• Journal of Venture Innovation
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• v.6 no.1
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• pp.17-34
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• 2023

This study tried to find a way to increase major satisfaction to overcome the difficulties of college due to the recent decrease in the number of educated population. In particular, problem-solving ability and digital literacy, which are essential in the era of the 4th industrial revolution, were set as influencing factors and mediators and tried to verify them. Therefore, in order to find out the effect of problem-solving ability on major satisfaction and the mediating effect of digital literacy, a study was conducted targeting junior college secretarial majors. A total of 193 questionnaires were analyzed, and regression analysis was performed to verify the hypothesis, and bootstrapping was performed using the SPSS PROCESS macro model 4 to verify the significance of the mediating effect. The results of the study are as follows. First, it was found that problem-solving ability had a positive(+) effect on major satisfaction. Second, problem-solving ability was found to have a positive(+) effect on all four sub-factors of digital literacy. Third, as a result of analyzing the mediating effect of digital literacy in the relationship between problem-solving ability and major satisfaction, among the four sub-factors of digital literacy, information literacy, critical understanding, and information analysis ability completely mediated between problem-solving ability and major satisfaction. has been shown to be effective. On the other hand, the ability to comply with norms was found to have no mediating effect. In this study, it was verified that problem-solving ability affects major satisfaction, and it was found that it is necessary to make various efforts to cultivate problem-solving ability. In addition, based on these research results, suggestions for preparing practical measures to increase major satisfaction were suggested.

• Journal of the Korean Applied Science and Technology
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• v.40 no.5
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• pp.988-1000
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• 2023

Hesperetin(HT) is a potent antioxidant flavonoid aglycone derived from hesperidin(HD). The antioxidant, anti-inflammatory, and antimicrobial activities of HT and its cyclodextrin(CD) inclusion complexes were compared in vitro. HT was prepared by enzymatic hydrolysis of HD, and HT/CD complexes were prepared using 𝛽-cyclodextrin(𝛽-CD) and hydroxypropyl-𝛽-cyclodextrin(HP-𝛽-CD) by solvent co-evaporation method. The solubility of the HT/HP-𝛽-CD inclusion complex increased 93.5-fold compared to HT, and the solubility of HT/𝛽-CD increased 22.5-fold. The HT/HP-𝛽-CD inclusion complex showed a similar effect as HT on radical scavenging activity in antioxidant assays, whereas the HT/𝛽-CD inclusion complex showed slightly lower activity than HT. Cytotoxicity was low in the following order; HT/HP-𝛽-CD, HT/𝛽-CD, and HT in murine macrophage RAW264.7 cells. Treatment with HT and HT/CD inclusion complexes reduced the levels of inflammatory mediators such as nitric oxide(NO), tumor necrosis factor-𝛼(TNF-𝛼) and interleukin-6(IL-6) in the cells. HT and HT/HP-𝛽-CD inclusion complex were more effective than HT/𝛽-CD inclusion complex at relatively low concentrations. Inhibitory effects were tested on skin-pathogenic bacteria, Staphylococcus aureus and Pseudomonas aeruginosa, and they showed an antimicrobial effect on S. aureus in the order of HT = HT/HP-𝛽-CD > HT/𝛽-CD, but they did not show any significant inhibitory effect on P. aeruginosa. In conclusion, HT, the aglycone form of HD, and its CD inclusion complexes showed various biological activities. HT/HP-𝛽-CD inclusion complex, which is the highly soluble form of HT, showed relatively higher activity compared to HT/𝛽-CD inclusion complex.

• Korean Journal of Veterinary Research
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• v.63 no.3
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• pp.27.1-27.9
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• 2023

Lespedeza cuneata (LC) is a perennial plant used in herbal medicine to treat numerous diseases, including prostatic hyperplasia, diabetes, early atherosclerosis, and hematuria. Reference collections of bioactive compounds of LC are crucial for the determination of their pharmacological properties. However, little is known regarding its anti-oxidative and anti-inflammatory effects in alveolar macrophage (MH-S) cells. This study examined whether LC can inhibit reactive oxygen species and Coal fly ash (CFA) induced inflammation in MH-S cells. The anti-oxidative effects of LC were evaluated using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays, anti-inflammatory effects were examined using nitric oxide (NO) assay, and cytotoxicity was analyzed using methyl thiazolyl tetrazolium assay. The expression of inflammatory cytokine genes was assessed through a reverse-transcription polymerase chain reaction. Our results revealed that LC exhibited high radical scavenging activity and a dose-dependent (7.8-1,000 ㎍/mL) inhibition of oxidation as compared to ascorbic acid and Trolox. It also inhibited CFA-induced NO production in MH-S cells. Moreover, it suppressed the CFA exposure-mediated expression of pro-inflammatory mediators and cytokines, including inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), interleukin (IL)-1β, IL-6, and tumor necrosis factor-α. These results suggest that LC is a potent antioxidant and anti-inflammatory agent that can be useful as a nutraceutical product.

• Information Systems Review
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• v.22 no.3
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• pp.59-80
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• 2020

Excellent FinTech firms create value by finding customer needs or addressing customer problems to provide customers with differentiated solutions through information technologies and organizational innovation capability. Accordingly, the survival and growth of FinTech firms rely on the innovation performance for solving customer problems. This study assumes that IT relatedness and entrepreneurial culture play a mediating role in the relationship between service orientation and innovation performance. To examine it, designed and demonstrated is a structural model from the perspective of dynamic organizational capability. The results show that IT relatedness and entrepreneurial culture play a mediating role between service orientation and innovation performance. Although IT relatedness and entrepreneurial culture were partial mediators in each divided model, the integration model showed there was no direct effect of service orientation on innovation performance. The practical implication is that FinTech companies need to understand customer problems accurately, set up appropriate service goals and align all strategies to achieve them. With these strategic alignments, higher innovation performance can be achieved by enabling IT resources and capabilities to be actively utilized in all functions of the organization and institutionalizing the entrepreneurial culture.

• The Journal of the Convergence on Culture Technology
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• v.10 no.2
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• pp.565-574
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• 2024

ChatGPT is causing significant reverberations across all sectors of our society, and this holds true for the field of education as well. However, scholarly and societal discussions regarding ChatGPT in academic settings have primarily focused on issues such as plagiarism, with relatively limited research on the positive effects of utilizing generative AI. Additionally, amidst the educational crisis of the post-COVID era, there is a growing recognition of the need to enhance academic engagement. In light of these concerns, we investigated how academic engagement varies based on students' levels of ChatGPT literacy and examined whether students' academic confidence and perceived academic competence serve as mediators between ChatGPT literacy and academic engagement. An analysis using SPSS was conducted on the data collected from 406 college students. The results showed that ChatGPT literacy had a positive effect on academic engagement, and academic confidence mediated the relationship between ChatGPT literacy and academic engagement. Also, when the mediating effect of perceived academic competence was significant only when it was serially mediated. Based on these findings, we discussed the theoretical contributions of identifying the theoretical mechanism between ChatGPT literacy and academic engagement. In addition, practical implications regarding the importance of ChatGPT literacy education were described.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.50 no.1
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• pp.19-27
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• 2024

This study is to propose Lagerstroemia indica flower as an anti-acne cosmetic material, and confirmed the sebum control, anti-inflammatory, and antioxidant effects using Lagerstroemia indica flower extract (LIFE) . As a result of evaluating the sebum control effectiveness, it was confirmed that LIFE inhibited the production of sebum excessively induced with palmitic acid up to 65%. Subsequently, it was confirmed that LIFE has an antibacterial effect and the ability to inhibit lipase activity against Cutibacterium acnes (C. acnes), which mainly appears in acne lesions, and can also reduce the inflammatory response caused by virulence factors secreted by C. acnes. It was also confirmed that LIFE inhibited the secretion of nitrogen monoxide (NO) and prostaglandin E2 (PGE2), which are inflammatory mediators induced by LPS in macrophages, by 75% and 54%, respectively, and that it also had a high DPPH radical scavenging ability similar to that of ascorbic acid. These results suggest that LIFE, a natural extract, can be used as an anti-acne material to relieve and treat acne, a complex disease, by controlling sebum production and having antibacterial and lipase activity inhibiting against C. acnes, and anti-inflammatory, antioxidant properties.

• Korean Journal of Clinical Laboratory Science
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• v.55 no.4
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• pp.306-313
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• 2023

Sepsis is a systemic inflammatory response, with manifestations in multiple organs by pathogenic infection. Currently, there are no promising therapeutic strategies. Signal transducer and activator of transcription 3 (STAT3) is a cell signaling transcription factor. Niclosamide is an anti-helminthic drug approved by the Food and Drug Administration (FDA) as a potential STAT3 inhibitor. C57BL/6 mice were treated with an intraperitoneal injection of lipopolysaccharide (LPS). Niclosamide was administered orally 2 hours after the LPS injection. This study found that Niclosamide improved the survival and lung injury of LPS-induced mice. Niclosamide decreased the levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in serum. The effects of Niclosamide on phosphoinositide 3-kinase (PI3K), AKT, nuclear factor-κB (NF-κB), and STAT3 signaling pathways were determined in the lung tissue by immunoblot analysis. Niclosamide reduced phosphorylation of PI3K, AKT, NF-κB, and STAT3 significantly. Furthermore, it reduced the phosphorylation of STAT3 by LPS stimulation in RAW 264.7 macrophages. Niclosamide also reduced the LPS-stimulated expression of proinflammatory mediators, including IL-6, TNF-α, and IL-1β. Niclosamide provides a new therapeutic strategy for murine sepsis models by suppressing the inflammatory response through STAT3 inhibition.

• Industry Promotion Research
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• v.9 no.1
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• pp.123-132
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• 2024

The purpose of this study was to improve the understanding of stress coping in the very old and elderly and to improve life satisfaction through stress reduction as the population ages. To this end, this study aimed to test the mediating effect of social support on the relationship between stress coping and life satisfaction among very old people. In particular, we paid attention to the differences in stress coping from the existing elderly population and took the view that they should be studied as an independent group. To confirm this, we analysed 275 men and women aged 85 years and older who responded to the fifth supplementary survey of the National Elderly Security Panel (KReIS) conducted by the National Pension Service. IBM SPSS 26 was used to test the mediating effect of social support on the effect of stress coping measures on life satisfaction in the very old elderly. The results of the significance test of the independent variables on the mediating variable showed that stress coping was positively significant, i.e., the higher the level of stress coping, the higher the life satisfaction. In addition, the results of the significance test of the effects of the independent variables and mediators on the dependent variable showed that coping with stress had a significant effect, and the mediator, social support, also had a significant effect on life satisfaction. Therefore, this study suggests the need for social support to improve the level of life satisfaction through coping with stress in the very old elderly.

• The Journal of the Convergence on Culture Technology
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• v.10 no.3
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• pp.593-604
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• 2024

This study examined the effect of leadership competence on job embeddedness among child co-residence workers to mitigate the negative impact of human resource management on their low job tenure and treatment. The study initially tested the mediating effects of social capital and organizational culture between the two variables, thereby suggesting ways to enhance job attendance among workers in children's shared family homes. The results of the study are as follows. Leadership competencies among child co-residence workers were found to have a positive effect not only on job embeddedness but also on social capital and organizational culture. Social capital and organizational culture were identified as mediators in the relationship between leadership competencies and job commitment The primary significance of this study lies in its identification of the relationship between leadership competence and job attendance - a factor previously overlooked. This finding offers a pathway to increase job attendance. Furthermore, the study expands the scope of relevant variables to include leadership competence, social capital, and organizational culture. Finally, it sheds light on the mediating effects of social capital and organizational culture on the relationship between leadership competence and job embeddedness.

• Information Systems Review
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• v.19 no.1
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• pp.101-121
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• 2017

This study explored the emotional and social implications of social media "like" behavior and examined the difference in this behavior across gender. Most studies on social media have analyzed the "like" behavior quantitatively and determined the number of "likes" produced and exchanged. The current study presented a different view by applying a social perspective and analyzing the user intrinsic motives embedded in the "like" behavior. Specifically, we identified empathy and social support as the "like" motivations and used relationship building and information sharing as the mediators. Furthermore, we hypothesized that empathy and social support exhibit different effects on the use of social media across gender: the female group shows strong empathy, and the male group shows strong social support. Validation was performed through a survey of 285 social media users. The results confirmed that empathy and social support have significant effects on the use of social media. However, gender difference in the use of social media was not evident and was only partially evident in the effects of empathy and social support.