As the information technology including Internet not only opened the cyber world but also has evolved as a platform that enables a new generation of businesses and remolds the shape of thinking and the rules of supply chain management (SCM). By using the Theory of Constraints, which seems simple but robust to review the traditional SCM context, the paper proposes a conceptual framework to handle the SCM issues. From the strategic perspective, this paper focuses on three policy constraints: supplier-manufacturer oriented constraints, manufacturer-distributor oriented constraints, and supply chain oriented constraints. To optimize the throughput and sustain the competitiveness of supply chain members in the dynamic business environment, the companies should utilize the potential competency of information technology and consistently perform the activities of removing and/or reinforcing the constraints.