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http://dx.doi.org/10.15230/SCSK.2018.44.2.191

Effect of Isoquercitrin-containing Nelumbo nucifera Leaves Extract on Skin Wrinkle Improvement  

Moon, Eunjung (Charmzone R&D Center, Charmzone Co. Ltd.)
Jeon, Junmyeong (Charmzone R&D Center, Charmzone Co. Ltd.)
Lee, Gahee (Charmzone R&D Center, Charmzone Co. Ltd.)
Baik, Minyoung (Charmzone R&D Center, Charmzone Co. Ltd.)
Lee, Dae Woo (R&D Center, Dermalab Co.Ltd.)
Publication Information
Journal of the Society of Cosmetic Scientists of Korea / v.44, no.2, 2018 , pp. 191-200 More about this Journal
Abstract
In this study, we conducted research to find anti-wrinkle skin care ingredients from natural sources via the measurement of procollagen type 1 levels in the medium of normal human dermal fibroblast (NHDF) and found that a Nelumbo nucifera leave extract (NLE) was as the best effective ingredient. By the high performance liquid chromatography analysis, we confirmed isoquercitrin was one of the main compounds of NLE. Moreover, it also increased the procollagen type 1 production without cytotoxicity of NHDF. NLE and isoquercitrin exerted free radical scavenging activity. Especially, isoquercitrin exhibited strong intracellular antioxidant capacity in human skin-derived cells, HaCaT and NHDF. Finally, we performed clinical test for the inhibitory effect of NLE on skin wrinkle formation. A randomized study was conducted in 22 healthy female volunteers, aged between 30 and 65 yrs, with moderate to moderately severe facial wrinkles. Volunteer applied a 1.7% NLE cream (isoquercitrin 51 ppm) and a control cream at each facial side (left/right) twice daily for 8 weeks. The 1.7% NLE cream improved skin roughness through reducing the wrinkle of the craw's feet significantly without any skin side effect. Our results demonstrate that NLE and isoquercitrin can increase the collagen production and exert antioxidant activity. Therefore, we expect that the new non-toxic herbal extract, isoquercitrin-containing NLE will be interesting natural ingredient of cosmetics with anti-wrinkle efficacy.
Keywords
hair treatment; polymers; shampoo; fine coacervate; hair damage;
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