Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Antifntique Effect and Improvement of Hematotoxicity by Dongchongxiacno (Paecilomyces japonica )

누에동충하초(Paecilomyces japonica)의 항피로효과 및 조혈장해 개선효과

  • Published : 2002.09.01
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Abstract

Cordyceps is reputed for its broad biological activities and as a tonic for replenishing vital function in Chinese traditional medicines. As an attempt to obtain fundamental data for the development of new type Cordyceps, the effects of the fruiting bodies of cultivated fungus of Paecilomyces japonica grown on silkworm larvae on fatigue and hematotoxicity were investigated. The antifatigue activity of dongchongxiacao (Paecilomyces japonica) was studied in mice using weight loaded forced swimming performance method. The water extract of dongchongxiacao(25 mg/kg of body weight, intraperitoneal injection at 12 and 36 hours before irradiation and 30 minute and 24 hours after irradiation) showed a significant antifatigue effect in normal mice and radiation-induced fatigue mice (p<0.0005). In the experiment on the improvement of hematotoxicity, a significant difference from the irradiated controls was seen at day 3 of the group treated with dongchongxiacao and substantial differences from the irradiated controls at day 7 was also detected.

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References

  1. Chin J Integr Med v.14 Amelioration of aminoglycoside nephrotoxicity by Cordyceps sinensis in old patient Bao ZD;Wu ZG;Zheng F
  2. Chin Med J v.104 Effects of Cordyceps sinensis on murine T lymphocyte subsets Chen GZ;Chen GL
  3. Link Nature v.166 Cordycepin, a metabolic product isolated from cultures of Cordyceps militaris(Linn.) Cunningham KG;Manson W;Spring ES;Hutchison SA https://doi.org/10.1038/166009a0
  4. Chin J Integr Med v.12 Effect of Cordyceps sinensis on T-lymphocyte subsets in chronic renal failure Guan YJ;Hu Z;Hou M
  5. Biol Pharm Bull v.16 Polysaccharides in fungi. XXXII. Hypoglycemic activity and chemical properties of a polysaccharide from the cultural mycelium of Cordyceps sinensis Kiho T;Hui J;Yamane A;Ukai S https://doi.org/10.1248/bpb.16.1291
  6. Biol Pharm Bull v.19 Polysaccharides in fungi. XXXVI. Hypoglycemic activity of a polysaccharide(CS-F30) from the cultural mycelium of Cordyceps sinensis and its effect on glucose metabolism in mouse liver Kiho T;Yamane A;Hui J;Usui S;Ukai S https://doi.org/10.1248/bpb.19.294
  7. Arch Microbiol v.113 Ophiocordin, an antifungal antibiotics of Cordyceps ophioglossoides Kneifel H;Konig WA;Loeffler W;Muller R https://doi.org/10.1007/BF00428591
  8. Iconography of vegetable wasps and plant worms Kobayashi Y;Shimizu D
  9. Cancer Invest v.12 Growth inhibitors against tumor cells in Cordyceps sinensis other than cordcepin and polysaccharides Kuo YC;Lin CY;Tsai WJ;Wu CL;Chen CF;Shiao MS https://doi.org/10.3109/07357909409023046
  10. Am J Chin Med v.24 Cordyceps sinensis as an immunomodulatory agent Kuo YC;Tsai WJ;Shiao MS;Chen CF;Lin CY https://doi.org/10.1142/S0192415X96000165
  11. Phytotherapy Res v.11 Studies on pharmacological activities of cultivated Cordyceps sinensis Liang YL;Liu Y;Yang JW;Liu CX https://doi.org/10.1002/(SICI)1099-1573(199705)11:3<237::AID-PTR49>3.0.CO;2-2
  12. Chin Med J v.16 Antioxidation of Paesilomyces sinensis (S. pnov) Liu Y;Wu C;Li C
  13. Jpn J Pharmacol v.70 Effects of the mycelial extract of cultured Cordyceps sinensis on in vivo hepatic energy metabolism in the mouse Manabe N;Sugimoto M;Azuma Y;Taketomo N;Yamashita A;Tsuboi H;Tsunoo A;Kinjo N;Nian-Lai H;Miyamoto H https://doi.org/10.1254/jjp.70.85
  14. Chem Pharm Bull v.37 Isolation of galactosaminoglycan moiery (CO-N) from protein-bound polysaccharide of Cordyceps ophioglossoides and its effects against murine tumors Ohmori T;Tamura K;Fukui K;Kawanishi G;Mitsuyama M;Nomoto K;Miyazaki T https://doi.org/10.1248/cpb.37.1019
  15. Atlas of entomopathogenic fungi Samson RA;Evans HC;Latge JP
  16. The Final Repory of the Collaborative Research of National Sericulture and Entomology Research Institute Screening and evaluation of pharmacologically active principles from cultivated fungus of Cordyceps sp. growing on the silkworm, Bombyx mori L. Shin KH
  17. Chin Med J v.105 Effects of Cordyceps sinensis on natural killer activity and colony formation of B16 melanoma Xu RH;Peng XE;Chen GZ;Chen GL
  18. Carbohydr Res v.125 Structure and antitumor activity of an alkalisoluble polysaccharide from Cordyceps ophioglossoides Yamada H;Kawaguchi N;Ohmori T;Takeshita Y;Taneya SI;Miyazaki T https://doi.org/10.1016/0008-6215(84)85146-0
  19. J Altern Complement Med v.4 The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis Zhu JS;Halpern GM;Jones K https://doi.org/10.1089/acm.1998.4.3-289
  20. J Altern Complement Med v.4 The scientific rediscovery of an ancient Chinese herbal medicine: Cordyceps sinensis Zhu JS;Halpern GM;Jones K https://doi.org/10.1089/acm.1998.4.429
  21. 한국의 동충하초 성재모
  22. 생약학회지 v.31 눈꽃 동충하초의 약물활성 심진영;이연실;임순성;신국현;현진이;김성연;이은방
  23. 식품과학과 산업 v.32 동충하초 : 새로운 기능성식품 소재 한대석;송효남;김상희
  24. 식품과학과 산업 v.32 동충하초의 현황, 문제점 및 연구방향 한대석;송효남;김영언
  25. 서울대학교 생양연구소업적집 v.23 한국인삼의 항산화 활성성분에 관한 연구(IV). 항산화 활성 성분의 항피로 효과 한병훈;박명환;한용남;신상철