• Structural Engineering and Mechanics
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• v.70 no.3
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• pp.279-287
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• 2019

This paper intends to introduce a near-tip grid refinement and to explore its usefulness in the crack analysis by the natural element method (NEM). As a sort of local h-refinement in FEM, a NEM grid is locally refined around the crack tip showing the high stress singularity. This local grid refinement is completed in two steps in which grid points are added and Delaunay triangles sharing the crack tip node are divided. A plane-state plate with symmetric edge cracks is simulated to validate the proposed local grid refinement and to examine its usefulness in the crack analysis. The crack analysis is also simulated using a uniform NEM grid for the sake of comparison. The near-tip stress distributions and SIFs that are obtained using a near-tip refined NEM grid are compared with the exact values and those obtained using uniform NEM grid. The convergence rates of global relative error to the total number of grid points between the refined and non-refined NEM grids are also compared.

• JSTS:Journal of Semiconductor Technology and Science
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• v.14 no.5
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• pp.609-614
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• 2014

The fringe field effects on the transient characteristics of nano-electromechanical (NEM) memory cells have been discussed by using an analytical model. The influence of fringe field becomes stronger as the size of a cell decreases. By using the proposed model, the dependency of NEM memory transient characteristics on cell parameters has been evaluated.

• Proceedings of the KSME Conference
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• 2004.11a
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• pp.474-479
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• 2004

According to our previous study, it is confirmed that the Petrov-Galerkin natural element method (PGNEM) completely resolves the numerical integration inaccuracy in the conventional Bubnov-Galerkin natural element method (BG-NEM). This paper is an extension of PG-NEM to two-dimensional nonlinear dynamic problem. For the analysis, a constant average acceleration method and a linearized total Lagrangian formulation is introduced with the PG-NEM. At every time step, the grid points are updated and the shape functions are reproduced from the relocated nodal distribution. This process enables the PG-NEM to provide more accurate and robust approximations. The representative numerical experiments performed by the test Fortran program, and the numerical results confirmed that the PG-NEM effectively and accurately approximates the nonlinear dynamic problem.

• Biomolecules & Therapeutics
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• v.17 no.4
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• pp.379-387
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• 2009

We have previously reported that N-ethylmaleimide (NEM) induces apoptosis through activation of $K^+$, $Cl^-$-cotransport (KCC) in HepG2 human hepatoblastoma cells. In this study we investigated the possible role of phospholipase $A_2$ ($PLA_2$)-arachidonic acid (AA) signals in the mechanism of the NEM-induced apoptosis. In these experiments we used arachidonyl trifluoromethylketone ($AACOCF_3$), bromoenol lactone (BEL) and p-bromophenacyl bromide (BPB) as inhibitors of the calcium-dependent cytosolic $PLA_2$ ($cPLA_2$), the calcium-independent $PLA_2$ ($iPLA_2$) and the secretory $PLA_2$ ($sPLA_2$), respectively. BEL significantly inhibited the NEM-induced apoptosis, whereas $AACOCF_3$ and BPB did not. NEM increased AA liberation in a dose-dependent manner, which was markedly prevented only by BEL. In addition AA by itself induced $K^+$ efflux, a hallmark of KCC activation, which was comparable to that of NEM. The NEM-induced apoptosis was not significantly altered by treatment with indomethacin (Indo) and nordihydroguaiaretic acid (NDGA), selective inhibitors of cyclooxygenase (COX) and lipoxygenase (LOX), respectively. Treatment with AA or 5,8,11,14-eicosatetraynoic acid (ETYA), a non-metabolizable analogue of AA, significantly induced apoptosis. Collectively, these results suggest that AA liberated through activation of $iPLA_2$ may mediate the NEMinduced apoptosis in HepG2 cells.

• Nuclear Engineering and Technology
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• v.49 no.4
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• pp.792-800
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• 2017

The essential requirement of a material to be used for engineering purposes at nuclear establishments is its ability to attenuate the most penetrating ionizing radiations, gamma $({\gamma})-rays$. Mostly, high-Z materials such as heavy concrete, lead, mercury, and their mixtures or alloys have been used in the construction of nuclear establishments and thus termed as nuclear engineering materials (NEM). The NEM are classified into two categories, namely opaque and transparent, depending on their behavior towards the visible spectrum of EM waves. The majority of NEM are opaque. By contrast, various types of glass, which are transparent to visible light, are necessary at certain places in the nuclear establishments. In the present study, ${\gamma}-ray$ shielding behaviors (GSB) of six glass samples (transparent NEM) were evaluated and compared with some opaque NEM in a wide range of energy (15 keV-15 MeV) and optical thickness (OT). The study was performed by computing various ${\gamma}-ray$ shielding parameters (GSP) such as the mass attenuation coefficient, equivalent atomic number, and buildup factor. A self-designed and validated computer-program, the buildup factor-tool, was used for various computations. It has been established that some glass samples show good GSB, thus can safely be used in the construction of nuclear establishments in conjunction with the opaque NEM as well.

• Structural Engineering and Mechanics
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• v.76 no.4
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• pp.505-512
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• 2020

This paper presents an error estimation technique for 2-D crack analysis by an enriched natural element (more exactly, enriched Petrov-Galerkin NEM). A bare solution was approximated by PG-NEM using Laplace interpolation functions. Meanwhile, an accurate quasi-exact solution was obtained by a combined use of enriched PG-NEM and the global patch recovery. The Laplace interpolation functions are enriched with the near-tip singular fields, and the approximate solution obtained by enriched PG-NEM was enhanced by the global patch recovery. The quantitative error amount is measured in terms of the energy norm, and the accuracy (i.e., the effective index) of the proposed method was evaluated using the errors which obtained by FEM using a very fine mesh. The error distribution was investigated by calculating the local element-wise errors, from which it has been found that the relative high errors occurs in the vicinity of crack tip. The differences between the enriched and non-enriched PG-NEMs have been investigated from the effective index, the error distribution, and the convergence rate. From the comparison, it has been justified that the enriched PG-NEM provides much more accurate error information than the non-enriched PG-NEM.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.18 no.2
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• pp.113-121
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• 2005

In order to resolve a common numerical integration inaccuracy of meshfree methods, we introduce an improved natural clement method called Petrov-Galerkin natural element method(PG-NEM). While Laplace basis function is being taken for the trial shape function, the test shape function in the present method is differently defined such that its support becomes a union of Delaunay triangles. This approach eliminates the inconsistency of tile support of integrand function with the regular integration domain, and which preserves both simplicity and accuracy in the numerical integration. In this paper, the validity of the PG-NEM is verified through the representative benchmark problems in 2-d linear elasticity. For the comparison, we also analyze the problems using the conventional Bubnov-Galerkin natural element method(BG-NEM) and constant strain finite clement method(CS-FEM). From the patch test and assessment on convergence rate, we can confirm the superiority of the proposed meshfree method.

• Journal of Nutrition and Health
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• v.48 no.4
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• pp.310-318
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• 2015

Purpose: The aim of this study is to investigate anti-arthritis activity using natural eggshell membrane (NEM). Methods: NEM was administered at 52 mg/kg, 200 mg/kg, and 400 mg/kg to SD-Rat, where arthritis was induced by monosodium iodoacetate (MIA) at 3 mg. NO production in serum was measured using Griess reagent. Cytokines including IL-$1{\beta}$, and IL-6 were measured by Luminex and $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP were measured by ELISA. The cartilage of patella volume was examined and 3-D high-resolution reconstructions of the cartilage of patella were obtained using a Micro-CT system. Results: Production of NO, IL-$1{\beta}$, IL-6, $PGE_2$, MMP-2, MMP-9, TIMP-1, $LTB_4$, and hs-CRP in serum was decreased, respectively, in comparison with control. The cartilage of patella volume increased significantly. In addition, the NEM group showed a decrease in the cartilage of patella, synovial membrane, and transformation of fibrous tissue. Conclusion: The results for NEM showed significant anti-arthritis activity. These results may be developed as a raw material for new health food to ease the symptoms mentioned above.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.9
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• pp.23-44
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• 2004

Das Forschungsziel dieser Untersuchung ist es, den linguistischen Begriff der Analogie zu definieren, und die auftretenden analogischen Ausgleichsprozesse vom Mittelhochdeutschen zum Neuhochdeutschen und auch im Neuhochdeutschen selbst insbesondere im System der starken Verben vorzuzeigen und zu $erkl\"{a}ren$. Und diese Forschungsergebnisse sind wie folgt. $Au{\ss}er$ dem Phonemwandel, der immer das Phonemsystem tangiert, gibt es M$Lautver\"{a}nderungen$, die auf assoziativer Ubertragung von Lautungen aus konkurrierenden sprachlichen Formen beruhen, die sog. Analogiebildungen. $N\"{a}mlich$ in der sprachlichen Entwicklung vom Mittelhochdeutschen zum Neuhochdeutschen zeigt sich eine sehr starke innere Tendenz der Sprache, diese durch $gesetzm\"{a}{\ss}igen$ Lautwandel entstandene Formenvielfalt innerhalb eines Paradigmas zu vereinheitlichen. Das $hei{\ss}t$; Analogischer Ausgleich ist als universaller sprachlicher Simplifizierungsprozess zu werten. Diese sprachlichen Ausgleichsprozesse werden als analogischer Ausgleich bzw. paradigmatischer Ausgleich bezeichnet. $Gem\"{a}{\ss}$ der Klassifikation von Frey teile ich auch analogischen Ausgleich Bereichen ein: a) im Stammsilbenvokalismus b) im Stammsilbenkonsonantismus c) in den Konjugationsendungen. (equation omitted) (c) Analogischer AusgIeich der Konjugationsendungen: Die Endung der 1. Pers. P1. $Pr\"{a}s$. Ind. im Althochdeutschen, -ames wird durch die Endung der 1. Pers. P1. $Pr\"{a}s$. Konj., -em ersetzt. $fr\"{h}ahd$. wir nem-ames > ahd. wir nem-em > mhd. wir nem-en > nhd. wir nehm-en Die Endung der 3. Pers. P1. $Pr\"{a}s$. Ind. im Mittelhochdeutschen, -ent wird durch die Endung der 1. Pers. P1. $Pr\"{a}s$. Ind., -en ersetzt. ahd. sie nem-ant > fruhmhd. sie nem-ent > mhd. sie nem-en > nhd. sie nehm-en Als Markierung der 2. Pers. Sg. war -st urprunglich nur in der 2. Pers. Sg. $Pr\"{a}s$. Ind. vorhanden: ahd. nim-ist > mhd. nim-est > nhd. nimm-st Von hier aus breitet es sich aus in die 2. Pers. Sg. Pras. Konj. ahd. nem-es > mhd. nem-est > nhd. nehm-est Vom $Pr\"{a}s$. Ind/Konj. breitet sich -st in das $Pr\"{a}t$. Ind. aus; ahd. nam-i > fruhmhd. naem-e > mhd. naem-est > nhd nahm-st Und $schlie{\ss}lich$ greift es vom $Pr\"{a}t$. Ind. auch auf den Konj. $\"{u}ber$. ahd. nam-is > mhd. nem-est > nhd. $n\"{a}hm-st$

• 한국정보디스플레이학회:학술대회논문집
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• 2009.10a
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• pp.83-86
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• 2009

BiNem$^{(R)}$ displays have entered volume manufacturing in 2009. Applications range from e-labels to e-readers. We have developed 6-inch $960{\times}720$ pixels passive matrix BiNem prototypes achieving 40 % brightness and fluid user interface based on partial image / dynamic pointer addressing. Active-matrix addressing is proposed to provide even faster operation.