• Journal of Oriental Neuropsychiatry
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• v.21 no.3
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• pp.87-93
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• 2010

Objectives : The oriental medicine Jangwonhwan originally described in the Korean medical text, DonguiBogam(amnesia chapter). Recently, a modified formula of Jangwonhwan(LMK02-Jangwonhwan), was shown to reduce $\beta$-amyloid deposition in the brain of Tg-APPswe/PS1dE9 mouse model for Alzheimer's disease. This experiment aimed to investigate the acute oral toxicity of LMK02 in SD rats by up-and-down procedure determinations. Methods : Quality control of tablet form of LMK02 was established by estimating indicative components, Ginsenoside Rg3 of Red Ginseng and Decursin of Angelicagigas Nakai. The toxicity of LMK02 was investigated in 6 week old, specific pathogen free(SPF), Sprageu-Dawley rats. 3 female rats received 5,000 mg/10 ml/kg of test substance and their death rate, clinical sings, weight changes and autopsy findings had been observed for 2 weeks. Results : Any specific symptoms or death were resulted in this experiment. No significant changes in rats' weight. No significant differences in atopsy. Conclusions : The minimum lethal dose(MLD) of LMK02 for female Sprauge-Dawley rats were more than 5,000mg/kg in this experiment.

• Restorative Dentistry and Endodontics
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• v.41 no.1
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• pp.6-11
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• 2016

Objectives: The purpose of this in vitro study was to evaluate the accuracy of working length (WL) determination of four electronic apex locators (EALs), namely, Root ZX (RZX), Elements diagnostic unit and apex locator (ELE), SybronEndo Mini Apex locator (MINI) and Propex pixi (PIXI) using Stainless steel (SS) and nickel-titanium (NiTi) hand files. The null hypothesis was that there was no difference between canal length determination by SS and NiTi files of 4 EALs. Materials and Methods: Sixty extracted, single rooted human teeth were decoronated and the canal orifice flared. The actual length (AL) was assessed visually, and the teeth were embedded in an alginate model. The electronic length (EL) measurements were recorded with all four EALs using SS and NiTi files at '0.5' reading on display. The differences between the AL and EL were compared. Results: The results obtained with each EAL with SS and NiTi files were compared with AL. A paired sample t test showed that there was a statistical significant difference between EAL readings with SS and NiTi files for RZX and MINI (p < 0.05). The accuracy of RZX, ELE, MINI and PIXI within ${\pm}0.5 mm$ of AL with SS/NiTi files were 93.3%/70%, 90%/91.7%, 95%/68.3%, and 83.3%/83.3%, respectively. Conclusions: The results of this study indicate that Root ZX was statistically more accurate with NiTi files compared to SS files, while MINI was statistically more accurate with SS files compared to NiTi files. ELE and PIXI were not affected by the alloy type of the file used to determine WL.

• Journal of Life Science
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• v.27 no.5
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• pp.524-529
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• 2017

This study was aimed to produce a transgenic zebrafish expressing the human KCNE1 gene. Initially, the entire CDS of the human KCNE1 gene was amplified from a human genomic DNA sample by polymerase chain reaction using a primer set engineered with restriction enzyme sites (EcoRI, BamHI) at the 5' end of each primer. The resultant 402 bp KCNE1 amplicon flanked by EcoR1 and BamH1 was obtained and subsequently cloned into a plasmid vector pPB-CMVp-EF1-GreenPuro. The integrity of the cloned CDS sequence was confirmed by DNA sequencing analysis. Next, the recombinant vector containing the human KCNE1 (pPB-CMVp-hKCNE1-EF1-GreenPuro) was introduced into fertilized eggs of zebrafish by microinjection. Successful expression of the recombinant vector in the eggs was confirmed by the expression of the fluorescence protein encoded in the vector. Finally, in order to assure that the stable expression of the human KCNE1 gene occurred in the transgenic animal, RNAs were extracted from the animal and the presence of KCNE1 transcripts was confirmed by RT-PCT as well as DNA sequencing analysis. The study provides a methodology to construct a useful transgenic animal model applicable to the development of diagnostic technologies for gene therapy of LQTS (Long QT Syndrome) as well as tools for cloning of useful genes in fish.

• Journal of Science and Technology Studies
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• v.12 no.2
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• pp.117-157
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• 2012

This paper investigated the biomedical medicalization of "depression"which is growing fast in Korea in terms of the treatment mechanism. Depression has been regarded as a mental disease that occurs with mixing various causations because what was the cause of this disease was not clarified until a recent date. Thus, as depression treatment, the medicine and the psycho-socio therapy have been used. However, from 1990s, as the brain science was introduced in the western society, and the high-tech diagnostic equipment of the brain disease and new drugs for the mental disease were developed, depression was rapidly redefined as 'the brain nerve system illness'that is easy to be taken and is able to obtain the permanent relief with the regular care. Under the influence of the redefinition of depression and the new treatment of it, recently, 8% of depression patients per year emerge as the aggressive cure subjects in the Korean psychiatric circle. However, according to the Korean psychiatric circle's unofficial calculation, it is estimated that only 10% of depression patients are receiving the accurate treatment but over 80% of the patients are not. If so, what does this estimation mean? Based on this question, this paper critically investigated the biomedical medicalization of depression.

• Journal of rehabilitation welfare engineering & assistive technology
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• v.10 no.1
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• pp.87-92
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• 2016

In this paper, we improved classification performance of benign and malignant lung nodules by including the parenchyma features. For small pulmonary nodules (4-10mm) nodules, there are a limited number of CT data voxels within the solid tumor, making them difficult to process through traditional CAD(computer aided diagnosis) tools. Increasing feature extraction to include the surrounding parenchyma will increase the CT voxel set for analysis in these very small pulmonary nodule cases and likely improve diagnostic performance while keeping the CAD tool flexible to scanner model and parameters. In AdaBoost learning using naive Bayes and SVM weak classifier, a number of significant features were selected from 304 features. The results from the COPDGene test yielded an accuracy, sensitivity and specificity of 100%. Therefore proposed method can be used for the computer aided diagnosis effectively.

• Journal of KIISE
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• v.43 no.4
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• pp.419-429
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• 2016

Generating a 3D surface model from coronary artery segmentation helps to not only improve the rendering efficiency but also the diagnostic accuracy by providing physiological informations such as fractional flow reserve using computational fluid dynamics (CFD). This paper proposes a method to generate a triangular surface mesh using vessel structure information acquired with coronary artery segmentation. The marching cube algorithm is a typical method for generating a triangular surface mesh from a segmentation result as bit mask. But it is difficult for methods based on marching cube algorithm to express the lumen of thin, small and winding vessels because the algorithm only works in a three-dimensional (3D) discrete space. The proposed method generates a more accurate triangular surface mesh for each singular vessel using vessel centerlines, normal vectors and lumen diameters estimated during the process of coronary artery segmentation as the input. Then, the meshes that are overlapped due to branching are processed by mesh merging and merged into a coronary mesh.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.19 no.2
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• pp.152-159
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• 2005

In this paper, we propose a diagnosis algorithm using fusion wかd based on PCA and LDA to detect fault states of the induction motor that is applied to various industrial fields. After yielding a feature vector from the current value measured by an experiment using PCA and LDA, training data is made to produce each matching value. In a diagnostic step, two matching values yielded by PCA and LDA are fused by probability model and finally verified. Since the proposed diagnosis algorithm takes only merits of PCA and LDA it shows excellent results under noisy environments. The simulation results to verify the usability of the proposed algorithm showed better performance than the case just using conventional PCA or LDA.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.137-145
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• 2015

Mobile's health care and diagnostic capabilities are accepted as the most innovative sectors, and the combination with wearable device is being predicted as the future's most promising industries. However, the level of consumer acceptance and utilization is still insufficient compared to the development of technology. This study explores the use intention of wearable device based on previous studies about health apps. In particular, health-related use efficacy of the app, app use intention and app satisfaction are analyzed through a structural equation model. The use of health-related apps revealed that there is a statistically significant relationship with the use of the wearable device. The results suggest that the importance of app use efficacy, satisfaction, apps use should be considered for the successful diffusion of wearable health devices.

• Proceedings of the Korean Society of Agricultural Engineers Conference
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• 1999.10c
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• pp.155-161
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• 1999

The land reclamation area of Saemangeum(Kunsan) is located between 126$^{\circ}$10' E~126$^{\circ}$50' E and 35$^{\circ}$35' N~356$^{\circ}$05'N at the western coast of the Korean peninsula. The are many small islands including extensive areas of semi-diurnally flooded and dewatered tidal flats. The reclamation area of Saemangeum has a range of 5.6m spring tide and the maximum tidal current speed is about 1.41m s-1 in ordinary spring tide. Most of the sediments deposited on the tidal flats are transported from the Geum river, the Manjyung river and The Dongjin river. The soil in this area consists of silty sand with the depth of 10m to 30m . The wind in winter is strong from the direction of northwest. In the past twenty years, land reclamation projects for agricutural purpose or industrial cocmplex have been mostly implemented along the western coast of Korea. Saemangeum coastal area is being constructed the33km sea dike and 40, 100ha reclamation area. The purpose of this study is to find the residual circulations in four seasons after the dike construction by a robust diagnostic and prognostic numerical model. Heat flux at the sea surface in January ,May , August , October was asopted on the basis on the daily inflow of solar radiation at the earth surface, assuming an average atomospheric transmission and no clouds , as a function of latitude and time of year(George L.P.J.E William, 1990). The discharge from the Geum , the Mankyung and the Dongjin rivers was adopted on the basis of experience formula of river flow in January , May ,August, October (The M. of C.Korea, 1993) . Water temperature and salinity along the open boundaries are obtained from the results of field observation s.

• Journal of Korean Society for Atmospheric Environment
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• v.34 no.4
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• pp.517-533
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• 2018

We utilize the CAMx (Comprehensive Air Quality Model with eXtensions) system and the PSAT (Particulate Source Apportionment Technology) diagnostic tool to determine the $PM_{2.5}$ concentration and to perform its source apportionment in the southeastern region of South Korea. For a year-long simulation, eight local authorities in the region such as Pohang, Daegu, Gyeongju, Ulsan, Busan-Gimhae, Gosung-Changwon, Hadong, and all remaining areas in Gyeongsangnam-do, are selected as source areas based on the emission rates of $NO_x$, $SO_x$, VOC, and primary PM in CAPSS (Clean Air Policy Support System) 2013 emissions inventory. The CAMx-PSAT simulation shows that Pohang has the highest $PM_{2.5}$ self-contribution rate (25%), followed by Hadong (15%) and Busan-Gimhae (14%). With the exception of Pohang, which has intense fugitive dust emissions, other authorities are strongly affected by emissions from their neighboring areas. This may be measured as much as 1 to 2 times higher than that of the self-contribution rate. Based on these estimations, we conclude that the efficiency of emission reduction measures to mitigate $PM_{2.5}$ concentrations in the southeastern region of South Korea can be maximized when the efforts of local or regional emission controls are combined with those from neighboring regions. A comprehensive control policy planning based on the collaboration between neighboring jurisdictional boundaries is required.