1. Objective : The purpose of this study is to understand the origin, changes and composition of Soeumin's Bojungikgi-tang. 2. Methods : 1) Analyzed the context of the progressive transformation of soeumin's Bojungikgi-tang in related passages from "Donguibogam (東醫寶鑑)", "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午 本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)", "Dongmuyugo (東武遺稿)" 2) Examined the differences between the utilization of Soeumin's Bojungikgi-tang in pre-existing manuscripts according to pathological pattern and more specifically at a pathological stage. 3) Analyzed the total primary effect of the herbs as a prescriptive category, as well as the herbal properties of each component. 3. Results and Conclusions : 1) Originally Dongwon's Bojungikgi-tang was prescribed as a stomach & spleen organ tonifying medicine so it was easily applied and established as a prescription appropriate for Soeumin constitutional types with a weaker spleen organ. 2) From Gabobon(甲午本), Soeumin's Bojungikgi-tang was modified, excluding Bupleurum falcatum(柴胡), Cimicifuga heracleifolia (升麻) and substituting Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉) which are herbs appropriate for the Soeumin constitutional type. 3) In the Gabobon(甲午本), the Gegi-tang which has yang raising properties is included in the Soeumin's Bojungikgi-tang. In Sinchukbon(辛丑本), the Gegi-tang of the Soeumin's Bojungikgi-tang in the Gabobon was excluded and the Gegi-tang mutated into Hwangigyeji-tang. 4) In the Gabobon(甲午本), as the Soeumin's Bojungikgi-tang was prescribed for Soeumin disease regardless of favorable-unfavorable patterns and mild-severe patterns, the stage of the disease when to prescribe Soeumin's Bojungikgi-tang was not clarified. 5) As of the Sinchukbon(辛丑本) edition, as Soeumin's prescriptions have been obvious, the soeumin's Bojungikgi-tang was applied to Mang-yang disease with Hwangigyeji-tang and Seungyangikki-tang 6) As of the Sinchukbon(辛丑本) edition, the Soeumin's Bojungikgi-tang has been applied to parients having both exterior-heat Mang-yang disease and Greater-yin disease, at the same time. 7) As of the Sinchukbon(辛丑本) edition, finally, the Soeumin's Bojungikgi-tang formula has been established as gathering Qi and middle tonification with Panax ginseng(人蔘), Astragalus membranaceus(黃芪), keeping the spleen healthy with Artractylodes japonica(白朮), keeping the spleen strong with Angelica acutiloba(當歸), rooting the spleen with Citrus reticulata(陳皮), raising Yang and middle jiao with Teucrium chamaedrys(藿香), Ophiopogon japonicus(蘇葉), middle tonification with Glycyrrhiza glabra(甘草灸), Zingiber officinale(生薑), Zizyphus jujuba(大棗).

1. Objectives : It is very important to classify people into Sasang constitution correctly in SCM. There have been many researches for this and several tools have been developed for diagnosis of Sasang constitution. In our study, we introduce a new web application for Integrated Sasang Constitutional Diagnosis (ISCD) ${\beta}$-version and algorithm on the base of face, body shape, voice and questionnaire. 2. Development : The web application of ISCD ${\beta}$-version was designed to be used easily for subject, staffs, and oriental medical doctors. For this purpose, we developed a web-application of Integrated Sasang Constitutional Diagnosis ${\beta}$-version using mysql database, tomcat web system, JSP, JAVA, and C++ languages. 3. Current State : The ISCD ${\beta}$-version could be accessed at http://210.218.196.115/SDT/login.jsp. The ISCD ${\beta}$-version consisted of 3 parts, for staffs, subject and oriental medical doctors. The system has been managed since February 2011. Currently 7 oriental hospitals have used the system and 1,439 subjects have been diagnosed by the system. 4. Conclusion and future work : Although many researchers have tried to develop a system or an algorithm for diagnosis of subject's constitution, we could have not used the system based on objective information of human body type, characters, symptoms. In this study, we describe a web application of objective diagnosis algorithm as ISCD ${\beta}$-version. This system may help an oriental medical doctors to make a decision of Sasang constitutional diagnosis easily and correctly.

1. Objectives : In this study we derived constitutional characteristics both by using questionnaire on character and symptom and by collecting objective measurement data through face, body shape. Furthermore, by developing a program, we intend to help one's diagnosis of Sasang constitution. 2. Methods : Through November 2007 to July 2009, we obtained questionnaire, face, and body shape data of 958 constitution confirmed subjects within the age range of 10-80 from 19 oriental medical facilities in the country. According to sex, we divided the subjects into two groups as real constitution and non-constitution group respectively. We analyzed the questionnaire through chi-square test (p<.01) and facial and body shape data through unpaired T-test (p<.01). By using weight law for questionnaire and euclidean distance for body shape and face data, we expressed constitution possibility to develop a supplementary program. 3. Results : The concordance rates of constitutional diagnosis by using the program for Taeeumin, Soeumin, Soyangin are, 76.7%, 61.5%, 67.4% resulting in 69.6% in male and 64.1%, 64.7%, 65.1%, resulting in 64.7% In female respectively. New cases tested on the program showed concordance rate of 65% in male and 62% in female with real constitution. 4. Conclusion : The constitutional diagnostic program based on the face, body shape and questionnaire, may have significant meaning as a supplementary tool in the constitutional diagnosis for clinical expert.

1. Objectives : This investigation compares the subjective appetite ratings across male groups of different Sasang constitutional types. 2. Methods : We recruited 36 male participants aged 20-36 with BMI 18.5-30. The subjective appetite ratings was assessed using VAS before and after standard meal.(6 time points : 30 Minutes Pre-prandial, Immediately before Meal, 15, 30, 60, 120 Minutes Post-prandial) 3. Results : In comparison of subjective appetite ratings between Sasang constitutional types, Soyang-type showed a pattern like high appetite, high hunger, low satiety, high 'how much I can eat', Soeum-type showed a pattern like low appetite, low hunger, high satiety, low 'how much I can eat', and Taeeum-type showed a pattern like low appetite, low hunger. 4. Conclusions : The results of this study suggest that the subjective appetite ratings could be different across different Sasang constitutional types.

1. Objective : It is well-known that even if some people are born with same constitution, their symptoms can be different according to Exterior and Interior diagnosis. This study aimed to suggest different clinical symptoms according to Exterior and Interior group in individual Sasang constitution. 2. Methods : We collected 706 physiological and pathological data of subjects from August 2009 to July 2011 using case report form of Questionnaire. The Sasang constitutional diagnosis and Exterior and Interior diagnosis were conducted by Sasang constitutional experts. All data were analyzed with Chi-square test and significant p value was 0.05. 3. Results : There are different symptoms between Exterior and Interior group in Taeeumin as followed, the frequence of famine and burp, the part of sweat, brown or not in color of stool, painful or not in evacuating, the frequence of loose feces, the frequence of abdominal inflating, the costive feeling frequence after evacuating, foam in urine or not, urination times, amount of Coldness and Hotness in belly, the frequence of turning fale in face. Soeumin as followed, digestion well or not, amount of sweat in exercise, the brown or not in color of stool, the frequence of turning fale in face, athe frequence of clearness in urine and feeling hot. Soyangin as followed, amount of appetite, amount of sweat in hot weather, sweat in neck or not, the red color in urine or not, Coldness and Hotness in foot or not, amount of drinking. 3. Conclusions : We may suggest that physiological and pathological symptoms are different between exterior and interior group in individual Sasang constitution respectively.

1. Objective : The purpose of this study is to investigate the effects of TAM (Taraxacum mongolicum) on Th2 cytokine production in MC/9 mast cells. 2. Methods : The effects of TAM was analyzed by ELISA and Real-time PCR in MC/9 mast cells. Levels of IL-5, IL-13 were measured using enzyme-linked immunosorbent assays(ELISA). mRNA levels of IL-4, IL-5, IL-6, IL-13 were analyzed with Real-time PCR. 3. Results : 1) TAM inhibited the IL-4 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 2) TAM inhibited the IL-13 production significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$, $200{\mu}g/ml$. 3) TAM inhibited the IL-4 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4) TAM inhibited the IL-5 mRNA expression significantly in comparison to PI-control group at concentration of $50{\mu}g/ml$, $100{\mu}g/ml$. 5) TAM inhibited the IL-6 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 6) TAM inhibited the IL-13 mRNA expression significantly in comparison to PI-control group at concentration of $100{\mu}g/ml$. 4. Conclusions : These results indicate that TAM (Taraxacum mongolicum) has the effect of decreasing the Th2 cytokine production in the MC/9 mast cell.

1. Objectives : The purpose of this case study is to report that the general symptoms in 83 years-old female pateint with diaphragmatic hernia improved through oral administration of Taeeumjowi-tang(太陰調胃湯) 2. Methods : We considered the patient as Taeeumin, and administered Taeeumjowi-tang(太陰調胃湯) to improve chief complaints, such as general weakness, anorexia, sense of distension, dyspnea. The change of symptoms were evaluated by VAS(visual analogue score). 3. Results : The patient received hospital treatment for 4 weeks, and the chief complaints such as general weakness, anorexia, sense of distension, dyspnea improved in general 4. Conclusions : The patient with the above symptoms (general weakness, anorexia, sense of distension, dyspnea) was confirmed as diaphragmatic hernia by chest CT scan. But the patient decided not to have surgical operation. Observating the progress, we treated the patient through oral administration of Taeeumjowi-tang(太陰調胃湯), acupuncture and moxibustion treatment. And the general symptoms improved.