• BMB Reports
• /
• v.51 no.3
• /
• pp.119-125
• /
• 2018

The Hippo pathway plays prominent and widespread roles in various forms of human carcinogenesis. Specifically, the Yes-associated protein (YAP), a downstream effector of the Hippo pathway, can lead to excessive cell proliferation and the inhibition of apoptosis, resulting in tumorigenesis. It was reported that the YAP is strongly elevated in multiple types of human malignancies such as breast, lung, small intestine, colon, and liver cancers. Recent work indicates that, surprisingly, Hippo signaling components' (SAV1, MST1/2, Lats1/2) mutations are virtually absent in human cancer, rendering this signaling an unlikely candidate to explain the vigorous activation of the YAP in most, if not all human tumors and an activated YAP promotes the resistance to RAF-, MAPK/ERK Kinase (MEK)-, and Epidermal growth factor receptor (EGFR)-targeted inhibitor therapy. The analysis of YAP expressions can facilitate the identification of patients who respond better to an anti-cancer drug treatment comprising RAF-, MEK-, and EGFR-targeted inhibitors. The prominence of YAP for those aspects of cancer biology denotes that these factors are ideal targets for the development of anti-cancer medications. Therefore, our report strongly indicates that the YAP is of potential prognostic utility and druggability in various human cancers.

• East Asian mathematical journal
• /
• v.33 no.4
• /
• pp.353-380
• /
• 2017

The purpose of this study is to analyze the multiplication units in the elementary school mathematics. In the 2015 revised curriculum, students learn multiplication in $2^{nd}$ grade. The multiplication units is divided into two: multiplication and multiplication facts. In these two units, we mainly analyze situations involving multiplication, models for teaching multiplication, and multiplication strategies for teaching multiplication facts in relation to Subject Matter Knowledge. We called these contents Multiplication Matter Knowledge. We examined the precedent study with regard to multiplication at the elementary mathematics. As results, we prepared an analysis framework for this study. This study was conducted according to qualitative research methods, expecially 'qualitative contents analysis'. The contents here refer to Multiplication Matter Knowledge that can be found in the elementary mathematics textbooks and working books etc. As results of analysis, We can confirm that various multiplication situations and multiplication models are presented in the textbooks. And it has been examined that various multiplication properties are presented in the textbook according to the multiplication strategy levels. We insist elementary school teachers should be aware of these Multiplication Matter Knowledge. This study aims to provide elementary school teachers with basic data in these contexts.

• School Mathematics
• /
• v.16 no.4
• /
• pp.783-802
• /
• 2014

The purpose of this study was to explore in detail students' understanding of fraction as quotient. A total of 158 sixth graders in 6 elementary schools were surveyed by 8 tasks in relation to fraction as quotient. As a result, students used various partitioning strategies to solve the given sharing tasks such as partitioning the singleton unit, the composite unit, or the whole unit of the dividend. They also used incorrect partitioning strategies that were not appropriate to the given context. Students' partitioning strategies and performance of fraction as quotient varied depending on the given contexts and models. This study suggests that students should have rich experience to partition various units and reinterpret the context based on the singleton unit of the dividend.

• KSCI Review
• /
• v.14 no.1
• /
• pp.165-173
• /
• 2006

To support service based on context-aware in ubiquitous computing environment, there are required context managing, context reasoning and context modeling technologies. In this paper, we propose a hierarchical ontology-based context management model and design a context-aware middleware based on this model for supporting active application adaptability and reflecting users' requirements dynamically in contextual changes. It also provides efficient support for inferencing, interpreting, acquiring and discovering various contexts to build context-aware services and presents a resolution method for context conflict which is occurred in execution of service. The proposed middleware can support the development and operation of various context-aware services, which are required in the ubiquitous computing environment.

• Nuclear Engineering and Technology
• /
• v.54 no.5
• /
• pp.1845-1850
• /
• 2022

In-vessel corium retention (IVR) during external reactor vessel cooling (ERVC) is a key severe accident management strategy adopted in advanced nuclear power plants. The injection of nanofluids has been regarded as a means of enhancing CHF when using the IVR-ERVC strategy to safeguard high-power nuclear reactors. However, a critical practical concern is that various types of debris flowing from the contaminant sump during operation of an ERVC system might degrade CHF enhancement by nanofluids. Our objective here was to experimentally assess the viability of nanofluid use to enhance CHF in practical ERVC contexts (e.g., when fluids contain various types of debris). The types and characteristics of debris expected during IVR-ERVC were examined. We performed pool boiling CHF experiments using nanofluids containing these types of debris. Notably, we found that debris did not cause any degradation of the CHF enhancement characteristics of nanofluids. The nanoparticles are approximately 1000-fold smaller than the debris particles; the number of nanoparticles in the same volume fraction is 1 billion-fold greater. Nanofluids increase CHF via porous deposition of nanosized particles on the boiling surface; this is not hindered by extremely large debris particles.

• International Journal of High-Rise Buildings
• /
• v.12 no.1
• /
• pp.35-47
• /
• 2023

The transport system and its infrastructure are not only the fundamental means of sustaining the operation of contemporary cities, but also important drivers for the evolution of urban form. Rail transit, critical to improving the operational efficiency and optimizing the spatial layout in cities, is one of the critical conditions for high-density areas with limited land and concentrated resources to be compact to take on complex challenges. As a node element of infrastructure, rail transit entrances are the most important points connecting the rail transit system with urban space. Although influenced by urban form, their quantity and location also influence and shape the evolution of urban space form. Based on the development gap of high-density areas in various contexts, focusing on various rail transit stations in Asia, this research analyzes the correlation between rail transit entrances and peripheral high-density urban form in a delicate, dynamic and granular way. The research considers both horizontal and vertical perspectives, in combination with the urban evolution process in time series, to explore the development trend of high-density urban form in Asia from the aspect of correlation, and building a new foundation for research on urban form, suitable for different types of cities.

• Journal of Korean Society of Industrial and Systems Engineering
• /
• v.46 no.4
• /
• pp.142-151
• /
• 2023

Sentiment analysis is a method used to comprehend feelings, opinions, and attitudes in text, and it is essential for evaluating consumer feedback and social media posts. However, creating sentiment dictionaries, which are necessary for this analysis, is complex and time-consuming because people express their emotions differently depending on the context and domain. In this study, we propose a new method for simplifying this procedure. We utilize syntax analysis of the Korean language to identify and extract sentiment words based on the Reason-Sentiment Pattern, which distinguishes between words expressing feelings and words explaining why those feelings are expressed, making it applicable in various contexts and domains. We also define sentiment words as those with clear polarity, even when used independently and exclude words whose polarity varies with context and domain. This approach enables the extraction of explicit sentiment expressions, enhancing the accuracy of sentiment analysis at the attribute level. Our methodology, validated using Korean cosmetics review datasets from Korean online shopping malls, demonstrates how a sentiment dictionary focused solely on clear polarity words can provide valuable insights for product planners. Understanding the polarity and reasons behind specific attributes enables improvement of product weaknesses and emphasis on strengths. This approach not only reduces dependency on extensive sentiment dictionaries but also offers high accuracy and applicability across various domains.

• Korea Trade Review
• /
• v.46 no.6
• /
• pp.127-142
• /
• 2021

The Pohang Youngilman Port is the only international trade port in the Daegu-Gyeongbuk region, but its cargo throughput has been stagnated since its opening. Finding out ways to revitalize the port has been a big issue in the region, taking its potential business effects on the surrounding areas into consideration. This study, therefore, aimed to critically evaluate the government policies and empirically analyze business environments of the Pohang Youngilman Port as a fundamental to reach solutions for its revitalization. The policy evaluation showed that there are discrepancies in viewing contexts, implementations and mechanisms of the port at each government level, which resulted in implementing various but inconsistent solutions. Also, the interview results were analyzed to point out the fundamental problems, such as limited cargo volume due to weak hinterland development, lack of shuttle shipping between Busan New Port and Pohang Youngilman Port, and lack of large shippers to diverse the shipping network. This study has academic and managerial implications in suggesting measures for facilitation of the Pohang Youngilman Port by amalgamating various viewpoints of governments and stakeholders, which can be used for policy development as well as practical solutions for the port.

• Child Health Nursing Research
• /
• v.30 no.2
• /
• pp.97-107
• /
• 2024

Purpose: This study aimed to investigate the impact of family resilience on caregiver well-being across various age groups of children diagnosed with ADHD (attention-deficit/hyperactivity disorder) groups (0-5, 6-11, and 12-17 years). Methods: Utilizing secondary data from the 2022 US National Survey of Child Health, this cross-sectional study involved 2,752 children who were formally diagnosed with ADHD. Statistical analysis included descriptive analysis, Spearman's rank correlation, chi-square tests, and linear regression, conducted using SPSS version 27. Results: The study revealed a moderate positive correlation (r=.35, p<.001) between family resilience and caregiver well-being. Controlling for covariates, family resilience accounted for 25.2%, 21.1%, and 22.1% of caregiver well-being variance in age groups 0-5, 6-11, and 12-17 years, respectively. Additionally, factors like employment status, family structure, and caregiver age showed varying influences on caregiver well-being across these developmental stages. A consistent pattern emerged across these age groups: unemployment and non-traditional family structures were associated with negative impacts on caregiver well-being, whereas older caregiver age positively influenced well-being. Conclusion: This research underscores the importance of age-specific family resilience strategies to improve caregiver well-being and family interactions in ADHD contexts. Investigating these aspects through qualitative studies across various cultures could deepen our understanding of well-being and inform culturally sensitive interventions.

• Journal of Educational Research in Mathematics
• /
• v.11 no.2
• /
• pp.363-384
• /
• 2001

The purpose of this thesis is, through analysing the characteristics of the definitions in Korean school mathematics textbooks, to explore the levels of them and to make suggestions for definition - teaching as a mathematising activity, Definitions used in academic mathematics are rigorous. But they should be transformed into various types, which are presented in school mathematics textbooks, with didactical purposes. In this thesis we investigated such types of transformation. With the result of this investigation we tried to identify the levels of the definitions in school mathematics textbooks. And in school mathematics textbooks there are definitions which carry out special functions in mathematical contexts or situations. We can say that we understand those definitions, only if we also understand the functions of definitions in those contexts or situations. In this thesis we investigated the cases in school mathematics textbooks, when such functions of definition are accompanied. With the result of this investigation we tried to make suggestions for definition-teaching as an intellectual activity. To begin with we considered definition from two aspects, methods of definition and functions of definition. We tried to construct, with consideration about methods of definition, frame for analysing the types of the definitions in school mathematics and search for a method for definition-teaching through mathematization. Methods of definition are classified as connotative method, denotative method, and synonymous method. Especially we identified that connotative method contains logical definition, genetic definition, relational definition, operational definition, and axiomatic definition. Functions of definition are classified as, description-function, stipulation-function, discrimination-function, analysis-function, demonstration-function, improvement-function. With these analyses we made a frame for investigating the characteristics of the definitions in school mathematics textbooks. With this frame we identified concrete types of transformations of methods of definition. We tried to analyse this result with van Hieles' theory about levels of geometry learning and the mathematical language levels described by Freudenthal, and identify the levels of definitions in school mathematics. We showed the levels of definitions in the geometry area of the Korean school mathematics. And as a result of analysing functions of definition we found that functions of definition appear more often in geometry than in algebra or analysis and that improvement-function, demonstration-function appear regularly after demonstrative geometry while other functions appear before demonstrative geometry. Also, we found that generally speaking, the functions of definition are not explained adequately in school mathematics textbooks. So it is required that the textbook authors should be careful not to miss an opportunity for the functional understanding. And the mathematics teachers should be aware of the functions of definitions. As mentioned above, in this thesis we analysed definitions in school mathematics, identified various types of didactical transformations of definitions, and presented a basis for future researches on definition teaching in school mathematics.