• BMB Reports
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• v.55 no.6
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• pp.281-286
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• 2022

Hepatocellular carcinoma is a major health burden, and though various treatments through much research are available, difficulties in early diagnosis and drug resistance to chemotherapy-based treatments render several ineffective. Cancer stem cell model has been used to explain formation of heterogeneous cell population within tumor mass, which is one of the underlying causes of high recurrence rate and acquired chemoresistance, highlighting the importance of CSC identification and understanding the molecular mechanisms of CSC drivers. Extracellular CSC-markers such as CD133, CD90 and EpCAM have been used successfully in CSC isolation, but studies have indicated that increasingly complex combinations are required for accurate identification. Pseudogene-derived long non-coding RNAs are useful candidates as intracellular CSC markers - factors that regulate pluripotency and self-renewal - given their cancer-specific expression and versatile regulation across several levels. Here, we present the use of microarray data to identify stemness-associated factors in liver cancer, and selection of sole pseudogene-derived lncRNA ZNF204P for experimental validation. ZNF204P knockdown impairs cell proliferation and migration/invasion. As the cytosolic ZNF204P shares miRNA binding sites with OCT4 and SOX2, well-known drivers of pluripotency and self-renewal, we propose that ZNF204P promotes tumorigenesis through the miRNA-145-5p/OCT4, SOX2 axis.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.4
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• pp.345-353
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• 2007

We have obtained a topographical image nondestructively for a Cu thin film in liquid using a near-field scanning microwave microscope (NSMM), its operating frequency was 3.5 to 5.5 GHz. We have kept a distance of 10 nm between tip and sample using a quartz tuning fork shear force feedback system. As an end of tip was attached to one prong of the quartz tuning fork has a length of 2 mm, the only tip of tuning fork was immersed in water tank. A loss cause by evaporation in water tank is regulated with actuator was connected to a supplementary tank. Moreover, using a revise program of LabView, we could increase the accuracy of a measurement in liquid.

• Management Science and Financial Engineering
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• v.7 no.1
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• pp.1-26
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• 2001

Assume a company sells two products (a and B) in a retail market. the company adopts a specific promotion mechanism, Tie-in Promotion, in which product A's promotional discount coupon is distributed whenever a consumer purchases product B. Product A will later e sold at a markdown price when consumers eventually take the opportunity to redeem the coupon. in the integrated tie-in promotion and stocking policy, we assume managers of two products coordinate by sharing information on the demand forecast and deciding the order quantities and tie-in promotion program to maximize joint profits. The optimal integrated tie-in policy is analyzed. The integrated tie-in promotion model is then compared with two other base models: (1) a decentralized Newsboy model in which no promotion is considered, and (2) an individual promotion model in which managers design a promotion program to promote one of the two products directly. The factors that make an integrated tie-in promotion a better approach are studied.

• Korean Journal of Childcare and Education
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• v.11 no.2
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• pp.151-175
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• 2015

This study configured an integrated math program in which young children can directly participate through storytelling, a teaching technique that has recently earned great popularity. The purpose of the study is to have a positive effect on their mathematical disposition and self-efficacy through the adoption of this program. The program consists of the following five themes: 'understanding of the basic concept of numbers and calculation', 'understanding of the basic concept of space and figure', 'basic measurement', 'understanding of rules' and 'basic data collection and result representation'. The specific activities for each theme planned and executed according to a detailed plan were designed for 20 classes including integrated activities such as story sharing, fine arts and games. The study's participants were 48 five-year old children. The result of the research was that the experimental group's mathematical disposition and self-efficacy score was significantly higher than the control group. The Storytelling-Integrated Math Program was effective in young children's cultivating mathematical disposition and improving self-efficacy. Considering the reality that there has been some confusion and difficulty in carrying out storytelling math and an integrated math program based on the NURI curriculum, it appears that this study could provide a specific and effective teaching-learning program to teachers who want to introduce a program like this.g

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.42 no.1
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• pp.47-55
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• 2005

This work describes an 8b 240 MS/s CMOS ADC as one of embedded core cells for high-performance displays requiring low power and small size at high speed. The proposed ADC uses externally connected pins only for analog inputs, digital outputs, and supplies. The ADC employs (1) a two-step pipelined architecture to optimize power and chip size at the target sampling frequency of 240 MHz, (2) advanced bootstrapping techniques to achieve high signal bandwidth in the input SHA, and (3) RC filter-based on-chip I/V references to improve noise performance with a power-off function added for portable applications. The prototype ADC is implemented in a 0.18 um CMOS and simultaneously integrated in a DVD system with dual-mode inputs. The measured DNL and INL are within 0.49 LSB and 0.69 LSB, respectively. The prototype ADC shows the SFDR of 53 dB for a 10 MHz input sinewave at 240 MS/s while maintaining the SNDR exceeding 38 dB and the SFDR exceeding 50 dB for input frequencies up to the Nyquist frequency at 240 MS/s. The ADC consumes, 104 mW at 240 MS/s and the active die area is 1.36 ㎟.

• 제어로봇시스템학회:학술대회논문집
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• 2000.10a
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• pp.123-123
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• 2000

Polishing a die that has free-form surfaces is a time-consuming and tedious job, and requires a considerable amount of high-precision skill. In order to reduce the polishing time and cope with the shortage of skilled workers, a user-friendly automatic polishing system was developed in this research. The polishing system with five degrees of freedom is able to keep the polishing tool normal to the die surface. The polishing system is controlled by a PC-NC controller. And, to easily onerate the developed polishing system, this stud)r developed a integrated program in the Windows environment. This program consists of 4 modules: polishing module, a graphic simulator, a polishing data generation module, and a teaching. Also, the automatic teaching system was developed to easily obtain a teaching data. The developed teaching system consists of a three dimensional joystick and a proximity sensor. In order to evaluate stability of the driving program and the leaching system, polishing experiments of the die of saddle shape were carried out.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.45 no.5
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• pp.437-446
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• 2017

An integrated flight simulation program for multicopter drones is presented. The program includes rigid body dynamics, propeller thrust, battery energy, control, and air. Using this program, users can monitor and analyze the states of drones along flight trajectories. As a programming language, Modelica has been chosen, that specializes in simulation program development. Modelica enables users to develop simulation programs efficiently due to acausal and object oriented properties. For missions including horizontal and vertical maneuvers, many dynamical states of drones have been analyzed with simulation results.

• Journal of Advanced Navigation Technology
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• v.14 no.6
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• pp.791-799
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• 2010

In this paper, integrated navigation algorithm is designed for land transport sector which is needed high accuracy and monitoring program is developed for lane departure warning. High accuracy position information which is possible lane separation is needed for lane departure warning, so position detection algorithm based GPS/DR which combine GPS with dead reckoning is proposed. For the verification of the designed integrated navigation algorithm, we drived to acquire data and showed post-processing experiment results with monitoring program. Vehicle driving movie and aerial photograph in monitoring program is designed to show lane keeping and lane separation.

• Journal of Korean Society on Water Environment
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• v.26 no.4
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• pp.637-647
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• 2010

The Universal Soil Loss Equation (USLE)-based modeling systems have been widely used to simulate soil erosion studies. However the GIS-based USLE modeling systems have limitation in gully erosion evaluation which is one of the most important factor in soil erosion estimation. In this study, the integrated soil erosion evaluation system using with Sediment Assessment Tool for Effective Erosion Control (SATEEC) system, nLS and Unit Stream Power-based Erosion/Deposition (USPED) model was developed to simulate gully erosion. Gully head location using nLS model, USPED for gully erosion, and the SATEEC estimated sheet and rill erosion were evaluated and combined together with the integrated soil erosion evaluation system. This system was applied to the Haean-myeon watershed, annual average sediment-yield considering sheet, rill and gully erosion was simulated as 101,933 ton/year at the study watershed. if the integrated soil erosion evaluation system is calibrated and validated with the measured data, this system could be efficiently used in developing site-specific soil erosion best management system to reduce soil erosion and muddy water inflow into the receiving waterbody.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.5
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• pp.551-558
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• 2020

The purpose of this study was to develop an integrated program to improve the creative and emotional ability of lower grade students. This program aimed to cultivate creative thinking and creative personality for problem solving, and to learn how to interact positively with others by developing emotional expression and control. Creative thinking ability includes fluency, flexibility, originality, elaboration, imagination, and sensitivity. Creative personality includes curiosity, sensitivity, adventure, humor, independence, task commitment, and problem solving leadership. We selected 6 creative thinking skills such as mind-map and brainstorming. Emotional factors consist of self /other understanding, control of emotional effect, self-expression emotionally, and respect for others for cooperation. The integrated program consisted of 12 themes, and the class time was set to 40 minutes, which is the same as the elementary curriculum. The program was conducted by a teacher with 10 years' experience.