• Nuclear Engineering and Technology
• /
• v.53 no.11
• /
• pp.3543-3562
• /
• 2021

The methods and performance of a 3D pin-by-pin neutronics code based on the 2D/1D decoupling method are presented. The code was newly developed as an effort to achieve enhanced accuracy and high calculation performance that are sufficient for the use in practical nuclear design analyses. From the 3D diffusion-based finite difference method (FDM) formulation, decoupled planar formulations are established by treating pre-determined axial leakage as a source term. The decoupled axial problems are formulated with the radial leakage source term. To accelerate the pin-by-pin calculation, the two-level coarse mesh finite difference (CMFD) formulation, which consists of the multigroup node-wise CMFD and the two-group assembly-wise CMFD is implemented. To enhance the accuracy, both the discontinuity factor method and the super-homogenization (SPH) factor method are examined for pin-wise cross-section homogenization. The parallelization is achieved with the OpenMP package. The accuracy and performance of the pin-by-pin calculations are assessed with the VERA and APR1400 benchmark problems. It is demonstrated that pin-by-pin 2D/1D alternating calculations within the two-level 3D CMFD framework yield accurate solutions in about 30 s for the typical commercial core problems, on a parallel platform employing 32 threads.

• BMB Reports
• /
• v.56 no.9
• /
• pp.508-513
• /
• 2023

The phytochemical quercetin has gained attention for its anti-inflammatory and anti-tumorigenic properties in various types of cancer. Tumorigenesis involves the aberrant regulation of kinase/phosphatase, highlighting the importance of maintaining homeostasis. Dual Specificity Phosphatase (DUSP) plays a crucial role in controlling the phosphorylation of ERK. The current study aimed to clone the DUSP5 promoter, and investigate its transcriptional activity in the presence of quercetin. The results revealed that quercetin-induced DUSP5 expression is associated with the serum response factor (SRF) binding site located in the DUSP5 promoter. The deletion of this site abolished the luciferase activity induced by quercetin, indicating its vital role in quercetin-induced DUSP5 expression. SRF protein is a transcription factor that potentially contributes to quercetin-induced DUSP5 expression at the transcriptional level. Additionally, quercetin enhanced SRF binding activity without changing its expression. These findings provide evidence of how quercetin affects anti-cancer activity in colorectal tumorigenesis by inducing SRF transcription factor activity, thereby increasing DUSP5 expression at the transcriptional level. This study highlights the importance of investigating the molecular mechanisms underlying the anti-cancer properties of quercetin, and suggests its potential use in cancer therapy.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.268.2-269
• /
• 2002

The recombinant histamine-releasing factor (rHRF) has been reported to induce a secretion of histamine and cytokines from inflammation-related cell types such as basophils and eosinophils. and to function as a growth factor in immune B cells. Recently. decreased expression level of HRF protein was observed in brain of patients with Alzheimer disease and Downs syndrome. suggesting a possible significant role in neurological systems. (omitted)

• 제어로봇시스템학회:학술대회논문집
• /
• 1992.10a
• /
• pp.123-128
• /
• 1992

This paper presents an autotuning algorithm of scaling factor in order to improve system performance. We define the scaling factor of fuzzy controller as a function of error and error change. This function is tuned by the output of performance evaluation level utilizing the error of overshoot and rising time. Simulation results show that the proposed algorithm has good tuning performance for a system with parameter change.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.293.2-293.2
• /
• 2002

Bisphenol A ［BPA. 2.2-bis(4-hydroxyphenyl)propane］ is reported to have estrogenic activity: however. its influence on cytokine production or immune system function remains unclear. In this study. we investigated the effects of BPA on the production of nitric oxide (NO) and tumor necrosis factor-a (TNF-a), and on the level of inducible nitric oxide synthase (iNOS) and TNF-a gene expression in mouse macrophages. BPA alone did not affect NO or TNF-a production. (omitted)

• Journal of Korean Academy of Nursing
• /
• v.27 no.4
• /
• pp.831-842
• /
• 1997

The purpose of the study was to test the reliability and validity of the Korean version of Task Self-Efficacy Scale for activities of dally living (ADL). The Task Self-Efficacy Scale was developed by Roberts(1996) for low-intensity exercise study with older people to predict their performance of ADL. The scale was translated and back translated by bilingual persons, and then was modified to resolve variations in the translations. The Korean version of Self-Efficacy Scale for ADL was then administered to 193 elderly people including 95 hospitalized patients and 98 outpatients or healthy people. Face to face interview was used to fill out the structured questionnaire, and each interview took approximately 30 minutes. The subjects for the study were 80 women and 112 men with an age range of 65 to 95 years(M=71 years) of whom 82.6% classified themselves as moderate or quite active Most subjects(80.2%) had an education level of elementary school or less. The Self-Efficacy Scale for ADL is measured on a 0 to 10 VAS, assessing three areas of ADL : self care activities, household tasks, and motor tasks. The higher the score is, the higher person's confidence in performing ADL. Psychometric testing revealed that the scale was found to be internally consistent, showing a Cronbach's alpha of .97 The scale was significantly correlated with subjects' level of activity and subjective assessment of their health status. Moderate correlation with health-related hardiness scale also supported the validity. Factor analysis was performed to confirm whether the scale represents the three sub-areas as suggested in the literature. The results of the factor analysis led to a three factor solution according to Kaiser's criterion, but the items were not strongly and cleanly loaded for the third factor. This can be explained in that, among the three sub-ADL areas of the self-efficacy scale, the areas of self care activities and household tasks seem to have similar levels of difficulty in performance with not enough differences for the self-efficacy scale to distinguish between the two areas. Therefore, one factor solution was suggested since ADL can be seen as a unit of activities at similar level of difficulty in performance. One factor solution explained 68.1% of variance of the 19-item scale and all items were correlated over .6 with the factor, showing that the selected factor solution fits the model. The results indicated that the Korean version of Task Self-Efficacy Scale for ADL was reliable and valid in producing useful information to evaluate the effects of various interventions toward promoting health and quality of life for elderly people.

• Journal of the Korean Data and Information Science Society
• /
• v.18 no.2
• /
• pp.525-534
• /
• 2007

It is a common practice in many research areas that multiple range tests for a between subject factor such as Tukey are applied to a within subject factor in a repeated measures design. Tukey procedure, however, sometimes detects no pairs with different means even when the hypothesis of all equal level means is rejected. This study attempts to provide a rationale for the proposition that Tukey is inappropriate post hoc procedure for a within subject factor in which the observations are correlated. We introduce two multiple range tests, Bonferroni and Scheffe, for a within subject factor and show that Bonferroni is more appropriate than Scheffe for pairwise multiple comparisons. Subsequent simulation study indicates that Tukey has significantly less power than Bonferroni in detecting actual difference between means of some pairs when the observations of a within subject factor are highly correlated.

• Journal of Korean Academy of Nursing
• /
• v.16 no.3
• /
• pp.31-37
• /
• 1986

The purpose of this study is to develop a ratio scale measuring organizational charateristics in nursing. 599 staff nurses working at 10 educational hospitals in Seoul were participated during the period from July 1 to July 31, 1985. Subjects were instructed to rate at one to five points likert type scale according to the level of positive characteristics affecting the nursing organizational effectiveness. As a result of factor analysis given to 50 items with varimax rotation and rearrangement on the asis of factor loading 0.3, there are 4 factors consisted of 33 items presented: factor 1 : leadership of head nurses and interaction(11 items) factor 2 : leadership of supervisors and top managers(11 items) factor 3 : interaction with supervisors(5 items) factor 4 : organizational climate(6 items) Reliability of the factors were tested by Cronbach's Alpha, and the result was α=0.67∼0.84 Further studies are needed to identify the relationship between this tool and the effectiveness of various organization in nursing.

• Journal of the Korean Society for Railway
• /
• v.6 no.4
• /
• pp.239-245
• /
• 2003

In this paper, the track impact factor of conventional line was evaluated using the data for wheel load measured in field and the properties of current operating trains. The equation for track impact factor was presented through the statistical analysis of variational ratio in wheel load and compared with other design equations in domestic and foreign countries. A review on the safety of track system in conventional line was made from the relationship between the velocity and the corresponding impact factor. It was found that the impact factor from the proposed equation is a little less than the values from the equations adopted in both AREA and domestic railway, while it is same as the equation for continuous welded rail(CWR) in Japan. Therefore it could be said that the track satisfies a criteria for dynamic load caused by the train and the corresponding level of safety is guaranteed for dynamic load of the train

• Korean journal of food and cookery science
• /
• v.30 no.3
• /
• pp.360-367
• /
• 2014

This study analyzed the Importance-Performance Analysis of selective attributes of Ethnic Food Restaurant. A total of 369 questionnaires were analyzed. Five factors were obtained from factor analysis of Importance variance of selective attributes of Ethnic food restaurant: Factor 1 "Quality", Factor 2 "Service", Factor 3 "Physical environment", Factor 4 "Uniqueness", Factor 5 "Health". Also, "Quality", "Physical environment", "Uniqueness" factors influenced overall satisfaction. In addition, according to the IPA results, selective attributes with low satisfaction and high importance in the second quadrant were 'Sanitation that comfort hospitality', 'Level of service' and 'Price'. These results suggest that when customers select Ethnic food restaurant, they consider 'food price' and 'food quality'. Therefore, manager of ethnic food restaurant should take these improvement factors into consideration in order to meet consumer's expectations.