• Journal of Oriental Neuropsychiatry
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• v.9 no.1
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• pp.1-24
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• 1998

The effects of Hyungbangjiwhangrang on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed.1. As the learning trials of Morris water maze processed repeatedly, sham group achiened 201.64${\pm}$33.13 seconds in 1st trial, 153.14${\pm}$61.80 seconds in 2nd, 106.21${\pm}$46.81 seconds in 3rd, 76.64${\pm}$48.40 seconds in 4th, and 52.29${\pm}$38.25 seconds in 5th. The control group achieved 224.08${\pm}$29.16 in 1st trial, 191.77${\pm}$67.97 seconds in 2nd, 177.77${\pm}$65.44 seconds in 3rd, 140.92${\pm}$68.27 seconds in 4th, and 126.46${\pm}$79.15 seconds in 5th. The sample group achieved 223.36${\pm}$23.33 seconds in 1st trial, 215.86${\pm}$38.93 seconds in 2nd, 190.79${\pm}$51.57 seconds in 3rd, 155.79${\pm}$62.67 seconds in 4th, and 127.93${\pm}$62.11 seconds in 5th. Therefore, these data shows that all three groups were improved in learning capacity as trials were repeated, but the shame group showed prominent improvement in learning compared with the control group(p<0.05).2. In memory retention test of Morris water maze that counts the staying time in the target area, sham group stayed for 15.36${\pm}$5.39 seconds, the control group stayed for 5.54${\pm}$5.64 seconds, and the sample group stayed for 7.43${\pm}$6.09 seconds. The analysis of the memory retention data shows that the sham group marked more significant improvement stati- stically in memory retention compared with the control group(p<0.05).3. In the learning of radial arm maze, the number and rate of animals that arrive the learning criteria amounted 12 out of 14, 85.7% in sham group, 4 out of 13, 30.8% in the control group, and 10 out of 14, 71.4% in the sample group So, the sample group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Hyungbangjiwhangtang can be supposed to have the improving effects on the learning and memory of AD rats induced by eletronical injury of nbM.

• Journal of Life Science
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• v.20 no.9
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• pp.1299-1305
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• 2010

Cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB), and C-reactive protein (CRP) are routine cardiac markers for the diagnosis of cardiovascular disease. Recently, brain natriuretic peptide (BNP) has garnered attention as a marker of heart failure. This study was retrospectively designed to investigate the relationships between preoperative BNP, other cardiac markers levels and perioperative parameters in seventy-four adult patients that underwent off-pump coronary artery bypass grafting (OPCAB) and to assess its usefulness for predicting postoperative outcomes. Preoperative levels of BNP, cTnI, CK-MB, and CRP had significantly positive or negative correlations with echocadiographic parameters. There were significantly positive relationships between BNP, cTnI, CK-MB, and CRP concentration. Postoperative mechanical ventilation time had a positive correlation to preoperative levels of cTnI, CK-MB, and CRP, while ICU-staying period had a positive correlation with BNP, cTnI and CK-MB. These results reveal that a preoperative level of BNP is a good predictor and that its combination with cTnI, CK-MB, and CRP might be useful for diagnosis and comprehensive risk stratification of patients with coronary heart diseases, as well as prognosis of perioperative outcomes in OPCAB patients.

• Journal of Life Science
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• v.20 no.10
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• pp.1458-1467
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• 2010

The present study was retrospectively designed to define whether preoperative levels of leukocytes and D-dimer are potentially useful factors in predicting perioperative outcomes of coronary heart disease (CHD). There was no relationship between preoperative leukocyte counts (Pre-OP leukocyte) and preoperative D-dimer levels (Pre-OP D-dimer). Pre-OP leukocyte counts each had positive correlation with cardiac troponin-I, creatine kinase-MB or C-reactive protein (cardiac markers) levels at preoperative and postoperative periods. Pre-OP D-dimer levels were positively associated with each cardiac marker at the same periods. Pre-OP leukocyte counts positively related with aspartate aminotransferase and alanine aminotransferase (liver markers), whereas Pre-OP D-dimer level positively or negatively correlated with bilirubin (liver marker), creatinine (renal marker) or glucose levels at preoperative and/or postoperative periods. Pre-OP leukocyte and Pre-OP D-dimer were inversely associated with Pre-OP high density lipoprotein cholesterol levels or left ventricular ejection fraction. Pre-OP leukocyte counts each had positive correlation operation duration and postoperative mechanical ventilation-time (PMVT), whereas Pre-OP D-dimer levels had positive relationship with PMVT, intensive care unit-staying period and hospitalization. The retrospective data suggest that Pre-OP leukocyte and Pre-OP D-dimer levels may be clinically useful factors for predicting perioperative outcomes in patients with CHD.

• Journal of Yeungnam Medical Science
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• v.16 no.2
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• pp.277-282
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• 1999

Background: For effective and systematic management of patients in the emergency department(ED), the data on patient arrival and status in ED of Yeungnam University Hospital were evaluated. Materials and Methods: During the seven days from Apr. 1 to Apr. 7, 1998, the general patient information such as onset time and place, factors associated with transportation, causes of admission, cared department and patient disposition were recorded. Results: Total of 464 patients visited the ED during the seven days, and the mean number of patients per day was 66.3. Male to female ratio was 1:0.71. Daily staying patients were 17.3, and 83.6 patients were cared totally each day. The methods of transportation and distribution of patients according to region and event were as follows: visit by walk(57.3%). transportation by car(58.0%), place of event in residence(85.3%), regional distribution in Taegu(81.5%), and direct visit(97.4%). Cause of admission due to diseases was 74.6%. The percentages of departments which cared the patients were internal medicine 26.6%, pediatrics 16.8%, orthopedics 8.6%, neurology 8.2%, neurosurgery 7.8% and other department including emergency medicine 8.2%, respectively. Patient dispositions were admission 38.4%, discharge 61.0% and death on arrival(DOA) 0.6%, but referred patient-to-another-hospital was zero. Conclusion: Improvements in several aspects of ED's caring system such as "fast tracking" system and reinforcement of disease and trauma caring system, would be helpful for effective management of emergency patients.

• Journal of Oriental Neuropsychiatry
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• v.26 no.2
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• pp.117-130
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• 2015

Objectives: Banhahoobak-tang has been used to treat plum-pit qi, chest and hypochondriac distension, moist or greasy tongue coat, and wiry slow or wiry slippery pulse. It might be used to control coughing and vomiting. We observed that Banhahoobak-tang extract (BHTe) had anti-psychological stress effect. The objective of this study was to determine the effect of BHTe on restoring the transcriptional regulation of genes related to psychological stress. Methods: After giving psychological stress to mice, BHTe was orally administered at 100 mg/kg/day for five days. After extracting whole brain tissue from the mice, the gene expression changes were determined by microarray. Transcription factor binding site (TFBS) analysis showed up- and down-regulated genes related to psychological stress were protected by BHTe and segregated according to the structure of TFBS. We performed text based Pubmed search to select significant target genes involved in psychological stress affected by BHTe. Results: 1. Serum corticosterone level was decreased in the BHTe administered group, although the psychological stress was increased. 2. The BHTe administered group had no significant change in noradrenaline content in brain tissue, but the psychological stress group had decreased level. 3. The BHTe administered group had increased time of staying at open-arm than the psychological stress group. 4. Microarray revealed that TANK and RARA genes were up-regulated genes while AES, CDC42, FOS, NCL, and PVR were down-regulated genes by psychological stress but restored by BHTe.

• Journal of Korean Academy of Fundamentals of Nursing
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• v.6 no.3
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• pp.522-531
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• 1999

This research identifies the ingress to egress primary factors that causes a patient to receive delayed emergency medical care. This material was collected between February 1st to 28th, 1998. Research envolved 4,118 people who visited the college emergency medical center in Kyeongido Province, South Korea. Medical records were examined, using the retrospective method. to determine the length of stay and the main cause for waiting. Results are as follows : 1. The age group with the highest admission rate was 10 and under, approximately 1,394 (33.9%). Followed by an even distribution for ages between 11-50 at 10-15% for their respective ranges. The lowest admission rate was 50 years and above. 2. From the 4,118 records examined, 3,489 received outpatient treatment (84.7%); 601 were admitted for inpatient care (14.6%); 25 arrived dead on arrival (0.6%); and 4 people died at the hospital. 3. Between 7PM to 12AM, 42.9% were admitted to the EMC. The hours from 9PM to 11PM recorded the highest admission rate and 5AM to 8AM was the lowest From 8PM to 12AM, the most beds were occupied. 4. For most patients. the average length of stay was approximately 2.2 hours. By medical department, external medicine was the longest for 2.8 hours. Pediatrics was the shortest for 1.6 hours. The average waiting period for inpatient admission was 2.6 hours. Inpatient admission for pediatrics and external medicine was 3.4 hours and 2.2 hours respectively. 5. Theses are primary factors for delay at EMC: 1) pronged medical consultations to decide between inpatient versus outpatient treatment, and delaying to be inpatient, 2) when you call physicians they are delayed to come 3) Understaffing during peak or critical hours, 4) Excessive consulting with different medical departments, 5) some patients require longer monitoring periods, 6) medical records are delayed in transit between departments, 7) repeated laboratory tests make delay the result, 8) overcrowded emergency x-ray place causes delay taking x-ray and portable x-ray, 9) the distance between EMC and registration and cashier offices is too far. 10) hard to control patient's family members. The best way to reduce EMC waiting and staying time is by cooperation between departments, both medical and administrative. Each department must work beyond their job description or duty and help each other to provide the best medical service and satisfy the patient needs. The most important answer to shortened the EMC point from ingress to egress is to see things from a patient point of view and begin from there to find the solution.

• Journal of the Economic Geographical Society of Korea
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• v.11 no.2
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• pp.216-232
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• 2008

This paper aim to review the extent of Park Je-Ga's geographical interest and knowledge and where he intended to make good use of them through Bukhakui(北學議). In particular, it was classified and interpreted as the contents related to agricultural, industrial and commercial geography focusing on the contents of the economic geography. As for the contents related to agricultural geography, it suggests minutely and precisely the necessity and concrete methodology for farmland, seeding, fertilization, breeding of cattle, sericulture and fruits. As for the contents related to industrial geography, it lays emphasis on the pursuit of the modernization of ours by means of accepting high-tech, industrial engineering and knowledge from Western scholars who were staying in Beijing. As for the contents related to commercial geography, it puts emphasis on the conversion of idle labor capacity of the nobility to practical production capacity, the pursuit of economic vitalization by opening land transportation through wheels and the trade by sea with neighboring countries such as Qing, Japan, Ryukyu, Vietnam and so on. It can be known through this study that Park Je-Ga was a realist who made an effort to raise the economic power of the region and the country with using his endeavor of economic geographical interest and knowledge. His economic geographical interest and knowledge were connected directly with practical use. If his economic geographical knowledge and way of thinking had been accepted successfully at that time, the economic power in the latter half of the Joseon dynasty could have leaped to a considerable degree.

• Journal of Digital Convergence
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• v.15 no.12
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• pp.95-100
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• 2017

The purpose of this study is to analyze the implications of the case of France, which has already implemented the social integration policy with the interest of the social integration of migrants in advance of Korea. First, we analyzed the system and system of social integration policy in France. Second, we analyzed the social integration policy promotion system in France, and examined the ministries and the agencies that direct the integration policies of the migrants. Third, the implications for the integration policy of Korean immigrants were derived through the above analysis. As a result, France was promoting a consistent social integration policy at the level of the central government, and all members of the society participated in the social integration program. It also encouraged participation in the program in conjunction with social integration programs. Based on this, we concluded that the social integration policy of our country should be modified somewhat. First, it is necessary to pursue the unity of policy by uniting the ministries that can manage migrant social integration policy in our country. Second, the main target of the social integration policy of our country should include not only immigrants who migrated from abroad but also Koreans. Third, Korea should encourage migrants to participate more in social integration programs and at the same time increase their participation rate by disadvantage of staying.

• Journal of Digital Contents Society
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• v.13 no.2
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• pp.151-157
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• 2012

Even though the protective facility is well made with the development of medicine, the spatial dose within the radiation section could increase the exposure of the workers. The spatial dose is always present in distribution room within the Department of Nuclear Medicine, so the spatial dose of the interior distribution room is measured and analyzed for the prediction of the exposure dose. The spatial dose rate was $6.78{\pm}0.083{\mu}Sv/h$ in the $^{18}F$ distribution room of department of Nuclear Medicine, $9.248{\pm}0.013{\mu}Sv/h$ in $^{99m}Tc$, and $^{131}I$ distribution room. In addition, in case of $^{18}F$ distribution room, the yearly external exposure dose was $42.5{\mu}Sv$ when the nurse does IV in 1m in distance. It also showed that the spatial dose rate on the direction of right oblique showed higher than others by the standard of distribution window of distribution room. Therefore, the staying time of the workers should be short during distributing radiopharmaceuticals in the distribution room and the design of the distribution protection is necessary to reduce the exposure in the direction of right oblique of the protection. The utmost endeavors are required to reduce the worker's individual exposure dose while doing IV.

• Journal of dental hygiene science
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• v.14 no.3
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• pp.379-389
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• 2014

This study intended to examine the health status and quality of life among the elderly patients who stayed in geriatric hospitals for a long period of time. The study involved 222 elderly who were older than 65-year-old, an oral examination was conducted in 10 geriatric hospitals located in the metropolitan area and Chungcheong-do. Cross-tabulation, one-way ANOVA, t-test, and Stepwise multiple regression were performed for analysis. The average number of teeth among the subjects was 11.22 and that of dental caries was 1.17. Also, the average number of teeth mobility was 0.93 and halitosis was detected among 81.9%. Only 29.70% reported absence or a kind of systemic disease and 70.31% of the subjects was shown to have more than two kinds of complex disease. In addition, 87.8% of the subjects had depression and among them, 55.40% showed serious depression. The average score on quality of life was 2.62 points and as for the related factors, the number of remaining teeth and dental caries were counted along with care grade, hospitalization period, and age. According to such results, the oral health status among the elderly patients staying long in geriatric hospitals were not good in general; also they showed high level of systemic disease and depression and low quality of life.