1 |
Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B.S., Miroux, B., Couplan, E., Alves-Guerra, M.C., Goubern, M., Surwit, R., et al. (2000). Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat. Genet. 26, 435-439.
DOI
|
2 |
Back, P., Braeckman, B.P., and Matthijssens, F. (2012). ROS in aging Caenorhabditis elegans: damage or signaling? Oxid. Med. Cell Longev. 2012, 608478.
|
3 |
Basu Ball, W., Kar, S., Mukherjee, M., Chande, A.G., Mukhopadhyaya, R., and Das, P.K. (2011). Uncoupling protein 2 negatively regulates mitochondrial reactive oxygen species generation and induces phosphatase-mediated anti-inflammatory response in experimental visceral leishmaniasis. J. Immunol. 187, 1322-1332.
DOI
|
4 |
Beckman, K.B., and Ames, B.N. (1998). The free radical theory of aging matures. Physiol. Rev. 78, 547-581.
DOI
|
5 |
Boveris, A., Oshino, N., and Chance, B. (1972). The cellular production of hydrogen peroxide. Biochem. J. 128, 617-630.
DOI
|
6 |
Brenner, S. (1974). The genetics of Caenorhabditis elegans. Genetics 77, 71-94.
|
7 |
Chan, C.B., MacDonald, P.E., Saleh, M.C., Johns, D.C., Marban, E., and Wheeler, M.B. (1999). Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes 48, 1482-1486.
DOI
|
8 |
Chavez, V., Mohri-Shiomi, A., Maadani, A., Vega, L.A., and Garsin, D.A. (2007). Oxidative stress enzymes are required for DAF-16-mediated immunity due to generation of reactive oxygen species by Caenorhabditis elegans. Genetics 176, 1567-1577.
DOI
|
9 |
Chen, C.H., Chen, Y.C., Jiang, H.C., Chen, C.K., and Pan, C.L. (2013). Neuronal aging: learning from C. elegans. J. Mol. Signal. 8, 14.
DOI
|
10 |
Cho, I., Hwang, G.J., and Cho, J.H. (2015). pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans. Mol. Cells 38, 729-733.
DOI
|
11 |
Deierborg, T., Wieloch, T., Diano, S., Warden, C.H., Horvath, T.L., and Mattiasson, G. (2008). Overexpression of UCP2 protects thalamic neurons following global ischemia in the mouse. J. Cereb. Blood Flow Metab. 28, 1186-1195.
DOI
|
12 |
Divakaruni, A.S., and Brand, M.D. (2011). The regulation and physiology of mitochondrial proton leak. Physiology (Bethesda) 26, 192-205.
DOI
|
13 |
Duan, W., and Mattson, M.P. (1999). Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J. Neurosci. Res. 57, 195-206.
DOI
|
14 |
Echtay, K.S. (2007). Mitochondrial uncoupling proteins--what is their physiological role? Free Radic. Biol. Med. 43, 1351-1371.
DOI
|
15 |
Echtay, K.S., and Brand, M.D. (2007). 4-hydroxy-2-nonenal and uncoupling proteins: an approach for regulation of mitochondrial ROS production. Redox Rep. 12, 26-29.
DOI
|
16 |
Echtay, K.S., Murphy, M.P., Smith, R.A., Talbot, D.A., and Brand, M.D. (2002). Superoxide activates mitochondrial uncoupling protein 2 from the matrix side. Studies using targeted antioxidants. J. Biol. Chem. 277, 47129-47135.
DOI
|
17 |
Echtay, K.S., Esteves, T.C., Pakay, J.L., Jekabsons, M.B., Lambert, A.J., Portero-Otin, M., Pamplona, R., Vidal-Puig, A.J., Wang, S., Roebuck, S.J., et al. (2003). A signalling role for 4-hydroxy-2-nonenal in regulation of mitochondrial uncoupling. EMBO J. 22, 4103-4110.
DOI
|
18 |
Erlanson-Albertsson, C. (2003). The role of uncoupling proteins in the regulation of metabolism. Acta. Physiol. Scand. 178, 405-412.
DOI
|
19 |
Farkas, D.L., Wei, M.D., Febbroriello, P., Carson, J.H., and Loew, L.M. (1989). Simultaneous imaging of cell and mitochondrial membrane potentials. Biophys. J. 56, 1053-1069.
DOI
|
20 |
Fahn, S., and Cohen, G. (1992). The oxidant stress hypothesis in Parkinson's disease: evidence supporting it. Ann. Neurol. 32, 804-812.
DOI
|
21 |
Gates, A.C., Bernal-Mizrachi, C., Chinault, S.L., Feng, C., Schneider, J.G., Coleman, T., Malone, J.P., Townsend, R.R., Chakravarthy, M.V., and Semenkovich, C.F. (2007). Respiratory uncoupling in skeletal muscle delays death and diminishes agerelated disease. Cell Metab. 6, 497-505.
DOI
|
22 |
Haines, B., and Li, P.A. (2012). Overexpression of mitochondrial uncoupling protein 2 inhibits inflammatory cytokines and activates cell survival factors after cerebral ischemia. PLoS One 7, e31739.
DOI
|
23 |
Hansford, R.G., Hogue, B.A., and Mildaziene, V. (1997). Dependence of H2O2 formation by rat heart mitochondria on substrate availability and donor age. J. Bioenerg. Biomembr. 29, 89-95.
DOI
|
24 |
Harman, D. (1956). Aging: a theory based on free radical and radiation chemistry. J. Gerontol. 11, 298-300.
DOI
|
25 |
Harman, D. (1972). The biologic clock: the mitochondria? J. Am. Geriatr. Soc. 20, 145-147.
DOI
|
26 |
Harman, D. (2009). Origin and evolution of the free radical theory of aging: a brief personal history, 1954-2009. Biogerontology 10, 773-781.
DOI
|
27 |
Hekimi, S., Lapointe, J., and Wen, Y. (2011). Taking a "good" look at free radicals in the aging process. Trends Cell Biol. 21, 569-576.
DOI
|
28 |
Ji, C., Guo, W., Zhang, M., Lu, X., Ni, Y., and Guo, X. (2012). Caenorhabditis elegans ucp-4 regulates fat metabolism:suppression of ucp-4 expression induced obese phenotype and caused impairment of insulin like pathway. Gene 491, 158-164.
DOI
|
29 |
Hwang, A.B., Ryu, E.A., Artan, M., Chang, H.W., Kabir, M.H., Nam, H.J., Lee, D., Yang, J.S., Kim, S., Mair, W.B., et al. (2014). Feedback regulation via AMPK and HIF-1 mediates ROSdependent longevity in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA 111, E4458-4467.
DOI
|
30 |
Iser, W.B., Kim, D., Bachman, E., and Wolkow, C. (2005). Examination of the requirement for ucp-4, a putative homolog of mammalian uncoupling proteins, for stress tolerance and longevity in C. elegans. Mech. Ageing Dev. 126, 1090-1096.
DOI
|
31 |
Kamath, R.S., Martinez-Campos, M., Zipperlen, P., Fraser, A.G., and Ahringer, J. (2001). Effectiveness of specific RNA-mediated interference through ingested double-stranded RNA in Caenorhabditis elegans. Genome Biol 2, 1-10.
|
32 |
Korshunov, S.S., Skulachev, V.P., and Starkov, A.A. (1997). High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett. 416, 15-18.
DOI
|
33 |
Koziel, A., Sobieraj, I., and Jarmuszkiewicz, W. (2015). Increased activity of mitochondrial uncoupling protein 2 improves stress resistance in cultured endothelial cells exposed in vitro to high glucose levels. Am. J. Physiol. Heart Circ. Physiol. 309, H147-156.
DOI
|
34 |
Lin, M.T., and Beal, M.F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787-795.
DOI
|
35 |
Loew, L.M., Tuft, R.A., Carrington, W., and Fay, F.S. (1993). Imaging in five dimensions: time-dependent membrane potentials in individual mitochondria. Biophys. J. 65, 2396-2407.
DOI
|
36 |
Murphy, M.P., Echtay, K.S., Blaikie, F.H., Asin-Cayuela, J., Cocheme, H.M., Green, K., Buckingham, J.A., Taylor, E.R., Hurrell, F., Hughes, G., et al. (2003). Superoxide activates uncoupling proteins by generating carbon-centered radicals and initiating lipid peroxidation: studies using a mitochondria-targeted spin trap derived from alpha-phenyl-N-tert-butylnitrone. J. Biol. Chem. 278, 48534-48545.
DOI
|
37 |
Mao, W., Yu, X.X., Zhong, A., Li, W., Brush, J., Sherwood, S.W., Adams, S.H., and Pan, G. (1999). UCP4, a novel brain-specific mitochondrial protein that reduces membrane potential in mammalian cells. FEBS Lett. 443, 326-330.
DOI
|
38 |
Mattiasson, G., and Sullivan, P.G. (2006). The emerging functions of UCP2 in health, disease, and therapeutics. Antioxid. Redox Signal. 8, 1-38.
DOI
|
39 |
Mello, C., and Fire, A. (1995). DNA transformation. Methods Cell Biol 48, 451-482.
DOI
|
40 |
Nicholls, D.G., and Locke, R.M. (1984). Thermogenic mechanisms in brown fat. Physiol. Rev. 64, 1-64.
DOI
|
41 |
Pan, C.L., Peng, C.Y., Chen, C.H., and McIntire, S. (2011). Genetic analysis of age-dependent defects of the Caenorhabditis elegans touch receptor neurons. Proc. Natl. Acad. Sci. USA 108, 9274-9279.
DOI
|
42 |
Pfeiffer, M., Kayzer, E.B., Yang, X., Abramson, E., Kenaston, M.A., Lago, C.U., Lo, H.H., Sedensky, M.M., Lunceford, A., Clarke, C.F., et al. (2011). Caenorhabditis elegans UCP4 protein controls complex II-mediated oxidative phosphorylation through succinate transport. J. Biol. Chem. 286, 37712-37720.
DOI
|
43 |
Sanchis, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Gregoire, F., Easlick, J., Raimbault, S., Levi-Meyrueis, C., et al. (1998). BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. J. Biol. Chem. 273, 34611-34615.
DOI
|
44 |
Tank, E.M., Rodgers, K.E., and Kenyon, C. (2011). Spontaneous age-related neurite branching in Caenorhabditis elegans. J. Neurosci. 31, 9279-9288.
DOI
|
45 |
Sohal, R.S., and Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63.
DOI
|
46 |
Sullivan, P.G., Rippy, N.A., Dorenbos, K., Concepcion, R.C., Agarwal, A.K., and Rho, J.M. (2004). The ketogenic diet increases mitochondrial uncoupling protein levels and activity. Ann. Neurol. 55, 576-580.
DOI
|
47 |
Talbot, D.A., Lambert, A.J., and Brand, M.D. (2004). Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3. FEBS Lett. 556, 111-115.
DOI
|
48 |
Toth, M.L., Melentijevic, I., Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., et al. (2012). Neurite sprouting and synapse deterioration in the aging Caenorhabditis elegans nervous system. J. Neurosci. 32, 8778-8790.
DOI
|
49 |
Votyakova, T.V., and Reynolds, I.J. (2001). DeltaPsi(m)-Dependent and -independent production of reactive oxygen species by rat brain mitochondria. J. Neurochem. 79, 266-277.
|
50 |
Yang, J.S., Nam, H.J., Seo, M., Han, S.K., Choi, Y., Nam, H.G., Lee, S.J., and Kim, S. (2011). OASIS: online application for the survival analysis of lifespan assays performed in aging research. PLoS One 6, e23525.
DOI
|
51 |
Yoneda, T., Benedetti, C., Urano, F., Clark, S.G., Harding, H.P., and Ron, D. (2004). Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117, 4055-4066.
DOI
|
52 |
Yu, X.X., Mao, W., Zhong, A., Schow, P., Brush, J., Sherwood, S.W., Adams, S.H., and Pan, G. (2000). Characterization of novel UCP5/BMCP1 isoforms and differential regulation of UCP4 and UCP5 expression through dietary or temperature manipulation. FASEB J. 14, 1611-1618.
DOI
|