Objectives : The purpose of this study is to research on the characteristics of outpatients and distributions of diseases in ophthalmology, otolaryngology of Korean medicine in 2012-2016 and compare the result with previous studies. Methods : This study is based on the analysis of medical records of total 2,319 outpatients in ophthalmology, otolaryngology of Korean medicine at Kyung Hee Korean medicine hospital from January 1, 2012 to December 31, 2016. We searched on the demographic characteristics of outpatients and the distributions of diseases in order of frequency by age and sex. Then, we compared these results to previous results of papers at same hospital in 2000 and 2007. Results : The common diseases in 2012-2016 were dry eye syndrome in ophthalmology(32.14%), tinnitus and hearing loss in otology(72.69%), rhinitis in rhinology(82.20%) and laryngopharyngitis in laryngology(67.77%). The most increasing diseases in the distribution between 2004-2006 and 2012-2016 were retinopathy in ophthalmology(+366.77%), etc including the eustachian tube disorder in otology(+151.55%), olfactory disorder in rhinology(+167.50%) and laryngopharyngitis in laryngology(+126.20%). Conclusions : If we accumulate these kinds of epidemiologic studies on ophthalmology, otolaryngology of Korean medicine, it will be great help to make Korean medical preparations for the increasing diseases on these fields.

Objectives : The aim of this study is to report the effect of Capsosiphon fulvescens(Maesangi) extract(MSE) on contact dermatitis(CD). Methods : CD induced by Dermatophagoides farinae body(Dfb) in NC/Nga mice. 4% sodium dodecyl sulfate(SDS) $150{\mu}l$ and Dfb(10mg/ml) ointment 100mg were topically treated twice a week for four weeks. MSE 200 mg/kg was topically treated every 4weeks. Every week, we examined the skin lesions, weight of spleen and lymph node, epidermal thickness, production of Tumor necrosis factor-alpha($TNF-{\alpha}$) and interleukin-6(IL-6). Results : MSE reduced features of Dfb-induced skin lesions, weight of spleen and production of $TNF-{\alpha}$. MSE significantly reduced weight of lymph node, epidermal thickness, number of mast cells and production of IL-6. Conclusions : MSE may have a potential therapeutic effects for CD by suppressing allergic inflammation.

Objectives : This Study was conducted to investigate the melanin synthesis effect of Eclipta prostrata and to determine the relationship between melanin synthesis effect of Eclipta prostrata and cAMP/PKA melanin synthesis pathway. Methods : We measured melanin contents, tyrosinase activity, expression of TRPs, p-CREB in B16F10 cells cultured with Eclipta prostrata ethanol extracts(EEP). And after treatment with H89 and dibutyryl cAMP, which inhibit or promote the activation of PKA, we observed changes in melanin synthesis and tyrosinase activity stimulated by EEP. Results : EEP increased melanin synthesis by promoting the expression of tyrosinase and TRP-1. It also promoted expression of p-CREB. H89 suppresses melanogenic effect and expression of tyrosinase, TRP-1 in B16F10 stimulated by EEP. Dibutyryl cAMP promotes melanogenic effect of EEP. Conclusions : The results of this study suggest that melanin synthesis effect of EEP is related to induction of tyrosinase and TRP-1 expression through the cAMP/PKA pathway.

Objectives : In order to find out the whitening effects of Leonuri Herba, this study was designed to identify the effects and the action mechanism of LHE(Leonuri Herba extract) on Malignant melanoma cell lines. Methods : After treating LHE on the B16F10 cell-Malignant melanoma cell line-, the cell survival rate, melanin biosynthesis rate, intra&extracellular tyrosinase activity rate, SOD-like activity, tyrosinase mRNA gene expression were investigated. The results were compared with control group without LHE treatment or with positive control group treated with whitening efficacy substance. Results : B16F10 cell survival rate, melanin biosynthesis rate, and intra&extracellular tyrosinase activity were significantly inhibited depending on the concentration of treated LHE. Melanin biosynthesis rate and tyrosinase activity rate were also decreased when ${\alpha}-MSH$ was combined with LHE. In addition, the SOD-like activity was increased in a concentration-dependent manner in the treatment with the LHE, indicating signigicant activity at high concentrations, and the tyrosinase mRNA gene expression was decreased in both the LHE-treated group, the LHE and ${\alpha}-MSH-treated$ group. Conclusions : LHE seems to inhibit melanin synthesis through inhibition of tyrosinase activity and inhibition of tyrosinase mRNA gene expression. It also has the effect of promoting SOD-like activity and may be used clinically as a skin whitening agent in the future.

Objectives : The purpose of this study is to investigate the effect of laser therapy for diabetic ulcer by using methods of systematic review. Methods : In this review, PubMed, Cochrane library, Web of Science, CNKI, CiNii, J-STAGE, NDSL and OASIS were used as the search engines. The search period is from the start date of the search engine to October 3, 2016. Randomized controlled trials(RCTs) using laser therapy for diabetic ulcer were searched and extracted by two independent researchers. Risk of bias(RoB) of Cochrane was used to assess methodological quality of studies. Results : Finally, five RCTs were selected. The follow-up period ranged from 15 days to 20 weeks. InGaAlP laser, GaAlAs laser and light emitting diode(LED) were used to treat diabetic ulcer. The clinical trials used sham laser irradiation or standard treatment as control in comparison to laser therapy. The endpoints included ulcer size, rate of healing and time to healing with follow-up period. The RCTs demonstrated therapeutic outcomes with no adverse effect. Most items of RoB were unclear and methodological quality was low. Conclusions : Our analysis suggests that laser therapy has therapeutic effects for diabetic ulcer. However, more systematic and stringent clinical trials will be required.

Objectives : The purpose of this study was to investigate the treatment trend for allergic rhinitis in Korean Medicine. Methods : We conducted an online survey for Korean Medicine Doctors who were registered in the association of Korean Medicine. The questionnaire was consisted of patient characteristics, diagnosis status, treatment status, and future research needs. Results : Data from total of 396 respondents were analyzed. More than 70% of the patient came to the Korean Medicine Clinic after visiting the Western Medicine Clinic in 43.9% of the respondents. 55.6% of the respondents performed combination therapy. History taking, nasal examination, x-ray, and Korean Medicine diagnostic test were used for diagnosis. The mean duration of treatment ranged from $4.9{\pm}2.91$ to $15.2{\pm}8.45$ for pediatric and early childhood patients and from $17.5{\pm}16.15$ to $5.3{\pm}3.85$ weeks for adolescents and adult patients. The mean number of treatment times was from $9.8{\pm}7.00$ to $33.5{\pm}24.45$ for pediatric and early childhood patients and from $10.8{\pm}11.55$ to $40.4{\pm}48.18$ times for adolescents and adult patients. 64.5%, 48.0%, and 91.2% of the respondents used herbal medication in national health insurance coverage, herbal medication uninsured in health insurance and herbal prescription filled at each medical institution, respectively for pediatric and early childhood patients and 67.6%, 42.8% and 86.1% for adolescents and adult patients. 36.9% and 36.4% of respondents answered that the study of acupuncture and herbal medicine are needed preferentially. Conclusions : The results of this survey will be used to develop clinical practice guideline that reflect actual clinical practice.

Objectives : To identify whether pattern identification using nasal endoscopy for rhinitis can be applied as a tool for evaluating rhinitis in routine care setting, we performed a inter-rater reliability study on this pattern identification. Methods : Two Korean medicine doctors assessed 290 left/right nasal endoscopy photograph cases of rhinitis patients with pattern identification using nasal endoscopy. This pattern identification consist of four assessment items, nasal membrane color(pale/hyperemia), nasal membrane humidity(dryness/dampness), rhinorrhea(watery/yellow), and turbinate membrane edema(atrophic/edematous). Cohen's kappa statistic and Percentage agreement were used to evaluate the inter-rater reliability. Results : Inter-rater percentage agreement and Kappa coefficient for left nasal endoscopy photograph cases was from 'slight' to 'moderate'(% agreement: 40.00-67.59%/Kappa: 0.06-0.407). Only the agreement of 'rhinorrhea (watery/yellow)' item was moderate(% agreement: 67.59%/Kappa: 0.407). Inter-rater percentage agreement and Kappa coefficient for right nasal endoscopy photograph cases was also from 'slight' to 'moderate'(% agreement: 42.41-68.97%/Kappa: 0.109-0.465). Only the agreement of 'rhinorrhea(watery/yellow)' item was moderate(% agreement: 68.97%/Kappa: 0.465). Conclusions : It is necessary to resolve problems such as cut-off value setting, bipolar evaluation values(pale/hyperemia, dryness/dampness, watery/yellow, atrophic/edematous) and weighting items. Further rigorous studies that overcome the limitations of the current research are warranted.

Objectives : This study was designed to signpost the study of brain, intelligence and memory, while interpreting the concept of 'Chongmyeong(聰明)' neotrically and linking it to the clinic of Korean medicine. Methods : In this paper, the meaning of the word 'Chongmyeong(聰明)' is divided into two parts, intelligence and memory. We also explored the relationship between brain science and 'Chongmyeong(聰明)' based on complex system theory, cognitive science and embodied cognition. Results : Through the process of refining the concept of 'Chongmyeong(聰明)' neoterically, we proposed the new method to understand the concept of 'Chongmyeong(聰明)'. Conclusions : The concept of 'Chongmyeong(聰明)' should be interpreted not as a reductionistic viewpoint of brain science but as a viewpoint of brain science based on visual and auditory system and complex system. Human cognition is physically embodied in the environment, from the viewpoint of embodied cognition that it is constituted and formed in an interactive context with society and culture connected with the environment.

Objectives : The purpose of this study is to investigate recent clinical studies on the effect of acupuncture on hearing loss. Methods : Based on the PubMed search with the key search terms of 'hearing loss, acupuncture', dated from 2004 to 2017, 1 controlled trials, 3 case reports and 3 case series was found, and were analyzed for this study. Results : 1. The most commonly used acupoints were Shuaigu(GB8) and Fengchi(GB20). 2. The most commonly used meridians were the du channel, the gall bladder meridian of foot-shaoyang, and the triple bunner meridian of hand shaoyang. 3. Acupuncture treatment was effective for conductive and sensorineural hearing loss, especially sudden sensory neural hearing loss. 4. More clinical studies are needed to prove the effectiveness of the acupuncture on hearing loss. To be more objective on the study results, we can measure auditory brainstem response for hearing loss after acupuncture treatment.

Objectives : The purpose of this study is to report the effectiveness of Korean Medicine Treatment on 101 psoriasis patients for 6 months. Methods : Psoriasis Area and Severity Index(PASI) is used for measuring the degree of psoriasis with photos of total 101 psoriasis patients who have visited Korean medical clinic from October 11, 2013 to August 31, 2017. And we analyzed the PASI score according to gender, age, period of treatment, being used steroid or not. Results : 1. The ratio of male to female was 44.55 : 55.45. The mean age of patients was 34.65 years old(All patients were constituted with 9.9% of 10~19 year-old group, 31.7% of 20~29 year-old group, 26.7% of 30~39 year-old group, 12.9% of 40~49 year-old group, 15.8% of 50~59 year-old group and 3.0% of 60~69 year-old group). 2. PASI score was significantly higher in men than in women before treatment, but there was no significant difference of PASI score improvement after 2, 4 and 6 months treatment in both men and women. 3. PASI score improvement according to age after 2, 4 and 6 months treatment was no significant difference. 5. In initial visit, the steroid group patients were 61 and non-steroid group patients were 40. PASI score in initial visit between steroid group and non-steroid group was no significant difference. And PASI score after 2, 4 and 6 months treatment was no significant difference. Conclusions : PASI score was significantly decreased after 2, 4 and 6 months treatment compared with before treatment. PASI score improvement was significantly increased in proportion to the period of treatment.

Objectives : The purpose of this study is to report the effectiveness of Sihochunggan-tang gagambang and Gagamchengyoung-tang in the seven patients with seborrheic dermatitis. Methods : This case study was conducted for seven seborrheic dermatitis patients, who have visited Korean Medicine Clinic from 2013.10.01 to 2017.09.30. All seven patients were treated with Sihochunggan-tang gagambang and Gagamchengyoung-tang and acupucture. During taking medicine, we let them avoid bad food like fatty food and alcohol. We evaluated the symptom change through photographs and used Visual Analogue Scale(VAS) as the assessment method. Results : VAS such as skin severity of symptoms, sleep disorder, pruritus was decreased as a result of Sihochunggan-tang gagambang and Gagamchengyoung-tang and acupucture treatment in seven seborrheic dermatitis patients. Conclusions : After the treatment, the grade of VAS was decreased and most symptoms of seven patients were improved. As a result of examining VAS scores and photographs, Sihochunggan-tang gagambang and Gagamchengyoung-tang can be effective on the seborrheic dermatitis in seven cases in our study.

Objectives : The purpose of this study is to present 3 cases reports of psoriasis treated by Damwi-hwan - focused on lipid metabolic abnomarilty. Methods : We administered Damwi-hwan to three patients who showed psoriasis with lipid metabolic abnormality and evaluated the results by Psoriasis Area and Severity Index(PASI). Results : After the treatment three patients showed improvements in PASI. PASI of patient 1 changed from 15.4 to 0.4; patient 2 from 32.7 to 1.2 ; patient 3 from 7.6 to 0.6. Conclusions : The results suggest that Damwi-hwan can be an effective treatment for psoriasis who has lipid metabolic abnormality.

Objectives : The purpose of this study is to report the effect of Hwangryunhaedoktang-Gamibang on Postmenopausal Hot Flushes. Methods : This case study was done on 3 Postmenopausal Hot Flush patients who have visited Korean Medicine Clinic. Hwangryunhaedoktang-Gamibang was prescribed to all 3 patients and evaluated the symptom change through photographs and questionnaire. Investigator's Global Assessment(IGA) was used to evaluate the objective symptom and Visual Analogue Scale(VAS) was used to evaluate the subjective change. Results & Conclusions : The IGA and VAS were decreased in all patients. Most symptoms of 3 patients were improved. As a result of examining IGA, VAS scores and photographs, Hwangryunhaedoktang-Gamibang can be effective on Postmenopausal hot flush.