Objectives : This study aimed to validate the effect of herbal medicine intervention to relieve the symptoms of psoriasis using systematic review and meta-analysis and provide the newest reason of effectiveness of Korean medicine to psoriasis. Methods : Data were collected through electronic database including Pubmed, Cochrane CENTRAL, NDSL OASIS, Koreantk. Two experts assessed risk of bias of randomized controlled trials by Cochrane group's Risk of Bias tool after searching, reviewing and selecting papers. Data were analyzed using Review Manager(RevMan) 5.3 and Comprehensive Meta Analysis 2.0. Results : Total number of selected trials was 16 randomized controlled trials. This study evaluated the risk of bias and effectiveness of herbal medicine to psoriasis. There were high frequency uncertain in selection bias, performance bias and detection bias. In this meta-analysis, Korean medicine treatment was more effective than western medicine (ES:0.507, 95%CI:0.147-0.867) and placebo (ES:0.955, 95%CI:0.598-1.312). Conclusions : Herbal medicine intervention can be an effective for treatment in psoriasis. But enhancing levels of evidence, we must try to accumulate clinical researches of herbal medicine to psoriasis in Korea.

Background : Tinnitus is common disorder with many possible causes and a symptom of many different diseases but has no effective treatment. Approximately 20% of tinnitus patients experience the disorder to a degree that their quality of life and productivity are impaired. Objectives : 1. Through symptoms of tinnitus, we tried to find out the relationship of Heo-sil(虛實) and Jang bu byun jeung(臟腑辨證). 2. By testing THI, we tried to evaluate the quality of life between high-grade tiny noise and low-grade roar tinnitus patients group. Methods : 34 patients were recruited in this study who was ill with tinnitus. They wrote out the questionnaire about tinnitus and the tinnitus Handicap Inventory(THI). Results : 1. The vast majority of high-grade tiny noise patients are Heojeung(虛症). 2. The vast majority of low-grade roar patients are Siljeung(實症). 3. The number of patients with intermittent and persistent tinnitus is similar. 4. In high-grade tiny noise, Sin jung hyu son type(腎精虧損型) patients are less comfortable with quality of life than Bi wi heo yak type(脾胃虛弱型) patients. 5. Low-grade roar patients are less comfortable with quality of life than high-grade tiny noise atients Conclusions : Jang bu byun jeung(臟腑辨證) and Distinguishing between Heo(虛) and Sil(實) is expected to have positive effects on tinnitus treatment.

Objectives : Adenophorae Radix(AR) is the dried root of Adenphora triphylla var. japonica HARA. AR has the efficacy of clarifying lung, emitting pus, expelling wind, stopping pruitus and so on. Recently, various studies are being done about anti-oxidative, immunomodulatory and anti-inflammatory effects of AR. So, we expected AR has an availability that can improve symptoms of atopic dermatitis(AD). Methods : In this study, we measured body weight, weight of ear, thickness of ear skin and dorsum skin, symptom score, reproduction rate of splenocytes in vivo and in vitro of mouse with AD induced by DNCB. We experimented with five groups of 9 mice, such as normal group, control group, AR spread(ARS) group, AR feeding(ARF) group, AR spread&feeding(ARSF) group. Results : Control group of body weight significantly reduced and APSF group significantly increased in the first and second week. In weight of ear and thickness of ear skin and dorsum skin, control group significantly increased and ARSF group significantly decreased. In macrophotography viewpoint of dorsal skin, ARS group, ARF group and ARSF group decreased severe pigmented skin lesion, erythema and desquamation as compared with control group. Especially ARSF group showed significant drop. ARS group, ARF group and ARSF group compared to control group were improved in histopathology observation. In vitro and in vivo, treatment group of AR increased proliferation rate of splenocytes, specially in vitro significantly. Conclusions : This experiment indicates Adenophorae Radix extracts is effective on AD induced by DNCB in mice.

Objectives : Allergic contact dermatitis(ACD) is a type IV delayed hypersensitivity reaction that results from cumulative exposures and subsequent sensitization to an environmental chemical. Lonicerae Caulis(LC) can clear away heat and relieve toxin, disperse wind and heat, dredge the channel. The present study was designed to investigate the effects of LC on allergic contact dermatitis(ACD) induced by 2,4-dinitrochlorobenzene(DNCB) in mice. Methods : In this experiment, the effects of LC on changes in body weights, ear and dorsum skin thicknesses, ear weights, clinical aspects on the dorsum skin, histopathological changes, spleen/body ratio, cytokines were investigated. In addition, the effects on proliferations of splenocytes were also investigated in vitro and vivo study. Results : LC spread(SPR) group and LC spread and administered(SPR+ADM) group showed diminished ear thicknesses. In SPR+ADM group, ear weights were lowered significantly compared to contact dermatitis control(CTL) group. LC treatment diminished erythema, desquamation and keratosis which were induced by repeated painting of DNCB. In histopathological observation, spongiosis and edema were diminished in SPR and SPR+ADM group. In cytokines, SPR+ADM group were increased in IL-10, and SPR and SPR+ADM group were decreased in TNF-${\alpha}$ compared with control group. Conclusions : These data suggest that LC can decrease symptoms of ACD, then LC is useful to treat patient with ACD.

Objectives : The aim of this study is to evaluate possibility of DITI as prognosis evaluation tool of facial palsy. Methods : We investigate prognosis of facial palsy through EMR(Electronic Medical Record) of inpatient from December 2016 to June 2017. We evaluated the sex, age distribution, length of hospital stay, paralysis site, number of treatment after discharge, change of H-B Grade at entrance and exit, temperature difference of both sides of DITI, and Nerve Conduction Study(NCS) with reference to EMR recorded symptom change. Results : 1. Significant correlations were not found between DITI and House-Brackmann Grade change, NCS(%), the date of admission. 2. There was a negative correlation between NCS(%) and hospitalization period in patients with facial palsy. The higher the NCS, the faster the recovery rate of facial palsy. 3. In patients with facial palsy, the temperature difference between the two sides after the DITI image shows that the affected side tends to be lower than the normal side. Conclusions : In this study, only DITI temperature difference between both sides of face is not significant in determining the prognosis of facial palsy. Further research is needed to conduct DITI at the same time and to improve accuracy through a sufficient assessment of the degree of facial palsy.

Objectives : This study aimed to analyze the recent acupuncture clinical trial on atopic dermatitis and to suggest the plan about how to improve its quality. Methods : Data were collected through electronic database including MEDLINE. We set up the search terms for "atopic dermatitis AND acupuncture" and limited period of data within 6 years and type for RCT(Randomized Clinical Trial), SR(Systemic Review). Results : Total 5 studies were selected. Two were RCTs, and the rest were SRs. RCTs were insufficient about acupoint selection criteria and foundation. SRs both pointed out that systematic clinical trial is required. Conclusions : Based on these, we suggested the plan as follows. 1. Selection criteria - We should reevalute the participants by using diagnostic criteria and scales. 2. Selection acupoints - We should present the foundation that why we choose these acupoints. 3. Establishing acupuncture and control group - We should make control group clearly after calculating the number of participants statistically. 4. Blinding - We should propse the method, type, procedure and evaluation about randomization. 5. Evaluation scale - We should select the suitable scales for research objectives.

Objectives : The aim of this study is to review domestic clinical studies about dizziness in Korean medicine. Methods : Population key words "현훈(Hyeonhoon), 현기증(Hyeongijeung), 어지럼(Eojireom), 어지러움(Eojireoum), 실신(Silsin), 眩暈(Hyeonhoon), 眩氣症(Hyeongijeung), 失神(Silsin)" were searched on five database systems(DBpia, KISS, KMbase, NDSL, RISS) from September, 13th to September, 15th, 2016. 60 clinical studies were collected and classified by published journal, year, etiologic disease, study design, dizziness assessment tools of studies, study results, evaluation of disease pattern and process, interventions(herbal medicine and acupuncture treatment points), and number of studies which chose that prescription. Results & Conclusions : Dizziness was researched constantly since 1998 and 7 clinical stuides were issued 2007, the most. The journal which the most studies were presented was Journal of korean oriental internal medicine(12 studies over 60, 20%). Original article were 12(20.0%) and case reports were 48(80.0%) among 60 studies. BPPV was reported as a etiologic disease on 9 studies(20.45%) among 44 studies. VAS was used mainly as dizziness assessment tools of studies(26 studies over 38, 68.42%). 9 studies(15.0%) got evaluation of disease pattern and process among 60. Banhabaekchulcheonma-tang was reported as a herbal medicine prescription on 9 over 44 studies(20.45%) and ST36 was chosen acupuncture point most(24 over 45 studies, 53.33%). It doesn't have enough representativenes but has meaning to apprehend present tendency to treat dizziness in Korean medicine clinical studies.

Objectives : The purpose of this study is to analyze recent research trend on pathology of Meniere's Disease and review the results in Korean Medicine. Methods : We searched MEDLINE on the title "Meniere's Disease" and "pathology" in recent 5 years and searched OASIS with KISS on the title "Meniere's Disease". Results : We found 21 studies on MEDLINE, 9 studies on OASIS and KISS about Meniere's Disease. The results are as follow. 1. In western medicine, the pathology of Meniere's disease is supposed to be related with endolymphatic hydrops and autoimmunity. The causes of endolymphatic hydrops are studied in various viewpoints such as disorder of endolymph drainage and homeostasis abnormality of endolymph. And autoimmunity is assumed to be associated with genetic factor. 2. In Korean medicine, Meniere's disease were mainly treated with acupuncture and hebal medicine. Conclusions : Korean medicinal approaches on pathology of Meneire's disease can be significant in view of endolymphatic hydrops. And on the basis of those outcomes, much more studies have to be researched for Korean medicinal treatment of Meneire's disease.

Objectives : This study is designed for analysis of trend and curative effect of Korean medicine for idiopathic external ophthalmoplegia. Methods : Research studies related to objectives were gathered through OASIS and KTKP and analyzed. Results : 21 case reports were selected. 5 korean medicine therapies, Herb, acupuncture, moxibustion, electroacupuncture, and pharmacopuncture, were executed. Restorative herb including Bojungikki-tang was frequently used in herb therapy. Facial and cephalic acupoints and non-facial, non-cephalic acupoints which individually differ were mostly simultaneously executed as acupuncture therapy. Also, moxibustion was partly performed. Electroacupuncture was carried out to affected area with electric stimulation at the strength of 1Hz and 4Hz. Hominis placental pharmacopuncture, 0.1cc or 0.5cc for each acupoint, was injected on disease area. After analyzing number of Korean medicine treatment and period of Korean medicine treatment from 21 case reports, the recovery period of idiopathic external ophthalmoplegia, 36.6 treatment session/36.69 days, was assessed to be more than one month shorter than previously known recovery period. Number of treatment sessions and treatment period for 11 cases when pharmacopuncture or electroacupunture was applied were 10/29, 35/29.96, which was 15 days shorter in terms of treatment period and 10 times less in terms of number of treatment sessions compared to cases when pharmacopuncture or electroacupunture was not applied. Conclusions : Korean medicine treatment can be effective for recovery of idiopathic external ophthalmoplegia.

Objectives : The objective of this study is to analyze the research of Korean medicine for the treatment of sinusitis. Methods : We searched domestic journals for this analysis with the title 'Sinusitis, Rhinosinusitis, Biyeon(鼻淵)'. We searched 'KISS, OASIS, Korean traditional knowledge portal'. Results : Total numbers of searched articles are 103. We selected 14 papers; 5 systematic reviews, 9 clinical trials. Systematic reviews deal with cause, treatment, herbal medicine and acu-points of sinusitis. Clinical trials deal with treatment cases of Korean medicine which are failed to treatment of western medicine which is antibiotics and surgery. Conclusions : Positive effect of Korean medicine on sinusitis is reported but cases are less and research cases are limited. We conclude that well-designed clinical studies are needed.

Objectives : The purpose of this study is to analyze the trends of domestic experimental research of external treatment in Korean medicine and use it as a basic data to expand the therapeutic field of Korean medicine. Methods : In December 2016, two authors searched for experimental studies of external treatment in Korean medicine researches in 6 Korean databases. Results : Among the 379 researches that were initially searched, two authors reviewed 190 researches, excluding duplicate researches, and finally 11 researches were selected for the study. The target disease was confined to the skin and mucosa, and the most of selected Korean medicine was based on the literature. Conclusions : Considering the range of application of the external treatment described in the literature and the domestic market for external medicine, it is expected that the development of various external medicine using herbal medicine will be expected in the future.

Objectives : The study was done to verify the relation between early-onset androgenetic alopecia(AGA) and metabolic syndrome(MetS). Methods : Data were collected through electronic database including KoreaMed, National Assembly Library, KMBASE, NDSL, KCI, KERIS, Google Scholar, Pubmed, Cochrane CENTRAL and EBSCO MEDLINE. A total of 13 case-control studies related to the MetS of early-onset alopecia patients were used for the systematic review and meta-analysis. Risk of bias of included studies were assessed by RoBANS tool. RevMan5.3, CMA3 were used for the meta-analysis. Results : In 13 evaluated articles, most frequent bias was the participant selection bias that was found in 10 articles. Significant association between early-onset AGA and MetS was found in 10(76.9%) out of 13 articles in the systematic review. In meta-analysis, early-onset male AGA was associated with increased risk of metabolic syndrome(OR: 3.73, 95% CI:2.49 -5.61). Conclusions : AGA, particularly early -onset male AGA, is significantly associated with MetS. Therefore all patients with early onset male AGA should be suggested to take preventive treatment to reduce the risk of MetS and various problems associated with it.

Objectives : The purpose of this study is to report 20 patients who have been diagnosed with sudden sensorineural hearing loss(SSNHL) in the Korean medical hospital for last 3 years. Methods : 20 patients who have been hospitalized with a SSNHL in Korean medical hospital from June 2014 to June 2017 were analyzed by reviewing the patients' charts. Results : In the study group, Pure tone audiometry was performed in 17 patients. 3 of them showed 'Marked improvement' in pure tone audiometry. And 6 of them showed 'Slight Improvement.' On the other hand, 9 of them showed 'No response' or even got worse. However, the symptoms accompanied with hearing loss like tinnitus, aural fullness, vertigo improved most of patients. Conclusions : This study shows that the Korean medical treatment is effective in the SSNHL.

Objectives : This study was carried out to investigate the effect of Gyulpidaehwangbakcho-tang on rhinitis with nasal obstruction. Methods : We treated 18 rhinitis patients with nasal obstruction. We used the Visual Analogue Scale(VAS), and recorded the condition of patients as +++, ++, +, -. Results : After the treatments, all patients VAS of nasal obstruction was remarkably decreased. Conclusions : This study suggests that Gyulpidaehwangbakcho-tang is effective on rhinitis with nasal obstruction.

만성 비소 중독으로 의심되는 피부염 환자를 양방 치료 없이 평혈음을 기본으로 한 한약과 침 치료 등 한방 단독 치료를 통하여 제반 증상을 호전시켰음을 관찰하여 보고한다.

Objectives : The purpose of this study is to report the effect of traditional Korean medical treatment and auricular acupuncture on the patient suffered from epiphora. Methods : One patient suffering from epiphora was treated with traditional Korean medical treatment including auricular acupuncture. HRQL(Health-related quality of life) and VAS(Visual Analogue Scale) were measured and compared to evaluate its treatment effectiveness. Results : We attained results which show recovery from watery eye, pain, eye strain in symptoms and improvement on quality of life. Conclusions : In this study, traditional Korean medical treatment can be effective in obtunding symtoms and improving quaility of life for patients suffering from epiphora.

Objectives : The purpose of this study is to report the efficacy of using oriental medical treatment with Melonix Calyx Vomiting Therapy for Cholinergic urticaria patient. Methods : We experienced one case of Cholinergic urticaria patient treated with oriental medical treatment and Melonix Calyx Vomiting Therapy(MCVT). MCVT is traditional treatment, which induces vomiting by eating Melonix Calyx powder with water. To evaluate the results of this treatment, we measured the decrease of pruritus, number of wheals, redness. Decrease of pruritus, number of wheals was assessed by Urticaria Activity Score(UAS) and quality of life was assessed by Chronic urticaria quality of life questionnaire(CU-Q2oL). Results : UAS decreased from 6 to 0, and severity score of redness decreased from 3 to 0. CU-Q2oL score decreased from 78 to 23. Conclusions : This study suggests that using MCVT with oriental medical treatment is effective on Cholinergic urticaria.

Objectives : The purpose of this study is to report the efficacy of using oriental medical treatment(herbal medicine, acupuncture) with melonis Calyx Vomiting Therapy(MCVT) for trigeminal neuralgia. Methods : We experienced one cases of trigeminal neuralgia treated with oriental medical treatment and melonis Calyx Vomiting Therapy. MCVT is a traditional treatment, which induces vomiting by eating melonis Calyx powder with water. To evaluate the results of this treatment, we used the Visual Analogue Scale(VAS) and sleeping time. Results : After using MCVT with oriental medical treatment, VAS, sleeping time and clinical symptoms of the patient were improved remarkably. Conclusions : This study suggests that using MCVT with oriental medical treatment is effective on trigeminal neuralgia.

Objectives : The purpose of this study is to report the effectiveness of Gagamhwajung-hwan in five severe alopecia areata patients. Methods : This case study was conducted for five severe alopecia areata patients who visited Korean Medicine Clinic. Herbal medicine(Gagamhwajung-hwan) was prescribed to all five patients. Improvements of patients were evaluated by photographs and SALT(Severity of alopecia tool) scale. Results : According to photographs, hair loss of each patient was completely improved. SALT scale was also decreased in all five patients. Conclusions : This study shows the possibility of using Gagamhwajung-hwan to treat severe alopecia areata.

오랜 기간 치료에도 불구하고 치료에 반응하지 않았던 결절성 양진 환자에게 장내 세균 검사에 따른 Probiotics 요법과 한의학적 치료를 통해 양호한 치료 효과를 거두었다. 하지만 치료사례가 1례여서 장내 세균의 불균형과 결절성양진의 연관성을 입증하기에는 역부족이고 한의학적인 치료가 양진을 개선하는 구체적인 기전을 밝히기에는 한계가 있다. 향후 난치성 질환인 결절성 양진에 대한 다양한 치료 연구가 필요하리라 생각된다.