• Journal of Microbiology and Biotechnology
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• v.14 no.1
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• pp.1-14
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• 2004

More than twenty years have passed since the approval of the first recombinant DNA product for therapeutic use (recombinant human insulin, 1982). However, the biotechnology industry is still facing a shortage of manufacturing capacity due to the increasing demand of therapeutic proteins. This demand has prompted the search for a growing number of biological production systems but, nevertheless, the Gram-negative bacterium Escherichia coli remains one of the most attractive production hosts. This review highlights the most important features and developments of plasmid vector design, emphasizing the different reported strategies for improving the expression and secretion of heterologous proteins using the cellular machinery of E. coli.

• Korean Journal of Optics and Photonics
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• v.11 no.6
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• pp.405-410
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• 2000

We propose a novel design concept to improve extinction ratio by minimizing $Cv_e-Cv_o$ . Improvements of loss and fabrication error limit are also obtained by this hybrid design of the lateral shift and curved waveguide to control transfer coefficients, $Cv_e and Cv_o$ . The concept of lateral shift merges two transfer coefficients, and additional curved waveguide controls mode profile asymmetrically to help this minimizing effect of $Cv_e-Cv_o$ with no serious decrease in transfer efficiency. For a given InP based waveguide structure, the mode propagation analysis with an effective index approximation provided a calculational improvement of extinction ratio to -39 dB and fabrication error limit to $57.19\mu\textrm{m}$, with a structure design of $300\mu\textrm{m}$ waveguide curvature and $0.1\mu\textrm{m}$lateral shift. shift.

• Korean Journal of Optics and Photonics
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• v.4 no.1
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• pp.101-107
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• 1993

We carried out the useful theoretical calculation for the optimum design of a 1.48 ${\mu}m$ diode laser pumped E$r^{3+}$ doped fiber amplifier. The model we established is based on the rate equations of three level laser system and the overlap integral between fundamental mode L$P_{01}$ and E$r^{3+}$ doped area. We determined several fiber parameters (N.A., V value, fiber length, E$r^{3+}$ concentration, cutoff wavelength etc.) for the optimum design of a high optical gain. We found that our theoretical results are very useful to the design of E$r^{3+}$ doped fiber used in EDFA.

• Proceedings of the SAREK Conference
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• 2007.06a
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• pp.154-154
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• 2007

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.05a
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• pp.687-691
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• 2011

In this paper, we design an 8-bit eSuse OTP (one-time programmable) memory in consideration of EM (electro-migration) and eFuse resistance variation based on a $0.18{\mu}m$ generic process, which is used for an analog trimming application. First, we use an external program voltage to increase the program power applied an eFuse. Secondly, we apply a scheme of precharging BL to VSS prior to RWL (read word line) activation and optimize read NMOS transistors to reduce the read current flowing through a non-programmed cell. Thirdly, we design a sensing margin test circuit with a variable pull-up load out of consideration for the eFuse resistance variation of a programmed eFuse. Finally, we increase program yield of eFuse OTP memory by splitting the length of an eFuse link.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2000.07a
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• pp.288-293
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• 2000

BPM simulation was used in order to fabricate the LiNbO$_3$optical waveguide with optical source of He-Ne laser(λ=0.6328[$\mu$m]). we observed electric field E$_{x}$, E$_{y}$ in the x,y-direction are simulated at the LiNbO$_3$substrate (X1 55[$\mu$m]$\times$Z1 5000[$\mu$m]), where the depth, width and buffer layer of waveguide are 0.2[$\mu$m],4[$\mu$m] and 0.02[$\mu$m] respectively. By applying these parameters of single waveguide to simulate a X-switch, we have chosen index change of 0.002, width of 3[$\mu$m] and angle of 0.4$^{\circ}$~0.6$^{\circ}$of optical waveguide and under these conditions, optical beam propagates cross-side at 0.4$^{\circ}$. When applied switching voltage of 25[V], optical beam of X-switch turns cross-side to bar-side at intersection angle 0.4$^{\circ}$, index change of 0.002, waveguide width of 3[$\mu$m], electrode gap 2[$\mu$m]. By the above results, we can obtain design conditions of theoretical analysis of an X-switch optical waveguide.e.e.

• Proceedings of the KIEE Conference
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• 2004.07d
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• pp.2370-2373
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• 2004

In this paper we describe the design of a Dual-Redundant Power Controller(DRPC) for Control Rod Control System(CRCS). The CRCS also provides information regarding rod motion, rod position, and status of the Rod Control System. It has Hot/Stand-by type, and also has the function of fault detection for controller itself and power modules. We have implemented the various functions with the dual-redundant Power Controller. Due to the developed DRPC, we are assured that the commmecial use by this controller be made before long.

• 한국태양에너지학회:학술대회논문집
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• 2011.04a
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• pp.48-53
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• 2011

In this study, it is to verify the applicability for a simplified model(IEC61400-2, Design Require-ments for Small Wind Turbines, 2006-03) is the international standard is used to the structural design. In the design process of a wind turbine, the safety of a designed wind turbine is one of the most important factors. The simplified model can be used to determine the design load for small wind turbines. So, this paper has been re-evaluated a small wind turbine design loads that produced already. As a result, the material characteristic value(Rchar) of Blade, Rotor shaft and the tower are $90E6[N/m^2]$, $441E6[N/m^2]$ and $94E6[N/m^2]$. Therefore, the value of the applied safety factor to each part of the survival probability of 95% are satisfied.

• Journal of the Korea Institute of Building Construction
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• v.18 no.3
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• pp.277-283
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• 2018

This study is conducted to improve the manufacturing process of the modular construction method, which is a pre-fabricated construction method recognized for its advantage on the shortening of construction time. This study first identified the factors that result in shortening of pre-fabrication processes in the current module-processing factory. In addition, those identified factors were further considered for installing the M.E.P. system that is being outsourced on the main module in the production line. A manufacturing process of the construction modules, which considers installation of a M.E.P. system most suitable for shortening the time on the outsourcing of modular construction, is introduced throughout the research. Furthermore, this study suggests the factors in need of improvement during design phase of modular construction and improvement measures to consider the quality of unit modules by focusing on the module parts that are most exposed to defects.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.7
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• pp.1455-1462
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• 2012

In this paper, a BCD process based high-reliability 24-bit dual-port eFuse OTP Memory for PMICs is designed. We propose a comparison circuit at program-verify-read mode to test that the program datum is correct by using a dynamic pseudo NMOS logic circuit. The comparison result of the program datum with its read datum is outputted to PFb (pass fail bar) pin. Thus, the normal operation of the designed OTP memory can be verified easily by checking the PFb pin. Also we propose a sensing margin test circuit with a variable pull-up load out of consideration for resistance variations of programmed eFuse at program-verify-read mode. We design a 24-bit eFuse OTP memory which uses Magnachip's $0.35{\mu}m$ BCD process, and the layout size is $289.9{\mu}m{\times}163.65{\mu}m$ ($=0.0475mm^2$).