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http://dx.doi.org/10.15616/BSL.2015.21.2.77

Soybean Peptides Induce Apoptosis in HeLa Cells by Increasing Oxidative Stress  

Sung, Ho Joong (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Jeong, Yu Jin (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Kim, Jihyun (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Jung, Eunsun (Biospectrum Life Science Institute)
Jun, Jin Hyun (Department of Biomedical Laboratory Science, College of Health Science, Eulji University)
Publication Information
Biomedical Science Letters / v.21, no.2, 2015 , pp. 77-83 More about this Journal
Abstract
Soy proteins have been extensively studied because of its multiple health benefits. However, the effects of soy proteins on human cervical cancer cells are still unclear. Therefore, this study investigated the effects of soy proteins on HeLa cells and human fibroblasts by using soybean peptides (SPs). SPs selectively increased the generation of reactive oxygen species and apoptosis in HeLa cells but not in fibroblasts. In addition, SPs suppressed the migration of HeLa cells. Although the molecular mechanisms underlying the effects of SPs on human cervical cancer cells need to be investigated further, our findings provide insights on the therapeutic effects of soy protein on cervical cancer.
Keywords
Soybean peptides; Reactive oxygen species; Apoptosis; Migration; HeLa cells;
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