• 한국환경과학회지
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• 제21권12호
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• pp.1495-1501
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• 2012

In this study, an experiment was conducted on influent water with low concentrations of organic matter, such as river water or secondary treatment water of a sewage treatment plant, according to HRT changes by using aerobic biofilm. In the biofilm process, as the biofilm increases in thickness, the inner membrane can be low in oxygen transfer rate and become anaerobic conditions, while the detachment of biomass from biofilm occurs. To overcome these limitations in the detachment of microorganisms in biofilm, the yarn, which was made from poly propylene(PP), was weaved and manufactured into a tube. Then, a test was carried out by injecting air so that the interior of the biofilm could create aerobic conditions. The results of the experiment showed that the removal efficiency of $TCOD_{cr}$ reached 66.1~81.2% by HRT 2hr, and 50.9 ~61.8% after HRT 1 hr. The removal efficiency of $SCOD_{cr}$ was 45.9 to 55.1% by HRT 1hr, and 26.1% in HRT 0.5hr, showing the highest removal efficiency in HRT 1hr. The SS removal efficiency was at 81.8 to 94.6%, and the effluent SS concentration was very low, indicating less than 2.2 mg/L in all HRT's. As a result, the $SCOD_{cr}$ and $NH_4{^+}$-N that were removed per specific surface area and attached to microbial biofilm showed the highest efficiency in HRT 1hr with 8.37 $gSCOD_{cr}/m^2{\cdot}d$, 2.93 $gNH_4{^+}-N/m^2{\cdot}d$. From the result of reviewing the characteristics of biofilm growth, microorganisms were found to be attached, and increased by 36 days. Later, they decreased in number through detachment, but showed a tendency to increase again 41 days later due to microbial reproduction.

• 한국정보통신학회논문지
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• 제14권1호
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• pp.197-204
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• 2010

본 논문은 저 전압 및 저 왜곡 스위치형 커패시터 (switched-capacitor, SC)를 적용한 새로운 형태의 몸체효과 보상형 스위치 구조를 제안한다. 제안된 회로는 저 전압 SC회로를 위해서 rail-to-rail 스위칭을 허용하며, 기존의 부트스트랩 된 회로 (19dB)보다 더 우수한 총 고조파 왜곡을 가진다. 설계된 2-1 캐스케이드 시그마 델타 변조기는 통신 송수신 시스템내의 오디오 코덱을 위한 고해상도 아날로그-디지털변환을 수행한다. 1단 폴드형 캐스코드 연산증폭기 및 2-1 캐스케이드 시그마 델타 변조기는 0.25 마이크론 이중 폴리 3-금속 표준 CMOS 공정으로 제작되었으며, 2.7V에서 동작한다. 연산증폭기의 1% 정착시간은 16 pF의 부하 용량에 대해 560ns를 보였다. 제작된 시그마 델타 변조기에 대한 검사는 비트 스트림 검사 및 아날로그 분석기를 이용하여 수행 되었다. 다이크기는 $1.9{\times}1.5\;mm^2$였다.

• 대한의생명과학회지
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• 제12권3호
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• pp.131-137
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• 2006

RGS is a negative regulator of G-protein signaling and can be identified by the presence of a conserved $120{sim}125$ amino acid motif, which is referred to as the RGS box. A number of RGSs are induced in response to a wide variety of stimuli. Increased levels of RGSs lead to significant decreases in GPCR responsiveness. To obtain further evidence of a role of RGS proteins in rat C6 astrocytoma cells, we first determined the expression profile of RGS-specific mRNA in C6 cells using reverse transcription-polymerase chain reaction (RT-PCR) with a poly dT18 primer and transcript-specific primers. We found that RGS2, RGS3, RGS6, RGS9, RGS10, RGS12, and RGS16 were differentially expressed in C6 astrocytoma cells. The highest expression rate was found for RGS3, followed by RGS16, RGS10 and RGS9, whereas the expression level for RGS2 was barely detectable. We next assessed whether forskolin regulated the expression of RGSs expressed in C6 astrocytoma cells. The present study found that forskolin dose-dependently stimulated the expression of RGS2 transcripts. This up-regulation of RGS2 gene was abrogated by H-89, potent and broad-spectrum protein kinase A (PKA) inhibitors. Actinomycin D completely inhibited the up-regulation of RGS2 gene induced by forskolin $(10{\mu}M)$, indicating that the regulation of RGS2 gene is controlled at the transcriptional level. In addition, forskolin did significantly activate transcriptional cAMP response element (CRE) in either HEK 293 cells or C6 cells and did not modulate the $NF-{\kappa}B$ and AP-l activity as measured by luciferase reporter gene assay. Finally, forskolin induced the expression of RGS2 mRNA in C6 astrocytoma cells, which depend on the PKA pathway and CRE transcriptional pathways.

• Steel and Composite Structures
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• 제21권3호
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• pp.589-604
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• 2016

Kenya has recently experienced worrying collapse of buildings during construction largely attributable to the poor quality of in-situ concrete and poor workmanship. The situation in the country is further compounded by rapid deterioration of infrastructure, hence necessitating the development of alternative structural systems such as concrete filled unplasticized poly vinyl chloride (UPVC) tubes as columns. The work herein adds on to the very limited and scanty work on use of UPVC tubes in construction. This study presents the findings of experimental and analytical work which investigated the structural response of composite concrete filled UPVC tubes under compressive load regime. UPVC pipes are cheaper than steel tubes and can be used as formwork during construction and thereafter as an integral part of column. Key variables in this study included the strength of infill concrete, the length to diameter ratio (L/D) of the plastic tube, as well as the diameter to thickness ratio (D/2t) of the plastic tube. Plastic tubes having varying diameters and heights were used to confine concrete of different strengths. Results obtained in the study clearly demonstrate the effectiveness of UPVC tubes as a confining medium for infill concrete, attributable to enhanced composite interaction between the UPVC tube and infill concrete medium. It was determined that compressive strength of the composite column specimens increased with increased concrete strength while the same decreased with increased column height, albeit by a small margin since all the columns considered were short columns. Most importantly, the experimental confined concrete strength increased significantly when compared to unconfined concrete strength; the strength increased between 1.18 to 3.65 times the unconfined strength. It was noted that lower strength infill concrete had the highest confined strength possibly due to enhanced composite interaction with the confining UPVC tube. The study further proposes an analytical model for the determination of confined strength of concrete.

• Bulletin of the Korean Chemical Society
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• 제35권8호
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• pp.2335-2341
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• 2014

Chemical investigation on the methanol extract of the starfish Ctenodiscus crispatus resulted in the isolation of five steroids, (22E,$24{\zeta}$)-26,27-bisnor-24-methyl-$5{\alpha}$-cholest-22-en-$3{\beta}$,5,$6{\beta}$,$15{\alpha}$,25-pentol 25-O-sulfate (1), (22E,24R,25R)-24-methyl-$5{\alpha}$-cholest-22-en-$3{\beta}$,5,$6{\beta}$,$15{\alpha}$,25,26-hexol 26-O-sulfate (2), (28R)-24-ethyl-$5{\alpha}$-cholesta-$3{\beta}$,5,$6{\beta}$,8,$15{\alpha}$,28,29-heptaol-24-sulfate (3), (25S)-$5{\alpha}$-cholestane-$3{\beta}$,5,$6{\beta}$,$15{\alpha}$,$16{\beta}$,26-hexaol (4), and ${\Delta}7$-sitosterol (5). Their structures were identified by extensive spectroscopic analyses, including 1D, 2D NMR and MS and chemical methods. Compound 4 showed cytotoxicity against human hepatoma HepG2 and glioblastoma U87MG cells via inhibition of cell growth and induction of apoptosis. Induction of apoptosis by 4 was demonstrated by cell death, DNA fragmentation, increased Bax/Bcl-2 protein ratio and the activation of caspase-3, caspase-9 and poly (ADP-ribose) polymerase (PARP).

• 센서학회지
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• 제24권4호
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• pp.252-257
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• 2015

This paper proposes a single slope A/D converter (SSADC) that is possible to process the signal of the ultraviolet, visible and infrared rays with a single chip. And the proposed SSADC is a type of single channel ADC. In the conventional SSADC, it is possible to process the only one signal with a kind of the sensor because the speed of the operating frequency and the slope of ramp signal generated by the ramp generator are fixed. In order to improve the disadvantages, a ramp generator which has variable slope in ramp function is designed and $3{\times}1$ MUX(multiplexer) is adopted so that we can change the speed of the operating frequency and the slope of ramp signal. Therefore, the multiple signal processing of the wanted sensors can be possible. The designed circuit is layout by the $0.35-{\mu}m$ CMOS 2-poly 4-metal technology process and is checked through DRC and LVS tools.

• The Plant Pathology Journal
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• 제22권2호
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• pp.155-160
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• 2006

A strain of Pepper mottle virus (PepMov) was isolated from chili pepper plants in Korea. In host range study, this virus, designated PepMoV-SNU1, shared most characteristics with PepMoV isolates reported previously. Thermal inactivation point ($45^{\circ}C\;to\;75^{\circ}C$) and dilution end point ($10^{-1}\;to\;10^{-4}$) of PepMoV-SNU1 showed differences depending on the propagation hosts. Cylindrical and pinwheel-shaped inclusions were always observed in pepper leaf tissues infected with the virus alone. Unexpectedly, a special structure of pinwheel shaped inclusion surrounded with unknown small spots was also observed in the leaf section when co-infected with a strain of pepper mild mottle virus. The partial sequence of coat protein gene and 3' untranslated region of PepMoV-SNU1 showed 98% identity with those of other PepMoV isolates. A primer pair derived from 3' end of the coat protein gene and poly A tail regions were designed. Optimal detection condition of PepMoV-SNU1 by RT-PCR was tested to determine appropriate annealing temperature and additional volumes of oligo-dT (18-mer), dNTP, and Taq polymerase. Under the optimized condition, an expected 500 Up PCR-product was detected in pepper leaves infected with PepMoV-SNU1 but not in healthy plants.

• 전기전자학회논문지
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• 제14권1호
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• pp.33-39
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• 2010

본 논문에서는 5Gb/s의 직렬 링크 인터페이스에 적용 가능한 적응형 수신기를 제안한다. 효율적인 이득 제어를 위해 등화필터의 출력단 대신 슬라이서의 내부 신호를 적용한 LMS(Least Mean Square) 알고리즘을 구현하였다. 제안된 방식은 등화기의 대역폭에 영향을 미치지 않는다. 또한 비슷한 DC 크기의 신호를 가지는 슬라이서(slicer)의 내부 신호를 이용하였기 때문에 수동소자를 이용한 필터를 제거함으로써 칩 면적 및 전력소모를 줄일 수 있다. 제안된 적응형 등화기는 25dB까지 보상이 가능하며 디스플레이포트를 위한 15-m STP 케이블과 FR-4 전송선로에 적용 가능하다. 제안된 회로는 $0.18{\mu}m$ 1-폴리 4-메탈 CMOS 공정 기술이 적용하여 구현하였으며 $200{\times}300{\mu}m^2$의 칩 면적을 차지한다. 제작된 칩의 측정 결과 1.8V 공급전원에서 6mW의 매우 적은 전력소모를 나타내고 2Gbps 동작을 확인하였다. 안정된 RF용 버랙터(Varactor)를 사용하는 공정을 적용할 경우 5Gbps 동작범위를 만족할 것으로 예상된다.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2014년도 제46회 동계 정기학술대회 초록집
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• pp.218.2-218.2
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• 2014

그래핀은 높은 전기 전도도와 열전도도, 기계적 강도를 가지고 있고 동시에 높은 전자이동도($200,000cm^2{\cdot}V{\cdot}^1{\cdot}s{\cdot}^1$) 특성을 갖는 물질로써 차세대 소재로 각광받고 있다. 하지만 그래핀을 소자에 응용하기 위해서는 전사공정과 lithography 공정 과정에서 발생되는 PMMA(Poly methyl methacrylate) residue를 완벽하게 제거해야 하는 문제점이 있다. 특히, lithography 공정 중 완벽하게 PMMA residue 가 제거되지 않고 잔류해 있을 경우에 소자의 life time, performance에 악영향을 준다는 보고가 있다. 이와같은 문제를 해결하기 위해 화학적 cleaning, 열처리를 통한 cleaning, 전류 인가에 의한 cleaning과 같은 방법들을 이용하여 그래핀의 PMMA residue를 제거하는 공정들이 보고되고 있지만, 화학적 cleaning 방법의 경우 chloroform 이라는 독성물질 사용으로 인해 산업적으로 응용이 어렵고, 열처리 방법은 전극 등의 금속이 $200^{\circ}C$ 이상의 높은 온도에서 장시간 노출될 경우 쉽게 손상을 입으며, 전류 인가에 의한 cleaning 방법은 국부적으로만 효과를 볼 수 있기 때문에 lithography 공정 후 PMMA residue를 효과적으로 제거하기에는 한계를 보이고 있다. 본 연구에서는 Ar을 이용하는 Ion beam 시스템을 통해 beam energy를 제어함으로써 PMMA residue를 효과적으로 제거하는 연구를 진행하였다. 최적화된 플라즈마 발생 조건을 찾기 위해 QMS(Quadrupole Mass Spectrometer)를 이용하여 입사하는 ion energy와 flux 양을 컨트롤 하였고, 250 W에서 최적화된 ion energy distribution 영역이 존재한다는 것을 확인할 수 있었다. 또한, 25 Gauss 정도의 electro-magnetic field를 이용하여 Ar의 ion energy를 10 eV 이하로 낮추어 damage를 최소화함으로써 효과적으로 그래핀을 cleaning 할 수 있었다. Cleaning과정에서 ion bombardment에 의해 발생한 damage는 $250^{\circ}C$에서 6시간 동안 annealing 공정을 거치면서 회복되는 것을 Raman spectroscopy의 D peak ($1335cm{\cdot}^1$) / G peak ($1572cm{\cdot}^1$) ratio 로 확인할 수 있었고, PMMA residue의 cleaning 여부는 G peak ($1580cm{\cdot}^1$)의 blue shift와 2D peak ($2670cm{\cdot}^1$)의 red shift를 통해 확인하였다. 그리고 AFM (Atomic Force Microscopy)을 이용하여 cleaning 공정과정에서 RMS roughness가 4.99 nm에서 2.01 nm로 감소하는 것을 관찰하였다. 마지막으로, PMMA residue의 cleaning 정도를 정량적으로 분석하기 위해 XPS (X-ray Photoelectron Spectroscopy)를 이용하여 sp2 C-C bonding이 74.96%에서 87.66%로 증가함을 확인을 할 수 있었다.

• 한국통신학회논문지
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• 제37권8A호
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• pp.712-719
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• 2012

본 논문은 오디오 신호 처리 시스템의 저속 고해상도 ADC를 위해 설계된 CMOS 단일비트 3차 델타시그마 변조기를 설계하였다. 변조기 내 적분기에 사용되는 연산증폭기의 전력소모를 감소시키기 위해서 연산증폭기내 바이어스 전류원에 차단/동작 기능을 하는 스위치를 장착시켰다. 또한 변조기내 스위치의 위치를 최적화 하여 기존의 스위칭 방식에서 발생하는 주파수 특성 변화를 최소화하였다. 단일 비트 3차 델타시그마 변조기 구조를 선택하였으며, 제안한 델타 시그마 변조기의 성능측정결과 전원 전압 3.3V, 샘플링 주파수 6.4MHz, 입력주파수 20KHz에서 17.1mW의 전력소모를 나타냈다. SNDR은 84.3dB, 유효비트수는 13.5비트를 나타내었다.