Tetrandrine Exerts a Radiosensitization Effect on Human Glioma through Inhibiting Proliferation by Attenuating ERK Phosphorylation |
Ma, Ji-wei
(Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University)
Zhang, Yong (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) Ye, Ji-cheng (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) Li, Ru (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) Wen, Yu-Lin (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) Huang, Jian-xian (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) Zhong, Xue-yun (Division of Pathology, Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Medical College, Jinan University) |
1 | Chen, X. L., Ren, K. H., He, H. W. and Shao, R. G. (2008) Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis. Cancer Biol. Ther. 7, 1073-1078. DOI |
2 | Cho, H. S., Chang, S. H., Chung, Y. S., Shin, J. Y., Park, S. J., Lee, E. S., Hwang, S. K., Kwon, J. T., Tehrani, A. M., Woo, M., Noh, M. S., Hanifah, H., Jin, H., Xu, C. X. and Cho, M. H. (2009) Synergistic effect of ERK inhibition on tetrandrine-induced apoptosis in A549 human lung carcinoma cells. J. Vet. Sci. 10, 23-28. DOI |
3 | Michalski, A., Bouffet, E., Taylor, R. E., Hargrave, D., Walker, D., Picton, S., Robinson, K., Pizer, B. and Bujkiewicz, S. (2010) The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intrinsic pontine glioma. J. Neurooncol. 100, 81-88. DOI |
4 | Ng, L. T., Chiang, L. C., Lin, Y. T. and Lin, C. C. (2006) Antiproliferative and apoptotic effects of tetrandrine on different human hepatoma cell lines. Am. J. Chin. Med. 34, 125-135. DOI |
5 | Ostrom, Q. T., Gittleman, H., Stetson, L., Virk, S. M. and Barnholtz-Sloan, J. S. (2015) Epidemiology of gliomas. Cancer Treat. Res. 163, 1-14. |
6 | Park, H. S., You, G. E., Yang, K. H., Kim, J. Y., An, S., Song, J. Y., Lee, S. J., Lim, Y. K. and Nam, S. Y. (2015) Role of AKT and ERK pathways in controlling sensitivity to ionizing radiation and adaptive response induced by low-dose radiation in human immune cells. Eur. J. Cell Biol. 94, 653-660. DOI |
7 | Stepanenko, A. A., Andreieva, S. V., Korets, K. V., Mykytenko, D. O., Baklaushev, V. P., Chekhonin, V. P. and Dmitrenko, V. V. (2016) mTOR inhibitor temsirolimus and MEK1/2 inhibitor U0126 promote chromosomal instability and cell type-dependent phenotype changes of glioblastoma cells. Gene 579, 58-68. DOI |
8 | Sun, X., Xu, R., Deng, Y., Cheng, H., Ma, J., Ji, J. and Zhou, Y. (2007a) Effects of tetrandrine on apoptosis and radiosensitivity of nasopharyngeal carcinoma cell line CNE. Acta Biochim. Biophys. Sin. (Shanghai) 39, 869-878. DOI |
9 | Du, W., Pang, C., Xue, Y., Zhang, Q. and Wei, X. (2015) Dihydroartemisinin inhibits the Raf/ERK/MEK and PI3K/AKT pathways in glioma cells. Oncol. Lett. 10, 3266-3270. DOI |
10 | Dai, X. F., Ding, J., Zhang, R. G., Ren, J. H., Ma, C. M. and Wu, G. (2013) Radiosensitivity enhancement of human hepatocellular carcinoma cell line SMMC-7721 by sorafenib through the MEK/ERK signal pathway. Int. J. Radiat. Biol. 89, 724-731. DOI |
11 | Kuipers, G. K., Slotman, B. J., Wedekind, L. E., Stoter, T. R., Berg, J., Sminia, P. and Lafleur, M. V. (2007) Radiosensitization of human glioma cells by cyclooxygenase-2 (COX-2) inhibition: independent on COX-2 expression and dependent on the COX-2 inhibitor and sequence of administration. Int. J. Radiat. Biol. 83, 677-685. DOI |
12 | Ferrante, A., Seow, W. K., Rowan-Kelly, B. and Thong, Y. H. (1990) Tetrandrine, a plant alkaloid, inhibits the production of tumour necrosis factor-alpha (cachectin) hy human monocytes. Clin. Exp. Immunol. 80, 232-235. |
13 | Gao, J. L., Ji, X., He, T. C., Zhang, Q., He, K., Zhao, Y., Chen, S. H. and Lv, G. Y. (2013) Tetrandrine suppresses cancer angiogenesis and metastasis in 4T1 tumor bearing mice. Evid. Based Complement. Alternat. Med. 2013, 265061. |
14 | Huang, Y. C., Wei, K. C., Chang, C. H., Yang, J. T., Ho, J. T., Shen, C. C., Su, C. F., Cho, D. Y., Ma, H. I., Lin, J. W., Lee, E. J., Wu, J. J., Tsai, M. D., Chang, C. K., Howng, S. L. and Chang, C. N. (2011) A retrospective survey of patients with malignant gliomas treated in the neuro-oncological care system under the Universal National Health Insurance program in Taiwan. J. Clin. Neurosci. 18, 784-788. DOI |
15 | Lee, J. H., Kang, G. H., Kim, K. C., Kim, K. M., Park, D. I., Choi, B. T., Kang, H. S., Lee, Y. T. and Choi, Y. H. (2002) Tetrandrine-induced cell cycle arrest and apoptosis in A549 human lung carcinoma cells. Int. J. Oncol. 21, 1239-1244. |
16 | Wu, K., Zhou, M., Wu, Q. X., Yuan, S. X., Wang, D. X., Jin, J. L., Huang, J., Yang, J. Q., Sun, W. J., Wan, L. H. and He, B. C. (2015) The role of IGFBP-5 in mediating the anti-proliferation effect of tetrandrine in human colon cancer cells. Int. J. Oncol. 46, 1205-1213. DOI |
17 | Sun, X. C., Cheng, H. Y., Deng, Y. X., Shao, R. G. and Ma, J. (2007b) Tetrandrine: a potent abrogator of G2 checkpoint function in tumor cells and its mechanism. Biomed. Environ. Sci. 20, 495-501. |
18 | Sun, Y., Liu, W. Z., Liu, T., Feng, X., Yang, N. and Zhou, H. F. (2015) Signaling pathway of MAPK/ERK in cell proliferation, differentiation, migration, senescence and apoptosis. J. Recept. Signal Transduct. Res. 35, 600-604. DOI |
19 | Wu, J. M., Chen, Y., Chen, J. C., Lin, T. Y. and Tseng, S. H. (2010) Tetrandrine induces apoptosis and growth suppression of colon cancer cells in mice. Cancer Lett. 287, 187-195. DOI |
20 | Xiao, W., Graham, P. H., Power, C. A., Hao, J., Kearsley, J. H. and Li, Y. (2012) CD44 is a biomarker associated with human prostate cancer radiation sensitivity. Clin. Exp. Metastasis 29, 1-9. DOI |
21 | Xiao, W., Jiang, Y., Men, Q., Yuan, L., Huang, Z., Liu, T., Li, W. and Liu, X. (2015) Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int. J. Oncol. 46, 360-368. DOI |
22 | Yu, J., Liu, F., Sun, M., Sun, Z. and Sun, S. (2011) Enhancement of radiosensitivity and the potential mechanism on human esophageal carcinoma cells by tetrandrine. Cancer Biother. Radiopharm. 26, 437-442. DOI |
23 | Liu, W., Kou, B., Ma, Z. K., Tang, X. S., Lv, C., Ye, M., Chen, J. Q., Li, L., Wang, X. Y. and He, D. L. (2015) Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells. Asian J. Androl. 17, 850-853. |
24 | Li, T., Song, T., Ni, L., Yang, G., Song, X., Wu, L., Liu, B. and Liu, C. (2014) The p-ERK-p-c-Jun-cyclinD1 pathway is involved in proliferation of smooth muscle cells after exposure to cigarette smoke extract. Biochem. Biophys. Res. Commun. 453, 316-320. DOI |
25 | Liang, X., So, Y. H., Cui, J., Ma, K., Xu, X., Zhao, Y., Cai, L. and Li, W. (2011) The low-dose ionizing radiation stimulates cell proliferation via activation of the MAPK/ERK pathway in rat cultured mesenchymal stem cells. J. Radiat. Res. 52, 380-386. DOI |
26 | Lin, Y., Wang, Y., Liu, X., Yan, J., Su, L. and Liu, X. (2016) A novel derivative of tetrandrine (H1) induces endoplasmic reticulum stressmediated apoptosis and prosurvival autophagy in human non-small cell lung cancer cells. Tumour Biol. 37, 10403-10413. DOI |
27 | Ma, J. W., Zhang, Y., Li, R., Ye, J. C., Li, H. Y., Zhang, Y. K., Ma, Z. L., Li, J. Y., Zhong, X. Y. and Yang, X. (2015) Tetrandrine suppresses human glioma growth by inhibiting cell survival, proliferation and tumour angiogenesis through attenuating STAT3 phosphorylation. Eur. J. Pharmacol. 764, 228-239. DOI |
28 | Asati, V., Mahapatra, D. K. and Bharti, S. K. (2016) PI3K/Akt/mTOR and Ras/Raf/MEK/ERK signaling pathways inhibitors as anticancer agents: structural and pharmacological perspectives. Eur. J. Med. Chem. 109, 314-341. DOI |
29 | McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Franklin, R. A., Montalto, G., Cervello, M., Libra, M., Candido, S., Malaponte, G., Mazzarino, M. C., Fagone, P., Nicoletti, F., Basecke, J., Mijatovic, S., Maksimovic-Ivanic, D., Milella, M., Tafuri, A., Chiarini, F., Evangelisti, C., Cocco, L. and Martelli, A. M. (2012a) Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget 3, 1068-1111. DOI |
30 |
Ahmed, K. M., Nantajit, D., Fan, M., Murley, J. S., Grdina, D. J. and Li, J. J. (2009) Coactivation of ATM/ERK/NF- |
31 | Bases, R., Mendez, F. and Franklin, W. A. (1994) Enhanced repair endonuclease activities from radiation-arrested G2 phase mammalian cells. Int. J. Radiat. Biol. 65, 591-603. DOI |
32 | McCubrey, J. A., Steelman, L. S., Chappell, W. H., Abrams, S. L., Montalto, G., Cervello, M., Nicoletti, F., Fagone, P., Malaponte, G., Mazzarino, M. C., Candido, S., Libra, M., Basecke, J., Mijatovic, S., Maksimovic-Ivanic, D., Milella, M., Tafuri, A., Cocco, L., Evangelisti, C., Chiarini, F. and Martelli, A. M. (2012b) Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget 3, 954-987. DOI |
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