Korean Journal of Oriental Medicine (한국한의학연구원논문집)

Korean Institute of Oriental Medicine (한국한의학연구원)
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Effects of Carthami Flos on Human Colorectal Adenocarcinoma Cells

홍화가 인체 대장암세포에 미치는 효과

  • Han, Song-Ee (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Kim, Jung-A (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Song, Ho-Joon (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Chae, Han (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Kwon, Young-Kyu (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University) ;
  • Kim, Byung-Joo (Division of Longevity and Biofunctional Medicine School of Korean Medicine, Pusan National University)
  • 한송이 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 김정아 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 송호준 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 채한 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 권영규 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 김병주 (부산대학교 한의학전문대학원 양생기능의학부)
  • Received : 2011.03.17
  • Accepted : 2011.08.05
  • Published : 2011.08.30
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Abstract

Objective : The purpose of this study was to investigate the anti-cancer effects of Carthami Flos in some kinds of human colorectal adenocarcinoma cells. Method : We used two kinds of human colorectal adenocarcinoma cell lines, such as HT-29 and WiDr cells. We examined cell death by MTT assay and observed the morphological changes with Carthami Flos. Result : We showed that the combination of sub-optimal doses of Carthami Flos and cisplatin noticeably suppresses in HT-29 cells and doxorubicin in WiDr cells. Furthermore, we studied the caspase 3 activity to identify the apoptosis. Conclusion : Our findings provide insight into unraveling the effects of Carthami Flos in human colorectal adenocarcinoma cells and developing therapeutic agents against colorectal cancer.

Keywords

References

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