• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2863-2868
• /
• 2014

Background: The 765G>C polymorphism in cyclooxygenase-2 (COX-2) gene has been extensively investigated for association with gastric cancer (GC). However, the results of different studies have been inconsistent. The aim of this study is to comprehensively evaluate the genetic risk of -765G>C polymorphism in the COX-2 gene for GC. Materials and Methods: We searched Pubmed, Embase, Medline, CNKI database, Wanfang database, Weipu database, and Chinese Biomedical database, covering all publications (last search been performed on Jan 10, 2014). Statistical analyses were performed using Revman 5.2 and STATA 10.0 software. Results: A total of 1,874 cases and 3,005 controls in 10 case-control studies were included in this meta-analysis. The results indicated that the variant C allele carriers (GC+CC) had a 69% increased risk of GC when compared with the homozygote GG (odds ratio (OR)=1.69, 95% confidence interval (CI), 1.10-2.61 for GC+CC vs GG). In the subgroup analysis by ethnicity, significant elevated risks were associated with C allele carriers in Asians (OR=1.75, 95%CI=1.40-2.18, and p<0.00001) and in Indians (OR=8.38, 95%CI=4.34-16.16, and p<0.00001) but not in Caucasians (OR=1.07, 95%CI=0.81-1.42, and p=0.62) or in Dutch (OR=0.53, 95%CI= 0.33-0.87, and p= 0.01).In the subgroup analysis by Helicobacter pylori (H. pylori) status, a significantly increased risk was identified among H. pylori (+) (OR=3.58, 95%CI=2.33-3.50, and p<0.00001) and H. pylori (-) (OR=2.32, 95%CI=1.46-3.69, and p=0.0004). Conclusions: This meta-analysis suggested that the -765G>C polymorphism in the COX-2 gene could be a risk factor for GC in Asians and Indians.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권6호
• /
• pp.2917-2922
• /
• 2014

Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

• 융합정보논문지
• /
• 제10권3호
• /
• pp.76-91
• /
• 2020

최근에 한국 고유종인 미선나무 (Abeliophyllum distichum Nakai; Oleaceae) 품종 옥황1호의 유전체가 성공적으로 해독되었다. Acteoside는 다양한 활성을 가지는 물질이며, 여러개의 생화학합성과정이 제시되어왔고, 이들을 통합 검토하여 정확한 생화학합성과정을 완성하였다. 유전체 데이터로부터 2차대사산물을 예측할 수 있는 MetaPre-AI^TM와 정확한 acteoside 생화학합성과정, InfoBoss Pathway Database를 활용하여, acteoside에 관여하는 모든 효소의 유전자를 옥황1호 유전체로부터 성공적으로 확인하였다. 이는 옥황1호는 acteoside 물질을 생산할 수 있는 가능성이 있음을 의미한다. 이에 고성능액체크로마토그래피를 사용하여 옥황1호의 캘러스 세포를 분석하여 acteoside과 이의 유도체인 isoacteoside를 확인하였다. 본 연구는 MetaPre-AI^TM은 유전체로부터 2차대사산물을 성공적으로 예측하였다. 이 방법은 화학물질보다 안정적인 DNA를 분석하여 2차 대사산물을 예측하는 효율적인 방법이 될 것이다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제5권9호
• /
• pp.425-432
• /
• 2016

정보시스템 감리의 중요성이 커지면서 공공기관이나 기업에서 높은 품질의 시스템을 구축하기 위해 많은 비용을 투자하고 있으며 효율적인 감리 작업을 수행할 수 있는 도구에 관한 연구도 많이 진행되고 있다. 정보시스템의 핵심인 데이터베이스 관련 감리 작업에서 다양한 모니터링 도구를 활용해 많은 검사항목에 대해 감리할 수 있지만, 데이터베이스 성능에 많은 영향을 미칠 수 있는 SQL 감리에는 기능적으로 부족한 면이 존재한다. 대다수의 모니터링 도구들은 메타 정보 기반으로 검사하기 때문에 메타 정보가 없거나 정확하지 않으면 SQL 감리 작업을 수행하기가 어렵고 SQL 문장의 구체적인 문제점을 도출할 수도 없다. 따라서 본 연구에서는 ANTLR를 활용한 SQL 검사기를 설계하고 구현한다. 구현된 SQL 검사기를 통해 기존의 수작업으로 SQL을 검사하는 것보다 효율적으로 수행할 수 있다. 그리고 기능적인 측면에서 다른 모니터링 도구에 비해 더 많은 검사 규칙을 SQL 검사 작업에 적용할 수 있다. 본 연구에서 제시한 SQL 검사기는 개발 단계부터 운영단계까지 감리 작업을 수행하여 정보시스템의 안정성을 높일 수 있다고 기대한다.

• 대한간호학회지
• /
• 제54권2호
• /
• pp.119-138
• /
• 2024

Purpose: This study aimed to identify research trends related to emotional leadership among nurse managers by conducting a systematic literature review and meta-analysis. This study sought to derive insights that could contribute to improving emotional leadership in nursing practice. Methods: A systematic review and meta-analysis were conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) and Meta-Analysis Of Observational Studies in Epidemiology (MOOSE) guidelines. Databases including PubMed, Cumulative Index to Nursing and Allied Health Literature, Scopus, Web of Science, Research Information Sharing Service, Koreanstudies Information Service System, Korean Medical Database, KoreaMed, ScienceON, and DBpia were searched to obtain papers published in English and Korean. Literature searches and screenings were conducted for the period December 1, 2023 to December 17, 2023. The effect size correlation (ESr) was calculated for each variable and the meta-analysis was performed using the statistical software SPSS 29.0, R 4.3.1. Results: Twenty-five (four personal, six job, and fifteen organizational) relevant variables were identified through the systematic review. The results of the meta-analysis showed that the total overall effect size was ESr = .33. Job satisfaction (ESr = .40) and leader-member exchange (ESr = .75) had the largest effect size among the job and organizational-related factors. Conclusion: Emotional leadership helps promote positive changes within organizations, improves organizational effectiveness, and increases member engagement and satisfaction. Therefore, it is considered an important strategic factor in improving organizational performance.

• Asia pacific journal of information systems
• /
• 제13권1호
• /
• pp.47-72
• /
• 2003

It is important to retrieve information that a user requires on the web. The web is an open system. The amount of information is increasing rapidly. While each of information was compiled into the database piece at a single platform in the past, it is now compiled into complicated structure at a multi-platform. Restructuring the multi-platform database is needed to efficiently retrieve information. MIRAS(Meta Information Retrieval Agent System) has a multi-platform database on web. This study applies the classification of the existent site's categories to restructure the database systematically. The empirical analysis shows that the suggested method is effective for information retrieval and multi-platform database restructuring. This study helps users to save on time-cost of searching information.

• 한국정보처리학회:학술대회논문집
• /
• 한국정보처리학회 2001년도 추계학술발표논문집 (하)
• /
• pp.1123-1126
• /
• 2001

현재 인터넷상에는 수많은 정보가 산재되어 있고, 사용자가 원하는 정보를 검색해주는 수많은 검색엔진들이 개발되어 사용되고 있다. 하지만 기존의 검색엔진은 사용자들이 입력한 질의어만을 가지고 단지 시소러스 사선만을 참조해서 검색결과를 나타내는 게 대부분이이서 사용자의 구미에 맞는 정보를 찾는데 어려운 점이 많았다. 이에 본 논문에서는 MetaDB안에 있는 보편적 Meta 데이터를 이용, 사용자의 간단한 정보 입력과 합께 퍼지연산을 적용시킨 매칭기법으로 사용자의 특성에 맞는 검색결과를 도출하는 퍼지 검색시스템을 제안한다.

• 여성건강간호학회지
• /
• 제19권1호
• /
• pp.23-35
• /
• 2013

Purpose: This study was to analyze the effect size of complementary and alternative intervention studies in reference to dysmenorrhea and menstrual distress. Methods: In order to conduct a meta-analysis, a total of 393 studies were retrieved from the database. Twenty-eight studies that were published from March 2001 to February 2011 were selected. Results: Intervention studies included seven studies on aromatherapy, five on auriculotherapy, three on each Koryo-Sooji-Chim and moxibustion, two on each heat therapy and magnetic therapy and six on other therapy. The effect size of the intervention studies on dysmenorrhea and menstrual distress was greater than 0.48 for Koryo-Sooji-Chim, moxibustion, aromatherapy, auriculotherapy and other therapy. Conclusion: This study suggests that drug free therapy can reduce the levels of menstrual distress, despite the small number of intervention studies and randomized controlled trials.

• 근관절건강학회지
• /
• 제26권3호
• /
• pp.155-166
• /
• 2019

Purpose: This study was a meta-analysis of the effects of self-management on pain in patients with osteoarthritis. Methods: Randomized controlled trials were identified by searching PubMed, EMBASE, CINAHL, Ovid-MEDLINE and Korean database using key words, 'self-management', 'osteoarthritis' and 'pain'. Data were analyzed using the R version program. Results: Twenty nine studies met the inclusion criteria with a total of 5,998 participants. There were significant differences in overall effects of self-management (SMD -0.53, 95% CI -0.77~-0.29, p<.001). Conclusion: The results of the study show that self-management was effective in reducing pain in patients with osteoarthritis. As a result, it should be used as basic data when using self-management for patients with osteoarthritis.

• 한국경영과학회지
• /
• 제17권1호
• /
• pp.65-65
• /
• 1992

Recently many organizations have attempted to build hypermedia systems to expand their working areas to internet-based virtual work places. It is thus important to manage corporate hypermedia documents effectively. Metadata play a critical role for managing these documents. This paper identifies metadata roles and components to build its schema. Furthermore a meta-information system HyDoMiS(Hyperdocument Meta-information System) is proposed by the use of this metadata schema. HyDoMiS performs three functions metadata management search and reporting The metadata management function is concerned with workflow document and database. The system is more likely to help implement and maintsain hypermedia information system effectively.