• Journal of KIISE
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• v.44 no.9
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• pp.878-886
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• 2017

This paper discusses performance bottlenecks that may occur when executing high-performance computing MPI applications in the Intel's next generation many-core processor called Knights Landing(KNL), as well as effective resource allocation techniques to solve this problem. KNL is composed of a host processor to enable self-booting in addition to an existing accelerator consisting of a many-core processor, and it was released with a new type of on-package memory with improved bandwidth on top of existing DDR4 based memory. We empirically verified an improvement of the execution performance of multiple MPI applications and the overall system utilization ratio by studying a resource allocation method optimized for such new many-core processor architectures.

• Biomolecules & Therapeutics
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• v.21 no.5
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• pp.405-410
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• 2013

Codonopsis lanceolata (Campanulaceae) traditionally have been used as a tonic and to treat patients with lung abscesses. Recently, it was proposed that the extract and some compounds isolated from C. lanceolata reversed scopolamine-induced memory and learning deficits. The purpose of this study was to evaluate the improvement of cognitive enhancing effect of C. lanceolata by steam and fermentation process in scopolamine-induced memory impairment mice models by passive avoidance test and Morris water maze test. The extract of C. lanceolata or the extract of steamed and fermented C. lanceolata (SFCE) was orally administered to male mice at the doses of 100 and 300 mg/kg body weight. As a result, mice treated with steamed and fermented C. lanceolata extract (SFCE) (300 mg/kg body weight, p.o.) showed shorter escape latencies than those with C. lanceolata extract or the scopolamine-administered group in Morris water maze test. Also, it exerted longer step-through latency time than scopolamine treated group in passive avoidance test. Furthermore, neuroprotective effect of SFCE on glutamate-induced cytotoxicity was assessed in HT22 cells. Only SFCE-treated cells showed significant protection at 500 ${\mu}g/ml$. Interestingly, steamed C. lanceolata with fermentation contained more phenolic acid including gallic acid and vanillic acid than original C. lanceolata. Collectively, these results suggest that steam and fermentation process of C. lanceolata increased cognitive enhancing activity related to the memory processes and neuroprotective effect than original C. lanceolata.

• Economic and Environmental Geology
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• v.29 no.2
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• pp.183-192
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• 1996

Much computing time and large computer memory are needed to solve the wave equation in a large complex subsurface layer using finite difference method. The time and memory can be reduced by decreasing the number of grid per minimun wave length. However, decrease of grid may cause numerical dispersion and poor accuracy. In this study, we present 49 points weighted average method which save the computing time and memory and improve the accuracy. This method applies a new weighted average to the coordinate determined by transforming the coordinate of conventional 5 points finite difference stars to $0^{\circ}$ and $45^{\circ}$, 25 points finite differenc stars to $0^{\circ}$, $26.56^{\circ}$, $45^{\circ}$, $63.44^{\circ}$ and 49 finite difference stars to $0^{\circ}$, $18.43^{\circ}$, $33.69^{\circ}$, $45^{\circ}$, $56.30^{\circ}$, $71.56^{\circ}$. By this method, the grid points per minimum wave length can be reduced to 2.5, the computing time to $(2.5/13)^3$, and the required core memory to $(2.5/13)^4$ computing with the conventional method.

• The Transactions of the Korea Information Processing Society
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• v.5 no.10
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• pp.2686-2703
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• 1998

The widening pClformnnce gap between processor and memory causes an emergence of the promising architecture, processor-memory (PM) integration In this paper, various design issues for P-M integration are studied, First, an analytical model of the DRAM access time is constructed considering both the bank conflict ratio and the DRAM page hit ratio. Then the points of both the performance improvement and the perfonnance bottle neck are found by the proposed model as designing on-chip DRAM architectures. This paper proposes the new architecture, called the delayed precharge bank architecture, to improve the perfonnance of memory system as increasing the DRAM page hit ratio. This paper also adapts an efficient bank interleaving mechanism to the proposed architecture. This architecture is verified !II he better than the hierarchical multi-bank architecture as well as the conventional bank architecture by executiun driven simulation. Eight SPEC95 benchmarks are used for simulation as changing parameters for the cache architecture, the number of DRAM banks, and the delayed time quantum.

• The Journal of Internal Korean Medicine
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• v.41 no.2
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• pp.159-165
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• 2020

Introduction: We report a rare case in which the symptoms of hypersomnia were caused by cerebral infarction that occurred in the hypothalamus and hypothalamus. Case Presentation: The patient underwent Korean medicine treatments using Gami-seonghyangjeonggi-san, acupuncture, electroacupuncture, and physical therapy for 37 days. We evaluated the degree of improvement in hypersomnolence based on the amount of sleeping time and the degree of memory impairment with the patient's suggestive conditions as observed by the patient's guardian, and one-sided facial palsy using the Yanagihara Scale. As treatment was applied, sleeping time was decreased from 22 to 9 hours a day. Memory impairment did not show clear improvements as the patient could not recognize others when they visited during the period in which the patient underwent treatment. One-sided facial palsy showed no improvements and there were no changes in the Yanagihara Scale results. Conclusion: This case showed that Korean medicine treatment could be effective to relieve some of the symptoms of thalamus and hypothalamus infarction. Further research is needed to confirm the effectiveness of Korean medicine treatment.

• Korean Journal of Adult Nursing
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• v.29 no.3
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• pp.266-277
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• 2017

Purpose: The purpose of this study was to design a mobile-application of a cognitive training program for people who have chemo-related cognitive complaints. Methods: The program was developed based on the network-based instructional system design proposed by Jung. The program consisted of several tasks centered on four cognitive domains: learning, memory, working memory, and attention. For memory learning, a target-image and all its elements (color, position, and number) were presented on the screen that had to be recognized among a number of distractor-figures. In working memory training, the previous learned target-figure according to the level of difficulty had to be remembered among many different figures. In attention training named "Find the same figure," two identical symbols in a grid-pattern filled with different images were presented on the screen, and these had to be simultaneously touched. In attention training named "Find the different figure," a different symbol in a grid pattern filled with same figures had to be selected. This program was developed to train for a minimum of 20 min/day, four days/week for six weeks. Results: This cognitive training revealed statistically significant improvement in subjective cognitive impairments (t=3.88, p=.006) at six weeks in eight cancer survivors. Conclusion: This cognitive training program is expected to offer individualized training opportunities for improving cognitive function and further research is needed to test the effect in various settings.

• Journal of KIISE:Computer Systems and Theory
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• v.30 no.9
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• pp.461-476
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• 2003

Due to the implementation ease and alleviation of memory bottleneck effect, NUMA architecture has dominated in the multiprocessor systems for the past several years. However, because the NUMA system distributes memory in each node, frequent remote memory access is a key factor of performance degradation. Therefore, efficient design of RAC(Remote Access Cache) in NUMA system is critical for performance improvement. In this paper, we suggest Multi-Grain RAC which can adaptively control the RAC line size, with respect to each application behavior Then we simulate NUMA system with multi-grain RAC using MINT, event-driven memory hierarchy simulator. and analyze the performance results. At first, with profile-based determination method, we verify the optimal RAC line size for each application and, then, we compare and analyze the performance differences among NUMA systems with normal RAC, with optimal line size RAC, and with multi-grain RAC. The simulation shows that the worst case can be always avoided and results are very close to optimal case with any combination of application and RAC format.

• Journal of Pharmacopuncture
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• v.20 no.1
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• pp.10-17
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• 2017

Objectives: Boswellic acid (BA), a compound isolated from the gum-resin of Boswellia carterii, is a pentacyclic terpenoid that is active against many inflammatory diseases, including cancer, arthritis, chronic colitis, ulcerative colitis, Crohn's disease, and memory impairment, but the mechanism is poorly understood. This study investigated the effects of boswellic acid on spatial learning and memory impairment induced by trimethyltin (TMT) in Wistar rats. Methods: Forty male Wistar rats were randomly divided into 5 groups: Normal group, TMT-administrated rats (8.0 mg/kg, Intraperitoneally, i.p.) and TMT + BA (40, 80 and 160 mg/kg, i.p.)-administrated rats. BA was used daily for 21 days. To evaluate the cognitive improving of BA, we performed the Morris water maze test. Moreover, to investigate the neuroprotective effect of BA, we determined the acetylcholinesterase (AchE) activity, the malondialdehyde (MDA) level as a marker of lipid peroxidation, and the glutathione (GSH) content in the cerebral cortex. Results: Treatment with TMT impaired learning and memory, and treatment with BA at a dose of 160 mg/kg produced a significant improvement in learning and memory abilities in the water maze tasks. Consistent with behavioral data, the activity of AChE was significantly increased in the TMT-injected rats compared to the control group (P < 0.01) whereas all groups treated with BA presented a more significant inhibitory effect against AChE than the TMT-injected animals. In addition, TMT reduced the GSH content and increased the MDA level in the cerebral cortex as compared to the control group) P < 0.01). On the other hand, treatment with BA at 160 mg/kg slightly increased the GSH content and reduced the MDA level in comparison to the TMT-administered group (P < 0.01). Conclusion: The above results suggest that the effect of BA in improving the cognitive function may be mediated through its antioxidant activity.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.33 no.6
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• pp.454-459
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• 2020

In this study, a TiO₂/TiO_2-x-based resistance variable memory was fabricated using a DC/RF magnetron sputtering system and ALD. In order to analyze the effect of oxygen plasma treatment on the performance of resistance random access memory (ReRAM), the TiO₂/TiO_2-x-based ReRAM was evaluated by applying RF power to the TiO_2-x oxygen-holding layer at 30, 60, 90, 120, and 150 W, respectively. The ReRAM was fabricated, and the electrical and surface area performances were compared and analyzed. In the case of ReRAM without oxygen plasma treatment, the I-V curve had a hysteresis curve shape, but the width was very small, with a relatively high surface roughness of the oxygen-retaining layer. However, in the case of oxygen plasma treatment, the HRS/LRS ratio for the I-V curve improved as the applied RF power increased; stable improvement was also noted in the surface roughness of the oxygen-retaining layer. It was confirmed that the low voltage drive was not smooth due to charge trapping in the oxygen diffusion barrier layer owing to the high intensity ReRAM applied with an RF power of approximately 150 W.

• Biomolecules & Therapeutics
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• v.25 no.3
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• pp.249-258
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• 2017

To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-${\zeta}$ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-${\zeta}$ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.