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Chen, M.Y., Chen, Y.P., Wu, M.S., Yu, G.Y., Lin, W.J., Tan, T.H., and Su, Y.W. (2014). PP4 is essential for germinal center formation and class switch recombination in mice. PLoS One 9, e107505.
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Chowdhury, D., Xu, X., Zhong, X., Ahmed, F., Zhong, J., Liao, J., Dykxhoorn, D.M., Weinstock, D.M., Pfeifer, G.P., and Lieberman, J. (2008). A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication. Mol. Cell 31, 33-46.
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3 |
Goodarzi, A.A., Kurka, T., and Jeggo, P.A. (2011). KAP-1 phosphorylation regulates CHD3 nucleosome remodeling during the DNA double-strand break response. Nat. Struct. Mol. Biol. 18, 831-839.
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4 |
Hu, C., Zhang, S., Gao, X., Gao, X., Xu, X., Lv, Y., Zhang, Y., Zhu, Z., Zhang, C., Li, Q., et al. (2012). Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 phosphorylation in DNA damage response. J. Biol. Chem. 287, 18937-18952.
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Jackson, S.P. and Bartek, J. (2009). The DNA-damage response in human biology and disease. Nature 461, 1071-1078.
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Kim, H., Dejsuphong, D., Adelmant, G., Ceccaldi, R., Yang, K., Marto, J.A., and D'Andrea, A.D. (2014). Transcriptional repressor ZBTB1 promotes chromatin remodeling and translesion DNA synthesis. Mol. Cell 54, 107-118.
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Lee, D.H., Acharya, S.S., Kwon, M., Drane, P., Guan, Y., Adelmant, G., Kalev, P., Shah, J., Pellman, D., Marto, J.A., et al. (2014). Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks. Mol. Cell 54, 512-525.
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Lee, D.H. and Chowdhury, D. (2011). What goes on must come off: phosphatases gate-crash the DNA damage response. Trends Biochem. Sci. 36, 569-577.
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Lee, D.H., Pan, Y., Kanner, S., Sung, P., Borowiec, J.A., and Chowdhury, D. (2010). A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination. Nat. Struct. Mol. Biol. 17, 365-372.
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Lee, D.H., Goodarzi, A.A., Adelmant, G.O., Pan, Y., Jeggo, P.A., Marto, J.A., and Chowdhury, D. (2012). Phosphoproteomic analysis reveals that PP4 dephosphorylates KAP-1 impacting the DNA damage response. EMBO J. 31, 2403-2415.
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11 |
Lee, J., Adelmant, G., Marto, J.A., and Lee, D.H. (2015). Dephosphorylation of DBC1 by protein phosphatase 4 is important for p53-mediated cellular functions. Mol. Cells 38, 697-704.
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12 |
Liu, B., Wang, Z., Ghosh, S., and Zhou, Z. (2013). Defective ATM-Kap-1-mediated chromatin remodeling impairs DNA repair and accelerates senescence in progeria mouse model. Aging Cell 12, 316-318.
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13 |
Lee, J. and Lee, D.H. (2014). Leucine methylation of protein phosphatase PP4C at C-terminal is critical for its cellular functions. Biochem. Biophys. Res. Commun. 452, 42-47.
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14 |
Li, M., Li, X., Xu, S., Xue, P., Li, Q., Lu, Q., Jia, Q., Zhang, L., Li, X., and Li, X. (2016). Protein phosphatase 4 catalytic subunit is overexpressed in glioma and promotes glioma cell proliferation and invasion. Tumour Biol. 37, 11893-11901.
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15 |
Li, X., Liang, L., Huang, L., Ma, X., Li, D., and Cai, S. (2015). High expression of protein phosphatase 4 is associated with the aggressive malignant behavior of colorectal carcinoma. Mol. Cancer 14, 95.
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16 |
Liu, J., Xu, L., Zhong, J., Liao, J., Li, J., and Xu, X. (2012). Protein phosphatase PP4 is involved in NHEJ-mediated repair of DNA double-strand breaks. Cell Cycle 11, 2643-2649.
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17 |
Mohammed, H.N., Pickard, M.R., and Mourtada-Maarabouni, M. (2016). The protein phosphatase 4 - PEA15 axis regulates the survival of breast cancer cells. Cell. Signal. 28, 1389-1400.
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18 |
Lyu, J., Kim, H.R., Yamamoto, V., Choi, S.H., Wei, Z., Joo, C.K., and Lu, W. (2013). Protein phosphatase 4 and Smek complex negatively regulate Par3 and promote neuronal differentiation of neural stem/progenitor cells. Cell Rep. 5, 593-600.
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19 |
Martin-Granados, C., Philp, A., Oxenham, S.K., Prescott, A.R., and Cohen, P.T. (2008). Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases. Int. J. Biochem. Cell Biol. 40, 2315-2332.
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20 |
Matsuoka, S., Ballif, B.A., Smogorzewska, A., McDonald, E.R., 3rd, Hurov, K.E., Luo, J., Bakalarski, C.E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007). ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316, 1160-1166.
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21 |
Mu, J.J., Wang, Y., Luo, H., Leng, M., Zhang, J., Yang, T., Besusso, D., Jung, S.Y., and Qin, J. (2007). A proteomic analysis of ataxia telangiectasiamutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J. Biol. Chem. 282, 17330-17334.
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22 |
Nakada, S., Chen, G.I., Gingras, A.C., and Durocher, D. (2008). PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep. 9, 1019-1026.
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23 |
Noon, A.T., Shibata, A., Rief, N., Lobrich, M., Stewart, G.S., Jeggo, P.A., and Goodarzi, A.A. (2010). 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair. Nat. Cell Biol. 12, 177-184.
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24 |
Weng, S., Wang, H., Chen, W., Katz, M.H., Chatterjee, D., Lee, J.E., Pisters, P.W., Gomez, H.F., Abbruzzese, J.L., Fleming, J.B., et al. (2012). Overexpression of protein phosphatase 4 correlates with poor prognosis in patients with stage II pancreatic ductal adenocarcinoma. Cancer Epidemiol. Biomarkers Prev. 21, 1336-1343.
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Pereira, S.R., Vasconcelos, V.M., and Antunes, A. (2011). The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins. Crit. Rev. Toxicol. 41, 83-110.
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26 |
Sripathy, S.P., Stevens, J., and Schultz, D.C. (2006). The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol. Cell. Biol. 26, 8623-8638.
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Toyo-oka, K., Mori, D., Yano, Y., Shiota, M., Iwao, H., Goto, H., Inagaki, M., Hiraiwa, N., Muramatsu, M., Wynshaw-Boris, A., et al. (2008). Protein phosphatase 4 catalytic subunit regulates Cdk1 activity and microtubule organization via NDEL1 dephosphorylation. J. Cell Biol. 180, 1133-1147.
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28 |
Voss, M., Campbell, K., Saranzewa, N., Campbell, D.G., Hastie, C.J., Peggie, M.W., Martin-Granados, C., Prescott, A.R., and Cohen, P.T. (2013). Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with gamma-tubulin. Cell Cycle 12, 2876-2887.
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29 |
Wang, B., Zhao, A., Sun, L., Zhong, X., Zhong, J., Wang, H., Cai, M., Li, J., Xu, Y., Liao, J., et al. (2008). Protein phosphatase PP4 is overexpressed in human breast and lung tumors. Cell Res. 18, 974-977.
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30 |
Wu, G., Ma, Z., Qian, J., and Liu, B. (2015). PP4R1 accelerates cell growth and proliferation in HepG2 hepatocellular carcinoma. OncoTargets Ther. 8, 2067-2074.
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31 |
Shi, Y. (2009). Serine/threonine phosphatases: mechanism through structure. Cell 139, 468-484.
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Xie, J., Chen, Z., Zhang, X., Chen, H., and Guan, W. (2017). Identification of an RNase that preferentially cleaves A/G nucleotides. Sci. Rep. 7, 45207.
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33 |
Xie, Y., Juschke, C., Esk, C., Hirotsune, S., and Knoblich, J.A. (2013). The phosphatase PP4c controls spindle orientation to maintain proliferative symmetric divisions in the developing neocortex. Neuron 79, 254-265.
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34 |
Zhao, H., Huang, X., Jiao, J., Zhang, H., Liu, J., Qin, W., Meng, X., Shen, T., Lin, Y., Chu, J., et al. (2015). Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-alpha-induced hepatic insulin resistance. Sci. Rep. 5, 18093.
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35 |
Ziv, Y., Bielopolski, D., Galanty, Y., Lukas, C., Taya, Y., Schultz, D.C., Lukas, J., Bekker-Jensen, S., Bartek, J., and Shiloh, Y. (2006). Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATMand KAP-1 dependent pathway. Nat. Cell Biol. 8, 870-876.
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