Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Oral Administration of Processed Sulphur on Hepatotoxicity

법제 유황 경구투여가 간독성에 미치는 영향

  • Song, In-Sun (Image Oriental Medical Clinic) ;
  • Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University)
  • 송인선 (이미지한의원) ;
  • 윤대환 (동신대학교 한의과대학 경혈학교실) ;
  • 유화승 (대전대학교 한의과대학 동서암센터)
  • Published : 2007.08.25
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Abstract

This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.

Keywords

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