• Journal of Pharmaceutical Investigation
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• v.15 no.2
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• pp.53-62
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• 1985

Pivampicillin hydrochloride is a kind of broad spectrum antibiotics with bactericidal action, and is used in many countries, although it has bitter taste, unpleasant odour and side effects of irritating gastric mucosa, nausea, penicillin allergy, etc. For the improvement of such side effects of pivampicillin hydrochloride, microcapsules, with wall of ethylcellulose, have been prepared by coacervation method. The shape was observed through the scanning electron microscope, the release of the drug into an aqueous medium was studied and the effects of core: ethylcellulose ratio were interpreted as well as making sensory evaluation of taste and odour. There was decreasing trend in dissolution rate of the drug with the increase of core: ethylcellulose ratios, and the smaller microcapsules released their contents more rapidly. A linear relationship was established between the amount of ethylcellulose and the time for 60% release of the drug, and the release pattern was found to have similar characteristics to the release of the drug from an insoluble porous matrix. The release of the drug in the artificial intestinal fluids (pH 6.8) was found to be similar to that in water, while the release in the artificial gastric juice (pH 1.2) was slightly slower. Bioavailability of microcapsule was compared with that of pivampicillin hydrochloride in rabbits using serum concentration and urinary excretion measurements. Microcapsule gave showed slightly higher serum level than pivampicillin hydrochloride from 2 hours after administration, while no significant difference was observed in the accumulated urinary excretion rate between pivampicillin hydrochloride and microcapsule. The ulcer index of pivampicillin hydrochloride administered group was 2.6, and microcapsule administered group was 1.5, while control group was 0.8. Therefore it may be concluded that microencapsulation of pivampicillin hydrochloride is a useful pharmaceutical approach to protect the gastrointestinal tract from being injured by direct contact of pivampicillin hydrochloride without any significant difference of bioavailability.

• Journal of Powder Materials
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• v.20 no.1
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• pp.19-23
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• 2013

Ru films were successfully prepared by plasma-enhanced atomic layer deposition (PEALD) using $Ru(EtCp)_2$ and $NH_3$ plasma. To optimize Ru PEALD process, the effect of growth temperature, $NH_3$ plasma power and $NH_3$ plasma time on the growth rate and preferred orientation of the deposited film was systemically investigated. At a growth temperature of $270^{\circ}C$ and $NH_3$ plasma power of 100W, the saturated growth rate of 0.038 nm/cycle was obtained on the flat $SiO_2$/Si substrate when the $Ru(EtCp)_2$ and $NH_3$ plasma time was 7 and 10 sec, respectively. When the growth temperature was decreased, however, an increased $NH_3$ plasma time was required to obtain a saturated growth rate of 0.038 nm/cycle. Also, $NH_3$ plasma power higher than 40 W was required to obtain a saturated growth rate of 0.038 nm/cycle even at a growth temperature of $270^{\circ}C$. However, (002) preferred orientation of Ru film was only observed at higher plasma power than 100W. Moreover, the saturation condition obtained on the flat $SiO_2$/Si substrate resulted in poor step coverage of Ru on the trench pattern with an aspect ratio of 8:1, and longer $NH_3$ plasma time improved the step coverage.

• Journal of Korean Library and Information Science Society
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• v.44 no.3
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• pp.125-152
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• 2013

The purpose of this study is to construct a substantive theory that described and explained how pregnant women are seeking information in context of pregnancy. A qualitative design based on the method of grounded theory was utilized. In-depth interviews were conducted with 16 pregnant women, selected by theoretical sampling who receiving antenatal care 3 different university hospitals. The interview data were transcribed and systematically analyzed according to the open coding, axial coding and selective coding. 'Increasing Sense of Self-Control over Pregnancy' was the core category for describing and guiding the process of seeking information during the pregnancy. To construct a theory of 'Increasing Sense of Self-Control over Pregnancy' in this study, eight hypothetical statement were generated from the relationships among the core category and the other categories, thus four patterns were derived as follows: 'Desperately Seeking', 'Actively Seeking', 'Unconcernedly Seeking', 'Resignedly Seeking'. The implications of the findings are discussed in terms of development of LIS theory in Korea, theory development of information behavior, education for LIS, and information service practice. The suggestions for further research are provided.

• Korean Journal of Optics and Photonics
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• v.23 no.4
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• pp.135-142
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• 2012

We have developed a measurement method of the refractive index profile of an optical fiber by using diffraction phase microscopy. In the microscope system, the reference light was extracted directly from the probe light that passed through the sample by means of pinhole filtering with a diffraction grating. The spatial interference pattern produced by the probe light and the reference light was processed to generate the phase image of the sample fiber. The index profile was obtained by the inverse Abel transform of the phase profile. In order to remove the background phase that originated from the index difference between the cladding and the surrounding medium, the background phase was calculated from the phase data of the cladding to make a core phase profile that can be directly transformed to the index profile of the core without the full phase image that includes the entire cladding part.

• Journal of Ecology and Environment
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• v.44 no.2
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• pp.106-114
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• 2020

Background: Determining patterns of habitat use is key to understanding of animal ecology. Approximately 1% of bird species use brood parasitism for their breeding strategy, in which they exploit other species' (hosts) parental care by laying eggs in their nests. Brood parasitism may complicate the habitat requirement of brood parasites because they need habitats that support both their host and their own conditions for breeding. Brood parasitism, through changes in reproductive roles of sex or individual, may further diversify habitat use patterns among individuals. However, patterns of habitat use in avian brood parasites have rarely been characterized. In this study, we categorized the habitat preference of a population of brood parasitic lesser cuckoos (Cuculus poliocephalus) breeding on Jeju Island, Korea. By using compositional analyses together with radio-tracking and land cover data, we determined patterns of habitat use and their sexual and diurnal differences. Results: We found that the lesser cuckoo had a relatively large home range and its overall habitat composition (the second-order selection) was similar to those of the study area; open areas such as the field and grassland habitats accounted for 80% of the home range. Nonetheless, their habitat, comprised of 2.54 different habitats per hectare, could be characterized as a mosaic. We also found sexual differences in habitat composition and selection in the core-use area of home ranges (third-order selection). In particular, the forest habitat was preferentially utilized by females, while underutilized by males. However, there was no diurnal change in the pattern of habitat use. Both sexes preferred field habitats at the second-order selection. At the third-order selection, males preferred field habitats followed by grasslands and females preferred grasslands followed by forest habitats. Conclusions: We suggest that the field and grassland habitats represent the two most important areas for the lesser cuckoo on Jeju Island. Nevertheless, this study shows that habitat preference may differ between sexes, likely due to differences in sex roles, sex-based energy demands, and potential sexual conflict.

• Journal of Korean Academy of Nursing
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• v.30 no.1
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• pp.171-182
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• 2000

This study was performed to investigate the effect of kangaroo care on body weight, physiological responses and behavioral states in premature infants. The subjects were 32 premature infants, fifteen for the kangaroo care group and seventeen for the control group, who hospitalized in a neonatal intensive care unit at a university-affiliated hospital. The kangaroo care was applied 8 times during the twenty five days with 40 minutes for each session. The kangaroo care provides the skin-to-skin contact during which a premature infant wearing a diaper and a hat is placed on its mother's chest. As for the measures, body weight was measured everyday. The levels of epinephrine, norepinephrine and 17-OHCS were measured twice, before beginning the first intervention and after finishing the last intervention. While each session of the care is undergoing, such physiological responses were measured periodically as heart rate, respiration rate, oxygen saturation, core temperature and skin temperature. The results were as follows : 1. The weight gain was significantly greater in the kangaroo care group than that in the control group during the period of performing the kangaroo care. 2. No significant difference was revealed between the two groups in heart rate, respiration rate, oxygen saturation and core temperature. The kangaroo care group also showed significant increases in the skin temperature. 3. The differences in the levels of epinephrine, norepinephrine and 17-OHCS were not significant between the kangaroo care and the control groups. The level of norepinephrine in the two groups was significantly increased over time. 4. Sleep pattern changed significantly in the kangaroo group from a very restless sleep to a very quiet sleep. These results suggest that kangaroo care is an effective nursing intervention for premature infants in gaining weight, achieving stable physiological responses and facilitating a quiet sleep.

• Journal of IKEEE
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• v.17 no.3
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• pp.260-266
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• 2013

The open bit line is vulnerable to noise compared to the folded bit line when read/write for the DRAM. According to the increasing DRAM densities, the core circuit operating conditions is exacerbated by the noise when it comes to the open bit line 6F2(F : Feature Size) structure. In this paper, the interference effects were analyzed by the data patterns between the bit line by experiments. It was beyond the scope of existing research. 68nm Tech. 1Gb DDR2, Advan Tester used in the experiments. The noise effects appears the degrade of internal operation margin of DRAM. This paper investigates sense amplifier power line splits by experiments. The noise can be improved by 0.2ns(1.3%)~1.9ns(12.7%), when the sense amplifier power lines split. It was simulated by 68nm Technology 1Gb DDR2 modeling.

• Journal of the Korean Geophysical Society
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• v.7 no.3
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• pp.171-183
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• 2004

Electrical resistivity survey is widely used to investigate the stability of center-core type fill dam against the seepage phenomenon. In this study, we analyze the resistivity information obtained on a earth fill dam and compare it with the geotechnical SPT result. The analysis shows that the zones showing low resistivity value generally have low N value. However, some zones with high resistivity pattern do not accompany the increase of N value, and even showing low N value. These results imply that the direct identification of resistivity value to the real status of the core material of fill dam is impossible, and a highly resistive zone may be in serious status due to the effect increasing the resistivity value by the piping condition. Therefore, multiple exploration should be planned to reduce the uncertainty in application of geophysical methods to dam safety evaluation.

• Nuclear Engineering and Technology
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• v.20 no.1
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• pp.19-26
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• 1988

The low leakage leading pattern has features as the placement of some fresh fuel assemblies in the core interior to reduce the neutron fluence on the pressure vessel and to enhance the neutron economics. But as fresh fuel assemblies are loaded in the core interior, the local power tends to exceed safety limit due to the high reactivity of the fresh assemblies. Therefore, a large number of burnable poisons must be utilized in a low leakage scheme to suppress the high assembly power as well as the excess reactivity. In this study the effects of burnable poisons are treated as a perturbation on the power distribution, and the 'Power Sensitivity Coefficient' concept is adopted. An application study is performed for cycle 1 of the Korea Nuclear Unit-7 (KNU-7) to justify the usefulness of the reverse depletion method coupled with the above concept. To obtain the optimal burnable poision distribution at the given burnup step, the linear programming technique is adopted. The result shows maximum 4.5% error in the amount of burnable poisons between the calculated and the reference values. It is concluded that the design methodology which consists of the reverse depletion, the power sensitivity coefficient concept, and the linear programming technique can be used to find the optimal turnable poison distribution.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.8 no.1
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• pp.63-72
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• 2005

Chirisan National Park, the first and largest one out of 20 national parks in Korea, is divided into five zones. They are composed of nature preservation zone, natural environment zone, natural residential zone, concentrated residential zone, and collective facility zone. However, the park is not a continuous habitat: roads, trails, local residences, and various facilities created the habitat mosaics severely fragmented. We investigated the fragmentation pattern of the park due to roads and mountain trails using GIS. Based on perimeter length, area, and the ratio of perimeter to area of each patch, we obtained landscape analysis indices which reflect the regularity of the patch shape. The 1 m-wide hiking trails divided the park into 491 fragments. The legal trails with 1.5 m - 3 m width which have been heavily used by hikers generate 58 fragments. Even the nature preservation zone, corresponding to a core zone comprising 31.8% of the park area, was divided into 37 fragments because of the roads and mountain trails. With the different widths of buffer applied, the core sizes of the fragments were reduced. When the 60 m buffer was applied, the patch interior areas ranged from 0.0001 to 47.77 $km^2$ with a mean of 7.08 $km^2$. The landscape shape indices were far greater than 1 for most of the cases with a maximum value of 25. These results clearly indicate that Chirisan National Park is not a continuous habitat, but mosaics of small, irregularly shaped habitat fragments. It is necessary to take the size and shape of the fragmented habitats into consideration when nature conservation is planned, especially for large wildlife such as brown bears.