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http://dx.doi.org/10.4062/biomolther.2016.058

Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice  

Jeon, Se Jin (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Kim, Boseong (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Ryu, Byeol (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Kim, Eunji (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Lee, Sunhee (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Jang, Dae Sik (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Ryu, Jong Hoon (Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University)
Publication Information
Biomolecules & Therapeutics / v.25, no.3, 2017 , pp. 249-258 More about this Journal
Abstract
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time in the passive avoidance task, ameliorated alternation behavior in the Y-maze, and increased exploration time in the Morris water maze task, indicating the improvement of cognitive behaviors against cholinergic dysfunction. The biflorin-induced reverse of latency in the scopolamine-treated group was attenuated by MK-801, an NMDA receptor antagonist. Biflorin also enhanced cognitive function in a naïve mouse model. To understand the mechanism of biflorin for memory amelioration, we performed Western blot. Biflorin increased the activation of protein kinase C-${\zeta}$ and its downstream signaling molecules in the hippocampus. These results suggest that biflorin ameliorates drug-induced memory impairment by modulation of protein kinase C-${\zeta}$ signaling in mice, implying that biflorin could function as a possible therapeutic agent for the treatment of cognitive problems.
Keywords
Biflorin; N-methyl D-aspartate receptor; Cognition; Protein kinase C-${\zeta}$;
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