• 동의생리병리학회지
• /
• 제21권4호
• /
• pp.898-906
• /
• 2007

This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.

• 대한상한금궤의학회지
• /
• 제13권1호
• /
• pp.179-188
• /
• 2021

화폐상 습진(Nummular eczema) 병변으로 내원한 환자에게 고문자적 해석을 바탕으로 당귀회역탕(當歸回逆湯)을 진단하여 다음 결론을 얻었다. 1. 화폐상 습진(Nummular eczema) 환자에게 당귀회역탕(當歸回逆湯)을 30일 투약 후 DLQI 18점에서 0점, VAS 10에서 1로 개선되었다. 2. 『상한론(傷寒論)』 351조(條)에서 궐(厥), 세(細)를 피부병변부 발생의 원인과 관계된 병리적인 단어로 추론하고 고문자적으로 해석하여 당귀회역탕(當歸回逆湯)을 투여하고 치료함으로써 한의학적 임상 진단 방법을 구체화할 수 있는 가능성을 제시하였다.

• 한국병원경영학회지
• /
• 제27권3호
• /
• pp.39-49
• /
• 2022

Purposes: This study purposed to analyze the relationship between patient safety and patient-centerendess. Methodology: The comprehensive scores from patient safety assessment program and patient experience survey conducted by Health Insurance Review & Assessment Service were used as independent variables and dependent variables. This study analyzed the relationship between 4 patient safety-related areas(i.e. risk standardized readmission ratio, intensive care unit, preventive antibiotic, the drug evaluation) and 6 patient experience areas(i.e. nurse services, doctor services, medication & treatment, hospital environment, patient's right, overall experience) by using robust regression analysis. Findings: According to results, the score in 'patient's right' and 'risk standardized readmission ratio' areas were found to have a significant relationship, and 'overall experience' and the 'preventive antibiotic' areas. The ratio of senior beds and specialists was a general characteristics of hospitals that had a significant relationship on patient experience assessment. Practical Implication: The relationships between patient safety and patient experience assessment were varied depending on areas. Further study is needed to make clear the supposed relationship.

• The Korean Journal of Pain
• /
• 제31권1호
• /
• pp.3-9
• /
• 2018

Long QT syndrome is a cardiac repolarization disorder and is associated with an increased risk of torsades de pointes. The acquired form is most often attributable to administration of specific medications and/or electrolyte imbalance. This review provides insights into the risk for QT prolongation associated with drugs frequently used in the treatment of chronic pain. In the field of pain medicine all the major drug classes (i.e. NSAIDs, opioids, anticonvulsive and antidepressant drugs, cannabinoids, muscle relaxants) contain agents that increase the risk of QT prolongation. Other substances, not used in the treatment of pain, such as proton pump inhibitors, antiemetics, and diuretics are also associated with long QT syndrome. When the possible benefits of therapy outweigh the associated risks, slow dose titration and electrocardiography monitoring are recommended.

• 대한약학회:학술대회논문집
• /
• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
• /
• pp.398.3-399
• /
• 2002

Quality control by analytical ability with a certain level of precision and accuracy is important. This is true especially in pharmaceutical industries. for a failure in quality control can result in a failure in drug medication. in turn. sometimes a heavy damage to patient's health condition andlor the worst damage to company's reputation. On this backgroun, Kyungki KFDA prepared test pharmaceutical products, which were distributed to 114 pharmaceutical companies in kyungin Province in year 2000. (omitted)

• 대한간호학회지
• /
• 제14권2호
• /
• pp.12-18
• /
• 1984

The purpose of this study was to compare educational needs following open heart surgery assessed by nurses & patients themselves, Data were collected from Nov. 1983 to Jan. 1984 through administration of Questionnaire developed for this study by the researcher. The subjects were 45 patients who experienced open heart surgery and 29 nurses who taking care of these patients in chest surgery ward at Seoul National University Hospital. The Data were analyzed by T-test and One Way ANOVA according to dependent variables. The result were as follows 1. There are significant difference between educational needs, assessed by nurses and patients themselves. (p<0.05) The nurses reported higher score of educational needs than patients. 2. In comparison of content area of educational needs, there was significant difference according to respiratory care, fain, chest tube care and operation including heart function between two groups. But, there was no significant difference in diet, activity, complication, emotional care and medication between two groups. 3. The priorities in content area of educational needs rated by nurses and patients were similar.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• 제22권2호
• /
• pp.74-80
• /
• 2011

Attention-deficit hyperactivity disorder (ADHD) is a neurobehavioral disorder with an onset of symptoms before 7 years of age, often starting as early as the preschool years. The off-label use of methylphenidate (MPH) for 3- to 6-year-old preschool children with ADHD is being more common, although MPH is not licensed for use in children younger than age 6 years, in most countries. Despite the limited data, the review of the literature suggests that MPH meets evidence based criteria as beneficial and safe for carefully diagnosed ADHD preschool children. Carefully monitored administration of evidence-based psychotropic medication in preschool children with ADHD may be indicated if psychosocial treatments are ineffective.

• 수면정신생리
• /
• 제19권1호
• /
• pp.18-21
• /
• 2012

Parasomnias induced by hypnosedatives are rare but serious side effect. Such parasomnias have not been reported with all hypnosedatives. However, frequent use of hypnosedatives, particularly nonbenzodiazepine receptor agonists is associated with parasomnias. Associated symptoms are sleep eating, sleepwalking with object manipulation, sleep conversations, sleep driving, sleep sex and sleep shopping etc. Mechanisms include high affinity for $GABA_A$ receptor, interruption of the consolidation phase of memory formation by drug, pharmacokinetic or pharmacodynamic drug-drug interaction and concomitant administration with alcohol. Managements for parasomnias induced by hypnosedatives involve stopping medication, switch to other medications or nonpharmacological treatment, lowest effective dose of NBRAs (Non-Benzodiazepine Receptor Agonists), taking into consideration drug-drug interactions, identification and treatment of underlying disease states.

• 가정∙방문간호학회지
• /
• 제6권
• /
• pp.59-65
• /
• 1999

In oder to investigate the basic data for the standard of visiting nursing activities and educational program for Public Health Nurses in Health Center in Korea. the health record review carried out regard to visiting nursing services of 131 subjects with visiting nursing care. The results were as follows: 1. Rates of visiting nursing services offered by Public Health Nurse of Health Center(in decreasing order)were health education and disease management(98.5%), activity assess-ment(94.7%), counseling(90.8%), dietary care (61.1%), exercise treatment(60.3%), examination(58.8%), medication(48.9%), referral to hospital(32.8%, vaccination against flu and hepatitis(29.8%), support for welfare and administration(24.4%), position change(9.9%), connection to voluntary services(9.9%), wound dressing(7.6%) and referral for home health care nursing(3.1%). 2. The subjects consisted of 38.2% in male and 61.8% in female. 77.1% of the subjects had no job.

• Pediatric Gastroenterology, Hepatology & Nutrition
• /
• 제10권2호
• /
• pp.202-205
• /
• 2007

저자들은 6세 된 남아에서 4년간의 반복적이고, 발작적인 복통의 원인을 규명하던 중 만성 복통의 타 기질적 질환들이 배제되고, 뇌파 검사의 이상 소견과 함께 항경련제의 사용에 증상의 극적인 소실을 보여 복성 간질로 진단된 1예를 경험하고 문헌 고찰과 함께 보고하는 바이다.