In the latter half of the Joseon(朝鮮) Dynasty, the medical world was encountering a great change. It is said that a large stream between the first half and the latter half of the Joseon Dynasty was a qualitative transition from official relationships to private relationships, that is, from adjustments by governmental power to contractual relationships between individuals. Doctors who can be said to be the core of the medical world became to be left in severer competition. The fact that the number of people engaged in medical practice increased to the extent that doctors had to compete with each other implies that not only demand for medical care was increasing but also that medical care was becoming social service that must be shared by all people in the Joseon Dynasty rather than by small numbers of men of power. Anyway, it seems like that, in the competition that was becoming fiercer, they tried to establish their authority in diverse methods unlike before. As an authority to determine the social positions of doctors in the latter half of the Joseon Dynasty, the government was still occupying an important position, but doctors tried to show off their medical techniques utilizing excellent teachers or books. Meanwhile, they were making efforts to improve treating skills and thereby they were contributing to the development of medical techniques although they were sometimes criticised because of radical treatment or fierce drugs. In this process, it seems like that some doctors made efforts to establish the social meaning of medicine and their identity. In the short dialogue with Hong Yangho(洪良浩), Cho Gwangil(趙光一) was presenting the image of doctors as active and subjective beings. Pointing out the fact that in the society where feudal position systems were still impregnable, even the Confucian scholars who could be considered as a leading group could not but be passive in front of the sovereign power, he emphasized the fact that doctors could practice treatment as they liked. In that he re-discovered the meaning of treating people's diseases as a professional intellectual and that he was forming a subjective sense that medical techniques are active self expression, it can be carefully said that Cho Gwangil was obtaining his identity as a doctor. In the society in the Joseon Dynasty where the position systems were still valid and the value system under Neo-confucianism(性理學) supporting the system was impregnable, this change can be thought to be small yet quite meaningful.

This study was conducted to analyze the status of the traditional medicines registered by the Chinese state as intangible cultural heritages, and of Chinese acupuncture and moxibustion registered by UNESCO as world intangible cultural heritages in 2010, in connection with the need to have Traditional Korean Medicine skills similarly registered as world intangible cultural heritage items. Since UNESCO's adoption of the Convention on the Safeguarding of Intangible Cultural Heritages in 2003, the Chinese government has pushed ahead with efforts to explore and protect intangible cultural heritage items and have them registered as world intangible cultural heritages. Thus, Benchaogangmu (本草綱目) and Huangdineijing (黃帝內經) were listed on UNESCO's Memory of the World Register while Chinese acupuncture and moxibustion were registered as world intangible cultural heritage properties. For Traditional Korean Medicine skills to be listed as world intangible cultural heritage properties, steps should be taken first to include the skills in the list of domestic intangible cultural heritage items and to make further explorations in the sector. Such efforts are also important in terms of the need to establish the legitimacy of Traditional Korean Medicines.

The purpose of this study is to introduce the historical material documents 'Kumgo'("檢考"), 'Haeyeongkumandenglok'("海營檢案謄錄"), 'Wanyeong-kumjedenglok'("完營檢題謄錄冊") which were possessed by C.V. Starr East Asian Library, University Of California Berkeley. These documents are a kinds of the coroner's inquest reports that were made out by the provincial magistrate of the Chos$\u{o}$n dynasty in the nineteenth century. The important contents of these documents consist of the murder cases include the trial records of the persons who connected with the case and the reports of the corpse, etc. Especially, 'Kumgo'("檢考") is the investigator's guide book, the outline of this book is how to investigate the murder's case and how to make out the reports. The 'Haeyeong-kumandenglok'("海營檢案謄錄") is an old book of the transcribe from the many kinds of the murder case's reports which were occurred in Whanghae province("黃海道"), 1882-1884. The book of the 'Wanyeong-kumjedenglok ("完營檢題謄錄冊") is transcribe from the text of the murder's case decisions by the provincial magistrate, in Jeonra province("全羅道"), 1837-1839. The result of this study is as follows ; These documents have the valuable material factors especially in the fields of korean old law, social, woman history. and it seems that these documents will be used in the variety fields of the human scientific researches.

Objectives : This study was aimed to review the trend of dementia clinical studies in Korean Oriental Medicine and to suggest better clinical studies. Method : We collected 26 papers on dementia clinical studies in the internet site OASIS using the keyword 'Dementia'. Then we analyzed them. Results : There were 26 clinical study papers that were published between 1996 and 2010. Observational studies account for 61% of total clinical studies, whereas experimental studies account for only 31%. Effects of treatment in experimental studies was evaluated mainly by MMSE-K and K-DRS. Treatment period of experimental studies was longer than 100days. Conclusions : High quality experimental studies like randomized clinical trial(RCT) and intervention studies which use syndrome differentiation(辨證) have not yet been published. It is necessary to research and develop duration of treatment effect and tools for evaluating treatment effects.

Objective : This study reviews the articles about 'Side effect' published in the Japanese Journal of Oriental Medicine to better understand about side effects of herbal medication and to encourage clinicians, the authorities and the public to establish side effects reporting system. Method : We searched articles published in the Japanese Journal of Oriental Medicine by using keyword '副作用(Side effect)' in the CiNii. Results : Among the 118 articles collected, 14 are clinical articles about side effect of prescriptions, 13 are reports about side effect of prescriptions presented from Japanese Ministry of Health, Labour and Welfare, 36 are clinical articles about relief of side effects derived from taking western medicine by taking a herbal prescription, 8 are studies about the effect of a herbal prescription combined with western medicine or comparative studies between a herbal prescription and western medicine, and so on. Conclusions : Lots of articles deal with side effects of Aconiti Lateralis Radix Preparata, Bupleuri Radix and so on. When side effects occurred, removing a certain herbal drug or quitting a herbal prescription is helpful to relieve or disappear the side effects. And Side effects reporting system should be established to guide safe medication use and treatment for patients. In order to establish side effects reporting system, the standardization of herbal drugs is needed.

We in this paper propose a semantic search system using the basic ontology in Korean medicine field. The basic ontology provides a formalization of medicinal materials, formulas, and diseases of Korean medicine. Recently, many studies for the semantic search system have been proposed. However, they do not support the semantic search and reasoning in the domain of Korean medicine because they do not have the Korean medicine ontology. Our system provides the semantic search features of semantic keyword recommendation, associated information browsing, and ontology reasoning based on the basic ontology. In addition, they also have the features of ontology search of a form of table and graph, synonym search, and external Open API supports. The general search engines usually provide search results for the simple keyword, while our system can also provide the associated information with respect to search results by using ontology so that can recommend more exact results to users.

Objectives : We studied the ISP(information strategy plan) of oasis spanning 5 years. From this study we aimed at total road map to upgrade the service systematically and to carry out the related projects. If we do it as road map, oasis will be the core infra service contributing to the improvement of TKM(traditional korean medicine) research capability. Methods : We carried out 3 step ISP method composed of environmental analysis, current status analysis and future plan. We used paper, report and trend analysis document as base materials and did the survey to get opinions from users and TKM experts. We limited this study to drawing the conceptual design of oasis. Results : From environmental analysis we knew that China and USA built up the largest TM databases. We did the survey to get the activation ways of oasis. And we did the benchmarking on the advanced services through current status analysis. Finally we determined 'maximize the research value based the open TKM knowledge infra' as oasis' vision. And we designed oasis' future system which is composed of service layer, application layer and contents layer. Conclusion : First TKM related documents, research materials, researcher information and standards are merged to elevate the TKM information level. Concretely large scale TKM information infra project such as TKM information classification code development, TKM library network building and CAM research information offering are carried out at the same time.

The first medical text in which detailed treatments of diseases by combinations of materia medica are mentioned is the "Shanghanzabinglun(傷寒雜病論)". True meaning of the combinations of materia medica used in this text lies in the fact that the efficacy of a prescription transcends that of the linear sum of each materia medica. This kind of concept regarding the composition of a prescription has come to contribute to the formation of theories in prescriptionology; However, it is difficult to analyze and interpret the meaning of each prescription separately because of differences in interpreting methods, points of view, and terminologies used by members of different academical branches. Therefore, it is desirable that one should understand a prescription as having been modified from a basic prescription, and then bring the interactions of ingredients into the picture, finally understanding the efficacy and chief virtues of the targeted prescription. Nevertheless, with the massive information of prescriptions, which exist in the format of texts, it is impossible to efficiently take advantage of prescription analyzing methods, and therefore the range of analysis extremely restricted. In order to overcomes these weaknesses, this paper suggests that object-oriented prescription database be constructed and that a search program for education and research that could facilitate an efficient access to the database be developed as well.

Objectives : This study aimed to investigate the effect of four common types of Qigong position (standing, sitting, supine, and horse-riding position) on the autonomic nervous system. Method : Thirty healthy subjects participated in this study once a week for four weeks. Heart Rate Variability (HRV) was measured three times (before, during, and after the position) while the subject maintained one of four positions for ten minutes. Result : There were significant changes HRV in the standing position. In the sitting position, both the sympathetic and parasympathetic nerves were activated. On the other hand, in the spine position, heart rate (HR) was decreased. Activation of sympathetic and parasympathetic nerves was also observed in this position. Significant increases of indices related to awakening and concentration were observed accompanied by increase of HR and a sympathetic nerve was activated in the riding-horse position. Conclusions : In the present study, it was shown that each Qigong position caused various and significant changes in autonomic nervous system. It would be expected that these results can be applied to choose appropriate Qigong position according to objective of Qigong therapy although it is remained to further evaluate the effects of long-term maintenance of Qigong positions and repeated Qigong training.

Objectives : The aim of this study was to survey the usage frequency of Sasang constitutional herbal formula in the clinlcal field. Methods : We searched the case report forms from 2031 subjects in the 11 oriental hospitals and 10 oriental clinic. Subjects were diagnosed by the Sasang Constitution specialist in oriental hospital, who had remarkable improvement in their chief complain after Sasang Constitution medication. We counted the usage frequency of each constitutional herbal formula. Results and Conclusions : In TE type, Cheongsimnyeonja-tang, Yeoldahanso-tang, Jowiseungcheong-tang, Taeeumjowi-tang were used in high frequency. In SE type, various herbal formula were used in a similar frequency. In SY type, Yanggyeoksanhwa-tang, Hyeongbangjihwang-tang, Dokhwaljihwang-tang were used in high frequency. Additionally, the use of specific herbal formula was concentrated in SY type.

Objectives : Sasang typology is extensively studied for the Sasang constitution diagnosis objectification with various data, for example, questionaires, reference materials, etc and analyzed with the several statistical methods. In this study, we used ROC-curve (Receiver Operating Characteristic curve) analysis to diagnose Sasang constitution, which is a kind of epidemiologic research methods and is away from traditional statistical methods. Methods : We collected personality questionnaire which consists of 15 items, from 24 oriental medical clinics. We analyzed the sensitivity and specificity using ROC curve method based on the score of personality questionnaire and also investigated classification accuracy and cut-off value of Sasang constitution. Results : The AUC (area under the ROC curve) value was 0.508 (p=.5511) for Taeeumin, 0.629 (p<.0001) for Soeumin and 0.604(p<.0001) for Soyangin, respectively. so the classification accuracy for Soeumin was highest Soeumin for over 30 points and Soyangin for below 28 points respectively. Conclusions : We suggest that Taeeumin is not classified easily in the ROC-curve analysis. We may classify Soeumin and Soyangin but the accuracy of Sasang constitutional diagnosis is still low.

Objectives : The purpose of this study is to develop an apparatus which can take a facial image by self-operated capturing technique. The user can obtain one's facial image immediately after adjusting facial tilt and focusing distance. The system has been designed for classifying Sasang typology based on facial image. Methods : The system is composed of a Webcam, one-way glass mirror and mini LCD. The Webcam takes a facial image which is displayed on the mini LCD. Then the user can see and adjust to the right position in the real time through the image mirror-reflected from the mini LCD. The optical sensor is used to estimate the proper focusing distance. To verify the performance of the system, 11 characteristic points on the facial image are used and compared with high performance DSLR camera(D700) by applying the coefficient of variance and Bland-Altman Plot. Results : The developed system and D700 show enough agreement with the small coefficient of variance to analyse constitutional types with a facial im mage. However, the result of Bland-Altman plot shows that the width parameters have distortions owing to short focusing distance. Conclusions : The system is expected to be utilized on u-healthcare services for home environment after improving the distortion in the width parameters.

Objectives : In the clinical field, it is important to understand the factors that have effects on a certain disease or symptom. For this, many researchers apply Data Mining method to the clinical data that they have collected. One of the efficient methods for Data Mining is decision tree induction. Many researchers have studied to find the best split criteria of decision tree; however, various split criteria coexist. Methods : In this paper, we applied several split criteria(Information Gain, Gini Index, Chi-Square) to Sasang constitutional clinical information and compared each decision tree in order to find optimal split criteria. Results & Conclusion : We found BMI and body measurement factors are important factors to Sasang constitution by analyzing produced decision trees with different split measures. And the decision tree using information gain had the highest accuracy. However, the decision tree that produced highest accuracy is changed depending on given data. So, researcher have to try to find proper split criteria for given data by understanding attribute of the given data.

Objective : The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human colorectal adenocarcinoma cells. Method : We used two kinds of human colorectal adenocarcinoma cell lines, such as HT-29 and WiDr cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Result : We showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in HT-29 cells and doxorubicin in WiDr cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Conclusion : Our findings provide insight into unraveling the effects of Carthami Flos in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.

Objective : To establish the fundament for EBM of Traditional Korean Medicine, the papers on Bojungikgitang(Buzhongyiqi-tang) frequently used in medical institutions of Traditional Korean Medicine were analyzed through researching domestic and international papers. Methods : The papers were classified by the registration of domestic or international journals, the year of publishment, experimental fields and the kinds of studies on biological activities. Results : Among 2005 volumes of papers on Bojungikgi-tang(Buzhongyiqi-tang), 219 volumes were selected according to selective criteria. 71 volumes were published in domestic journals, 52 volumes were in Chinese journal, 96 volumes were in Japanese journal. The papers on instrumental analyses reported the quantification of standard compounds of herbal medicines in Bojungikgi-tang(Buzhongyiqi-tang) using HPLC method. The papers on biological activities of Bojungikgi-tang(Buzhongyiqi-tang) showed mainly immune regulation, anti-infection, anti-cancer, gastrointestinal activity, neuropsychiatric regulation, anti-inflammation, hepatoprotection, musculoskeletal regulation. Among biological activities, papers on immume regulation were reported mostly. Conclusions : The efficacy of Bojungikgi-tang(Buzhongyiqi-tang) could be related to immune regulation, gastrointestinal activity, anti-fatigue and further study need to be preceeded to establish the fundament for EBM of Bojungikgitang(Buzhongyiqi-tang).

Traditional medicines usually use combinational formula that is prepared by mixing different varieties of medicinal herbs and boiling them in water to yield a decoction. In recent years a modified method has been proposed and practiced wherein the individual herbs are boiled with water separately and later these extracts are mixed together for use. This practice has lead to a constant controversy concerning the chemical and biological equivalence between the preparations arriving out of these two methodologies. In this research, we attempted to study the effects of traditional and individual preparation of Ssanghwa-tang (ST) to evaluate their equivalence in terms of its antioxidant activity and polyphenol content. The study results indicate that the polyphenol contents as well as the extraction yields of these two preparations were very similar to each other.

Objective : The purpose of this study is to evaluate the effect of Yuebijiashu-tang with Low-Glycemic Diet on the obesity and to improve the oriental medical methods of treatment in obesity patients. Methods : Forty one patients were classified into four groups(Normal, Overweight, 1st Obesity, 2nd Obesity) by Body Mass Index(BMI). Weight, Body Fat Mass, Body Fat Rate, Waist Hip Rate, BMI and Obesity Index were compared in each group by t-test. Results : In distribution of sex, male was 7(17.1%), female was 34(82.9%). Mean age was 37${\pm}$11 and the patients in twenties were the most. Among four groups, the number of 1st obesity groups was the most. In the change of body composition, the reduction of weight was 6.82${\pm}$2.67kg, the reduction of body fat mass was 5.53${\pm}$2.30kg, the reduction of BMI was $2.51{\pm}0.85kg/m^2$, the reduction of body fat rate was 4.61${\pm}$2.17%, the reduction of waist hip rate was 0.019${\pm}$0.013. Conclusion : This study shows that Yu$\'{e}$biji$\~{a}$sh$\`{u}$-t$\~{a}$ng with low-glycemic diet is effective on weight reduction.