Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice

  • Jeon, Se Jin (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Boseong (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu, Byeol (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Kim, Eunji (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Lee, Sunhee (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Jang, Dae Sik (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University) ;
  • Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
  • Received : 2016.03.15
  • Accepted : 2016.07.28
  • Published : 2017.05.01
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Abstract

To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-${\zeta}$ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-${\zeta}$ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.

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References

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