• Molecules and Cells
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• v.37 no.8
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• pp.628-635
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• 2014

2-(Trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient megakaryopoiesis. Here, we show that (R)-TEMOSPho blocks osteoclast maturation from progenitor cells of hematopoietic origin, as well as blocking the resorptive function of mature osteoclasts. The inhibitory effect of (R)-TEMOSPho on osteoclasts was due to a disruption of the actin cytoskeleton, resulting from impaired downstream signaling of c-Fms, a receptor for macrophage-colony stimulating factor linked to c-Cbl, phosphoinositol-3-kinase (PI3K), Vav3, and Rac1. In addition, (R)-TEMOSPho blocked inflammation-induced bone destruction by reducing the numbers of osteoclasts produced in mice. Thus, (R)-TEMOSPho may represent a promising new class of antiresorptive drugs for the treatment of bone loss associated with increased osteoclast maturation and activity.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.8
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• pp.1061-1067
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• 2018

In the $4^{th}$ industrial revolution of the latest, the development of the technique in the software field decides the success or failure of a country. With the trend of it, each country makes a countless effort on the education of software. This study reconstructed a questionnaire of the type of personality and conducted a research applied to learners with the help of professionals. I observed the attitude of learners during the programming class and the influence of it on the learning ability of self-oriented learning and learning motivation. As a result of it, there came up with a significant difference (at the side of self-oriented studying and the motivation of studying) depending on the type of personality of learners. Therefore, we can look forward to increasing the effects of self-oriented learning and self motivation by applying to the merits of each type of personality.

• Korean Journal of Construction Engineering and Management
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• v.10 no.5
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• pp.76-84
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• 2009

Korea's construction industry experienced no difficulty managing the costs of finishing work items in the apartment housing field thanks to the uniform specification and the standardized costs of finishing work items. Finishing work items have continuously become more high class and differentiated, which has caused the costs of finishing work items to rise. This study identified problems with the cost management when planning finishing work items and choosing their alternatives based on the current process applied to the planning stage of finishing work items. It also found problems with the information management of finishing work items including design, cost, and work information that took place in bulk. Based on the identified problems, the design, cost and work information of finishing work items was integrated so that they could management the costs and information when planning finishing work items and selecting their alternatives. Then a cost-based information management process was suggested for finishing work items by improving each of the project cost management elements. Finally, an information model for finishing work items was built by studying the ways to integrate the information hierarchy and library of finishing work items.

• Journal of Information Management
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• v.28 no.3
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• pp.46-73
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• 1997

In these days, there are many studies to improve the effectiveness of retrieval systems. One method is to use thesaurus in the systems. But the establishment of the saurus independently is very difficult and requiers a great deal of time and labor. The goal of this research is to examine which problems there are. The texts used in the thesis were "Thesaurus of ERIC descriptors(7th ed.1977)" and "KEID Thesaurus(1981)" established by translation. The results of the thesis were as follows, First, there were many differences of equivalence classes of terms between English and Korean. Second, the errors of translation made words inadequate to use as a descriptors. Third, because of differences of traditions, thought and culture, associative relationship and hierarchical relation did not coincide between terns, Fourth, because the terms of the thesaurus of ERIC descriptors serve Western usages, the terms used in Korea were not or insufficient. So it way necessary to add our own therms. As mentioned above, translating a thesaurus for use as a documentation language for indexing and retrieval is not the optimum way of building up a thesaurus.

• Nuclear Engineering and Technology
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• v.43 no.6
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• pp.583-592
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• 2011

The radiological characteristics for waste classification were assessed for neutron-activated decommissioning wastes from a CANDU reactor. The MCNP/ORIGEN2 code system was used for the source term analysis. The neutron flux and activation cross-section library for each structural component generated by MCNP simulation were used in the radionuclide buildup calculation in ORIGEN2. The specific activities of the relevant radionuclides in the activated metal waste were compared with the specified limits of the specific activities listed in the Korean standard and 10 CFR 61. The time-average full-core model of Wolsong Unit 1 was used as the neutron source for activation of in-core and ex-core structural components. The approximated levels of the neutron flux and cross-section, irradiated fuel composition, and a geometry simplification revealing good reliability in a previous study were used in the source term calculation as well. The results revealed the radioactivity, decay heat, hazard index, mass, and solid volume for the activated decommissioning waste to be $1.04{\times}10^{16}$ Bq, $2.09{\times}10^3$ W, $5.31{\times}10^{14}\;m^3$-water, $4.69{\times}10^5$ kg, and $7.38{\times}10^1\;m^3$, respectively. According to both Korean and US standards, the activated waste of the pressure tubes, calandria tubes, reactivity devices, and reactivity device supporters was greater than Class C, which should be disposed of in a deep geological disposal repository, whereas the side structural components were classified as low- and intermediate-level waste, which can be disposed of in a land disposal repository. Finally, this study confirmed that, regardless of the cooling time of the waste, 15% of the decommissioning waste cannot be disposed of in a land disposal repository. It is expected that the source terms and waste classification evaluated through this study can be widely used to establish a decommissioning/disposal strategy and fuel cycle analysis for CANDU reactors.

• Journal of Internet Computing and Services
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• v.7 no.2
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• pp.161-172
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• 2006

As the innovative technologies related to ubiquitous computing are being rapidly developed in recent IT trend, the concern for IT dysfunction(e.g., personal information abuse, information risk, threat, vulnerability, etc.) are also increasing. In our study, we suggested how to design and implement to multiple schemes for strong authentication mechanism in real system environments. We introduce the systematic and secure authentication technologies that resolve the threats incurring from the abuse and illegal duplication of financial transaction card in the public and financial institutions. The multiple schemes for strong authentication mechanism applied to java technology, so various application programs can be embedded, Independent of different platforms, to the smartcard by applying the consolidated authentication technologies based on encryption and biometrics(e.g., finger print identification). We also introduce the appropriate guidelines which can be easily implemented by the system developer and utilized from the software engineering standpoint of view. Further, we proposed ways to utilize java card based biometrics by developing and applying the 'smartcard class library' in order for the developer and engineers involved in real system environment(Secure entrance system) to easily understand the program. Lastly, we briefly introduced the potential for its future business application.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.6
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• pp.704-710
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• 2019

Programming learning has been recognized as a difficult subject for a long time. To solve these problems, various studies have been conducted. This study was conducted on motivation to break away from programming learning according to gender, one of the characteristics of learners. In this study, pre-post questionnaire surveys were conducted for male students and female students who were involved in scratch learning and Python learning. The results of the study showed that male students had higher confidence in programming learning than female students, but there was no significant difference in overall items. In addition, it was possible to find the difference in motivation to break out from the learning according to the major of students by gender. Through this study, it is expected that it will be helpful to prepare learning strategies to enhance learning motivation and satisfaction by considering learner characteristics in programming learning.

• Journal of the Korean Society for information Management
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• v.36 no.2
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• pp.57-77
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• 2019

Random Forest (RF), a representative ensemble technique, was applied to automatic classification of journal articles in the field of library and information science. Especially, I performed various experiments on the main factors such as tree number, feature selection, and learning set size in terms of classification performance that automatically assigns class labels to domestic journals. Through this, I explored ways to optimize the performance of random forests (RF) for imbalanced datasets in real environments. Consequently, for the automatic classification of domestic journal articles, Random Forest (RF) can be expected to have the best classification performance when using tree number interval 100~1000(C), small feature set (10%) based on chi-square statistic (CHI), and most learning sets (9-10 years).

• Journal of the Korea Institute of Information and Communication Engineering
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• v.23 no.7
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• pp.801-806
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• 2019

Recently, each university has been lecturing a lot on the liberal arts subject by emphasizing software education. However, students are often motivated by the difficulty of learning programming, the inability to recognize why they should learn programming, or even the fact that they do not try. The reason for the resilience is to guide programming learning to have the power to recover from the point of abandonment to proceed with the learning again. In this study, recovery elasticity pre-post-examination was conducted on the parts that learned scratches and those that learned Python. Studies have shown that while Scratch appears to be trying to accept and work harder, Python has been relatively more difficult than Scratch. It is expected that this study will help identify the factors that can sustain programming learning.

• Journal of the Korean Society for information Management
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• v.36 no.2
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• pp.255-273
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• 2019

Recently, the table of contents (TOC) has been becoming increasingly accessible and utilized. The study conducted descriptive statistics and comparative analysis of the table of contents in terms of parts of speech and subject in text. For this purpose, this study chose the books of the social sciences field from acquisition lists of an academic library, obtained Dewey class numbers of target books from KERIS union catalog, and extracted TOC data from online bookstore. Morphological analysis was performed on each book titles and TOCs, and descriptive statistics and frequency analysis were carried out. As a result, nouns made up roughly half of the morphemes of titles or the TOCs. TOCs had about 50 times more nouns than titles. The percentage of unique nouns that appeared only in the table of contents is estimated to be 95.2% of the TOC's total nouns. The table of contents also showed a differences in its lengths depending on the field of social science.