• Proceedings of the Korean Statistical Society Conference
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• 2000.11a
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• pp.193-200
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• 2000

Modelling the dependence via random effects in censored multivariate survival data has recently received considerable attention in the biomedical literature. The random effects models model not only the conditional survival times but also the conditional hazard rate. Systematic likelihood inference for the models with random effects is possible using Lee and Nelder's (1996) hierarchical-likelihood (h-likelihood). The purpose of this presentation is to introduce Ha et al.'s (2000a,b) inferential methods for the random effects models via the h-likelihood, which provide a conceptually simple, numerically efficient and reliable inferential procedures.

• Journal of Korean Society for Quality Management
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• v.23 no.2
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• pp.28-42
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• 1995

For quality improvement, Taguchi emphasizes the reduction of variation of the quality characteristic, Taguchi has used the signal-to-noise ratios for achieving minimum dispersion of the quality characteristic with its location adjusted to some desired target value ${\tau}$ Lim(1994) proposes a reasonable SN ratio based on a linking relationship of the variance and mean through simple data analysis technique. In this paper we investigate the efficiency of those two SN ratios and variance stabilizing transformations through Monte Carlo Simulations.

• Communications for Statistical Applications and Methods
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• v.7 no.1
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• pp.225-232
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• 2000

The linear and quadratic discrimination functions based on normal theory are widely used to classify an observation to one of predefined groups. But the discriminant functions are sensitive to outliers. A high breakdown procedure to estimate location and scatter of multivariate data is the minimum volume ellipsoid or MVE estimator To obtain high breakdown classifiers outliers in multivariate data are detected by using the robust Mahalanobis distance based on MVE estimators and the weighted estimators are inserted in the functions for classification. A samll-sample MOnte Carlo study shows that the high breakdown robust procedures perform better than the classical classifiers.

• Bulletin of the Korean Chemical Society
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• v.33 no.11
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• pp.3681-3685
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• 2012

We developed a simple and effective method for the SERS-based detection of protein-small molecule complexes and label-free proteins using avidin-induced silver aggregation. Upon excitation with light of the appropriate wavelength (633 and 532 nm), the aggregated silver nanoparticles generate a strong electric field that couples with the resonance of the molecules (atto610 and cytochrome c), increasing the characteristic signals of these molecules and resulting in sensitive detection. The detection limit of biotin with the proposed method is as low as 48 ng/mL. The most important aspect of this method is the induction of silver aggregation by a protein (avidin), which makes the silver more biocompatible. This technique is very useful for the detection of protein-small molecule complexes.

• Journal of Korean Society for Quality Management
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• v.24 no.2
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• pp.128-141
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• 1996

The advent of the quality-improvement movement caused a great expansion in the use of statistically designed experiments in industry. The regression method is often used for the analysis of data from such experiments. However, the data for a quality characterstic often takes the form of counts or the ratio of counts, e.g. fraction of defectives. For such data the analysis using generalized linear models is preferred to that using the simple regression model. In this paper we introduce the generalized linear model and show how it can be used for the analysis of non-normal data from quality-improvement experiments.

• Journal of the Korean Society of Costume
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• v.16
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• pp.111-123
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• 1991

We suppose that Poback-cheok appeared with wearing clothes in the ancient times. At first, man used body as a scale, and it is gradually diversified with social development. It is clear that also in the time of Shilla-Dynasty, the United Shilla-Dynasty and the Goryeo-Dynasty, the system of degree existed in historical relation to that of China. But we don't know it's real length, because there is no recording until the beginning of the Yi-Dynasty. The first recording about Poback-cheok appeared in the time of the King Sejong. Hwangjong-Cheok which is a original vessel of the degree system appears in the 7th years of the King Sejong. In the 12th years of the King Sejong, Ju-cheok, Youngjo-cheok and Joyegi-cheok appeared. In the 13th years of the King Sejong, Poback-cheok appeared as a new changed one. At that time, the length of Poback-cheok is recorded as 44.75cm in chapter of Oye and Jonsoo Pobaek-cheok is recorded as 46.73cm in Jeonjesangjeongso's picture, and it is recorded as 46.80cm in the Kyunggugdaijeon. The scale system is put in good order in the time of King Sejong. But it is confused by the war of 1636 after King Seonjo period. In the 26 th year of King Youngjo, it is reappeared as one of the King Sejong, and it is fixed as 46.80cm. The length is used until the proclamation in the 6th years of the Kwangmu(1902), and then the length of Pobaek-cheok is changed as 48.48 cm, that is measured by a Gok-cheok. After that time, the scale system is very confused during the introduction of new civilization and the Korean-Japanes Unit. So it is used longer or shorter(that is, 49.24cm or 48.91cm). And the metric system is introduced by Japanes in 1926, and it reached the present time. According to use, the actual thing with is used in the end of the Yi-Dynasty is various from 30cm to 70cm. And according to material and craft-man, it can be devided into Hwa-gag scale, Najeon-blacklacquer-scale, bamboo-scale, wooden-scale. The way of expression of measure is always followed by the decimal system. The other half part, except the part of expression of graduation, is put on decorate with a pattern. Also we can see the idea of living on this point.

• Journal of the Korean Society for Library and Information Science
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• v.11
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• pp.147-183
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• 1984

This is an analytical study on Munheongak (文獻閣) and it's catalogue. The major objective of the study is to get a recognition of Munheongak under the culture of Sukjong (肅宗) period in Korean library history. Most of early studies made on such a category have been concentrated on Jiphyunjeon (集賢殿), Hongmungwan (弘文館), Kyujanggak(奎章閣) and their backgrounds. In this study, the author has invest gated Kungwolji (宮闕志), Munheongakseomg (文獻閣書目) and other materials related to this subject. The findings of the study can be summarized as follows: 1. Munheongak was established by king Sukjong in the 26th year of his reign. According to some records of Kungkwolji, the reason of establishment of the library was to arrange the collection in the Sango (相庫) consisted of various kinds of materials. In case of books, most of them turned out to be Korean books. 2. Munheongak was sited to the estern side of Kyunghyundang (景賢堂), which was located on the Kyungdeokgung (慶德宮). After Youngjo (英祖) the place was called Kyungheuigung (慶熙宮) so as to avoid the name of the precedent king. But these days, both the buildings are not to be found. 3. After its establishment, the library could not play the role as a library because of the then political situation and sectionalism. During the period of the revival of the learning from Youngjo till Jeongjo(正祖) the function of the library was in a stagnant state. Kyujanggak played the part in its place. 4. Referring to the collection management, the Munheongakseomog is equipped with 101 titles, 2,525 volumes, which are arranged by means of the traditional Chinese classification system. 5. The classification scheme is based on the traditional Chinese classification system which might divide all subjects into four categories such as: Confucian classics division, Historical documents division, Master's division, and Collection of literature division. Some illustrations reveal that the classification system was directly influenced by Seogoseomg (書庫書目) : the influence reflected in the classes for the translated literature and writings, poems, genealogy about kings, etc. But some subdivisions such as a class of Annals, Historical Epcerpts were omitted in the classification scheme, which did not strike the balance in the system in terms of the present theory of classification. Most of bibliographical descriptions were also influenced by Seogoseomog but some elements were partly omitted. 6. The special feature of the collection building is the absence of books in Collection of literature division except only three kinds of books in examining the Munheongakseomog. Since this is rather a comprehensive study for such aspects as historical backround, catalogue, and cultural environment of Munheongak and its related record, it is advised that further and additional research should be made.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.29 no.3
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• pp.147-153
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• 2011

What kinds of environmental adaptation did people during the Chosun era take when climate change due to drought was perceived and natural disasters occurred? Research hypotheses is 'More environmental improvement projects were conducted when climate disasters were experienced than rituals for rain calling. In this study, frequency samples for Rituals for Rain (RR, 祈雨祭) defined as abnormal climate of drought, Climate Disaster(CD) and Environmental Improvement Projects(EIP) were extracted from "Chosunwangjoshillok(朝鮮王朝實錄)". The analysis among RR, CD, and EIP were studied for a regression model. Research hypothesis was statistically tested. RR took placed the order of Sejong(世宗), Sukjong(肅宗) and Youngjo(英祖), while climate disasters were extracted under the Jungjong(中宗), Sungjong(成宗) and Taijong(太宗). EIP were most active under Youngjo(英祖), Sungjong(成宗) and Taijong(太宗). During the former part of the Chosun dynasty, abnormal climate was more seriously considered than climate disasters, while the opposite pattern was shown during the latter part. In a regression analysis between EIP and CD, the equation of EIP = 0.632CD was determined. As a test result, the study hypothesis the entire Chosun dynasty was dismissed. However, it is possible to statistically support that more EIP were conducted in order to adapt to the climate change during the latter part of the dynasty when climate disaster were experienced.

• Journal of Korea Society of Digital Industry and Information Management
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• v.11 no.2
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• pp.1-10
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• 2015

As programs get more complicated and they are developed by various hands, the possibility that there are program bugs in the code has been increasing. And developers usually run unit tests to find these problems in the code. Besides, the developers are at the pain of getting stability of the code when they have to modify a code very often for clients requirements. In the methodlogy of TDD(Test Driven Development), developers write a unit test code first, and then write a program code for passing the unit test. The unit test must include the boundary condition test the reason why the possibility of occurring the bugs is very high. When failed to pass the test because of the value of a function is incorrect, not existed, out of the range or not matched etc, the program code will return the error code or occur the exception. In the document, the system is designed and implemented in order to insert the generated code automatically or suggest it to the developer, when the boundary condition test is failed. In conclusion, it is possible that the developer will get the code stability by searching the code and checking the code to be omitted automatically through this system.

• Molecules and Cells
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• v.41 no.3
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• pp.168-178
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• 2018

Intracellular communication via ubiquitin (Ub) signaling impacts all aspects of cell biology and regulates pathways critical to human development and viability; therefore aberrations or defects in Ub signaling can contribute to the pathogenesis of human diseases. Ubiquitination consists of the addition of Ub to a substrate protein via coordinated action of E1-activating, E2-conjugating and E3-ligating enzymes. Approximately 40 E2s have been identified in humans, and most are thought to be involved in Ub transfer; although little information is available regarding the majority of them, emerging evidence has highlighted their importance to human health and disease. In this review, we focus on recent insights into the pathogenetic roles of E2s (particularly the ubiquitin-conjugating enzyme E2O [UBE2O]) in debilitating diseases and cancer, and discuss the tantalizing prospect that E2s may someday serve as potential therapeutic targets for human diseases.