This paper treats with transitional development of medico-hygienical situation in district Yanbian along with the evolution in specific field of medicine. This work is particularly important in shaping TKM identity as TCM embraces Chao medicine asserting it as one included in TCM. This research deals with themes of migration of Chao minorities to this territory and their medico-hygienical situation. Lifted bans on immigration in late Qing dynasty with uncertainty of Korea(Chosun) triggered the immigration to this district. The flow was heavily strengthened under the influence of Westerners and Japanese imperialism into china which consequently provoked the ruin of Qing dynasty, the civil war between republicans and communist and the socio-political changes in Korea. As population growths, the establishment of hospitals and immigration of healthcare professionals were also increased. Though this district is located in Chinese mainland the influence of Japanese was also relevant which lead to medical practice reflection both sides. Mutual combination and influence of western(contemporary) medicine, TCM and TKM practices made the particularity of chao medicine.

The prime minister(樞密相公) Choi jongjun writes"Eouichwaryobang(御醫撮要方)"A.D. 1226 that is a Goryeo Period (A.D.$918{\sim}1392$). But today that has vanished, now. Inspite of the important worth of that book in Korea Traditional Medicine, there is no study about writer. So I research all the historical source about him. And I confront a historical source with the era for making a chronological table of Choi jongjun. I beliebe this survey make a great contribution towards the historical research of KTM. Now to conclude, In A.D. 1226, Choi Jongjun was Jung chuwonbusa(中樞院副使) or Chumseowonsa(簽書院事).

Below are the indications that cultural events in traditional Korean medicine nationwide give to the prospective 2013 DongUiBoGam World traditional Alternative Medicine Expo, especially to the se lection of the Expo's site. If the DongUiBoGam Expo is held as outdoor event, it can secure merits of current local council events' advantages: linking lived experiences to natural and historical resources. As in case of the EXOM and Hanghang EXPO that are held as indoor activivies in metropolitan area, if held the DongUiBoGam Expo can secure easily large-scale academic activities and health lectures. Thus, the key point for the DongUiBoGam Expo's success will he how to combine the good points of currently-held cultural outdoor and indoor activities in the field of traditional Korean medicine nationwide.

In a literary work may reflect the socio-enviromental situations of the time. Lee Injae wrote "Sujingyeongheomsinbang" in early $20^{th}$ century, in a time when japanese colonization began and with which the influence of so called modern medicine, western medicine, were increasing. Though this trend was ever increasing the system for education and propagation was not enough and the practice of TKM was still predominant in public. This book reflect the concern of the author about this transitional time. He stat ing that TKM has a strong point in internal medicine while western medicine in external or surgical diseases tries to consolidate both medicines. This opinion is still valid today or at least serve as a reference as this problem still remains us to solve.

Objective : The purpose of this report was to provide the information about activity and safety of Ssanghwa-tang by analyzing domestic papers and theses about Ssanghwa-tang. Methods : Domestic papers and theses related to Ssanghwa-tang were reviewed and analyzed. These papers were then classified by year, experimental method, and activity subject. Results : The following result s were obtained in this study. 1. The study of Ssanghwa-tang started from 1981 and continued steadily 1990s and it was decreased 2000s. 2. The paper of Ssanghwatang was entire domestic paper, 20 volumes. 3. In classified by experimental method and animal of Ssanghwa-tang paper, more than a half study used rat in vivo experiment. Furthermore clinical experiments were performed about anti-fatigue effect of Ssanghwa-tang and Ssanghwatang was proved a safety herbal medicine in acute toxicity experiment. 4. Decursin, glycyrrhizin, paeoniflorin were determined in Ssanghwa-tang by using HPLC analysis. 5. As these studies were classified by subject, papers related to anti-fatigue effect were most abundant by 7 papers. Besides there were several papers related to liver funtion, anti-inflammatory, alleviation, smooth muscle relaxation effect and so on. 6. According to experimental data, it is supported that Ssanghwa-tang was safety herbal medicine and it has a several activity about anti-fatigue, anti-inflammatory, alleviation, smooth muscle relaxation. Conclusion : Many study of basic science experiments and clinical experiments were performed and reported on Ssanghwa-tang in domestic journal. Ssanghwa-tang is being used in various ways associating with anti-fatigue, anti-inflammatory, alleviation and smooth muscle relaxation. furthermore Ssanghwatang was proved a safety herbal medicine in acute toxicity experiment. However, studies on randomized controlled trials of Ssanghwatang need to be completed at the clinical level.

Glehnia littoralis Fr. Schmidt et Miquel is an important medicinal plants in East Asian countries. This plant species naturally distributed in Korea, Japan, China, and Taiwan, but it is a rare plants living in the coastal dune in Korea. To investigate the genetic variation, genetic diversity and genetic evolutionary relationships of 14 different geographical G. littoralis, ITS sequence and random amplified polymorphic DNA (RAPD) were analyzed. On the basis of ITS sequences, it was clearly showed that the ITS1 and ITS2 sequences among 14 populations are identical regardless of geographical origin excepting 2 bp in pair-wise comparison of ITS1. Furthermore, RAPD results also showed that 14 different geographical G. littoralis produce various polymorphic patterns without critical relationship among neighboring regions. These combined results suggest that the geographical variation and genetic evolution of G. littoralis is stable and provide important information on genetic diversity, and conservation of this rare plant species in situ and ex situ.

Glehnia littoralis (Umbelliferae) is the medicinal plant used traditionally for treatment of immune-related diseases. Prostaglandins and nitric oxide (NO) have been implicated as important mediators in the processes of inflammation and carcinogenesis. For understanding the mechanisms for pharmacological activities of Glehnia littoralis, we evaluated the inhibitory activity of Glehnia littoralis on lipopolysaccharide (LPS)-induced prostaglandin $E_2$ ($PGE_2$) and NO production in mouse macrophage RAW264.7 cells. The results showed that the extract of Glehnia littoralis inhibited LPS- induced $PGE_2$ production effectively, but not NO. Additional study revealed that the extract of Glehnia littoralis suppressed cyclooxygenase-2 (COX-2) expression in a dose-dependent manner. Present study suggests that Glehnia littoralis may have anti-inflammatory and/or cancer chemopreventive activity through the inhibition of $PGE_2$ production by the suppression of COX-2 activity.

Objectives : We intended to know the association between Psychosocial Well-being Index(PWI) and health behaviors and also know the useful health guide according to Sasang Constitution Methods : We recruited the 137 subjects from oriental medical clinics around the country and the expert diagnosed Sasang constitution with drug response guide. We used the PWI-SF paper to estimate psychosocial well-being. We used excel program and analyzed with SPSS 14.0K Results : 1. PWI were associated with no passive smoking, everyday regular exercise, eating anything, much eating vegetable and sea-food, no eating snacks. 2. PWI were associated with no passive smoking, 4-5 times regular exercise a week, unconcern in sanitary thought, less or normal amount of meals in Soeumin, no smoking in Taeeumin, and there were not particularly associated ones in Soyangin Conclusions : Health behaviors for PWI are a little different according to Sasang Constitution.

This pilot study aimed to set up a reasonable method for measuring body segments parameters and finding out some useful body segments parameters to diagnose Sasang constitutions. In this study, we have tried to take a secure effort in measuring and diagnosing of Sasang constitutions based on the consensus among Sasang constitution experts. And we also have tried to find out some useful body segments parameters based on the actual data. We measured 9 clinically meaningful body lengths specified by Sasang constitution experts and analyzed these parameters statistically according to each Sasang constitution. We have found that Taeeumin female's ratio of foot length to height was significantly large and Soyangin's ratio was significantly small, but more data are needed to confirm this finding.

Sasanag Contitution Medicine(SCM) is the traditional medicine theory based on constitutional medicine in Korea. It is most import ant that a personal SCM type is determined accurately ahead of applying any Sasang treatments. For this, many researches have been studied to diagnose the SCM type using constitutional clinical data. The decision tree is a tree-structured data-mining methodology. Recently, in the Korean traditional medicine society, there have been several efforts to find diagnosing tools using the decision tree method. So, we developed a decision tree program based on web for analyzing constitutional clinical information. It can use various clinical data as input data, offer filtering function to select clinical data to be used. We can find useful factor to be influential on SCM types using this program.

A tongue shows physiological and clinicopathological changes of inner organs. Visual inspection of a tongue is not only convenient but also non-invasive. To develop an automat ic tongue diagnosis system for an objective and standardized diagnosis, the separation of the tongue are a from a facial image and the detection of coatings, spots and cracks are inevitable but difficult since the colors of a tongue, lips, and skin in a mouth as well as those of tongue furs and body are similar. The propose d method includes preprocessing with down-sampling and edge enhancement, over-segmentation, detecting positions with a local minimum over shading from the structure of a tongue, and correcting local minima or detecting edge with color difference. The proposed method produces the region of a segmented tongue, and then decomposes the color components of the region into hue, saturation and brightness, resulting in classifying the regions of tongue furs(coatings) into kinds of coatings and substance and segmenting them. Spots are detected by using local maxima and the variation of saturation, and cracks are searched by using local minima and the directivity of dark areas in brightness. The results illustrate the segmented region with effective information, excluding a non-tongue region and also give us accurate discrimination of coatings and the precise detection of spots and cracks. It can be used to make an objective and standardized diagnosis for an u-Healthcare system as well as a home care system.

The tongue diagnosis is a diagnostic method in the oriental medicine that uses shape, substance, coating, and movement of the tongue to determine the condition of health and disease characteristics in human. Since this information, however, could be affected by subjective sense and visual information, it is difficult to obtain the objective and reproducible results. This research aims at building a reproducible tongue diagnosis system using color chart that is attached close to the face contact region. The picture of color chart is taken simultaneously with a tongue and applied to color revision. The system, in addition, is focused on providing a clear tongue image through securing a sufficient photographing distance with a surface coating mirror. The lightning part which can suppress the reflection by sputum in maximum is implemented for the objectification and quantification of the tongue diagnosis system. The face contact region is designed for consideration of a testee's convenience. To evaluate the reproducibility of the system, the CVs (coefficient of variance, %) of $L{\ast}$, $a{\ast}$ and $b{\ast}$ of red, green and blue regions in color chart are calculated, respectively. The results of all CVs shows that the tongue diagnosis system is re liable and those consequences contribute to the objectification and quantification of the tongue diagnosis system.

Recently, skin diagnosis has been suggested as a promising tool for discrimination of Sasang Constitution, reported by examining the skin characteristics such as thickness, stiffness, slip, and skin textures like wrinkles and furrows. However, the works had a limitation in that clinical decision on the skin characteristics was made by relying upon oriental medicine doctors' subjective sense of touch. In order to objectify the skin diagnosis and claim its efficacy on the discrimination of the Sasang Constitutions, it is necessary to demonstrate its discrimination capability by providing numerical values in terms of physical quantities obtained from measurements using today's sensors and equipment technologies, which motivated this work as a priliminary step towards objectification of skin diagnosis. The skin characteristics focused in this work is the slip property of the back-hand skin that has been exploited using the dynamic friction measurement system. First, curved geometric effects of the back-hand skin on the measured lateral/vertical force signals were estimated using the artificially designed silicon coated structures, which led to a suggestion on a quality controlled experimental design based upon a empirical analysis model. Second, the experimental design thus suggested has been applied to the measurement of dynamic friction coefficients for two healthy male subjects of Taeumin (TE) and Soyangin (SY), respectively. The result shows that the dynamic friction coefficient is less for the SY subject than for the TE subject around the area of the skin used for diagnosis by the oriental medicine doctor, implying the TE subject's skin is more slippery than the SE subject's that is consistent with the oriental medicine doctor's diagnosis. Hopefully, this work can provide guidelines for obtaining quality data in friction measurement to be collected for discussion on the efficacy of the skin diagnosis and its objectification through statistical analysis.

In pulse diagnosis, the indentation pressure is one of the most important factors as well as the change of pulse shape and the distribution of pressure via time. But, on the oriental medical doctor's indentation pressure control, the understandings of the neurophysiological meanings and mechanisms have been lacked. So, in this paper, we considered on these issues and then proposed a proper system which can imitate the OMD's indentation pressure control mechanisms. As a result, both tactile information and kinesthetic information were found to be essential to the indentation pressure control so that a system, which can measure both the physical indent pressure and the displacement of an indentation arm, has been proposed. With this proposed system, while the indentation was being controlled through the moving step number of the step motor, the physical indentation pres sure and displacement of the indentation arm were measured. From these measured data, the relationships between the moving step number and both physical indentation pressure and displacement were revealed to have linear characteristics in early phase and to have nonlinear characteristics in latter phase. Additionally, three types of graph were generated whose X axis means the moving step number, the physical indentation pressure and the displacement respectively and Y axis means the pulse pressure. By comparing these graphs, we come to conclude that different concepts on indentation pressure control cause different diagnostic results on floating/sinking degrees for the same subject. Consequently, an indentation system for the pulse diagnosis should be able to provide both the tactile information and kinesthetic information, that is, the physical indentation pressure and the displacement of the indentation arm. In future, the proposed system should be optimized to the pulse diagnosis environment and how to combine the both information for more reliable diagnosis should be studied.

Pulse diagnosis refers to the process of diagnosing a patient by feeling an artery on the wrist based on the shape that the pulse take s while the hold-down pressure increase. The styloid process artery on the wrist is usually felt, and the pulse is taken on Chon, Gwan and Cheok using three fingers. This study is to examine the structural difference in the location of pulse diagnosis by measuring and analyzing blood diameter, blood depth, and blood flow velocity of the location of pulse diagnosis by using ultrasonic wave (VOLUSION730 PRO, GE Medical, U.S.A). This study also attempted to grasp whether the characteristics of blood vessels differ depending on Body Mass Index (BMI) and analyzed their correlation with Oriental medical pulse diagnosis. The male subjects without cardiovascular diseases were divided into the normal BMI group, the underweight group and the overweight group and 10 people of each group were measured, Blood depth, blood diameter and blood flow velocity at the location of pulse diagnosis (Chon, Gwan, Cheok) of the wrists of left and right hands were measured and the pulse wave was measured by using pulse diagnosis instrument (3-D Mac, DaeyoMedi, Korea).The results of this study showed that the characteristics of blood vessels differ depending on the degrees of obesity, and the characteristics of floating pulse and sinking pulse of Oriental medical pulses were related to the degrees of obesity. This shows that the characteristics of the blood vessels of subjects and BMI information are the major indicators for diagnosis and are the matters that must always be considered when developing the algorithm of pulse diagnosis.

The Korean Medicine Information has recently started due to lack of understanding and budgets. In this paper, the active region of Korean Medicine Information from outstanding cases in Korea and the trends of other nations was surveyed. As a results we found the problems that the available data is insufficient, the quality of data is not good and the unification of data is not easy from the analysis of information status and suggested the new directions. we suggest that Korea Medicine Information Center should be established to unify the information from Korea Medicine Organizations and to build information gathering network. we also suggest that well-organized information projects must be carried out in leadership of it from unified point of view. we mentioned the effects of Korea Medicine Information Center establishment.

Computerization is recognized as simple supporting tools up to recently but Information is made for the improvement of company's outcome beyond the assistant tools and is emerged as core tools of creating new opportunities for company in point of management strategy. But Information plays minor role in Korean Institute of Oriental Medicine(KIOM) yet. Information has not processed systematically because of lack of understanding and budget in KIOM. The purpose of this research is to make plan for knowledge information which is aimed to make effective supporting and strengthening the ability of KIOM's research, until 2013. Also we tried to find new project s for information and to apply the result to planned information projects. The final goal of this study is to make mid/long-term information plan of KIOM. We applied the general information strategy planning(ISP) method which is progressed as analysis of information technology, analysis of information status, design of future model and extraction of action plan order. First, we examined the information elements for the advanced management from analysis of management environment and analyzed information technology trends. Second, we list up the gaps and problems of KIOM's information status and define the future model to solve this problems. It is showed the road map of time and budget for future model to progress systematically inner-information of purpose. We hope that information of KIOM will be conducted successfully.

With sophisticated clinical skills and the effectiveness of Traditional Korean Medicine(TKM), many TKM doctors look forward to over seas expansion. About 450 TKM doctors had NCCAOM certificate, but only 40 TKM doctors arc in US now. Because The status of NCCAOM certificate in USA is not adequate enough for TKM doctors to perform medical treatments. In case of US, State medical boards depend to a large extent on the Educational Commission for Foreign Medical Graduates(ECFMG) for certification of international medical graduates (IMGs) seeking licensure in the United States. In addition to receiving certification that includes verification of education credentials, IMGs must pass Steps I and II of the USMLE. In order to obtain a license to practice in the United States, IMGs must successfully complete a residency in a program approved by the American Council of Graduate Medical Education(ACGME) and the complete Step III, the final step in the USMLE. TKM doctors, in the prospective of overseas expansion, applied to ECFMG and their applications have been rejected. This circumstance happened because Korea is unique country in the world with two different medical licensing system, Oriental and Western, both being physician workforce. Rejection by ECFMG occurred because of their minimal understanding of Korea's situation, while the responsibility to inform, propagate and protect TKM doctors own rights depend exclusively to Korean government, TKM doctor oneself and its related organizations, all the members should endeavor on it.

This study examined from "SangHanChangHwaHunJiJip" how medical exchange between doctors of Joseon and Japan affected medical science of Japan. "SangHanChangHwaHunJiJip" is a record that organized the written conversation between doctors and scholars of the Joseon and Edo period when the delegation so-called Joseon Tongsinsa visited Japan in 1719. Even though "SangHanChangHwaHunJiJip" was written by Japanese, but it was comprised of Joseon's advanced medical ideology, especially "DongEuiBogam" that has occupied an important part of the Joseon medical ideology. As a matter of fact, "SangHanChang HwaHunJiJip" contains general theme and medical subject. But until now, it has been hardly studied by medical historians. Many studies were generally made related to Joseon Tongsinsa, a governmental delegation, focused on literary and cultural exchange between Joseon and Japan by historians. "SangHanChangHwaHunJiJip" is no exception to this trend. We can find that doctors of the Joseon and Edo period entered into colloquium, a form of group discussion, about the clinical theme in "SangHanChangHwaHunJiJip". Concretely, the conversation between doctors of Joseon and Japan was about infant disease, infectious disease, folk remedies, medical herbs, moxa cautery, acupuncture, the study of nature, the study of medical books, etc. For example, when doctors of Japan ask a confirmed disease, doctors of Joseon explained it particularly. They had a great effect on in every cultural aspect of Japan, especially its medical field. Through this study of the medical questions and answers in "SangHanChangHwaHunJiJip", I came to know that the doctors of GiHae envoys gave great influence to the medical knowledge of Japan and the GiHae inherited and developed the medical tradition of SinMyo envoys. Through the examination of this study, I could deduct that "JeongJeongDongEuiBogam" which was published by the government of the Edo period is due to not only the contents of DongEuiBogam's advanced medical thought, but also the doctors of GiHae envoy. Also, "SangHanChangHwaHunJiJip" gives us an idea that doctors of GiHae envoys have medical trend of the OnBoHakFa and a group of Japanese doctors has medical trend of the study of nature. I am confident that the improvement of medical science and natural history of the Edo period is due to influence of medical exchange between Joseon and Japan. "SangHanChangHwaHunJiJip" confirms that medical exchange between two countries affected doctors and scholars of the Edo period.

"EuiBangShinGam" is a classic on oriental medicines written by Han Byung Lyun with the pen name Shin Oh in 1913. It was written under the base of the writer's own experience as well as in the light of 36 other classics on oriental medicines such as "DongEuiBoGam", Introduction to Medicine, and Complete Works of Jingyue. In an attempt to avoid difficult theories and list only the essential informations and formulas for clinical purposes, it attained its own characteristics of not only reorganizing DongEuiBoGam in a pragmatic way but also explaining diseases classified in western medicines in oriental medicines' point of view as well as suggesting medicine formulas regarding such explanations. As a result, it is a complete and efficient medical classic through which one can gain knowledge in both classic oriental medicines and combination of western and oriental medicines. Its special features are making a separate chapter for cholera and phthisis, which is also a contagious disease, and trying in the chapter to explain the disease s in words of oriental medicines; listing details of nine major epidemic and matching them with the diseases known in oriental medicines: and recording a case of enforcing sterilization and preventive injection against contagious diseases. Han Byung Lyun, the writ er of the book, was born in northern province of Ham Gyoung, Woong Bu, and the date of death is unknown. He is one of the eight members who conceived and started the idea of organizing the Organization of Practioners of Oriental Medicines, which was a nationwide organization under the motive of restoring Oriental Medicines against the policy under the colonial government of Japan. Living a era of Japanese Imperialism, he stressed the need to accept western medicines if its beneficial to oriental medicines in order to develop oriental medicines for progressive causes. This reflects that he was a person who tried in various ways to extend oriental medicines to another level by facing up to the reality and coming up with a measure to cope up with it. In fact, he was a oriental medicine doctor who tried to protect oriental medicines by founding academic organizations, publishing academic magazines, and writing himself many papers related to oriental medicines. EuiBangShinGam can he summarized as a classic on traditional korean medicine through which one can find out about realities of Japan Imperialism and the attempts of oriental medicine practitioners under the colonial policies of Japan to make oriental medicines more developed by adding one's own thoughts as well as keeping the old, and adjusting to such situations.