• Journal of Life Science
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• v.25 no.3
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• pp.293-298
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• 2015

Muscle atrophy, known as a sarcopenia, is defined as a loss of muscle mass resulting from a reduction in the muscle fiber area or density due to a decrease in muscle protein synthesis and an increase in protein breakdown. Schisandrae fructus (SF) extract of the fruits of Schisandra chinensis (Turcz) Baillon has been used as a tonic in traditional medicine for thousands of years. Although a great deal of work has been carried out on the therapeutic potential of SF, its pharmacological mechanisms of action in muscle diseases actions remain unclear. In the present study, we investigated the inhibitory effects of SF ethanol extracts on the production of muscle atrophy factors in C2C12 myotubes stimulated with 5-aminoimidazole-4-carboxamide-ribonucleotide (AICAR), an AMP-activated kinase (AMPK) activator, and sought to determine the underlying mechanisms of action. AICAR upregulated atrophy-related ubiquitin ligase muscle RING finger-1 (MuRF-1) and stimulated the levels of the forkhead box O3a (FoxO3a) transcription factor in the C2C12 myotubes. SF supplementation effectively and concentration- dependently counteracted AICAR-induced muscle cell atrophy and reversed the increased expression of MuRF-1 and FoxO3a. Our study demonstrates that SF can reverse the muscle cell atrophy caused by AICAR through regulation of the AMPK and FoxO3a signaling pathways, followed by inhibition of MuRF-1.

• Kyungpook Mathematical Journal
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• v.13 no.2
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• pp.253-264
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• 1973

• Kyungpook Mathematical Journal
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• v.16 no.1
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• pp.71-75
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• 1976

• Journal of the Korean Mathematical Society
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• v.13 no.1
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• pp.15-18
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• 1976

• Kyungpook Mathematical Journal
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• v.10 no.1
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• pp.37-42
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• 1970

• Kyungpook Mathematical Journal
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• v.20 no.1
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• pp.117-119
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• 1980

• Kyungpook Mathematical Journal
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• v.14 no.2
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• pp.171-184
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• 1974

• Communications of the Korean Mathematical Society
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• v.32 no.2
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• pp.287-304
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• 2017

Motivated mainly by certain interesting recent extensions of the generalized hypergeometric function [Integral Transforms Spec. Funct. 23 (2012), 659-683] by means of the incomplete Pochhammer symbols $({\lambda};{\kappa})_{\nu}$ and $[{\lambda};{\kappa}]_{\nu}$, we first introduce incomplete Fox-Wright function. We then define the families of incomplete extended Hurwitz-Lerch Zeta function. We then systematically investigate several interesting properties of these incomplete extended Hurwitz-Lerch Zeta function which include various integral representations, summation formula, fractional derivative formula. We also consider an application to probability distributions and some special cases of our main results.

• IMMUNE NETWORK
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• v.13 no.5
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• pp.222-226
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• 2013

Translocations involving chromosome 21q22 are frequently observed in hematologic malignancies including acute myeloid leukemia (AML), most of which have been known to be involved in malignant transformation through transcriptional dysregulation of Runt-related transcription factor 1 (RUNX1) target genes. Nineteen RUNX1 translocational partner genes, at least, have been identified, but not Homeobox A (HOXA) genes so far. We report a novel translocation of RUNX1 into the HOXA gene cluster in a 57-year-old female AML patient who had been diagnosed with myelofibrosis 39 months ahead. G-banding showed 46,XX,t(7;21)(p15;q22). The involvement of RUNX1 and HOXA genes was confirmed by fluorescence in situ hybridization.

• Kyungpook Mathematical Journal
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• v.46 no.3
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• pp.307-313
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• 2006

In this paper, we first establish an interesting new finite integral whose integrand involves the product of a general class of polynomials introduced by Srivastava [13] and the generalized H-function ([9], [10]) having general argument. Next, we present five special cases of our main integral which are also quite general in nature and of interest by themselves. The first three integrals involve the product of $\bar{H}$-function with Jacobi polynomial, the product of two Jacobi polynomials and the product of two general binomial factors respectively. The fourth integral involves product of Jacobi polynomial and well known Fox's H-function and the last integral involves product of a Jacobi polynomial and 'g' function connected with a certain class of Feynman integral which may have practical applications.