• Biomedical Science Letters
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• v.21 no.2
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• pp.77-83
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• 2015

Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.12a
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• pp.54-57
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• 2005

Endocrine disrupting effects of several pharmaceutical products were evaluated with fish. The test pharmaceuticals(caffeine, ketoconazole, acetaminophen and diltiazem) have been often detected in aquatic environment of Korea(from on going study of this research team). We analyzed vitellogenin induction by qualitative (Western blot) and quantitative (ELISA) assay. $17{\beta}$ -estradiol was used as a positive control. Some pharmaceuticals could give effects to male Oryzias latipes. They could induced vitellogenin under exposure of chemicals at male Oryzias latipes.

• Proceedings of the Korean Environmental Health Society Conference
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• 2005.11a
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• pp.179-182
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• 2005

Endocrine disrupting effects of several pharmaceutical products were evaluated with fish. The test pharmaceuticals(caffeine, ketoconazole, acetaminophen and diltiazem) have been often detected in aquatic environment of Korea(from on going study of this research team). We analyzed vitellogenin induction by qualitative (Western blot) and quantitative (ELISA) assay. $17{\beta}-estradiol$ was used as a positive control. Some pharmaceuticals could give effects to male Oryzias latipes. They could induced vitellogenin under exposure of chemicals at male Oryzias latipes.

• Journal of The Korea Institute of Healthcare Architecture
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• v.17 no.2
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• pp.35-44
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• 2011

The aim of this study is to review the literature addressed the methodology to measure and evaluate the health outcomes as evidences for health benefits through the study on the healing environment, garden, therapeutic garden and viewing landscape and so forth. The research methods and measures used to assess health effects in the reviewed studies have applied in a different way ranged from quantitative methods (physical measures or quantitative observations) to qualitative methods (qualitative observations and surveys). In a literature review of research articles on the health outcomes have been found various research methods and measures used to assess health effects. This study will be concentrated mainly on methodological considerations in order to find the significant evidences related to evidence-based design (EBD). Future research should build the body of methodological knowledge to find more empirical evidences as sound scientific data and to improve the effectiveness of design interventions.

• The Journal of Korean Society for School & Community Health Education
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• v.20 no.3
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• pp.43-52
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• 2019

Objectives: This study aims to understand the effects of job stress and emotional labor on perceptive health status of dental hygienist's. And provide basic data by for establishing the plan for the effective management of job stress and emotional labor and the promotion of health. Methods: Self-evaluation questionnaires were surveyed for 441 dental hygienist's who agreed to participate in the survey, using questionnaires used in the preceding study were modified and complemented. We analyzed the data with frequency analysis, descriptive statistics, t-test, chi-square test와 ANOVA, Spearman correlation coefficient by using IBM SPSS Statistics 21.0 (IBM Co., Armonk, NY, USA). The significance level for significance was set at 0.05. Results: health status were job stress, emotional labor significant negative correlation. The factors having significant effects on health problem were physical health status, the job culture of job stress, lack of job autonomy, organizational instability, and workplace culture. In addition, social health status was affected by emotional expressionism, relationship conflict, organizational instability, organizational system, and workplace culture. Conclusion: Recognizing the importance of the management of job stress and emotional labor in the working environment to dental clinic and hospital managers and managerial dental hygienists, a dental hygienist health promotion intervention program is needed to mitigate and cope with job stress and emotional labor.

• The Journal of the Korea Contents Association
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• v.17 no.11
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• pp.110-122
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• 2017

This study is to examine moderating effects of income and mediating effects of health related quality of life in the relationship between depression experience and suicidal behavior among menopausal middle-aged women in Korea. This study employed 1,182 middle-aged women aged 40 to 60 of the third year (2015) data from the 6th Korean National Health and Nutrition Examination Survey(KNHANES VI). The results are that first, depression experience were significantly associated with suicidal behavior. Secondly, health related quality of life appeared to mediate the relationship between depression experience and suicidal behavior. Thirdly, income was significantly moderated the relationship between depression experience and suicidal behavior in relatively low income group below average income after controlling for mediating effects of health related quality of life. These results showed that there is a need to enhance health policy for mental health care in middle-aged women and to expand intervention program for improvement of health related quality of life, and especially, intervention for improving mental health of low-income group.

• Korean Journal of Biological Psychiatry
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• v.27 no.1
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• pp.27-35
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• 2020

Objectives Ketamine has been reported to have antidepressant effects or psychotomimetic effects. The aim of this study was to investigate the behavioral effects of ketamine treatment at various sub-anesthetic doses in adolescent and adult naïve mice. Methods In each experiment for adolescent and adult mice, a total of 60 male Institute of Cancer Research mice were randomly divided into 6 groups, which were intraperitoneally treated with physiological saline, 10, 20, 30, 40, and 50 mg/kg ketamine for consecutive 3 days. At 1 day after last injection, the locomotor and depressive-like behaviors were evaluated in mice, using open field test (OFT) and forced swim test (FST), respectively. Results In case of adolescent mice, ketamine dose was negatively correlated with total distance traveled in the OFT (Spearman's rho = -0.27, p = 0.039). In case of adult mice, we found significant positive correlation between ketamine dose and duration of immobility in the FST (Spearman's rho = 0.45, p < 0.001). Immobility time in the 50 mg/kg ketamine-treated mice was significantly higher compared to the saline-treated mice (Dunnett's post-hoc test, p = 0.012). Conclusions We found that the repeated treatment with ketamine could decrease the locomotor or prolong the duration of immobility in mice as the dose of ketamine increased. Our findings suggest that sub-anesthetic doses of ketamine might induce schizophrenia-like negative symptoms but not antidepressant effects in naïve laboratory animals.

• Toxicological Research
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• v.27 no.1
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• pp.7-10
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• 2011

Coffee has been known to have both beneficial and harmful effects upon health. Coffee is one of the most widely consumed beverages, worldwide. Dementia/Alzheimer's disease (AD) and cardiovascular disease (CVD) are public health problems that are rapidly increasing in the aging population. Due to the high consumption of coffee, even small effects on an individual's health could have a large effect on public health. The aim of this review article is to provide an overview of previously published studies of coffee consumption on health. Herein, we focus on epidemiological and experimental findings to investigate whether coffee-drinking habits, and/or the quantity of coffee consumption, have any relationship to CVD, dementia/AD, and other chronic diseases. Although the underlying mechanisms are not fully understood, when comparing coffee drinkers with non-drinkers, moderate doses of caffeine showed protective effects against CVD and AD. We hypothesized that caffeine may be a novel therapy to treat CVD and dementia/AD.

• The Korean Journal of Health Service Management
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• v.7 no.4
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• pp.259-272
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• 2013

The purpose of this study is to examine the effects of self-leadership and self-efficacy on organizational performance, or more specifically, job satisfaction, organizational concentration and organizational citizenship behavior and then the effects of hospital organization members' job attitude on organizational performance, helping strengthen capability that individuals of the members have and ultimately improve that performance. Findings of the study can be summarized as follows. First, self-leadership has statistically significant effects on organizational citizenship behavior. Second, self-leadership has statistically significant influences on self-effectiveness, especially job satisfaction and organizational concentration. Third, how self-efficacy influences organizational effectiveness was examined to find that self-efficacy has significant effects on organizational concentration, but not on job satisfaction. Fourth, self-efficacy has no effect on organizational citizenship behavior. Fifth, how organizational effectiveness influences organizational citizenship behavior was investigated to find that effectiveness has statistically significant effects on organizational concentration, but not on job satisfaction.

• Clinical and Experimental Pediatrics
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• v.63 no.11
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• pp.422-428
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• 2020

In today's world, most children are exposed to various manmade electromagnetic fields (EMFs). EMFs are electromagnetic waves less than 300 GHz. A developing child's brain is vulnerable to electromagnetic radiation; thus, their caregivers' concerns about the health effects of EMFs are increasing. EMF exposure is divided into 2 categories: extremely low frequencies (ELFs; 3-3,000 Hz), involving high-voltage transmission lines and in-house wiring; and radiofrequencies (RFs; 30 kHz to 300 GHz), involving mobile phones, smart devices, base stations, WiFi, and 5G technologies. The biological effects of EMFs on humans include stimulation, thermal, and nonthermal, the latter of which is the least known. Among the various health issues related to EMFs, the most important issue is human carcinogenicity. According to the International Agency for Research on Cancer's (IARC's) evaluation of carcinogenic risks to humans, ELFs and RFs were evaluated as possible human carcinogens (Group 2B). However, the World Health Organization's (WHO's) view of EMFs remains undetermined. This article reviews the current knowledge of EMF exposure on humans, specifically children. EMF exposure sources, biological effects, current WHO and IARC opinions on carcinogenicity, and effects of EMF exposures on children will be discussed. As well-controlled EMF experiments in children are nearly impossible, scientific knowledge should be interpreted objectively. Precautionary approaches are recommended for children until the potential health effects of EMF are confirmed.