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Effect of Oral Administration of Processed Sulphur on Hepatotoxicity  

Song, In-Sun (Image Oriental Medical Clinic)
Youn, Dae-Hwan (Department of Meridian and Acupoint, College of Oriental Medicine, Dongshin University)
Yoo, Hwa-Seung (East-West Cancer Center, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.21, no.4, 2007 , pp. 898-906 More about this Journal
Abstract
This study was to evaluate the effects of oral administration of Processed Sulphur on Hepatotoxicity. Processed Sulphur was administered orally to rats for 28 days. We measured the body and liver weight index, heamtological and biomedical parameters. We also observed the histopathological changes of liver in rats. No significant differences in body weight, liver weight index, heamtological and biomedical parameters and histopathological changes of hepatocyte between control and Processed Sulphur fed group were found. Our data indicate that hepatotoxicity was not caused by oral medication of Processed Sulphur up to 60mg/200g/day for 28 days in rats. Therefore, Processed Sulphur appears to be safe and non-toxic in these studies and a no-observed adverse effect level (NOAEL) in rats is established at 60mg/200g/day. The data could provide satisfactory preclinical evidence of safety to launch clinical trial on standardized formulation of mineral extracts.
Keywords
Processed Sulphur; Hepatotoxicity; histopathology;
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Times Cited By KSCI : 1  (Citation Analysis)
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