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http://dx.doi.org/10.5352/JLS.2010.20.9.1299

Relationship and Clinical Usefulness between Preoperative Levels of Brain Natriuretic Peptide, Other Cardiac Markers and Perioperative Parameters in Patients with Coronary Artery Disease  

Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Kim, Yang-Weon (Department of Emergency Medicine, Inje University Busan Paik Hospital)
Hyun, Kyung-Yae (Department of Clinical Laboratory Science, College of Natural Sciences, Dong-Eui University)
Hwang, Soo-Myung (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Moon, Seong-Min (Biomedical Laboratory of Science, Department of Smart Foods and Drugs, Inje University)
Publication Information
Journal of Life Science / v.20, no.9, 2010 , pp. 1299-1305 More about this Journal
Abstract
Cardiac troponin-I (cTnI), creatine kinase-MB (CK-MB), and C-reactive protein (CRP) are routine cardiac markers for the diagnosis of cardiovascular disease. Recently, brain natriuretic peptide (BNP) has garnered attention as a marker of heart failure. This study was retrospectively designed to investigate the relationships between preoperative BNP, other cardiac markers levels and perioperative parameters in seventy-four adult patients that underwent off-pump coronary artery bypass grafting (OPCAB) and to assess its usefulness for predicting postoperative outcomes. Preoperative levels of BNP, cTnI, CK-MB, and CRP had significantly positive or negative correlations with echocadiographic parameters. There were significantly positive relationships between BNP, cTnI, CK-MB, and CRP concentration. Postoperative mechanical ventilation time had a positive correlation to preoperative levels of cTnI, CK-MB, and CRP, while ICU-staying period had a positive correlation with BNP, cTnI and CK-MB. These results reveal that a preoperative level of BNP is a good predictor and that its combination with cTnI, CK-MB, and CRP might be useful for diagnosis and comprehensive risk stratification of patients with coronary heart diseases, as well as prognosis of perioperative outcomes in OPCAB patients.
Keywords
Brain natriuretic peptide (BNP); cardiac troponin-I (cTnI); creatine kinase-MB (CK-MB); C-reactive protein (CRP); echocardiography; off-pump coronary artery bypass grafting (OPCAB);
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