• The Korea Journal of Herbology
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• v.29 no.2
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• pp.7-13
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• 2014

Objectives : Chronic mild stress (CMS) model is currently recognized as a better animal model of depression. The purpose of this study was to investigate the antidepressant-like effects of the Nelumbo nucifera leave extract using CMS model. Methods : The antidepressant-like effects of Nelumbo nucifera leaves extract was determined by using animal models of depression. Male ICR mice were divided into four groups: saline-treated normal, without CMS; saline-treated stress control; CMS+ Imipramine(20mg/kg); CMS+Nelumbo nucifera leaves extract(200mg/kg). All mice except the normal group exposed an unpredicted sequence of chronic mild stressors for 5 weeks. The behavior of mice were detected by sucrose preference test, forced swim test and tail suspension test. Then concentration of corticosterone in serum was detected by enzyme immunoassay. Results : Nelumbo nucifera leaves extract administration by daily gavage from the 3rd week exhibited an antidepressant-like effect on CMS-induced depression in mice. Nelumbo nucifera leaves extract administration at dose of 200 mg/kg significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. Conclusions : Chronic mild stress can affect mouse behavior and corticosterone level and cause depression. The present experiments not only further confirm the antidepressant-like effects of Nelumbo nucifera leaves extract in the sucrose preference test, forced swimming test and tail suspension test, but also the improving effects of Nelumbo nucifera leaves extract on the depression-like symptoms in the CMS model. Nelumbo nucifera leaves extract has the antagonism on CMS and produce antidepressive effects.

• Food Science and Biotechnology
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• v.16 no.5
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• pp.854-857
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• 2007

In this study, the crude methanol extract of mulberry leaves was fractionated with chloroform, ethyl acetate, n-butanol, and water, successively. The antioxidant activities of the fractions were examined with the 2-deoxyribose oxidation and linoleic acid peroxidation methods. The ethyl acetate fraction showed the strongest antioxidant activity. From it we isolated chlorogenic acid, caffeic acid, quercetin $3-O-{\beta}-D-glucopyranoside$, and kaempferol $3-O-{\beta}-D-glucopyranoside$ with preparatory octadecyl silane-high performance liquid chromatography (ODS-HPLC), and identified the compounds by nuclear magnetic resonance (NMR) and fast atom bombardment mass (FAB-MS) analyses. Overall, quercetin $3-O-{\beta}-D-glucopyranoside$ showed the strongest antioxidant activity by both the 2-deoxyribose oxidation and rat liver microsome peroxidation methods.

• The Korean Journal of Food & Health Convergence
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• v.4 no.2
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• pp.17-23
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• 2018

Carica papaya is an important medicinal plant used in the management of different disease conditions. Phytochemical screening was carried out using different chemical test, Percentage yield and total phenolic content was evaluated using Folin Ciocalteu method in different solvent system; methanol, ethanol, ethyl acetate, n-butanol and n-hexane respectively. The phytochemical screening of the studies showed the presence of flavonoids, saponins, tannins, terpenoids, glycosides, steroids, carbonhydrate, anthraquinone and alkaloids. The percentage yield of crude extract and total polyphenol content was high in methanol, ethanol and ethyl acetate when compared with n-butanol and n-hexane. The studies show that Carica papaya leave extracts is a potent source of secondary metabolites. The use of the plant in the management of diseases is justified.

• International journal of advanced smart convergence
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• v.7 no.4
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• pp.101-107
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• 2018

Visitors to a Web site leave access logs documenting their activity in the site. These access logs provide a valuable source of information about the visitors' access patterns in the Web site. In addition to the pages that the user visited, it is generally possible to discover the geographical locations of the visitors. Web servers also records other information such as the entry into the site, the URL, the used operating system and the browser, etc. There are several Web mining techniques to extract useful information from such information and visualization of a Web log is one of those techniques. This paper presents a technique as well as a case a study of visualizing a Web log.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.9 no.7
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• pp.1575-1581
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• 2005

Recently, further study is being done on the affect of crack on concrete structure and many people have made every endeavor not to leave it unsettled but to minimize it by repair works. In this paper we propose the image processing method that do not remain manual but automatically process the length, the direction and e width of cracks on concrete surface. First, we calibrate light's affect from image by using closing operation, one of morphology methods that can extract the feature of oracle and we extract the edge of crack image by sobel mask. After it, crack image is binarized by iteration binarization. And we extract the edge of cracks using noise elimination method that use an average of adjacent pixels by 3${\times}$3 mask and Glassfire Labeling algorithm. on, in this paper we propose an image processing method which can automatically measure the length, the direction and the width of cracks using the extracted edges of cracks. The results of experiment showed that the proposed method works better on the extraction of concrete cracks. Also our method showed the possibility that inspector's decision is unnecessary.

• The Korea Journal of Herbology
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• v.30 no.4
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• pp.129-135
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• 2015

Objectives : Clerodendron trichotomumThunberg grows wild fields and mountains in South Korea and China. They have been used for anti-hypertension disease. This study was performed in order to observe the effects ofClerodendron trichotomumThunberg tea on anti-hypertension.Methods : For the study ofClerodendron trichotomumThunberg tea, we had divided male SHR (Spontaneously Hypertensive Rat) to ten groups. Control group is SHR. The treatment group is SHR which is administered tea extract at dose of 200 mg/kg/day and 500 mg/kg/day orally for 8 weeks. We measured systolic blood pressure, diastolic blood pressure, number of pulse, body weight, total cholesterol and triglyceride from blood serum.Results : The level of systolic and diastolic blood pressure were significantly decreased by 12.5% and 44.9% inClerodendron trichotomumThunberg tea groups than control group. Heart rate ofClerodendron trichotomumThunberg tea groups, 24.5%, was significantly lower than control group. We found that treatment with the water extract fromClerodendron trichotomumThunberg leave and flower significantly decreased weight of body, total cholesterol and triglyceride to 20.4% and 27.7% compared to untreated control group, significantly (P< 0.05).Conclusions : These results suggest that leaf and flower tea ofClerodendron trichotomumThunberg tea is effective in prevention and treatment of hypertension and decreasing cholesterol. Long term consumption ofClerodendron trichotomumThunberg leaf and flower tea can be help in lowering high systolic and blood diastolic pressure, heart rate and blood serum in SHR.

• Journal of the Korea Fashion and Costume Design Association
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• v.11 no.3
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• pp.135-141
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• 2009

In this paper, Tagetes extracts were extracted from leave, root, stem and flower at $100^{\circ}C$ for 20 minutes. Silk fabrics were dyed with Tatetes Patula L. to investigate the dyeing properties in accordance with dye concentration, pH, temperature, time of pre-, simul- and post-treatment of mordants using the three types of mordants. As a result, the surface color of the silk fabrics was yellowish regardless of the types of mordants. However, the a values were decreased and b values were increased in the order of the dyeing using Al>Cu>Fe: Al mordanted silk fabrics were appeared in greenish yellow and Fe mordanted silk fabrics were done in redish yellow. K/S values of the silk fabrics treated with Fe mordant were 3 times higher than those of Al and Cu mordants according to the increase in dye concentration. This behaviour was shown even in the increase of mordant concentration due to the interaction of mordant and pigments of Tatetes Patula L. But, the types of mordants did not affect because the equilibrium was obtained in 20 minutes in a similar way. And it showed that the highest K/S value of the silk fabrics studied was pH 4 and $80^{\circ}C$ regardless of the types of mordants.

• Journal of the Korean housing association
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• v.22 no.3
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• pp.123-134
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• 2011

'Sohawjang' is the first apartment house built in Busan the modern period, 1944. 'Sohawjang' needs to be apprised its value as an very important object of study with architectural and dwelling historic meaning because multi-family houses built in Japanese Rule Era that now exist in Korea are very rare. Thus, this study attempted to leave records to archive by conducting face to face interviews and surveying on 'Sohawjang' which is seriously in danger of extinction and its original form damage as the first step. Especially, around Korea's Liberation, this study tried to extract transformation characteristics of residential space and cultural differences appeared on differences of occupants having different nationality. Through these results, this study attempted to examine the era of apartment house and transformation characteristics and values of modern dwelling historic dimension according to changes of users appeared in Busan modern period. Through this study, it offers basic data about introduction and transition processes of an apartment house in Korea. It has an meaning of suggestion reference data for original form preservations or regenerations.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.15 no.6
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• pp.1981-1995
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• 2021

When a person tries to conceal emotions, real emotions will manifest themselves in the form of micro-expressions. Research on facial micro-expression recognition is still extremely challenging in the field of pattern recognition. This is because it is difficult to implement the best feature extraction method to cope with micro-expressions with small changes and short duration. Most methods are based on hand-crafted features to extract subtle facial movements. In this study, we introduce a method that incorporates optical flow and deep learning. First, we take out the onset frame and the apex frame from each video sequence. Then, the motion features between these two frames are extracted using the optical flow method. Finally, the features are inputted into an improved MobileNetV2 model, where SVM is applied to classify expressions. In order to evaluate the effectiveness of the method, we conduct experiments on the public spontaneous micro-expression database CASME II. Under the condition of applying the leave-one-subject-out cross-validation method, the recognition accuracy rate reaches 53.01%, and the F-score reaches 0.5231. The results show that the proposed method can significantly improve the micro-expression recognition performance.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.2
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• pp.191-200
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• 2018

In this study, we conducted research to find anti-wrinkle skin care ingredients from natural sources via the measurement of procollagen type 1 levels in the medium of normal human dermal fibroblast (NHDF) and found that a Nelumbo nucifera leave extract (NLE) was as the best effective ingredient. By the high performance liquid chromatography analysis, we confirmed isoquercitrin was one of the main compounds of NLE. Moreover, it also increased the procollagen type 1 production without cytotoxicity of NHDF. NLE and isoquercitrin exerted free radical scavenging activity. Especially, isoquercitrin exhibited strong intracellular antioxidant capacity in human skin-derived cells, HaCaT and NHDF. Finally, we performed clinical test for the inhibitory effect of NLE on skin wrinkle formation. A randomized study was conducted in 22 healthy female volunteers, aged between 30 and 65 yrs, with moderate to moderately severe facial wrinkles. Volunteer applied a 1.7% NLE cream (isoquercitrin 51 ppm) and a control cream at each facial side (left/right) twice daily for 8 weeks. The 1.7% NLE cream improved skin roughness through reducing the wrinkle of the craw's feet significantly without any skin side effect. Our results demonstrate that NLE and isoquercitrin can increase the collagen production and exert antioxidant activity. Therefore, we expect that the new non-toxic herbal extract, isoquercitrin-containing NLE will be interesting natural ingredient of cosmetics with anti-wrinkle efficacy.