• Journal of the Korean Physical Society
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• 제73권9호
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• pp.1295-1302
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• 2018

In the present investigation, we have studied the magnetohydrodynamic (MHD) heat transfer of peristaltic flow in a tube. The analysis is made without imposing any assumption to obtain the streamline and isothermal line directly. Galerkin's finite element method has been used on the governing Navier-Stoke's equation in the form of ${\psi}-{\omega}$. The graphs of the computed longitudinal velocity, temperature and pressure are plotted against different value of the emerging parameter by using the stream function and vorticity. The results are valid beyond the long wavelength and the low Reynolds number limits. We conclude that higher values of the parameters are not independent of the time mean flow rate.

• Journal of the Korean Society for Industrial and Applied Mathematics
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• 제12권4호
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• pp.227-238
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• 2008

In this paper we extend primal-dual interior point algorithm for linear optimization (LO) problems to $P_*({\kappa})$ linear complementarity problems(LCPs) ([1]). We define proximity functions and search directions based on kernel functions, ${\psi}(t)=\frac{t^{p+1}-1}{p+1}-{\log}\;t$, $p{\in}$[0, 1], which is a generalized form of the one in [16]. It is the first to use this class of kernel functions in the complexity analysis of interior point method(IPM) for $P_*({\kappa})$ LCPs. We show that if a strictly feasible starting point is available, then new large-update primal-dual interior point algorithms for $P_*({\kappa})$ LCPs have $O((1+2{\kappa})nlog{\frac{n}{\varepsilon}})$ complexity which is similar to the one in [16]. For small-update methods, we have $O((1+2{\kappa})\sqrt{n}{\log}{\frac{n}{\varepsilon}})$ which is the best known complexity so far.

• Journal of Astronomy and Space Sciences
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• 제21권3호
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• pp.201-208
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• 2004

In this paper we have examined the effect of dust charge density on nonlinear ion acoustic solitary wave which propagates obliquely with respect to the external magnetic field in a dusty plasma. For the dusty charge density below a critical value, the Sagdeev potential $\Psi1(n)$ has a singular point in the region n < 1, where n is the ion number density divided by its equilibrium number density. If there exists a dust charge density over the critical value, the Sagdeev potential becomes a finite function in the region n < 1, which means that there may exist the rarefactive ion acoustic solitary wave. By expanding the Sagdeev potential in the small amplitude limit up to on4 near n=1, we find the solution of ion acoustic solitary wave. Therefore we suggest that the dust charge density plays an important role in generating the rarefactive solitary wave.

• Journal of Biomedical Engineering Research
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• 제34권3호
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• pp.117-122
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• 2013

Hyaluronic acid(HA) microbeads were synthesized by dropping the sodium hyaluronate(Streptococcus) solutions in NaOH into a solution mixture of divinyl sulfone(DVS) in 2-methyl-1-propanol, followed by stirring, cleaning and drying process at room temperature. The initial experimental conditions are crosslinking time(CLTi) of 5 h, crosslinking temperature(CLTe) of room temperature, injection air pressure(IAPr) of 5 psi, and DVS concentration( DVSc) of 0.2 vol%, respectively. Then, parametric studies were performed by varying the parameters to investigate the morphology, the porosity, the swelling ratio and the size of the beads. The microbead size pattern was not regular to function of the degree of crosslink. It was observed that the swelling ratio, the degree of crosslink, and the pore size can be controlled by adjusting the CLTi, CLTe and DVSc. Among the parameters investigated, the smallest bead size can be achieved by varying the CLTi parameter. The lowest swelling ratio, as an indication of the highest degree of crosslink, can be obtained by varying CLTe.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
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• pp.244-249
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• 2004

There have been many attempts to predict the secondary structure content of a protein from its primary sequence, which serves as the first step in a series of bioinformatics processes to gain knowledge of the structure and function of a protein. Most of them assumed that prediction relying on the information of the amino acid composition of a protein can be successful. Several approaches expanded the amount of information by including the pair amino acid composition of two adjacent residues. Recent methods achieved a remarkable improvement in prediction accuracy by using this expanded composition information. The overall average errors of two successful methods were 6.1% and 3.4%. This work was motivated by the observation that evolutionarily related proteins share the similar structure. After manipulating the values of the frequency matrix obtained by running PSI-BLAST, inputs of an artificial neural network were constructed by taking the ratio of the amino acid composition of the evolutionarily related proteins with a query protein to the background probability. Although we did not utilize the expanded composition information of amino acid pairs, we obtained the comparable accuracy, with the overall average error being 3.6%.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 한국생물정보시스템생물학회 2004년도 The 3rd Annual Conference for The Korean Society for Bioinformatics Association of Asian Societies for Bioinformatics 2004 Symposium
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• pp.250-261
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• 2004

A novel method for ab initio prediction of protein tertiary structures, PROFESY (PROFile Enumerating SYstem), is introduced. This method utilizes secondary structure prediction information and fragment assembly. The secondary structure prediction of proteins is performed with the PREDICT method which uses PSI-BLAST to generate profiles and a distance measure in the pattern space. In order to predict the tertiary structure of a protein sequence, we assemble fragments in the fragment library constructed as a byproduct of PREDICT. The tertiary structure is obtained by minimizing the potential energy using the conformational space annealing method which enables one to sample diverse low lying minima of the energy function. We apply PROFESY for prediction of some proteins with known structures, which shows good performances. We also participated in CASP5 and applied PROFESY to new fold targets for blind predictions. The results were quite promising, despite the fact that PROFESY was in its early stage of development. In particular, the PROFESY result is the best for the hardest target T0161.

• Molecules and Cells
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• 제39권9호
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• pp.680-686
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• 2016

Uncoupling proteins (UCPs) are mitochondrial inner membrane proteins that function to dissipate proton motive force and mitochondrial membrane potential. One UCP has been identified in Caenorhabditis elegans (C. elegans), namely UCP-4. In this study, we examined its expression and localization using a GFP marker in C. elegans. ucp-4 was expressed throughout the body from early embryo to aged adult and UCP-4 was localized in the mitochondria. It is known that increased mitochondrial membrane protential leads to a reactive oxygen species (ROS) increase, which is associated with age-related diseases, including neurodegenerative diseases in humans. A ucp-4 mutant showed increased mitochondrial membrane protential in association with increased neuronal defects during aging, and the neurons of ucp-4 overexpressing animals showed decreased neuronal defects during aging. These results suggest that UCP-4 may be involved in neuroprotection during aging via relieving mitochondrial membrane protential. We also investigated the relationship between UCP-4 and innate immunity because increased ROS can affect innate immunity. ucp-4 mutant displayed increased resistance to the pathogen Staphylococcus aureus compared to wild type. The enhanced immunity in the ucp-4 mutant could be related to increased mitochondrial membrane protential, presumably followed by increased ROS. In summary, UCP-4 might have an important role in neuronal aging and innate immune responses through mediating mitochondrial membrane protential.

• Journal of KSNVE
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• 제5권2호
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• pp.169-181
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• 1995

A theoretical model has been studied to describe the sound radiation analysis for structural vibration noise control of tire under the action of random moving line forces. When a tire is analyzed, it has been modeled as a curved beam with distributed springs and dash-pots which represent the radial, tangential stiffness and damping of tire, respectively. The reaction due to fluid loading on the vibratory response of the curved beam is taken into account. The curved beam is assumed to occupy the plane y = 0 and to be axially infinite. The material of curved beam and elastic foundation are assumed to be lossless, and governed by the law of Bernoulli-Euler beam theory. The expression for sound power is integrated numerically and its results examined as a function of Mach number(M), wavenumber ratio(.gamma.) and stiffness factor(.PSI.). The experimental investigation for structural vibration noise of tire under the action of random moving line forces has been made. Based on the STSF(Spatial Transformation of Sound Field) techniques, the sound power and sound radiation are measured. The experimental results show that operating condition, material properties and design factors of the tire have a great effect on the sound power and sound radiation characteristics.

• Bulletin of the Korean Chemical Society
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• 제29권9호
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• pp.1755-1760
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• 2008

Energy minimization and conformational studies of molecular ions generated by ESI (electrospray ionization) tandem mass spectrometry (MS/MS) can be used for the discrimination of stereoisomeric permethylated and sodium cationized trisaccharides. Sets of fucose-containing trisaccharides having different internal and terminal linkages have been synthesized to analyze the reducing terminal linkage positions using BT and IT fusion approaches. A detailed investigation has been undertaken on the conformational behaviors of four trisaccharide fragments from human milk and blood group determinants of Type 1 and Type 2, namely Fuc($\alpha$1- 3)Gal($\beta$1-3)GalNAc and Fuc($\alpha$1-3)Gal($\beta$1-X)GlcNAc where X = 3, 4 and 6 using molecular modeling methods. Three dimensional rigid and adiabatic phi-psi-energy maps (Surfer program) describing the energy as a function of rotation around corresponding glycosidic linkages were calculated by SYBYL molecular modeling and MM4 force field programs conjunction with cleavage energies of ESI MS/MS for the side group orientations. This approach predicted conformational behaviors exhibited by isomer saccharides for future applications on biologically active glycoconjugates and to exploit a faster method of synthesizing a series of structural isomeric oligosaccharides.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 1998년도 제13차 학술회의논문집
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• pp.285-288
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• 1998

A least-squares identification method is studied that estimates a finite number of coefficients in the series expansion of a transfer function, where the expansion is in terms of recently introduced generalized basis functions, We will expand and generalize the orthogonal functions as basis functions for dynamical system representations. To this end, use is made of balanced realizations as inner transfer functions. The orthogonal functions can be considered as generalizations of, for example, the pulse functions, Laguerre functions, and Kautz functions, and give rise to an alternative series expansion of rational transfer functions. We show that the Laplace transform of the expansion for some sets$\Psi_{\kappa}(Z)$ is equivalent to a series expansion . Techniques based on this result are presented for obtaining the coefficients $c_{n}$ as those of a series. One of their important properties is that, if chosen properly, they can substantially increase the speed of convergence of the series expansion. This leads to accurate approximate models with only a few coefficients to be estimated. The set of Kautz functions is discussed in detail and, using the power-series equivalence, the truncation error is obtained.