• Korean Journal of Radiology
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• 제22권11호
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• pp.1797-1808
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• 2021

Objective: To determine whether volumetric CT texture analysis (CTTA) using fully automatic tumor segmentation can help predict recurrence-free survival (RFS) in patients with intrahepatic mass-forming cholangiocarcinomas (IMCCs) after surgical resection. Materials and Methods: This retrospective study analyzed the preoperative CT scans of 89 patients with IMCCs (64 male; 25 female; mean age, 62.1 years; range, 38-78 years) who underwent surgical resection between January 2005 and December 2016. Volumetric CTTA of IMCCs was performed in late arterial phase images using both fully automatic and semi-automatic liver tumor segmentation techniques. The time spent on segmentation and texture analysis was compared, and the first-order and second-order texture parameters and shape features were extracted. The reliability of CTTA parameters between the techniques was evaluated using intraclass correlation coefficients (ICCs). Intra- and interobserver reproducibility of volumetric CTTAs were also obtained using ICCs. Cox proportional hazard regression were used to predict RFS using CTTA parameters and clinicopathological parameters. Results: The time spent on fully automatic tumor segmentation and CTTA was significantly shorter than that for semi-automatic segmentation: mean ± standard deviation of 1 minutes 37 seconds ± 50 seconds vs. 10 minutes 48 seconds ± 13 minutes 44 seconds (p < 0.001). ICCs of the texture features between the two techniques ranged from 0.215 to 0.980. ICCs for the intraobserver and interobserver reproducibility using fully automatic segmentation were 0.601-0.997 and 0.177-0.984, respectively. Multivariable analysis identified lower first-order mean (hazard ratio [HR], 0.982; p = 0.010), larger pathologic tumor size (HR, 1.171; p < 0.001), and positive lymph node involvement (HR, 2.193; p = 0.014) as significant parameters for shorter RFS using fully automatic segmentation. Conclusion: Volumetric CTTA parameters obtained using fully automatic segmentation could be utilized as prognostic markers in patients with IMCC, with comparable reproducibility in significantly less time compared with semi-automatic segmentation.

• Asian-Australasian Journal of Animal Sciences
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• 제14권3호
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• pp.378-381
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• 2001

Sulfamethazine has been widely used in swine for prevention or treatment of infections. Recently, the safety of the drug to consumers has been questioned because of carcinogenic effects. To prevent unwanted drug residues entering the human food chain, both government authorities and industries have established extensive control measures. The demands for reliable, simple, sensitive, rapid and low-cost methods for residue analysis of foods are increasing nowadays. In this study, we established a rapid prediction test for the detection of cattle with violative tissue residues of sulfamethazine. The recommended therapeutic dose of sulfamethazine (withdrawal time, 15 days) was administered to each of 10 cattle. Blood was sampled before drug administration and during the withdrawal period. The concentration of sulfamethazine in plasma, determined by a semi-quantitative ELISA, was compared to that of an internal standard (10 ppb). The absorbance ratio of internal standard to sample (B/Bs) was employed as an index to determine whether drug residues in cattle tissues were negative or positive. That is, a B/Bs ratio less than 1 was considered residue positive and if larger than 1 was considered negative. All 10 plasma samples from non-treated cattle showed negative to sulfamethazine. Sulfamethazine was detected in plasmas of treated cattle until Day 7 of withdrawal period. The present study showed that the semi-quantitative ELISA could be easily adapted in predicting residues of sulfamethazine in live cattle.

• The Plant Pathology Journal
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• 제30권4호
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• pp.425-431
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• 2014

Leaf scald caused by the infection of Rhynchosporium secalis, is a worldwide crop disease resulting in significant loss of barley yield. In this study, a systematic sequencing of expressed sequence tags (ESTs) was chosen to obtain a global picture of the assembly of genes involved in pathogenesis. To identify a large number of plant ESTs, which are induced at different time points, an amplified fragment length polymorphism (AFLP) display of complementary DNA (cDNA) was utilized. Transcriptional changes of 140 ESTs were observed, of which 19 have no previously described function. Functional annotation of the transcripts revealed a variety of infection-induced host genes encoding classical pathogenesis-related (PR) or genes that play a role in the signal transduction pathway. The expression analyses by a semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) revealed that Rar1 and Rpg4 are defense inducible genes, and were consistent with the cDNA-AFLP data in their expression patterns. Hence, the here presented transcriptomic approach provides novel global catalogue of genes not currently represented in the EST databases.

• 한국어류학회지
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• 제19권2호
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• pp.88-92
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• 2007

Marine birnavirus (MABV)에 무증상적으로 감염된 넙치 (Paralichthys olivaceus) 치어에 면역억제제의 일종인 Dexamathasone을 투여하였을 때 MABV의 감염강도에 영향을 미치는가를 조사하였다. Real time PCR 분석결과 dexamethasone을 투여한 그룹이 생리식염수를 주사한 그룹 및 no handling 그룹에 비해 유의적으로 낮은 Ct 값을 나타냈으며, 또한 semi-quantitative RT-PCR 분석결과에 있어서도 dexamethasone을 주사한 그룹이 대조구 그룹들에 비해 MABV 유전자가 유의적으로 높게 증폭되는 것으로 나타났다. 이러한 결과로부터 dexamethasone 투여가 넙치 치어에 감염된 MABV의 복제를 증가시킴을 확인하였다.

• Smart Structures and Systems
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• 제24권1호
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• pp.27-35
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• 2019

This paper proposes a quantitative criterion for optimization of actuator placement for the Prestress-Accumulation Release (PAR) strategy of mitigation of vibrations. The PAR strategy is a recently developed semi-active control approach that relies on controlled redistribution of vibration energy into high-order modes, which are high-frequency and thus effectively dissipated by means of the natural mechanisms of material damping. The energy transfer is achieved by a controlled temporary removal of selected structural constraints. This paper considers a short-time decoupling of rotational degrees of freedom in a frame node so that the bending moments temporarily cease to be transferred between the involved beams. We propose and test a quantitative criterion for placement of such actuators. The criterion is based on local modal strain energy that can be released into high-order modes. The numerical time complexity is linear with respect to the number of actuators and potential placements, which facilitates quick analysis in case of large structures.

• 약학회지
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• 제55권2호
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• pp.106-115
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• 2011

Systematic toxicological analysis (STA) means the process for general unknown screening of drugs and toxic compounds in biological fluids. In order to establish STA, in previous study we investigated pattern of drugs & poisons in autopsy cases during 2007~2009 in Korea, and finally selected 62 drugs as target drugs for STA. In this study, rapid and simple drug identification and quantitative analytical program by gas chromatography-mass spectrometry(GC-MS) was developed. The in-house program, "DrugMan", consisted of modified chemstation data analysis menu and newly developed macro modules. Total 55 drugs among 62 target drugs were applied to this program, they were 14 antidepressants, 8 anti-histamines, 5 sedatives/hypnotics, 5 narcotic analgesics, 3 antipsychotic drugs, and etc. For calibration curves, fifty five drugs were divided into four groups of range considering their therapeutic or toxic concentrations in blood specimen, i.e. 0.05~1 mg/l, 0.1~1 mg/l, 0.1~5 mg/l or 0.5~10 mg/l. Standards spiked bloods were extracted by solid-phase extraction (SPE) with trimipramine-D3 as internal standard. Parameters such as retention times, 3 mass fragment ions, and calibration curves for each drug were registered to DrugMan. A series of identification, semi quantitation of target drugs and reporting the results were performed automatically. Calibration curves for most drugs were linear with correlation coefficients exceeding 0.98. Sensitivity rate of DrugMan was 0.90 (90%) for 55 drugs at the level of 0.5 mg/l. For standard spiked bloods at the level of 0.5 mg/l for 29 drugs, semi quantitative concentrations were ranged 0.36~0.64 mg/l by DrugMan. If more drugs are registered to database in DrugMan in further study, it will be useful tools for STA in forensic toxicology.

• 광물과 암석
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• 제33권4호
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• pp.427-437
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• 2020

미래의 유망 자원으로 주목받고 있는 망가니즈단괴는 태평양이나 인도양의 심해저뿐만 아니라 북극해에서도 여러 곳에서 발견되고 있다. 망가니즈단괴는 성장과정에 따라 외형, 내부조직, 화학조성 및 광물조성 등 여러 가지 특성이 달라진다. 망가니즈단괴의 성장과정에 따른 내부조직과 화학조성은 다양한 연구를 통해 비교적 잘 알려져 있으나, 정량적인 광물조성은 분명하게 밝혀진 바가 없다. 망가니즈단괴를 구성하는 산화망가니즈광물들은 입자가 매우 작고 결정도가 낮기 때문에, 정량적인 분석이 어려워 전체 시료에 대한 정성적인 결과만이 보고되고 있다. 이번 연구에서는 북극 동시베리아해 망가니즈단괴의 내부조직을 관찰하고, 조직에 따른 광물조성의 변화를 알아보았으며, X선회절분석 그래프의 피크 면적비를 이용하여 망가니즈단괴를 구성하는 3가지 주요한 산화망가니즈광물 즉, 토도로카이트, 부서라이트, 버네사이트의 반정량 분석을 시도하였다. 동시베리아해 망가니즈단괴는 버네사이트, 부서라이트, 토도로카이트 순으로 함량비가 감소하며, 내부조직과는 뚜렷한 연관성을 나타내지 않았다. 그러나 단괴 내부에서 표면으로 갈수록 토도로카이트의 함량이 감소하는 경향을 나타내는데, 그 이유는 초기 침전 이후의 재결정작용 또는 단괴 내외부의 성장 속도 차이에 의한 것으로 간주된다. 피크 면적비를 이용한 산화망가니즈광물의 반정량분석은 단괴 내부에서의 광물조성 차이를 비교하는데에 좋은 방법으로 여겨지므로, 앞으로 망가니즈단괴의 광물학적 연구에 있어 유용하게 이용될 수 있을 것으로 기대된다.

• 대한기계학회논문집A
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• 제41권1호
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• pp.69-76
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• 2017

본 연구에서는 대표적 정성적 신뢰성 분석 기법인 FMEA(고장모드 및 영향 분석)와 준-정량적 분석 방법인 치명도 분석을 이용하여 소형 하이브리드 로켓 설계를 수행하였다. 설계 중인 하이브리드 로켓을 총 31개의 부품으로 나누고 각 부품에서 발생할 수 있는 총 72개의 고장모드를 고려하여 FMEA를 수행하였으며 고장모드의 원인과 영향을 분석하였다. 또한 고장모드들의 정성적인 심각도 평가를 수행하고, 고장모드의 고장률 데이터를 이용하여 치명도 분석을 추가적으로 수행하였다. 분석 결과 설계 시 중점적으로 고려해야 할 고장모드를 파악하였으며 하이브리드 로켓의 신뢰도를 높이기 위해 고장모드들의 설계 및 재질 변경 등의 개선 조치를 설계에 반영하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.5969-5973
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• 2012

Introduction: Andhra Pradesh (AP) is one of the largest tobacco producing states in India. About 29% of adults in AP currently use tobacco in some form. Almost 24% of males and 4% of females are smokers. The prevalence of tobacco use in the state is higher than the national average of 15% for male and 2% for female smokers. However, few attempts have been made to understand the current situation of tobacco control resources, activities and strategies in the context of such a high tobacco prevalence state. The present study aimed to identify the gaps in existing tobacco control program and areas where tobacco control efforts can be integrated. Methods: Data were collected using both quantitative and qualitative methods. Semi-structured interviews were undertaken with a total of 95 key officials of state health departments, program managers, and project directors in six districts to understand ongoing tobacco control efforts. To facilitate the interviews, semi-structured guides were developed. Simple descriptive statistical analysis was conducted on the quantitative data using SPSS version 17. Results: The results of the situational analysis suggest that a sufficient health workforce and infrastructure with the potential to integrate tobacco control activities is available in the surveyed districts. However, lack of integration of the tobacco control program intothe tuberculosis control program and the National Rural Health Mission was observed. Information, education and communication activities were lacking at block level health facilities. Conclusions: Our findings indicate that lack of trained health professionals, paucity of dedicated funds, lack of information, education and communication materials and low priority given to tobacco control activities are some of the factors which impede integration of tobacco control into existing health and developmental programmes in the districts of Andhra Pradesh, India.

• 한국ITS학회 논문지
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• 제12권3호
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• pp.19-28
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• 2013

본 연구는 반감응 신호제어 적용에 따른 정량적인 효과를 현장에서 수집된 자료를 활용하여 평가하였다. 이를 위하여 지방부도로에 현장을 선정하여 반감응 신호제어 시스템을 대규모로 설치하였다. 또한 이러한 시스템을 현장에서 구현하기 위한 신호제어 전략을 개발하고, 표준제어기의 내부 기능을 수정하여 교차로에 구현하였다. 그리고 교통량, 통행시간, 지체차량수의 3가지 효과척도를 이용하여 효과를 제시하였다. 분석결과로부터, 반감응 신호제어시스템 적용시 주방향의 용량이 증대되어 오전 및 오후 첨두시 평균적으로 9.4%, 11.3%의 통과교통량 증가가 각각 나타났다. 그리고 직진 차량에 대한 녹색시간 폭이 확대되어 평균적인 주행시간이 오전 첨두시에는 6.3%, 오후 첨두시에는 7.8% 감소하였다. 지체차량의 수도 오전 첨두시에는 36.4%, 오후 첨두시에는 23.9% 감소되어 반감응 도입에 따른 제어 효과가 큰 것으로 확인되었다. 따라서 주도로와 부도로 교통량의 편차가 크고, 횡단보도 보행자가 적은 특성이 있는 도로에는 반감응제어가 매우 효과적인 것으로 판단된다.