• 한국철도학회:학술대회논문집
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• 한국철도학회 2007년도 추계학술대회 논문집
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• pp.1132-1140
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• 2007

As it recently appears that Life Cycle Cost Analysis may be considered as new methodology for economic valuation of infrastructure many researches have been made to assess LCC(Life Cycle Cost) of each facility based on a reasonable methods. In general, LCC is composed of construction cost and expected maintenance repair cost. And especially, maintenance repair cost must be estimated to enhance the reliability through systematic and reasonable methods. However in Korea, because high speed railway steel bridges are recently constructed no direct statistical data are available for the account of the maintenance cost and then their maintenance characteristics are not linear yet. Therefore, the approach proposed in the paper utilizes a theoretical determination and degradation of the corrosion and fatigue of the bridges based on Rahgozar et al.(2006)'s model on fatigue notch factor considering into the corrosion to incorporate the corrosion effect into the fatigue strength reduction model. And then, the corresponding probability of failure is calculated in terms of the reliability index using S-N curve to formulate the fatigue limit state. Therefore, this paper proposes the minimum Life Cycle Cost through optimum maintenance plan analysis of high-speed railway steel bridges under construction. Finally, this paper reviews the proposed model in oder to confirm the applicability and feasibility by appling it to high speed railway steel bridges under construction

• Wind and Structures
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• 제30권4호
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• pp.379-392
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• 2020

The paper presents a Life-Cycle Cost-based optimization framework for wind-excited tall buildings equipped with Tuned Mass Dampers (TMDs). The objective is to minimize the Life-Cycle Cost that comprises initial costs of the structure, the control system and costs related to repair, maintenance and downtime over the building's lifetime. The integrated optimization of structural sections and mass ratio of the TMDs is carried out, leading to a set of Pareto optimal solutions. The main advantage of the proposed methodology is that, differently from the traditional optimal design approach, it allows to perform the unified design of both the structure and the control system in a Life Cycle Cost Analysis framework. The procedure quantifies wind-induced losses, related to structural and nonstructural damage, considering the stochastic nature of the loads (wind velocity and direction), the specificity of the structural modeling (e.g., non-shear-type vibration modes and torsional effects) and the presence of the TMDs. Both serviceability and ultimate limit states related to the structure and the TMDs' damage are adopted for the computation of repair costs. The application to a case study tall building allows to demonstrate the efficiency of the procedure for the integrated design of the structure and the control system.

• Biomolecules & Therapeutics
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• 제25권2호
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• pp.186-193
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• 2017

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study, we demonstrated that Tet has a radiosensitization effect on human glioma cells. It has been hypothesized that Tet has a radiosensitization effect on glioma cells by affecting the glioma cell cycle and DNA repair mechanism and that ERK mediates these activities. Therefore, we conducted detailed analyses of the effects of Tet on the cell cycle by performing flow cytometric analysis and on DNA repair by detecting the expression of phosphorylated H2AX by immunofluorescence. We used western blot analysis to investigate the role of ERK in the effect of Tet on the cell cycle and DNA repair. The results revealed that Tet exerts its radiosensitization effect on glioma cells by inhibiting proliferation and decreasing the expression of phosphorylated ERK and its downstream proteins. In summary, our data indicate that ERK is involved in Tet-induced radiosensitization of glioma cells via inhibition of glioma cell proliferation or of the cell cycle at G0/G1 phase.

• KIEAE Journal
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• 제14권5호
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• pp.103-109
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• 2014

Apartment housing should require the systematic maintenance to provide the decent living condition during its life. Each household should participate the maintenance activities and pay for the repair. Therefore, the required cost for repair would be needed to plan in the repair schedule because each household could not pay the much repair money at a time. After apartment constructed, a long term repair plan would be prepared in repair time, repair scope and a required cost. A few studies are said that the repair cost depends on the building deterioration, elapsed year and management factors. The above factors are not be certain to affect the repair management while it may be important to prepare the required money and the repair time. In this paper, it aimed at analyzing the correlation between the repair management and the management factors, especially total area, number of household. This would educe the unit cost per number of household and management area in the individual boiler and elevator with full change and full repair. The unit cost per number of household and area for full change are about 199,000 won/household and $1,954won/m^2$ in the individual boiler respectively. The unit cost of the elevator for full change is 94,000 won/household and $5,429won/m^2$ respectively. Second, this study shows that the elapsed year after construction would not be related the repair unit cost.

• Communications for Statistical Applications and Methods
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• 제17권6호
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• pp.865-877
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• 2010

본 논문에서는 보증기간이 종료된 이후의 수리가 가능한 시스템에 대한 주기적인 예방보전모형을 고려하는데, 무료수리보증, 비례수리보증 그리고 혼합수리보증과 같은 세 종류의 수리보증정책을 고려한다. 이러한 세 종류의 수리보증기간이 종료된 이후의 수리가 가능한 시스템에 대한 주기적인 예방보전모형에 대하여 각각 기대순환길이, 총기대비용 그리고 단위시간당 기대비용을 유도한다. 또한 유도된 단위시간당 기대 비용을 최소화하는 최적의 예방보전정책인 최적의 예방보전주기와 예방보전횟수를 결정하는 방법에 대하여 설명한다. 끝으로 고장시간이 와이블분포를 하는 경우에 최적의 주기적 예방보전정책을 결정하여 본다.

• KIEAE Journal
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• 제15권6호
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• pp.19-26
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• 2015

Purpose: The repair would require to conserve and improve the building function and performance since built. Each household is responsible for maintaining the public facilities and paying the required cost. Therefore, it needs to get the tool or method to forecast the required cost in the future. Before the repair cost is provided, it needs to catch the repair cost distribution and provide the unit cost for the repair cycle. In this study, it aimed at providing the repair cost unit and analyzing the repair cost distribution in a roof proofing work, elevator work and building painting, which are divided into a fully work and partly change. Results of this study are shown that first, the average repair cost for roof proofing work is provided with $166.59{\times}10^3won/household$ and $1.59{\times}10^3won/m^2$ of a full change, $33.22{\times}10^3won/household$ and $0.33{\times}10^3won/m^2$ for a partly work. In addition, elevator work is $557.45{\times}10^3won/household$ and $5.38{\times}10^3won/m^2$ for a full change, $32.92{\times}10^3won/household$ and $0.56{\times}10^3won/m^2$ for a partly repair. Painting has a $304.48{\times}10^3won/household$ and $2.94{\times}10^3won/m^2$. Second, the distribution pattern of repair unit cost has a weibull-typed distribution which has a long tail to the right.

• Journal of Welding and Joining
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• 제33권5호
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• pp.26-30
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• 2015

Hastelloy X in this study was applied in jet engine F-15 air fighter as shroud to isolate the engine from outer skin. After 15 years operation at elevated temperature the mechanical properties decreased gradually due to the precipitation of continues second phases in the grain boundaries and precipitated inside the grain. The crack happened at the edge of the shroud due to the thermal and mechanical stress from jet engine. Selective TEM analysis found that the grain boundaries consist of $M_{23}C_6$ carbide, $M_6$ Ccarbide and small percentage of sigma(${\sigma}$) phase. Furthermore, it was confirmed the nano size of ${\sigma}$ and miu (${\mu}$) phase inside the grain. In this study, it was investigated the microstructure of the degraded shroud component and HAZ of repair welded shroud. In the HAZ, it was observed the dissolution of the $M_{23}C_6$ carbides and smaller precipitates, the migration of the undissolved larger $M_{23}C_6$ carbide and $M_6$ Ccarbide. It is also observed the liquation due to the simply melt of the segregated precipitates in the grain boundaries. Interestingly, the segregated second phases which simply melt in the grain boundaries more easily happened at higher heat input welding condition. High temperature tensile test was done at $300^{\circ}C$, $700^{\circ}C$ and $900^{\circ}C$. It was obtained that the toughness of welded sample is lower compare to the non-welded sample. The solution heat treatment at $1170^{\circ}C$ for 5 minutes was suggested to obtain a better mechanical properties of the shroud. The high cycle fatigue number of the repair welded shroud shows a much lower compare to the shroud. In addition, the high cycle fatigue number at room temperature after solution heat treatment was almost double compare to the before solution heat treatment under 420-500MPa stress amplitude. However, the high cycle fatigue number of repaired welded sample was shown a much lower compare to the non- welded shroud and solution treated shroud. One of the main reasons to decrease the tensile strength and the high cycle fatigue properties of the repair welded shroud is the formation of the liquid phase in HAZ.

• 한국지진공학회논문집
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• 제6권5호
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• pp.29-36
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• 2002

교량의 내진성능확보를 위한 유지보수계획을 수립하는데 있어서, 전체 생애주기비용의 최소화를 통하여 최적의 검사 및 수리회수의 결정방법을 제시한다. 생애주기 비용에는 초기비용, 파괴비용 뿐만 아니라, 검사 및 보수비용이 포함된다. 시간에 따른 내진성능저하모델을 손상함수를 이용하여 표현하였으며, 손상감지정도에 따른 Event Tree Analysis를 통하여 유지보수에 따른 파괴확률을 랜덤진동이론을 이용하여 산출한다. 예제로서 10경간 연속교의 최적유지보수방법을 살펴본 결과, 가속도계수가 증가하고, 연약지반일수록 최적유지보수회수는 증가하는 것으로 나타났다.

• 한국도로학회논문집
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• 제9권4호
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• pp.159-169
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• 2007

본 연구에서는 효율적인 포장관리를 위해 경제성을 고려하여 생애주기비용(LCC)이 최소가 되는 시점에서 필요한 유지보수공법을 적용할 수 있는 포장관리시스템(PMS)을 개발하여 실제 포장관련 자료를 기반으로 한 유지관리방안을 제시하였다. 나아가 예산제약이 없는 경우를 대상으로 일정한 수준의 도로 서비스수준을 유지하기 위해 필요한 예산은 매년 차이가 있음도 확인하였다. Visual Basic 프로그램으로 개발하여 시스템의 응용성과 실효성의 검증을 위해 22개의 국도포장단면을 대상으로 현장조사를 시행하여 얻은 자료를 바탕으로 포장단면의 장기공용성 추정과 예산범위를 고려한 효율적인 유지관리 방안을 제시하였다.

• Molecules and Cells
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• 제42권7호
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• pp.546-556
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• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.