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http://dx.doi.org/10.5352/JLS.2010.20.10.1458

Clinical Usefulness of Preoperative Levels of Leukocyte and D-Dimer in Predicting Perioperative Outcomes of Cardiovascular Disease  

Choi, Seok-Cheol (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Kim, Yang-Weon (Department of Emergency Medicine, Inje University Busan Paik Hospital)
Hwang, Soo-Myung (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
Publication Information
Journal of Life Science / v.20, no.10, 2010 , pp. 1458-1467 More about this Journal
Abstract
The present study was retrospectively designed to define whether preoperative levels of leukocytes and D-dimer are potentially useful factors in predicting perioperative outcomes of coronary heart disease (CHD). There was no relationship between preoperative leukocyte counts (Pre-OP leukocyte) and preoperative D-dimer levels (Pre-OP D-dimer). Pre-OP leukocyte counts each had positive correlation with cardiac troponin-I, creatine kinase-MB or C-reactive protein (cardiac markers) levels at preoperative and postoperative periods. Pre-OP D-dimer levels were positively associated with each cardiac marker at the same periods. Pre-OP leukocyte counts positively related with aspartate aminotransferase and alanine aminotransferase (liver markers), whereas Pre-OP D-dimer level positively or negatively correlated with bilirubin (liver marker), creatinine (renal marker) or glucose levels at preoperative and/or postoperative periods. Pre-OP leukocyte and Pre-OP D-dimer were inversely associated with Pre-OP high density lipoprotein cholesterol levels or left ventricular ejection fraction. Pre-OP leukocyte counts each had positive correlation operation duration and postoperative mechanical ventilation-time (PMVT), whereas Pre-OP D-dimer levels had positive relationship with PMVT, intensive care unit-staying period and hospitalization. The retrospective data suggest that Pre-OP leukocyte and Pre-OP D-dimer levels may be clinically useful factors for predicting perioperative outcomes in patients with CHD.
Keywords
Leukocyte; D-dimer; cardiac marker; biochemical marker; coronary heart disease; perioperative outcomes;
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