hormonal assay and the results of Pathologic examination as the unilateral ovarian cysts with secondary pyometra.

A female 8-year-old Pug weighing 7.3 kg and a female 10-year-old Maltese dog weighing 3.5 kg showing anorexia and vomiting for a few weeks were referred to Veterinary Medical leaching Hospital, Seoul National University. Radiographic findings were an enlarged right kidney in a pug dog and a radiopaque material on the right ureteral region lateral to the third lumbar vertebrae with indefinite right kidney contour in a Maltese dog, repectively. Excretory urography performed in a Pug dog revealed a poor opacified enlarged right kidney with absent of pelvic recesses and pelvic dilation with proximal ureteral dilation on contralateral kidney. Ultrasonographic findings were enlarged kidney with dilated pelvis and echogenic sediment within the medulla in both dogs and especially an engorged proximal ureter and a thin rim of functional renal tissue remains in a Maltese dog. Those diagnostic findings indicated high possibility of pyelonephritis and these were confirmed by pathologic examination. Radiography and ultrasonography, although not giving final diagnosis for pyelonephritis, are useful for assessment and diagnosis of pyelonephritis.

A 3-year-old intact female korean pungsan dog showing chronic intermittent vomiting and anorexia was admitted to The Veterinary Medical leaching Hospital of Seoul National University. The patient had been received antiemetics, antacids or proton pump inhibitor for these symptoms but had not been recovered yet. All results of physical examination, complete blood count, serum chemical analysis, fecal test and radiography were normal. Gastric endoscopic examination was also performed and gastritis with hemorrhage on near antrum region was detected. In PCR assay of bioptic gastric tissues for detecting Helicobacter species infection, Helicobacter heilmannii infection was confirmed. After receiving triple therapy with amoxicillin, metronidazole and omeprazole for 21 days, all symptoms were recovered and had not been occurred again. Helicobacter heilmannii also were not detected.

A patient (Pointer+Viszula mixed breed, 4 months old, male), with chief historic sign of acute vomiting, hemorrhagic diarrhea, anorexia and dyspnea during 4 days was admitted to College of Veterinary Medicine, Kyungpook National University. Necropsy findings were revealed ulcer and hemorrhage contained hemorrhagic diarrhea in gastrointestinal tract, severe emphysema and hemorrhage in the lung and kidney and cardiac hypertropy. Histopathological changes showed emphysema, hyperemia and hemorrhage in the lung, severe hyperemia, hemorrhage, hepatic vacuolation and cellular necrosis in the liver, hyperemia, hemorrhage, necrosis of tubular epithelium in the kidney, hemorrhage in cardiac muscle and hyperemia, necrosis and sloughing of epithelium in the intestine. Histopathological diagnosis was made as paraquat poisoning.

Intranasal tumors were diagnosed in 21 dogs for 5 years. Sneezing, nasal discharge, nasal bleeding were the most common clinical signs. Diagnosis was performed by blood test, histological examination, radiography, and computed tomography. Among the 27 nasal tumors, adenocarcinornas, squamous cell carcinomas, and chondrosarcomas were relatively common. Breeds with nasal tumor were shetland sheepdog, mongrel, and shiba. The dogs were treated by surgical resection, radiotherapy, chemotherapy, cryosurgery, and radiofrequency ablation. Each therapy alone was not effective, but the combination of two or more therapies had good effects on progression of tumor and made the survival time extended.

Ciliary body neoplasms are uncommon and have been described infrequently in the dog. We report successful treatment of three cases of canine ciliary body tumors that were diagnosed histologically as adenoma, adenocarcinoma, and malignant melanoma, respectively. They were presented with typical clinical signs that include glaucoma, anterior segment inflammation, and vision loss. On orbital ultrasound. very echodense masses involved in the ciliary body structure were revealed. Iridocyclectorny and enucleation were performed in lieu of attempts at orbital biopsy.