• Advances in nano research
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• v.13 no.1
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• pp.87-96
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• 2022

Drug self-delivery systems can easily realize combination drug therapy and avoid carrier-induced toxicity and immunogenicity because they do not need non-therapeutic carrier materials. So, designing appropriate drug self-delivery systems for specific diseases can settle most of the problems existing in traditional drug delivery systems. Retinal pigment epithelium is very important for the homeostasis of retina. However, it is vulnerable to oxidative damage and difficult to repair. Worse still, the antioxidants can hardly reach the retina by non-invasive administration routes due to the ocular barriers. Herein, the targeted group (folic acid) and antioxidant (melatonin) have been grafted on the surface of ZnO quantum dots to fabricate a new kind of drug self-delivery systems as a protectant via eyedrops. In this study, the negative nanoparticles with size ranging in 4~6 nm were successfully synthesized. They could easily and precisely deliver drugs to retinal pigment epithelium via eyedrops. And they realized acid degradation to controlled release of melatonin and zinc in retinal pigment epithelium cells. Consequently, the structure of retinal pigment epithelium cells were stabilized according to the expression of ZO-1 and β-catenin. Moreover, the antioxidant capacity of retinal pigment epithelium were enhanced both in health mice and photic injury mice. Therefore, such new drug self-delivery systems have great potential both in prevention and treatment of oxidative damage induced retinal diseases.

• Advances in nano research
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• v.10 no.5
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• pp.461-470
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• 2021

Infection is one of the major mortality causes throughout the globe. Nuclear medicine plays an important role in diagnosis of deep infections such as osteomyelitis, arthritis infection, heart valve and heart prosthesis infections. Techniques such as labeled leukocytes are sensitive and selective for tracking the inflammations but they are not suitable for differentiating infection from inflammation. Anionic linear-globular dendrimer-G₂ was synthesized then conjugation to gemifloxacin antibiotic. The structures were identified by FT-IR, ¹H-NMR, C-NMR, LC-MS and DLS. The toxicity of gemifloxacin and dendrimer-gemifloxacin complex was compared by MTT test. Dendrimer-G₂-gemifloxacin was labeled by Technetium-99m and its in-vitro stability and radiochemical purity were investigated. In-vivo biodistribution and SPECT imaging were studied in a rabbit model. Identify and verify the structure of the each object was confirmed by FT-IR, ¹H-NMR, C-NMR and LC-MS, also, the size and charge of this compound were 128 nm and -3/68 mv respectively. MTT test showed less toxicity of the dendrimer-G₂-gemifloxacin than free gemifluxacin (P < 0.001). Radiochemical yield was > %98. Human serum stability was 84% up to 24 h. Biodistribution study at 50 min, 24 and 48 h showed that the complex is significantly absorbed by the intestine and accumulation in the lungs and affects them, finally excreted through the kidneys, biodistribution results are consistent with results from full image means of SPECT/CT technique.

• Advances in nano research
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• v.12 no.1
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• pp.73-79
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• 2022

Due to the extensive use of concrete structures in various applications, the improvement of their strength and quality has become of great importance. A new way of achieving this purpose is to add different types of nanoparticles to concrete admixtures. In this work, a mathematical model has been employed to analyze the vibration of concrete beams reinforced by graphene oxide (GO) nanoparticles. To verify the accuracy of the presented model, an experimental study has been conducted to compare the compressive strengths of these beams. Since GO nanoparticles are not readily dissolved in water, before producing the concrete samples, the GO nanoparticles are dispersed in the mixture by using a shaker, magnetic striker, ultrasonic devices, and finally, by means of a mechanical mixer. The sinusoidal shear deformation beam theory (SSDBT) is employed to model the concrete beams. The Mori-Tanaka model is used to determine the effective properties of the structure, including the agglomeration influences. The motion equations are calculated by applying the energy method and Hamilton's principle. The vibration frequencies of the concrete beam samples are obtained by an analytical method. Three samples containing 0.02% GO nanoparticles are made and their compressive strengths are measured and compared. There is a good agreement between our results and those of the mathematical model and other papers, with a maximum difference of 1.29% between them. The aim of this work is to investigate the effects of nanoparticle volume fraction and agglomeration and the influences of beam length and thickness on the vibration frequency of concrete structures. The results show that by adding the GO nanoparticles, the vibration frequency of the beams is increased.

• Advances in materials Research
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• v.12 no.3
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• pp.243-261
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• 2023

This study aims to analyze the mechanical buckling behavior of a single-walled carbon nanotube (SWCNT) integrated with a one-parameter elastic medium and modeled as a Kerr-type foundation under a longitudinal magnetic field. The structure is considered homogeneous and therefore modeled utilizing the nonlocal first shear deformation theory (NL-FSDT). This model targets thin and thick structures and considers the effect of the transverse shear deformation and small-scale effect. The Kerr model describes the elastic matrix, which takes into account the transverse shear strain and normal pressure. Using the nonlocal elastic theory and taking into account the Lorentz magnetic force acquired from Maxwell relations, the stability equation for buckling analysis of a simply supported SWCNT under a longitudinal magnetic field is obtained. Moreover, the mechanical buckling load behavior with respect to the impacts of the magnetic field and the elastic medium parameters considering the nonlocal parameter, the rotary inertia, and transverse shear deformation was examined and discussed. This study showed useful results that can be used for the design of nano-transistors that use the buckling properties of single-wall carbon nanotubes(CNTs) due to the creation of the magnetic field effect.

• Advances in aircraft and spacecraft science
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• v.10 no.1
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• pp.51-65
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• 2023

In this paper, the effect of deepness on in-plane free vibration behavior of a curved functionally graded (FG) nanobeam based on nonlocal elasticity theory has been investigated. Differential equations and boundary conditions have been developed based on Hamilton's principle. In order to figure out the size effect, nonlocal theory has been adopted. Properties of material vary in radial direction. By using Navier solution technique, the amount of natural frequencies has been obtained. Also, to take into account the deepness effect on vibrations, thickness to radius ratio has been considered. Differences percentage between results of cases in which deepness effect is included and excluded are obtained and influences of power-law exponent, nonlocal parameter and arc angle on these differences percentage are studied. Results show that arc angle and power law exponent parameters have the most influences on the amount of the differences percentage due to deepness effect. It has been observed that the inclusion of geometrical deep term and material distribution results in an increase in sensitivity of dimensionless natural frequency about variation of aforementioned parameters and a change in variation range of natural frequency. Finally, several numerical results of deep and shallow curved functionally graded nanobeams with different geometry dimensions are presented, which may serve as benchmark solutions for the future research in this field.

• Advances in nano research
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• v.14 no.4
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• pp.375-389
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• 2023

In this study, free vibration analysis of functionally graded (FG) porous truncated conical shell panels reinforced by graphene platelets (GPLs) has been investigated for the first time. Additionally, the effect of three different types of porosity distribution and five different types of GPLs patterns on dynamic response of the shell are also studied. Halpin-Tsai micromechanical model and Voigt's rule are used to determine Young modulus, shear modulus and Poisson's ratio with mass densities of the shell, respectively. The main novelties of present study are: applying 3D elasticity theory and the finite element method in conjunction with Rayleigh-Ritz method to give more accurate results unlike other simplified shell theories, and also presenting a general 3D solution in cylindrical coordinate system that can be used for analyses of different structures such as circular, annular and annular sector plates, cylindrical shells and panels, and conical shells and panels. A convergence study is performed to justify the correctness of the obtained solution and numerical results. The impact of porosity and GPLs patterns, the volume of voids, the weight fraction of graphene nanofillers, semi vertex and span angles of the cone, and various boundary conditions on natural frequencies of the functionally graded panel have been comprehensively studied and discussed. The results show that the most important parameter on dynamic response of FG porous truncated conical panel is the weight fraction of nanofiller and adding 1% weight fraction of nanofiller could increase 57% approximately the amounts of natural frequencies of the shell. Moreover, the porosity distribution has great effect on the value of natural frequency of structure rather than the porosity coefficient.

• Advances in nano research
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• v.12 no.3
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• pp.291-300
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• 2022

The behavior of hydrogen species on the surface of the catalyst during the Lewis acid transformation to form Brønsted acid sites over the spherical silica-supported WO_x catalyst was investigated. To understand the structure-activity relationship of Lewis acid transformation and hydrogen bonding interactions, we explore the potential of using the in situ diffuse reflection infrared Fourier transform spectroscopy (DRIFTS) with adsorbed ammonia and hydrogen exposure. From the results of in situ DRIFTS measurements, Lewis acid sites on surface catalysts were transformed into new Brønsted acid sites upon hydrogen exposure. The adsorbed NH₃ on Lewis acid sites migrated to Brønsted acid sites forming NH⁴⁺. The results show that the dissociated H atoms present on the catalyst surface formed new Si-OH hydroxyl species - the new Brønsted acid site. Besides, the isolated Si-O-W species is the key towards H-bond and Si-OH formation. Additionally, the H atoms adsorbed surrounding the Si-O-W species of mono-oxo O=WO₄ and di-oxo (O=)₂WO₂ species, where the Si-O-W species are the main species presented on the Inc-SSP catalysts than that of the IWI-SSP catalysts.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.10
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• pp.895-903
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• 2017

Quantum Cellular Automata(QCA) is one of the proposed techniques as an alternative solution to the fundamental limitations of CMOS. QCA has recently been extensively studied along with experimental results, and is attracting attention as a nano-scale size and low power consumption. Although the XOR gates proposed in the previous paper can be designed using the minimum area and the number of cells, there is a disadvantage that the number of added cells is increased due to the stability and the accuracy of the result. In this paper, we propose a gate that supplement for the drawbacks of existing XOR gates. The XOR gate of this paper reduces the number of cells by arranging AND gate and OR gate with square structure and propose a half-adder by adding two cells that serve as simple inverters using the proposed XOR gate. Also This paper use QCADesginer for input and result accuracy. Therefore, the proposed half-adder is composed of fewer cells and total area compared to the conventional half-adder, which is effective when used in a large circuit or when a half - adder is needed in a small area.

• Asia-pacific Journal of Multimedia Services Convergent with Art, Humanities, and Sociology
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• v.7 no.3
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• pp.301-310
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• 2017

Quantum-dot cellular automata(QCA) is an alternative technology for implementing various computation, high performance, and low power consumption digital circuits at nano scale. In this paper, we propose a new universal gate in QCA. By using the universal gate, we propose a novel XOR gate which is reduced time/hardware complexity. The universal gate can be used to construct all other basic logic gates. Meanwhile, the proposed universal gate is designed by basic cells and a rotated cell. The rotated cell of the proposed universal gate is located at the central of 3-input majority gate structure. In this paper, we propose an XOR gate using three universal gates, although more than five 3-input majority gates are used to design an XOR gate using the 3-input majority gate. The proposed XOR gate is superior to the conventional XOR gate in terms of the total area and the consumed clock because the number of gates are reduced.

• Advances in nano research
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• v.15 no.1
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• pp.49-57
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• 2023

As composite materials are used in many applications, the modern world looks forward to significant progress. An overview of the application of composite fiber materials in sports equipment is provided in this article, focusing primarily on the advantages of these materials when applied to sports equipment, as well as an Analysis of the influence of sports equipment of fiber-reinforced composite material on social sports development. The present study investigated surface morphology and physical and mechanical properties of S-glass fiber epoxy composites containing Al₂O₃ nanofillers (for example, 1 wt%, 2 wt%, 3 wt%, 4 wt%). A mechanical stirrer and ultrasonication combined the Al₂O₃ nanofiller with the matrix in varying amounts. A compression molding method was used to produce sheet composites. A first physical observation is well done, which confirms that nanoparticles are deposited on the fiber, and adhesive bonds are formed. Al₂O₃ nanofiller crystalline structure was investigated by X-ray diffraction, and its surface morphology was examined by scanning electron microscope (SEM). In the experimental test, nanofiller content was added at a rate of 1, 2, and 3% by weight, which caused a gradual decrease in void fraction by 2.851, 2.533, and 1.724%, respectively, an increase from 2.7%. The atomic bonding mechanism shows molecular bonding between nanoparticles and fibers. At temperatures between 60 ℃ and 380 ℃, Thermogravimetric Analysis (TGA) analysis shows that NPs deposition improves the thermal properties of the fibers and causes negligible weight reduction (percentage). Thermal stability of the composites was therefore presented up to 380 ℃. The Fourier Transform Infrared Spectrometer (FTIR) spectrum confirms that nanoparticles have been deposited successfully on the fiber.