• 대한화학회지
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• 제47권4호
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• pp.315-324
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• 2003

유기용매인 클로로포름 매질에서 소수성의 합금 나노 미립자를 만드는 새로운 방법에 대해 연구하였다. 소수성 합금 나노 미립자들은 계면활성제(sodium bis(2-ethyl hexyl)-sulfosuccinate, NaAOT)를 포함한 클로로포름 용액에 금속염 즉, $HAuCl_4,\AgNO_3,\Cu(NO_3)_2$을 사용하여 합금의 조성을 조절하여 혼합한 후 sodium borohydride $(NaBH_4)$로 환원시켜 합성하였다. Au/Ag, Au/Cu 합금 나노 미립자의 조성은 1:3, 1:1, 3:1의 몰비로 변화시키면서 합성하였다. UV/Visible, TEM, XPS를 사용하여 합금 나노 미립자의 특성을 측정하였다. Au/Cu 합금 나노 미립자의 표면 공명 흡수는 순수한 금인 경우의 최대흡수 파장인 520 nm에서 순수한 구리의 표면 공명 흡수인 570 nm까지 선형적으로 변하였고, Au/Ag 합금 나노 미립자는 순수한 은의 최대흡수 파장인 405 nm에서 순수한 금의 경우인 520 nm까지 선형적으로 변하였다. 합금 나노 미립자의 Au4f, Ag3d, Cu2p 전자의 구속 에너지는 합금의 조성 비율에 따라 달라지게 된다. 합성된 합금 나노 미립자들은 매우 균일하고 장시간 안정한 분산상태를 유지하였다. 이러한 결과로부터 본 연구에서 사용한 방법은 소수성의 합금 나노 미립자를 합성하는데 매우 효과적인 방법이라고 사료된다.

• 동아시아식생활학회지
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• 제21권4호
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• pp.514-519
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• 2011

해당화 150 g을 각각 증자법과 무증자법으로 처리한 쌀 3,000 g에 첨가하여 막걸리를 제조하였다. 이때 스타터균으로 누룩(150 g)과 효모(60 g)를 사용하여 $25^{\circ}C$에서 14일 동안 발효하였다. 무증자법으로 제조한 막걸리는 당도 $13.0^{\circ}$Bx, pH 4.3, 에탄올 농도 11.8%였으며, 증자법으로 제조한 막걸리는 당도 $14.0^{\circ}$Bx, pH 4.6, 에탄올 농도 14.4%였다. 최종 막걸리의 유산과 초산 함량은 무증자법으로 제조한 막걸리에서 유의적으로 높게(p<0.05) 나타났다. 또한, 아미노산 분석에서는 무증자법으로 제조한 막걸리에서 ${\gamma}$-amino-n-butyric acid 함량이 증가하여 생리 기능성이 향상된 결과를 보였다. 결론적으로, 본 연구 결과는 쌀의 전처리 공정이 막걸리의 맛과 기능성에 큰 영향을 준다는 것을 보여준다.

• 한국치위생학회지
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• 제10권2호
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• pp.393-411
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• 2010

Objectives : The purpose of this study was to examine factors related to the satisfaction level of patients with dental services. Methods : The subjects in this study were 200 patients at three different dental clinics in South Gyeongsang Province, on whom a survey was conducted from June 1 to July 31, 2009. The collected data were analyzed, and the findings of the study were as follows. Results : In regard to the general characteristics of the patients investigated, the women(61.5%) out-numbered the men. By age, those who were at the age of 30 and down made up the largest age group(47.0%). By academic background, the greatest group received junior-college education(54.0%). By occupation, the company employees constituted the largest group (50.5%). By income, the greatest group earned an income of 2 to 2.99 million won(75.0%). Second, as to connections between the characteristics of dental treatment and the reason of choosing the dental clinics, the largest group(70.4%) chose the dental clinics by word of mouth or the recommendation of others. Concerning the reason of dissatisfaction, the biggest group(72.7%) was unsatisfied with medical costs. As for the degree of explicit complaint, the greatest group(49.7%) sort of complained about what made them dissatisfied. Regarding the type of treatment, the biggest group(49.0%) received prosthodontic treatment. In relation to fear for dental treatment, the largest group(34.0%) feared receiving the treatment, and the biggest group(42.6%) did that due to the sound of machines. Third, satisfaction with services(0.762) had the closest correlation to overall satisfaction level, followed by satisfaction with employees(0.735), satisfaction with dentists(0.644) and satisfaction with convenient facilities (0.579). Fourth, the factors that affected overall satisfaction level were gender, the reason of choosing the dental clinic, satisfaction with dentists, satisfaction with employees, satisfaction with services and satisfaction with convenient facilities. The patients who were better satisfied with services(p<0.001), who were more contented with dentists(p<0.001), who chose the dental clinics by the recommendation of others(p<0.01), who were male(p<0.05), who were more gratified with employees(p<0.05) and who were more contented with convenient facilities expressed better overall satisfaction. Conclusions : The above-mentioned findings suggested that dental institutions should keep track of the expectations of patients to prepare differentiated strategies for marketing and human-resources development in consideration of their own circumstances to boost the satisfaction level of patients. Specifically, it's required to heighten the satisfaction level of patients with dentists.

• 부모자녀건강학회지
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• 제3권2호
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• pp.49-66
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• 2000

Pregnancy is a task of creation in which a women mobilizes her self and the resources available to her in the generation of a new person. Through the pregnancy, a mother has formed the new human relationship with a fetus. Maternal-fetal relationship is considered one of mechanism making the relationship of mother and child. It is important to well-being of mother and fetus, too. The earliest interaction between a mother and her child is during prenatal period. Maternal-fetal dyad is unique and perceived interactions with the fetus make the pregnancy real for the mother. Maternal behavior is "instinctive" and is formed in early childhood by copy of the mother. But, Rubin argues that this behavior is an open intellectual system rather than a prepackaged bundle of traits. There is openness to new learning and a high value placed on knowing which occurs with silent organization in thought. Thus, nurses and other health professionals provide prenatal care that optimally is part of the environment in which the maternal-fetal dyad develops. Thus it is appropriate for nurses to increases their understanding of the dyad and to explore ways to enhance its development. This study focusses on the interaction ability and response of fetus, and the maternal-fetal interaction. The research of fetal responses that involve physiological changes and motor movement have been shown to coccur to both external sensory stimuli and to maternal emotional states. The fetus does also have sensory capacity to be aware of some maternal behaviors, and the motor ability to respond in a way the mother can notice. Thus, very rudimentary interactions appear to be possible. Maternal awareness of fetal activity was supported by several studies. More interesting to the present study are description of maternal-fetal interaction and the finding that there appear to be levels of sensitivity to the fetus involved in maternal-fetal interactions. First, recognition comes that the fetus is separate from the maternal self. Next, the fetus engages in. Lastly, the parent may describe active interaction with the fetus, believing that mother and fetus are communicating on a meaningful level. Several interventions, developed to promote more active interaction between mother and fetus, have been reviewed. In general, the parents were taught to stimulate the fetus and to notice the fetus' responses. This type of intervention might increase the mother's sensitivity to her unborn baby, and she may have a head start toward learning how to res pond sensitivity to the newborn infant. Research In the area of maternal-fetal interaction is scarce. Sensitive behavior is construed as an appropriate and timely response to a signal of need from another person, but no such signal of need can be claimed regarding the fetus. The highest level of maternal-fetal interaction, therefore, might be based more on maternal representations of the imagined fetus than on factual evidence of fetal participation.

• 한국의류학회지
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• 제32권11호
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• pp.1692-1703
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• 2008

On 2008, China comes to be an era of opening the market for 30 years, being both the 4th economically biggest country and 2nd ranked clothing export country in the world. China plays a huge consuming market for the world, along with the competition arena for the numerous world fashion brands while more than 100 kinds of Korean fashion ones being launched into the China. By applying the analysis and investigation of preferred street style. in local area to the development of fashion items and design, the synergistic effect of university and industrial corporation might also be expected. This study aims to provide the basic resources for the development of fashion design on behalf of the Korean fashion brands launched into China and moreover to anticipate the requirement on the part of Chinese consumers by way of understanding the preferred fashion styles, through analysis and investigation of the street fashion in Dalian, northeastern area of China. Conclusively, in terms of clothing style, 80.5% of casual style and 19.5% of formal style were notified. The jean casual, and easy casual being dominant in the former, feminine style in the later. In view of the high frequency of T-shirt, sleeveless on the top, full-length pants and 7/9 length pants on the bottom. The simple and cool style seems to be favored, making them easy through the hot summer. The upper clothes exposed in body part of back, chest and shoulder, were frequently shown. In light of colours. white, black, red were preferred on top, blue and black were preferred on bottom. To deal with accessories, the shoulder bag mostly preferred among bags, the sandal, slippers, snickers in sequential order among shoes, the hair pins and rubber band(tied or, held up style), in hair accessories. Other items of hat, belt, and sunglasses, which could give a point to the summer style, were identified low frequency.

• 한국치위생학회지
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• 제9권4호
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• pp.606-619
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• 2009

Objectives : This study was to examine the state of customized visiting oral health programs in a bid to help facilitate the unified operation of the programs and the development of required guidelines. Methods : The subjects in this study were 49 dental hygienists who were professionals responsible for customized visiting health care programs across the nation. Results : 1. Regarding the form of employment of the dental hygienists were investigated many contract and daily workers. 2. As to the possession of equipment necessary for visiting oral health programs, denture cleaners(12.2%) were most widely possessed in some regions, followed by mobile scalers(10.2%) and mobile suctions(8.2%). In terms of expendable devices and materials, dental mirrors, pincettes and explorers were the most widely possessed dental checkup devices, and the most widely possessed oral hygiene supplies were toothbrushes, interdental brushes and denture cleaners. Those devices and materials were in more possession than the other types of devices and materials. The most widely possessed equipment for educational purpose was laptop computers, followed by beam projectors and screens. The most widely possessed teaching materials were dentiform, followed by CD-ROMs. 3. Those whom they visited the most for oral health care service were elderly people, followed by the disabled and patients with chronic diseases. The dental hygienists who went out to visit those people outnumbered the others who stayed at public health centers. Concerning the types of visiting oral health care service, the most prevalent service provided to the elderly included denture cleaning/management, oral massage and preventive treatment against dental caries. The most dominant service provided to the disabled involved education of the oral health care act, preventive treatment against dental caries and toothbrushing by professionals. The most common service offered to patients with chronic diseases was education of the oral health care act and oral health education. The dental hygienists paid a visit to a mean of 5.8 households a day. The average weekly number of households cared by the dental hygienists was 27.3. It took a mean of 37.1 minutes for them to take care of each household. 4. As for satisfaction level with the implementation of the visiting oral health programs, they expressed the greatest satisfaction at teamwork with professionals($3.56{\pm}0.94$), followed by the professionalism of their work($3.21{\pm}0.94$) and workload($3.08{\pm}0.94$). Their satisfaction level with the work conditions required for creative job performance($2.75{\pm}0.98$) and partnership with other institutions($2.64{\pm}1.03$) was below 3.0. In regard to the impact of their characteristics, marital status made a statistically significant difference to satisfaction level with workload. The unmarried dental hygienists were more pleased with their workload than the married ones(p<0.05). 5. As to needs for education for professionalism improvement, they asked for education about visiting oral health care skills the most, followed by education about oral health care for patients with chronic diseases, education of planning/evaluation and education of oral health care for the disabled. Conclusions : The top priority for the vitalization of the programs was the procurement of budget, followed by the procurement of equipment and educational media and the procurement of human resources.

• 한국식품영양과학회지
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• 제42권6호
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• pp.861-868
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• 2013

유전적으로 제2형 당뇨병이 유발되는 db/db 생쥐에 OF를 5% 수준으로 4주간 급여한 결과 지방 대사를 개선시켜, 혈장 총콜레스테롤, LDL-콜레스테롤, VLDL-콜레스테롤과 중성지방을 유의적으로(p<0.05) 감소시켰고, HDL-콜레스테롤은 유의적인 차이를 보이지 않았다. 혈장 총콜레스테롤의 감소는 간에서 HMG-CoA-R의 감소에 의한 콜레스테롤의 생성이 줄어든 것이고, 또한 콜레스테롤을 담즙산으로 합성하는 CYP7A1을 증가시켜 콜레스테롤을 담즙산의 형태로 배설시켰기 때문이다. 이 결과 분변 중 담즙산의 함량이 증가하였다. LDL-콜레스테롤의 감소는 LDL-콜레스테롤을 세포로 이동시켜 분해를 촉진하는 LDL-R의 증가로 확인할 수 있었다. db/db mice에서는 비만뿐 아니라 심각한 지방간이 유발되는데 OF의 급여로 AST와 ALT를 낮추어 간세포의 파괴를 완화시켰으며, 간 조직의 H&E 염색 소견에서도 지방간의 완화를 확인할 수 있었다. 또한 대조군으로 C57 생쥐에게 5% 수준으로 OF를 급여한 결과 OF를 급여하지 않은 대조군과 OF를 급여한 실험군의 혈장 중성지방, 총 콜레스테롤, HDL-콜레스테롤, LDL-콜레스테롤, VLDL-콜레스테롤, AST와 ALT 함량의 차이가 없었으며, 간조직 관찰에서도 차이를 나타내지 않았다. 이상의 결과를 종합할 때, OF는 당뇨병이 유발되지 않은 정상혈당의 생쥐에서는 지질대사에 아무런 영향을 주지 않았으며, 제2형 당뇨병인 db/db mice의 당뇨병 합병증인 지질대사 이상을 개선하는데 효과가 있는 것으로 사료되며, OF의 어떤 성분이 이와 같은 효과를 나타냈는지 보다 구체적인 성분 분석과 세부적인 연구를 통한 확인이 필요하다고 사료된다.

• Asian-Australasian Journal of Animal Sciences
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• 제23권12호
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• pp.1566-1577
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• 2010

Nandrolone, 19-nortestosterone, is a synthetic androgenic-anabolic steroid promoting muscle growth. Nandrolone is also present in pig meat and sera at non-negligible levels. A number of scientific reports have suggested a positive relationship between incidence of infertility and increased meat consumption in humans. The present study was designed to determine out the effect of feeding nandrolone on the testis of the male reproductive tract. Mixtures of food and nandrolone at different concentrations (0.005 ppm and 0.5 ppm) were supplied to pubertal male rats for 6 weeks. Body weight was recorded every week during the entire experimental period. At the end of the treatment, the testis, epididymis, and epididymal fat were collected and weighted. Sperm numbers in the caudal epididymis were counted. Differential gene or protein expression of steroidogenic enzymes in the testes among experimental groups was determined by semi-quantitative real-time PCR or western blotting analysis, respectively. Histological changes of the testis induced by nandrolone treatment were examined by hematoxylin and eosin staining. Immunohistochemical analysis was employed to detect changes in the localization of steroidogenic enzymes in the testes among experimental animals. There were no significant changes on body, testis, epididymis, and epididymal fat weights among experimental groups. A significant increase of caudal sperm number was found in the 0.5 ppm nandrolone-treated group. Histological examination of the testes noted a high frequency of germ cell sloughing in seminiferous tubules of 0.5 ppm nandrolone-treated rats. Even though transcript levels of $3{\beta}$-hydroxysteroid dehydrogenase (HSD) I, $17{\beta}$-HSD4, and $17{\alpha}$-hydroxylase were influenced by nandrolone treatments, protein levels of all molecules examined in the present study were not significantly affected. Immunohistochemical analysis showed no visible changes in the localization of steroidogenic enzymes in the testes among experimental groups. The current study showed that oral intake of nandrolone in male rats for 6 weeks did not cause significant damage to the testis. It is considered that a feeding effect of nandrolone on male fertility would not be remarkable.

• 대한본초학회지
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• 제35권6호
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• pp.11-19
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• 2020

Objective : The genus Glycyrrhiza has been used in food and traditional herbal medicine. Glycyrrhiza new varieties Wongam and Sinwongam have been developed by Korea Rural Development Administration and investigated to register on Korean Pharmacopoeia of the Ministry of Food and Drug Safety. The aim of this study is to investigate the immunomodulatory effect of Wongam and Sinwongam comparing with listed Glycyrrhiza species (Glycyrrhiza uralensis Fischer and G. glabra Linne) for evaluations about pharmacological effect of Glycyrrhiza new varieties. Methods : We studied the immunomodulatory effect of Wongam and Sinwongam compared with G. uralensis and G. glabra using THP-1 cell in vitro model. The cells were treated with phorbol 12-myristate 13-acetate (PMA) for differentiation and stimulated with lipopolysaccharides (LPS) to induce immune activation. We analyzed and compared the effects Glycyrrhiza new varieties and listed Glycyrrhiza species using nitric oxide (NO) assay, western blot, and reverse transcription-quantitative polymerase chain reaction analysis. 1) Results : Wongam and Sinwongam showed no cytotoxicity in THP-1 cells. Wongam and Sinwongam, and listed Glycyrrhiza species increased NO production, and cyclooxygenase (COX)-2 expression with or without LPS in differentiated THP-1 macrophages. Furthermore, Wongam and Sinwongam and listed Glycyrrhiza species upregulated the mRNA expressions of T helper type 1 (Th 1)-associated cytokines in LPS-stimulated THP-1 macrophages. Conclusion : These results indicated that Wongam and Sinwongam would have effect of enhancing immune response through the increase of NO and COX-2 expression, and activate Th1-associated cytokines. The findings of this study suggest the wide applicability of Glycyrrhiza new varieties.

• 한국약용작물학회지
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• 제21권2호
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• pp.91-96
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• 2013

This study describes the identification of Panax species using mitochondrial consensus primers. Initially, a total of thirty primers were tested in ten Korean ginseng cultivars and two foreign Panax species, P. quinquefolius and P. notoginseng. In the polymerase chain reaction (PCR) amplification results, three primers (cox1, nad1/2-3 and nad2/1-2) generated co-dominant polymorphic banding patterns discriminating Korean ginseng cultivars from P. quinquefolius and P. notoginseng. However, these primers could not generated polymorphisms among the Korean ginseng cultivars, and simply represented species-specific polymorphisms for P. quinquefolius and P. notoginseng. Primers PQ91 and PN418 were designed from the consensus sequence of nad1/2-3 region. Two banding patterns (A or B) were detected in PQ91. Korean ginseng cultivars and P. notoginseng shared the same banding pattern (A type) and P. quinquefolius was identified another banding pattern (B type). In the case of PN418, two banding patterns (A or B) were detected in the Korean ginseng cultivars and two foreign Panax species. Korean ginseng cultivars and P. quinquefolius shared the same banding pattern (A type) and P. notoginseng was identified another banding pattern (B type). The combination banding patterns of three Panax species, Korean ginseng cultivars (Panax ginseng C. A. Mey.), P. quinquefolius and P. notoginseng, was identified as 'AA', 'BA' and 'AB', respectively. Consequently, PQ91 and PN418 primer sets can be used to distinguish among Panax species.