• 대한약침학회지
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• 제26권1호
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• pp.1-9
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• 2023

Objectives: Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Nigella sativa to manage women with PCOS. Methods: A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of N. sativa in the management of women with PCOS. Results: Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed (N. sativa), thymoquinone, has potential for managing women with PCOS. Moreover, N. sativa may help to manage oligomenorrhea and amenorrhea in women with PCOS through its anti-inflammatory and antioxidant properties. Conclusion: N. sativa has potential for use as a herbal medicine for managing women with PCOS as an integrative medicine along with traditional and modern medicine in conjunction with calorie restriction and regular exercise.

• 한방재활의학과학회지
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• 제27권4호
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• pp.55-65
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• 2017

Objectives The purpose of this review is to analyze results of case studies and controlled studies about Carthmi-Flos pharmacopuncture. Based on the review, authors desire to suggest the study model including precise information and evident the effect of Carthmi-Flos pharmacopuncture objectively in treating clinical disorders. Methods We search 44 studies about Carthmi-Flos pharmacopuncture from 6 Korean web databases, using words 'Carthmi-Flos pharmacopuncture' in Korean alphabet. This study had been conducted throughout 1 month (July, 2017). We selected case studies and controlled trials in investigated 44 thesis, excluding experimental research and thesis not using the Carthmi-Flos pharmacopuncture for major treatment. Results We analyze 13 case reports and 7 controlled trials. As a result, Carthmi-Flos Pharmacopuncture was used mostly in musculoskeletal, neurological diseases. But this can be applied to internal diseases. Disorders reported effectively were carpal tunnel syndrome, degenerative knee joint arthritis, posterior neck pain, low back pain, radial nerve palsy, shoulder pain, lumbar compression fracture, alopecia areata, chronic daily headache, duverney fracture, oligomenorrhea, cervical disc herniation, rheumatoid arthritis and cervical headache. Conclusions As we analyzed, Carthmi-Flos pharmacopuncture is specifically effective in musculoskeletal and neurologic diseases. But there are various problems in study design. To design accurately, the study design should include much more specific information. And the result can be more precise by excluding other methods.

• 동의생리병리학회지
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• 제21권2호
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• pp.539-542
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• 2007

After analyzing the cases of treating female patients troubled with morbid leukorrhea, the writer drew the conclusions as follows. The shapes of patients with morbid leukorrhea show a large number of shapes of Gi type, Sin type or being inclined to be vigorous Gi, to have depressive syndrome due to disorder of Gi, to be Fire's nature flared upward, to become retention of phlegm and fluid, to become retention of Gi or to become retention of heat, or San syndromes. Accompanied syndromes of morbid leukorrhea appear over the body of upper, middle or lowe portion. In lower cho, the symptoms are menopathy, menstrual irregularities, menstrual irregularities, oligomenorrhea, itching of external genitals, San syndromes, infertility, lumbago which are connected with uterus. And in the middle cho, those are indigestion, nausea, distress in the stomach, vomiting, swallowing acid connected with digestive organs. And also in the upper cho, globus hystericus, chest distress, headache, dizziness, neck stiffness, heat in the upper, pimples connected with upper cho are appeared. Among the prescriptions of treatment for morbid leukorrhea, Ijintang was applied with the widest range of all. Besides that there were mainly prescribed for symptoms such as Gamisachil-tang, Haenggihyangso-san, Gamigwibi-tang, hyangsapyeongwi-san, Onkyung-tang, Banchong-san, Yongdamsagan-tang, Sogampaedok-san, Ojeok-etc.

• Clinical and Experimental Reproductive Medicine
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• 제13권1호
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• pp.21-28
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• 1986

It is now apparent that many cases of amenorrhea. oligomenorrhea. corpus luteum deficiency, galactorrhea, and infertility are due to hyperprolactinemia. We investigated the relationships between serum prolactin values and factors such as menstrual pattern, frequency of galactorrhea etc, in 135 hyperproIactinemic patients at the Seoul National University Hospital during a period of 6 years, from January, 1979 to December, 1984. The results was as follows: 1. Menstrual pattern changed according to the serum prolactin level. The frequency of amenorrhea is 1.7 percent in patients with serum prolactin levels ranged from $25{\sim}40ng/ml$, whereas 72.4 percent in patients with serum prolactin levels above 100ng/ml. 2. The incidence of galactorrhea in hyperprolactinemic patients was 3.1 percent and the frequency of galactorrhea had direct relationship with the serum prolactin level and/or the frequency of abnormal menstrual pattern. 3. The incidence of pituitary tumor in hyperprolactinemic patients was 104 percent and sixty percent of patients with serum prolactin levels above 100ng/ml had a pituitary tumor . 4. There was an inverse correlation between serum prolactin and progesletone value. 5. The frequency of anovulatory menstrual cycle evidenced by basal body temperature is 23.9 percent in patients with serum prolactin levels ranged from $20{\sim}40ng/ml$, whereas 76.9 percent in patients with serum prolactin levels above 100ng/ml.

• 대한한방부인과학회지
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• 제24권2호
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• pp.134-141
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• 2011

Objectives: The purpose of this study is to asses the effects of oriental medicine on premature ovarian failure. Methods: The patient in this case was 30-year-old female. The chief complain is oligomenorrhea. By serum hormone assay and history interview, we diagnosed premature ovarian failure. She was treated by oriental treatments, such as herbal medicine and acupuncture. And then we estimated the results of treatment by follow-up measurements of serum hormone level. Results: After treatments, symptoms of premature ovarian failure was improved, level of serum gonadotropin decreased and level of serum $E_2$ increased. We confirmed the improvement of case by follow-up measurements of serum hormone level. Conclusions: This results of serum hormone assay showed how medically effective oriental treatments of premature ovarian failure.

• Journal of Genetic Medicine
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• 제16권1호
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• pp.10-14
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• 2019

Purpose: The aim of this study was to investigate the clinicopathological features of premature ovarian insufficiency (POI) associated with chromosomal abnormalities. Materials and Methods: This was a retrospective study of POI patients with chromosomal abnormalities diagnosed between January 2009 and December 2017. The definition of POI is based on hypergonadotropinism of 40 or greater in follicle stimulating hormone (FSH) measurements at age 40 years or less. FSH was measured twice at least 4 weeks apart. Karyotyping using peripheral blood for chromosomal testing was conducted in all patients diagnosed with POI. We analyzed the clinical characteristics and genetic causes of patients who were diagnosed with POI. Results: Forty patients were diagnosed with POI including 9 (22.5%) with identified chromosomal abnormalities. The mean age at diagnosis was $23.1{\pm}7.8years$ (ranging between 14 and 39). Three patients did not experience menarche. The presenting complaints were short stature in one case, one case of amenorrhea with ambiguous external genitals, one case of infertility, and six related to menstruation such as oligomenorrhea or irregular rhythm. Turner syndrome was diagnosed in four cases, Xq deletion in one case, trisomy X in two cases, and 46,XY disorder of sexual development in two other patients. Conclusion: Patients diagnosed with POI carrying the same type of chromosomal abnormality manifest different phenotypes. The management protocol also needs to be changed depending on the diagnosis. A karyotype is indicated for accurate diagnosis and proper management of POI in patients, with or without stigmata of chromosomal abnormalities.

• 대한한방부인과학회지
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• 제22권2호
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• pp.189-208
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• 2009

Purpose: In oriental medicine, doctors have mainly made diagnosis and treatment with amenorrhea or delayed menstrual period based on overall analysis of symptoms and signs patients have. We think patients with amenorrhea or delayed menstrual period to have symptoms that are classified into one differentiation of syndromes, and then studied to make the index. This study has been carried out to investigate pattern identifications and classify symptoms according to them. Methods: We examined 52 patients who visited Dong-eui university oriental medical center from June 2005 to February 2009 for undergoing treatment for amenorrhea or delayed menstrual period and made OB & GY questionnaires up Results: We investigated whether the patients had symptoms concerned with symptom types by analyzing the result of DSOM(Diagnos System of Oriental Medicine, hearafter DSOM). It came out 51 cases among 52 with pathogenesis that was related to the symptom types. The symptom types of were surveyed into Insufficiency of Kidney and Liver(肝腎不足), Insufficiency of Qi and Blood(氣血虛弱), Insufficiency of Yin & Dryness of blood(陰虛血燥), stagnation of Qi and Blood(氣滯血瘀), phlegm and damp(痰濕阻滯), coldness of Blood(血寒), Heat of Heart(心火). Conclusion: As a result of the investigation, one case did not have symptoms of differentiation of syndromes of amenorrhea or delayed menstrual period. 29 cases had 1 or 2 differentiation of syndromes. 21 patients had such complex symptoms of diverse differentiation of syndromes that it was difficult to diagnose a differentiation of syndromes in clinical survey. It is necessary to put the priority among the differentiation of syndromes in diagnosis in the future.

• 대한한방부인과학회지
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• 제27권4호
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• pp.57-68
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• 2014

Objectives: The purpose of this research is to investigate the relationship between Sasang constitution and cold hypersensitivity. Methods: We investigated 391 outpatients who visited Dong-Eui Oriental Hospital OB & GY from June 12, 2013 to April 18, 2014. Among 134 patients who complained feeling of cold, we analyzed 107 patients whose Sasang constitution is confirmed. Results: 1. There were 21 persons 19.8% of under age 27, 28 persons 26.4% of age 28-34, 23 persons 21.7% of age 35-41, 18 persons 17% of age 42-48, 16 persons 15.1% of age over 49. 2. Among 107 patients, there were 52 persons 48.6% of Soeumin, 29 persons 27.1% of Taeeumin, 25 persons 23.4% of Soyangin, 1 person 0.9% of Taeyangin. And Taeyangin interior disease was 1 case 100%, Soyangin exterior disease was 22 cases 88% and interior disease was 3 cases 12%, Taeeumin exterior disease was 11 cases 37.9% and interior disease was 18 cases 62.1%, Soeumin exterior disease was 19 cases 36.5% and interior disease was 33 cases 3.5%. 3. In the distribution of cold-hypersensitive part, hands and feet with chills were 58 cases 4.7% by largest number, and the following was hands and feet in 24 cases 22.6%. 4. In the distribution of chief complaint, there were 25 cases 23.58% of menstrual pain, 19 cases 17.92% of postpartum symptoms, 17 cases 16.04% of oligomenorrhea and hypomenorrhea, 14 cases 13.21% of cold hypersensitivity. 5. In the distribution of chief complaint depending on age, menstrual pain of under age 27, postpartum symptoms of age 35-41 and cold hypersensitivity of over age 49 were at a high rate. Conclusions: Results suggest that patients with symptom of cold hypersensitivity have some tendencies in age, Sasang constitution, chief complaint, cold-hypertensive part.

• 대한한방부인과학회지
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• 제32권1호
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• pp.37-47
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• 2019

Objectives: The purpose of this study was to analyze the current characteristics and prescriptions of outpatients with Polycystic Ovary Syndrome (PCOS). Methods: We searched medical records from January 1, 2017 to December 31, 2017 and found out 31 patients who first visited with PCOS. Results: The average age of PCOS patients was $26.48{\pm}5.15years$ old, average height was $162.16{\pm}5.56cm$, average weight was $55.27{\pm}9.34kg$, and average BMI was $21.01{\pm}3.48kg/m^2$ A total of 24 patients who had received western treatment for PCOS in the past, 13 people received oral contraceptions, 4 hormones, 2 metformin, one hormone and metformin, also 4 people were treated for assisted reproductive technologies due to infertility. There were only two patients who combined Korean and Western treatments. The most common menstrual-related symptoms of PCOS patients were oligomenorrhea (48.4%) and dysmenorrhea (22.6%). Other symptoms were the highest in the cold symptoms (54.8%), followed by infertility (9.7%). The average number of patients visiting the hospital was $6.26{\pm}7.2$, with 22 (71.0%) coming from 1 to 5. The average treatment period for patients was $10.1{\pm}10.8weeks$, with 41.9% the largest for 1 to 4 weeks. Acupuncture (93.5%), moxibustion (96.8%) herbmed (96.8%) was treated to most PCOS patients. The most commonly used herbal medicines were Ongyeong-tang (35.5%), Ijin-tang-gami (19.4%), Dodam-tang-gami (12.9%), and Jogyeongjongok-tang-gami (12.9%). Conclusions: These results could be helpful to treat PCOS patients in Korean gynecologic clinical fields.

• 대한한방부인과학회지
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• 제34권3호
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• pp.175-191
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• 2021

Objectives: This study aims to analyze the medical record of eight cases of polycystic ovary syndrome (PCOS) in a local Korean medicine clinic, in order to provide evidence on Korean medicine treatment of PCOS and to suggest the direction of future studies. Methods: The medical records of eight cases diagnosed with PCOS based on 2003 Rotterdam Criteria and whose total testosterone level was 0.53 ng/ml and over were retrospectively analyzed. The primary outcome was total testosterone level, and the secondary outcomes included luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels, LH/FSH ratio, weight, last mentrual period (LMP), numerical rating scale (NRS) score of dysmenorrhea, and other associated symptoms pre- and post-treatment. Korean medicine treatment consists of the complex herbal prescription consisting of Yukmijihwang-tang, Baekho-tang, Daesiho-tang, and Gyejibokryeong-hwan, modified according to symptoms; acupuncture and electroacupuncture on 中脘 (CV12), 下脘 (CV10), 關元 (CV4), 石門 (CV5), 合谷 (LI4), 太衝 (LR3), 三陰交 (SP6), and 懸鍾 (GB39); and indirect moxibustion on 神闕 (CV8). Results: The average total testosterone level lowered statistically significantly after the treatment. The average FSH and LH levels lowered with insignificance, while the average LH/FSH ratio and weight lowered statistically significantly. During the treatment period of three to six months, every patient had the menstrual cycle shortened except for one case; and two cases with infertility problem succeeded in being pregnant. There was no adverse event. Conclusions: The Korean medicine treatment was found effective in treating PCOS, especially regarding hyperandrogenism, amenorrhea or oligomenorrhea, and infertility.