• Proceedings of the KSR Conference
• /
• 2007.11a
• /
• pp.1132-1140
• /
• 2007

As it recently appears that Life Cycle Cost Analysis may be considered as new methodology for economic valuation of infrastructure many researches have been made to assess LCC(Life Cycle Cost) of each facility based on a reasonable methods. In general, LCC is composed of construction cost and expected maintenance repair cost. And especially, maintenance repair cost must be estimated to enhance the reliability through systematic and reasonable methods. However in Korea, because high speed railway steel bridges are recently constructed no direct statistical data are available for the account of the maintenance cost and then their maintenance characteristics are not linear yet. Therefore, the approach proposed in the paper utilizes a theoretical determination and degradation of the corrosion and fatigue of the bridges based on Rahgozar et al.(2006)'s model on fatigue notch factor considering into the corrosion to incorporate the corrosion effect into the fatigue strength reduction model. And then, the corresponding probability of failure is calculated in terms of the reliability index using S-N curve to formulate the fatigue limit state. Therefore, this paper proposes the minimum Life Cycle Cost through optimum maintenance plan analysis of high-speed railway steel bridges under construction. Finally, this paper reviews the proposed model in oder to confirm the applicability and feasibility by appling it to high speed railway steel bridges under construction

• Wind and Structures
• /
• v.30 no.4
• /
• pp.379-392
• /
• 2020

The paper presents a Life-Cycle Cost-based optimization framework for wind-excited tall buildings equipped with Tuned Mass Dampers (TMDs). The objective is to minimize the Life-Cycle Cost that comprises initial costs of the structure, the control system and costs related to repair, maintenance and downtime over the building's lifetime. The integrated optimization of structural sections and mass ratio of the TMDs is carried out, leading to a set of Pareto optimal solutions. The main advantage of the proposed methodology is that, differently from the traditional optimal design approach, it allows to perform the unified design of both the structure and the control system in a Life Cycle Cost Analysis framework. The procedure quantifies wind-induced losses, related to structural and nonstructural damage, considering the stochastic nature of the loads (wind velocity and direction), the specificity of the structural modeling (e.g., non-shear-type vibration modes and torsional effects) and the presence of the TMDs. Both serviceability and ultimate limit states related to the structure and the TMDs' damage are adopted for the computation of repair costs. The application to a case study tall building allows to demonstrate the efficiency of the procedure for the integrated design of the structure and the control system.

• Biomolecules & Therapeutics
• /
• v.25 no.2
• /
• pp.186-193
• /
• 2017

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid, has been reported to have a radiosensitization effect on tumors. However, its effects on human glioma and the specific molecular mechanisms of these effects remain unknown. In this study, we demonstrated that Tet has a radiosensitization effect on human glioma cells. It has been hypothesized that Tet has a radiosensitization effect on glioma cells by affecting the glioma cell cycle and DNA repair mechanism and that ERK mediates these activities. Therefore, we conducted detailed analyses of the effects of Tet on the cell cycle by performing flow cytometric analysis and on DNA repair by detecting the expression of phosphorylated H2AX by immunofluorescence. We used western blot analysis to investigate the role of ERK in the effect of Tet on the cell cycle and DNA repair. The results revealed that Tet exerts its radiosensitization effect on glioma cells by inhibiting proliferation and decreasing the expression of phosphorylated ERK and its downstream proteins. In summary, our data indicate that ERK is involved in Tet-induced radiosensitization of glioma cells via inhibition of glioma cell proliferation or of the cell cycle at G0/G1 phase.

• KIEAE Journal
• /
• v.14 no.5
• /
• pp.103-109
• /
• 2014

Apartment housing should require the systematic maintenance to provide the decent living condition during its life. Each household should participate the maintenance activities and pay for the repair. Therefore, the required cost for repair would be needed to plan in the repair schedule because each household could not pay the much repair money at a time. After apartment constructed, a long term repair plan would be prepared in repair time, repair scope and a required cost. A few studies are said that the repair cost depends on the building deterioration, elapsed year and management factors. The above factors are not be certain to affect the repair management while it may be important to prepare the required money and the repair time. In this paper, it aimed at analyzing the correlation between the repair management and the management factors, especially total area, number of household. This would educe the unit cost per number of household and management area in the individual boiler and elevator with full change and full repair. The unit cost per number of household and area for full change are about 199,000 won/household and $1,954won/m^2$ in the individual boiler respectively. The unit cost of the elevator for full change is 94,000 won/household and $5,429won/m^2$ respectively. Second, this study shows that the elapsed year after construction would not be related the repair unit cost.

• Communications for Statistical Applications and Methods
• /
• v.17 no.6
• /
• pp.865-877
• /
• 2010

This paper considers the periodic preventive maintenance model for a repairable system following warranty expiration. We consider three types of warranty policies: free repair warranty, pro-rata repair warranty, and combination repair warranty. Under these preventive maintenance models, we derive the expressions for the expected cycle length, the total expected cost, and the expected cost rate per unit time. In addition, we explain the optimal preventive maintenance period and the optimal preventive maintenance number by minimizing the expected cost rate per unit time. Finally, the optimal periodic preventive maintenance policy is given for a Weibull distribution case.

• KIEAE Journal
• /
• v.15 no.6
• /
• pp.19-26
• /
• 2015

Purpose: The repair would require to conserve and improve the building function and performance since built. Each household is responsible for maintaining the public facilities and paying the required cost. Therefore, it needs to get the tool or method to forecast the required cost in the future. Before the repair cost is provided, it needs to catch the repair cost distribution and provide the unit cost for the repair cycle. In this study, it aimed at providing the repair cost unit and analyzing the repair cost distribution in a roof proofing work, elevator work and building painting, which are divided into a fully work and partly change. Results of this study are shown that first, the average repair cost for roof proofing work is provided with $166.59{\times}10^3won/household$ and $1.59{\times}10^3won/m^2$ of a full change, $33.22{\times}10^3won/household$ and $0.33{\times}10^3won/m^2$ for a partly work. In addition, elevator work is $557.45{\times}10^3won/household$ and $5.38{\times}10^3won/m^2$ for a full change, $32.92{\times}10^3won/household$ and $0.56{\times}10^3won/m^2$ for a partly repair. Painting has a $304.48{\times}10^3won/household$ and $2.94{\times}10^3won/m^2$. Second, the distribution pattern of repair unit cost has a weibull-typed distribution which has a long tail to the right.

• Journal of Welding and Joining
• /
• v.33 no.5
• /
• pp.26-30
• /
• 2015

Hastelloy X in this study was applied in jet engine F-15 air fighter as shroud to isolate the engine from outer skin. After 15 years operation at elevated temperature the mechanical properties decreased gradually due to the precipitation of continues second phases in the grain boundaries and precipitated inside the grain. The crack happened at the edge of the shroud due to the thermal and mechanical stress from jet engine. Selective TEM analysis found that the grain boundaries consist of $M_{23}C_6$ carbide, $M_6$ Ccarbide and small percentage of sigma(${\sigma}$) phase. Furthermore, it was confirmed the nano size of ${\sigma}$ and miu (${\mu}$) phase inside the grain. In this study, it was investigated the microstructure of the degraded shroud component and HAZ of repair welded shroud. In the HAZ, it was observed the dissolution of the $M_{23}C_6$ carbides and smaller precipitates, the migration of the undissolved larger $M_{23}C_6$ carbide and $M_6$ Ccarbide. It is also observed the liquation due to the simply melt of the segregated precipitates in the grain boundaries. Interestingly, the segregated second phases which simply melt in the grain boundaries more easily happened at higher heat input welding condition. High temperature tensile test was done at $300^{\circ}C$, $700^{\circ}C$ and $900^{\circ}C$. It was obtained that the toughness of welded sample is lower compare to the non-welded sample. The solution heat treatment at $1170^{\circ}C$ for 5 minutes was suggested to obtain a better mechanical properties of the shroud. The high cycle fatigue number of the repair welded shroud shows a much lower compare to the shroud. In addition, the high cycle fatigue number at room temperature after solution heat treatment was almost double compare to the before solution heat treatment under 420-500MPa stress amplitude. However, the high cycle fatigue number of repaired welded sample was shown a much lower compare to the non- welded shroud and solution treated shroud. One of the main reasons to decrease the tensile strength and the high cycle fatigue properties of the repair welded shroud is the formation of the liquid phase in HAZ.

• Journal of the Earthquake Engineering Society of Korea
• /
• v.6 no.5
• /
• pp.29-36
• /
• 2002

In the maintenance and retrofit planning of a bridge system, the optimal strategy for inspection and repair are suggested by minimizing the expected total life-cycle cost, which includes the initial cost, the costs of inspection, repair, and failure. Degradation of seismic performance is modeled by using a damage function. And failure probability is computed according to the degree of damage detection by random vibration theory and the event tree analysis. As an example to illustrate the proposed approach, a 10-span continuous bridge structure is used. The numerical results show that the optimum number of the inspection and the repair are increased, as the seismic intensity is increased and the soil condition of a site becomes more flexible.

• International Journal of Highway Engineering
• /
• v.9 no.4
• /
• pp.159-169
• /
• 2007

In this paper, a PMS(Pavement Management System) is presented for the public agency who wish to execute rational repair by referring to asset management information regarding road pavement. The aim of the paper is to provide the decision makers with the planning information regarding maintenance strategies for efficient road pavement management. We found that life cycle cost can be minimized and repair cost in each year fluctuates when repeating repair at the IRI management level. The validity of PMS application presented in this paper is investigated through case studies for conducted for 22 national highway road sections in Korea.

• Molecules and Cells
• /
• v.42 no.7
• /
• pp.546-556
• /
• 2019

Protein phosphatase 4 (PP4) is a crucial protein complex that plays an important role in DNA damage response (DDR), including DNA repair, cell cycle arrest and apoptosis. Despite the significance of PP4, the mechanism by which PP4 is regulated remains to be elucidated. Here, we identified a novel PP4 inhibitor, protein phosphatase 4 inhibitory protein (PP4IP) and elucidated its cellular functions. PP4IP-knockout cells were generated using the CRISPR/Cas9 system, and the phosphorylation status of PP4 substrates (H2AX, KAP1, and RPA2) was analyzed. Then we investigated that how PP4IP affects the cellular functions of PP4 by immunoprecipitation, immunofluorescence, and DNA double-strand break (DSB) repair assays. PP4IP interacts with PP4 complex, which is affected by DNA damage and cell cycle progression and decreases the dephosphorylational activity of PP4. Both overexpression and depletion of PP4IP impairs DSB repairs and sensitizes cells to genotoxic stress, suggesting timely inhibition of PP4 to be indispensable for cells in responding to DNA damage. Our results identify a novel inhibitor of PP4 that inhibits PP4-mediated cellular functions and establish the physiological importance of this regulation. In addition, PP4IP might be developed as potential therapeutic reagents for targeting tumors particularly with high level of PP4C expression.