• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.69-73
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• 2004

뮤코르 진균증은 드물게 발생하지만 종종 치명적일 수 있으며, Phycomycetes종의 기회 감염에 의해 발생한다. 이 미생물은 부생의 호기성 진균(saprophytic aerobial fungus)이며 구강 점막, 부비동과 목에 통상적으로 존재하며 부패해 가는 식물, 거름, 고당 함유 음식 등에 나타난다. 뮤코르 진균증은 다양한 유형의 임상 형태로 면역결핍환자들에서 빠른 진행과 높은 치사율로 나타난다. 그러나 건강한 사람에서 두경부 영역에 감염된 예는 거의 없다. 본 교실에서는 58세 당뇨병이 있는 남자 환자에서 상악에 발생한 뮤코르 진균증의 증례에서 외과적 절제술과 ampotericin B의 정맥내 투여로 치료 되었으며, 현재까지 특별한 재발 소견 없이 양호한 결과를 얻었기에 이를 문헌 고찰과 함께 보고하는 바이다.

• 한국식품영양학회지
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• 제27권6호
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• pp.1090-1095
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• 2014

Anthocyanins, a class of flavonoids, are natural water-soluble pigments, which are mainly found in vegetables and fruits. Anthocyanins have attractive pharmacological activities, such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic. The purpose of this study was to investigate the protective effects of anthocyanins-rich fraction (ANF) from Korean purple sweet potato variety, "Shinjami", against hydrogen peroxide ($H_2O_2$)-induced oxidative stress. In our results, pre-treatment of HepG2 cells with ANF ($10{\mu}g/mL$) significantly prevented cell death and maintained cell integrity, following exposure to 0.9 mM hydrogen peroxide. The $H_2O_2$-dependent production of intracellular ROS was also significantly decreased by pre-treatment with ANF (6 h, $10{\mu}g/mL$). In addition, ANF increased the mRNA levels of antioxidant enzymes, catalase and glutathione level in $H_2O_2$-treated HepG2 cells. These results indicated that ANF protected HepG2 cells against $H_2O_2$-induced oxidative stress by inducing protective system.

• Journal of Nutrition and Health
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• 제10권2호
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• pp.54-58
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• 1977

The iron contents in the foodstuffs used for treatment of anemia as dietary treatments in Part Tang-Aik(湯液編) of Tong-Eui-Bo-Gam, (which was treatments of herb medicine. in Royal family) are studied on the purpose of comparing these Korean traditional and oriental herb medicine with modern nutrition and medicine, focusing especially upon the scientific values residing in them. The iron contents in grains, reptilla, feathered tribes, mammals, and fruits advised good for anemia in Tong-Eui-Bo-Gam are in average per 100g weight base, 8.6, 5.0, 6.5, 3.4, and 2.12 mg each respectively, while in thoes not advised good for anemia in the same part, the iron contents are 2.34, 2.63, 1.4, 2.21 and 0.97mg each respectively. To compare these two groups, in the foodstuffs advised good for anemia in Korean traditional herb medicine represented in Tong-Eui-Bo-Gam, the iron contents are much higher than in those not advised groups. However, in classes of vegetables and fishes, the iron contents are reversed. In conclusion, it is very difficult to say that all the dietary treatments advised in Korean traditional herb medicine are scientific in modern medical view point, however, it has some value doubtlessly to research Korean traditional herb medicine in modern aspect. Furthermore, in this study, Korean traditional medicine, arguing being built upon thousands years of experiences has been found .to have some scientific bases such as high iron contents in food stuffs advised good for anemia represented in Tong-Eui-Bo-Gam.

• 대한지역사회영양학회지
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• 제12권6호
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• pp.790-797
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• 2007

This study was conducted to evaluate the nutrient intakes and the physical activities of mentally retarded persons (MRPs) accommodated in welfare institutions. A total of 194 cases of MRPs (130 males and 64 females) were surveyed through interviews of the 35 caregivers of the institutions during the period from March 2 to 12, 2005. The mean age of the 2nd degree is the highest, and the duration of institution stay of the 2nd degree is the longest. There were no significant differences in height, weight, but there were still significant differences in BMI by the degree of handicap. The MRPs with the 1st degree handicap consumed less nutrients than the MRPs with 2nd or 3rd degree handicaps, except for vitamins C and E. The mean activity factor was $1.737{\pm}0.422$ meaning 'active'. Among the comparative groups, the activity factor of the 2nd handicap degree MRPs was the highest. Note that the percentage of protein is the lowest in the case of the 1st degree handicap. The intake of the folic acid, in particular, was less than the Estimated Average Requirement (EAR) in case of all the MRPs while that of vitamin C, riboflavin and calcium was less than the EAR in case of $65{\sim}80%$ of the MRPs. MRPs with higher activity factors showed higher intakes of most nutrients except vitamin C. MRPs with higher marks in the 'balanced dietary habit' field showed more nutrient intakes. More consumption of vegetables and fruits by the MRPs was recommended. Also, more efficient dietary guidance was recommended for the MRPs.

• Journal of Pharmaceutical Investigation
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• 제35권4호
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• pp.249-254
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• 2005

Multidrug resistance (MDR) of cancer cells is, at least in part, associated with the overexpression of P-glycoprotein (P-gp). Many studies have demonstrated that natural compounds obtained from fruits, vegetables, teas and medicinal plants may modulate P-gp activity. The objective of the present investigation was to examine the effect of seven natural compounds on the P-gp activity in human uterine sarcoma cell line, MES-SA/DX5. Daunomycin uptake was significantly increased by biochanin A and silymarin (p<0.0001) whereas it was reduced by morin (p<0.01). The efflux of daunomycin from the cells was significantly inhibited by biochanin A, morin, cephalotaxine, berberine (p<0.05) and silymarin (p<0.0001). Biochanin A, berberine and silymarin significantly decreased $IC_{50}$ value of daunomycin (p<0.05) while morin increased it (p<0.05). These results suggest that some natural compounds such as biochanin A and silymarin may inhibit P-gp function and can be developed as MDR reversing agents to improve the efficacy of chemotherapeutic drugs when administered concomitantly.

• 디지털융복합연구
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• 제15권6호
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• pp.297-304
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• 2017

본 연구의 목적은 한국 청소년 천식 환자의 천식 악화와 항산화 식품 섭취와의 연관성을 알아보는 것이다. 이 연구는 제11차 청소년건강행태 온라인조사 참여자 중 천식으로 진단받은 1,578명의 자료를 이용하여 시행하였다. 알려진 천식 악화의 위험인자들과 사회인구적 변수들과 모든 식품 섭취 행태관련 변수들을 통계적으로 분석하였다. 항산화 식품섭취와 천식 악화와의 연관성을 추정하기위해 로지스틱 회귀분석을 최종적으로 사용하였다. 분석결과 남성 및 흡연경험은 천식악화와 관련이 있었고, 적은 항산화 식품 섭취 또한 천식악화를 의미 있게 높이는 것으로 나타났다. 따라서 천식 청소년을 대상으로 금연과 항산화식이섭취 교육이 중요하다. 과일과 야채를 적절히 섭취하도록 권장하는 것이 필요하다.

• 대한지역사회영양학회지
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• 제20권4호
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• pp.301-309
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• 2015

Objectives: While recent studies showed that coffee consumption reduced the risk of all-cause mortality, no study has examined the effect of coffee consumption on all-cause mortality related to sleep disorders. We aimed to examine whether sleep-related disorders would differently affect the association between coffee consumption and the risk of all-cause mortality among 8,075 adults aged 40 to 69 years. Methods: In a prospective cohort study, the study participants were biennially followed up for 12 years from 2001 to 2012. On each follow-up visit, the participants underwent comprehensive tests including anthropometric examinations, interviewer-administered questionnaires, and biochemical tests. Coffee consumption frequency and the amount were measured using a semi-quantitative food frequency questionnaire. Using death certificate data from Korean National Statistical Office, the vital status of each study participant was identified. Sleep-related disorders were examined with interviewer-administered questionnaires. We estimated Hazard ratios and the corresponding 95% confidence intervals from Cox Proportional Hazard models. Multivariable models were established after adjusting for center, total caloric intake, age, gender, body mass index, physical activity, education, smoking, drinking, hypertension, diabetes, total cholesterol, c-reactive protein, energy-adjusted food groups of refined grains, vegetables, fruits, meat, fish, and dairy. Results: Compared with those who had no coffee consumption, participants who had about three cups of coffee per day showed a reduced risk of all-cause mortality, after adjusting for covariates. Those who had a sleep-related disorder showed no significant effect of coffee consumption on the risk of all-cause mortality, whereas those who had no sleep-related disorders showed significantly reduced risk of all-cause mortality. Conclusions: Our findings suggested that approximately three cups of coffee per day would be beneficial to reduce the risk of all-cause mortality only among adults with no sleep-related disorders. Coffee consumption should be prudent for those with sleep-related symptoms.

• 한국경제지리학회지
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• 제20권2호
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• pp.121-136
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• 2017

본고에서는 2005년부터 2014년까지 47개국 57개 농식품 수출입 자료를 이용하여 글로벌 교역 네트워크의 측면에서 한국 농식품의 교역 구조를 파악하였다. 본 연구의 주요 분석 결과는 다음과 같다. 첫째, 상품별로 네트워크 구조의 차별성이 나타난다. 즉, 채소, 과실, 가공식품의 순으로 컴포넌트 수가 유의하게 큰 것으로 분석되었다. 둘째, 상품에 따라 커뮤니티 구조가 동태적으로 변화하는 과정이 차별적이다. 교역 네트워크 내에서 일부 상품의 커뮤니티 구조가 역동적으로 변화하는 반면에, 개방의 확대 추세에도 불구하고 구조 변화가 나타나지 않는 상품군이 상존한다. 셋째는 우리 농식품의 국제 경쟁력 강화 추세가 나타난다는 것이다. 57개 분석 대상 농식품의 상위 네트워크에서 한국의 외향 연결도수가 드러나는 상품은 총 26개 품목에 불과하다. 그럼에도 불구하고 일부 채소류와 가공식품 등에서 국제경쟁력의 확대 가능성이 있는 것으로 나타났다.

• 종양간호연구
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• 제10권2호
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• pp.210-217
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• 2010

Purpose: This survey was aimed to examine the current dietary restrictions practices for neutropenic patients among hospitals with 500 and more beds. Methods: Self-administered questionnaires were sent to 100 head or charge nurses of oncology or hemato-oncology wards by mail during October 2009, and 51 questionnaires were returned. The data were analyzed with descriptive statistics using SPSS (WIN version 12.0). Results: Of the hospitals surveyed, 47.1% (n=24) had guidelines on the dietary restrictions, and 80.4% (n=41) placed patients with neutropenia on restricted diets. The major decisional criteria of the dietary restriction was absolute neutrophil count (30.5%) and cooking status (29.2%). The most commonly restricted foods were raw fish or fresh meat (98.0%), uncooked intestine (98.0%), raw eggs (98.0%), draught beer (96.1%), and fresh fruits or vegetables (86.3%). Conclusion: The results showed variation in pattern of dietary restrictions and lower rate of guideline among hospitals, so that the need for the standard dietary restriction guideline is high. However, the role of diet in the development of infection in neutropenic patients is still unclear, which makes it difficult to establish dietary restriction guideline. Therefore, additional research are required to identify the relationship between dietary factors and infections.

• 한국식생활문화학회지
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• 제36권5호
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• pp.455-463
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• 2021

This study was conducted to examine the status of food consumption and nutrition intake of young adults according to food security using data from the Korea National Health and Nutrition Examination Survey (KNHANES) (2008~2018). A total of 10,655 young adults aged 19~34 years participated in the study. The subjects in the moderately/severely food insecure group consumed less fruits, vegetables, meat, nuts and seeds than those in food secure/mildly food insecure group after adjusting for confounding factors. The moderately/severely food insecure group significantly decreased mean adequacy ratio (MAR) and nutrient adequacy ratio (NAR) for protein, vitamin A, riboflavin, niacin, vitamin C, calcium, phosphorus and iron compared to the food secure/ mildly food insecure group. The percentages of the participants consuming a daily diet with carbohydrate, protein, vitamin A, thiamin, riboflavin, niacin, vitamin C, phosphorus and iron less than the estimated average requirement (EAR) increased in the moderately/severely food insecure group compared with the food secure group. This study suggested that the nutrition intake of young adults was related to food security status. These findings can be used as basic data for developing nutritional policies for young adults.