In this study, hydroxypropyl methylcellulose (HPMC) filaments were prepared by the wet spinning process, and the coagulation behaviors of HPMC dope and the morphology of wet spun HPMC filaments were investigated. THF, acetone, and iso-propanol showed a partial coagulation strength for HPMC dope though they did not produce a filament form. On the other hand, a high temperature water could coagulate the HPMC dope due to the gelation character of HPMC solution. However, the temporarily coagulated HPMC filament returned to a solution state when it came out of the coagulation bath. This problem, due to the reversible gelation behavior of HPMC, could be solved by adding salts in the water (coagulant). As the salt concentration increased in the coagulant, the coagulation strength was improved resulting in a reduced fiber forming temperature. Furthermore, ammonium sulfate was turned out to be the most effective salt to enhance the coagulation of HPMC in aqueous salt solution. The thermo-rheological measurements revealed that ammonium sulfate was the most effective in reducing the flocculation and the gelation temperatures among salts tested. The HPMC filament could be produced finally with the help of second coagulation bath containing organic solvent. Among the organic solvents, isopropanol was the best coagulant yielding the highest post drawing ratio of HPMC filament. The SEM observation indicated that the wet spun HPMC filament had irregular surface and cross section. The surface of HPMC could be smoother when the salt concentration was reduced to 8%.