• 대한가정학회지
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• 제44권2호
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• pp.137-152
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• 2006

The major purpose of this study was to investigate the causal effect of the primary triad experiences on dating relationship satisfaction through self-esteem among college students. The primary triad experiences were composed of the parents' differentiation level of couple relationship and the parent-child relationship including family rule, triangulation and communication. Dating relationship satisfaction included such subscales as problem-solving communication, global satisfaction, affection communication and time together. The study data were collected from 382 college students by using self-administered questionnaire method. The results showed that parents' differentiation was positively correlated with self-esteem and all components of dating relationship satisfaction and that family rule was negatively associated only with problem-solving communication. Triangulation was negatively related with most components of dating relationship satisfaction and self-esteem, while parent-child communication showed positive correlations with the same variables. Path analysis results showed that self-esteem mediated the effect of most variables of primary triad experiences on dating relationship satisfaction. In addition, variables of the primary triad experience had direct influences on most components of dating relationship satisfaction. Self-esteem was found to be the most powerful variable influencing dating relationship satisfaction. The findings of the study were discussed in terms of pre-marital education and counseling.

• 대한한의학원전학회지
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• 제20권4호
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• pp.119-126
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• 2007

The biological and pathological states of lung, spleen, liver and kidneys are determined by nature and emotion of sorrow, anger, joy and pleasure, It is considered that the music, besides medicine or acupuncture, can be a way of treating as a therapeutics for the treatment of Sasangin's diseases. This study is to find out a way of music therapy for the treatment of Sasangin's diseases. The ways of music therapy in each constitution based on 'the great and small of Viscera and Bowels' and 'the exhale and inhale, the drawing in and sending out' are as follows: 1. In case of Soeumin, a skip going up melodic progression, dotted rhythm and the major triad harmonic progression are recommended to improve the Qi of warm Yang. 2. In case of Soyangin, in regular sequence down melodic progression, a sixteenth note and the minor triad harmonic progression are recommended to improve the Qi of cool Yin. 3. In case of Taeumin, in regular sequence going up melodic progression, a sixteenth note and the bright and active the major triad harmonic progression are recommended to improve the Qi of dispersing exhale. 4. In case of Taeyangin, a skip down melodic progression, a quarter note and a diminished triad harmonic progression are recommended to improve the Qi of gathering inhale.

• 한국수학교육학회지시리즈E:수학교육논문집
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• 제28권2호
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• pp.219-234
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• 2014

음악과 수학은 구조적인 유사성이 많다. 음악에서 중요하게 사용하는 장,단3화음은 서로 음정의 순서가 뒤바뀐 전회(Inversion)관계가 되는데 이는 수학적으로 반사(reflection)에 해당한다. 기하학적인 표현은 수학에서뿐만 아니라 음악에서도 그 구조를 이해하는데 도움이 되는데 음악에서 조성관계를 나타낸 도표를 톤네츠(Tonnetz)라고 한다. 톤네츠를 활용하면 장,단3화음의 반사 관계를 쉽게 파악할 수 있고 또한 이도(transposition)를 평행이동(translation)으로 나타낼 수 있다. 본 연구에서는 기존의 톤네츠를 살펴보고 수학적 원리로 새롭게 구성한 S-Tonnetz를 소개한다.

• Molecules and Cells
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• 제42권1호
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• pp.56-66
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• 2019

Histidine triad nucleotide-binding protein (HINT) is a member of the histidine triad (HIT) superfamily, which has hydrolase activity owing to a histidine triad motif. The HIT superfamily can be divided to five classes with functions in galactose metabolism, DNA repair, and tumor suppression. HINTs are highly conserved from archaea to humans and function as tumor suppressors, translation regulators, and neuropathy inhibitors. Although the structures of HINT proteins from various species have been reported, limited structural information is available for fungal species. Here, to elucidate the structural features and functional diversity of HINTs, we determined the crystal structure of HINT from the pathogenic fungus Candida albicans (CaHINT) in complex with zinc ions at a resolution of $2.5{\AA}$. Based on structural comparisons, the monomer of CaHINT overlaid best with HINT protein from the protozoal species Leishmania major. Additionally, structural comparisons with human HINT revealed an additional helix at the C-terminus of CaHINT. Interestingly, the extended C-terminal helix interacted with the N-terminal loop (${\alpha}1-{\beta}1$) and with the ${\alpha}3$ helix, which appeared to stabilize the dimerization of CaHINT. In the C-terminal region, structural and sequence comparisons showed strong relationships among 19 diverse species from archea to humans, suggesting early separation in the course of evolution. Further studies are required to address the functional significance of variations in the C-terminal region. This structural analysis of CaHINT provided important insights into the molecular aspects of evolution within the HIT superfamily.

• 한국어병학회지
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• 제32권2호
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• pp.49-57
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• 2019

본 연구에서는 2012년부터 2018년 1월까지 국내 어류에서 참돔이리도바이러스병 (red sea bream iridoviral disease; RSIVD) 으로 확정 진단된 주요 분리주에 대하여 major capsid protein (MCP) 유전자의 염기서열을 바탕으로 Megalocytivirus의 유전적 관계를 명확히 했다. 또한, Megalocytivirus와 숙주 세포간 상호작용에 영향을 줄 수 있는 특이 유전자 2종, Vascular endothelial growth factor (VEGF) 및 Histidine triad motif인 HIT-like 단백질 (HIT)에 대한 염기서열 분석을 통해 유전적 상관관계를 고찰하였다. 국내 어류에서 분리된 39개의 megalocytiviruses는 2가지 유전형인 red sea bream iridovirus (RSIV)형과 turbot reddish body iridovirus (TRBIV)형으로 분류되었으며, RSIV형의 megalocytiviruses는 다시 유전아형인 RSIV-subgroup 1형과 2형으로 분류되었다. 그리고 VEGF 유전자 염기서열 분석 결과에서는 RSIV형의 바이러스에서 변이가 발생되었음을 확인할 수 있었으며, HIT-like 단백질 유전자는 RSIV형의 Megalocytivi rus에서만 발견되는 것을 알 수 있었다.

• 암석학회지
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• 제17권2호
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• pp.95-107
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• 2008

영주 신암리 마애삼존석불(보물 680호)은 흑운모 화강섬록암으로 구성되고 4 면의 수직 암벽의 앞면과 서면에 돋을새김으로 조각되어 있다. 암벽은 앞면이 $N50^{\circ}E\;85^{\circ}SE$이고, 시계방향으로 각각 $N25^{\circ}W\;90^{\circ}$, $N40{\sim}50^{\circ}E\;82{\sim}85^{\circ}NW$, $N20^{\circ}W\;75^{\circ}SW$을 나타내며 주변 지질의 북동-남서 및 북북서-남남동 절리조에 평행하다. 이 화강섬록암의 풍화암에서 주원소의 화학조성을 이용한 풍화지수는 $60.3{\sim}62.0$으로서 사장석이 용해되고 흑운모가 변질되어 점토광물을 생성시키는 풍화작용이 진행되었다. 마애삼존석불에서 손상은 풍화에 의해 절리, 갈색 녹, 변색현상, 입상분해 등으로 나타난다. 손상원인은 주로 변형작용, 수분, 기온변화, 미생물서식 등이다. 이 중에 수분이 화강섬록암 내의 절리와 미세한 틈을 따라 스며들어 광물을 용해하고 탈락할 뿐만 아니라 식물을 서식케 한 원인으로 판단된다.

• 한국경제지리학회지
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• 제9권2호
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• pp.225-242
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• 2006

본 연구는 내륙세관인 청주세관에서 통관이 이루어진 지역을 대상으로 국제무역의 배후지와 관문, 지향지의 관계를 상호작용형 속성행렬 4차원의 행렬체를 2차원화 시켜 주성분분석을 하여 국제무역의 공간적 분포 패턴을 파악하였는데, 그 결과는 다음과 같다. 배후지-관문-지향지의 지역결합에 의한 주요 공간적 패턴은 수출의 경우 10개, 수입의 경우 9개로 나타났다. 청주세관 통관지역에서의 주요 수출입상품의 구성은 대체로 유사하지만 '정밀기계 제품', '비금속광물'은 수출에서, '광물성 제품', '기계류 및 전자제품'은 수입에서 주로 이루어지는 점이 다르다. 또 관문은 수출입 모두 유사하지만 수입의 경우 인천공항의 이용이 더 많고 청주공항을 이용하는 상품도 있어 지역공항의 이용도를 높이고 있다. 그리고 충북 이외의 지역에서의 수입의 지향지가 두드러지게 나타난다.

• 대한후두음성언어의학회지
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• 제28권1호
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• pp.43-47
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• 2017

Laryngopharyngeal reflux disease (LPRD) is common in laryngologic practice. In Korea, up to 1 out of every 5 patients who visit otorhinolaryngology clinic is supposed to have LPRD with symptoms and physical findings. Major symptoms of LPRD include hoarseness, cough, reflux symptom and mild dysphagia. Even though LPRD is common, its diagnosis may be difficult, because its symptoms are nonspecific and the laryngeal findings are not always associated with symptom severity. In Recent study, 66.4% of Patient who has LPRD also associated with esophageal motility disorders. Esophageal achalasia is a disease of unknown etiology characterized by an absence of peristalsis in the body of esophagus and nonrelaxing hypertension of the lower esophageal sphincter. Common cause is loss of ganglion cells in Auerbachs plexus. The classic triad of symptoms in achalasia includes dysphagia, regurgitation and weight loss. LPRD and esophageal achalasia have similar symptoms but have different treatment of choice. The Differentiation diagnosis of theses disease is important and should be established by history, radiologic examination and endoscopic examination. We recently assessed a 59-year-old female patient who complained of an epigastric pain, dysphagia and chronic cough. LPRD was initially diagnosed on Laryngoscopic examination and Reflux Symptom Index, but patient was not relieved of any symptoms after treatment of Proton Pump Inhibitor for 3 months. After high resolution manometry, esophageal achalasia was finally diagnosed. We report this case regarding the diagnosis and treatment with review of literatures because we have to think about esophageal motility disorders as a differential diagnosis in laryngology.

• Bulletin of the Korean Chemical Society
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• 제28권8호
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• pp.1335-1340
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• 2007

β-Ketoacyl acyl carrier protein synthase (KAS) III is a particularly attractive target in the type II fatty acid synthetic pathway, since it is central to the initiation of fatty acid synthesis. Enterococcus faecalis, a Grampositive bacterium, is one of the major causes of hospital acquired infections. The rise of multidrug-resistant of most bacteria requires the development of new antibiotics, such as inhibition of the KAS III. In order to block the fatty acid synthesis by inhibition of KAS III, at first, three dimensional structure of Enterococcus faecalis KAS III (efKAS III) was determined by comparative homology modeling using MODELLER based on x-ray structure of Staphylococcus aureus KAS III (saKAS III) which is a gram-positive bacteria and is 36.1% identical in amino acid sequences with efKAS III. Since His-Asn-Cys catalytic triad is conserved in efKAS III and saKAS III, substrate specificity of efKAS III and saKAS III and the size of primer binding pocket of these two proteins are expected to be similar. Ligand docking study of efKAS III with naringenin and apigenin showed that naringenin docked more strongly with efKAS III than apigenin, resulting in the intensive hydrogen bond network between naringenin and efKAS III. Also, only naringenin showed antibacterial activity against E. faecalis at 256 μg/mL. This study may give practical implications of flavonoids for antimicrobial effects against E. faecalis.

• 철학연구
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• 제105권
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• pp.401-421
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• 2008

본 논문의 목적은 들뢰즈 영화철학의 구축에 있어서 칸트 철학이 행한 역할을 효과적 내지 긍정적인 측면에서 고찰하고, 그것을 통하여 들뢰즈 영화철학의 구성요소 중에서도 그다지 중요하게 다루어지지 않았던 칸트적 계기를 재조명해 보려는데 있다. 논의의 순서는 다음과 같다. 1. 들뢰즈 영화철학에 대한 베르그송, 니체, 스피노자라는 소위 '들뢰즈 3인방'을 배려하면서 그 조감도를 작성해 보려고 한다. 특히 들뢰즈의 말년의 주저인 "Cinema 1, 2권"을 중심으로 그 책의 구성을 분석하면서 들뢰즈의 영화철학의 구조를 파악하려고 한다. 2. 칸트 철학이 그 배열 안에서 어떤 위치에 있는가를 검증해 보려고 한다. 3. 거기로부터 들뢰즈 영화철학에 있어서 칸트적 계기의 의의 및 효과를 드러내 보려고 한다. 본고의 귀결이 칸트를 들뢰즈의 코페르니쿠스적 전회로서의 '사고의 이미지'론과 여러 가지 차원에서 결부지울 수 있다면 우리의 시도는 달성되었다고 보아도 좋을 것이다.